Putative aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MF, Family M17

Species:

Leishmania braziliensis

UniProt:

A4H6I8_LEIBR

TriTrypDb:

LbrM.11.0410 , LBRM2903_110008900

Length:

538

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 8
Pissara et al.	yes	yes: 36

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 12

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	21
GO:0110165	cellular anatomical entity	1	21
GO:0005654	nucleoplasm	2	1

Expansion

Sequence features

A4H6I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6I8

PDB structure(s): 5nth_A

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	21
GO:0006807	nitrogen compound metabolic process	2	21
GO:0008152	metabolic process	1	21
GO:0019538	protein metabolic process	3	21
GO:0043170	macromolecule metabolic process	3	21
GO:0044238	primary metabolic process	2	21
GO:0071704	organic substance metabolic process	2	21
GO:1901564	organonitrogen compound metabolic process	3	21

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	21
GO:0004177	aminopeptidase activity	5	21
GO:0005488	binding	1	21
GO:0008233	peptidase activity	3	21
GO:0008235	metalloexopeptidase activity	5	21
GO:0008237	metallopeptidase activity	4	21
GO:0008238	exopeptidase activity	4	21
GO:0016787	hydrolase activity	2	21
GO:0030145	manganese ion binding	6	21
GO:0043167	ion binding	2	21
GO:0043169	cation binding	3	21
GO:0046872	metal ion binding	4	21
GO:0046914	transition metal ion binding	5	21
GO:0070006	metalloaminopeptidase activity	6	21
GO:0140096	catalytic activity, acting on a protein	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	535	537	PF00675	0.332
CLV_NRD_NRD_1	76	78	PF00675	0.219
CLV_PCSK_KEX2_1	5	7	PF00082	0.528
CLV_PCSK_KEX2_1	76	78	PF00082	0.215
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.528
CLV_PCSK_SKI1_1	188	192	PF00082	0.458
CLV_PCSK_SKI1_1	337	341	PF00082	0.460
CLV_PCSK_SKI1_1	392	396	PF00082	0.350
CLV_PCSK_SKI1_1	76	80	PF00082	0.360
DOC_CKS1_1	220	225	PF01111	0.460
DOC_MAPK_gen_1	27	34	PF00069	0.252
DOC_MAPK_gen_1	366	375	PF00069	0.362
DOC_MAPK_gen_1	503	511	PF00069	0.437
DOC_MAPK_gen_1	57	66	PF00069	0.372
DOC_MAPK_MEF2A_6	176	185	PF00069	0.402
DOC_MAPK_MEF2A_6	503	511	PF00069	0.352
DOC_PP1_RVXF_1	186	192	PF00149	0.362
DOC_PP4_FxxP_1	504	507	PF00568	0.321
DOC_PP4_FxxP_1	66	69	PF00568	0.347
DOC_USP7_MATH_1	106	110	PF00917	0.451
DOC_USP7_MATH_1	426	430	PF00917	0.460
DOC_USP7_MATH_1	487	491	PF00917	0.349
DOC_USP7_MATH_1	514	518	PF00917	0.441
DOC_USP7_UBL2_3	172	176	PF12436	0.515
DOC_WW_Pin1_4	219	224	PF00397	0.385
DOC_WW_Pin1_4	469	474	PF00397	0.365
LIG_14-3-3_CanoR_1	6	13	PF00244	0.516
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BIR_III_4	388	392	PF00653	0.350
LIG_BRCT_BRCA1_1	62	66	PF00533	0.367
LIG_CtBP_PxDLS_1	252	258	PF00389	0.385
LIG_DLG_GKlike_1	116	124	PF00625	0.452
LIG_FHA_1	134	140	PF00498	0.277
LIG_FHA_1	176	182	PF00498	0.486
LIG_FHA_1	353	359	PF00498	0.379
LIG_FHA_1	84	90	PF00498	0.345
LIG_FHA_2	128	134	PF00498	0.304
LIG_FHA_2	385	391	PF00498	0.346
LIG_LIR_Apic_2	278	284	PF02991	0.460
LIG_LIR_Apic_2	467	473	PF02991	0.370
LIG_LIR_Apic_2	502	507	PF02991	0.315
LIG_LIR_Apic_2	63	69	PF02991	0.372
LIG_LIR_Gen_1	229	240	PF02991	0.350
LIG_LIR_Gen_1	343	354	PF02991	0.456
LIG_LIR_Gen_1	94	104	PF02991	0.296
LIG_LIR_Nem_3	229	235	PF02991	0.350
LIG_LIR_Nem_3	257	263	PF02991	0.359
LIG_LIR_Nem_3	343	349	PF02991	0.456
LIG_LIR_Nem_3	454	460	PF02991	0.350
LIG_LIR_Nem_3	94	99	PF02991	0.364
LIG_LYPXL_yS_3	457	460	PF13949	0.321
LIG_Pex14_2	504	508	PF04695	0.417
LIG_SH2_CRK	260	264	PF00017	0.359
LIG_SH2_CRK	281	285	PF00017	0.460
LIG_SH2_CRK	470	474	PF00017	0.472
LIG_SH2_NCK_1	232	236	PF00017	0.460
LIG_SH2_NCK_1	346	350	PF00017	0.372
LIG_SH2_NCK_1	96	100	PF00017	0.257
LIG_SH2_SRC	232	235	PF00017	0.321
LIG_SH2_STAP1	232	236	PF00017	0.370
LIG_SH2_STAP1	239	243	PF00017	0.310
LIG_SH2_STAT3	174	177	PF00017	0.538
LIG_SH2_STAT5	140	143	PF00017	0.407
LIG_SH2_STAT5	163	166	PF00017	0.439
LIG_SH2_STAT5	21	24	PF00017	0.550
LIG_SH2_STAT5	435	438	PF00017	0.385
LIG_SH2_STAT5	461	464	PF00017	0.381
LIG_SH2_STAT5	494	497	PF00017	0.353
LIG_SH2_STAT5	534	537	PF00017	0.282
LIG_SH2_STAT5	67	70	PF00017	0.362
LIG_SH2_STAT5	96	99	PF00017	0.408
LIG_SH3_3	138	144	PF00018	0.453
LIG_SH3_3	217	223	PF00018	0.342
LIG_SH3_3	452	458	PF00018	0.394
LIG_Sin3_3	332	339	PF02671	0.460
LIG_SUMO_SIM_anti_2	246	251	PF11976	0.236
LIG_SUMO_SIM_anti_2	371	378	PF11976	0.385
LIG_SUMO_SIM_anti_2	381	388	PF11976	0.385
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.215
LIG_TRAF2_1	12	15	PF00917	0.521
LIG_TYR_ITIM	230	235	PF00017	0.460
LIG_TYR_ITIM	455	460	PF00017	0.321
LIG_UBA3_1	33	39	PF00899	0.272
MOD_CK1_1	16	22	PF00069	0.430
MOD_CK1_1	378	384	PF00069	0.359
MOD_CK1_1	38	44	PF00069	0.486
MOD_CK1_1	483	489	PF00069	0.425
MOD_CK1_1	517	523	PF00069	0.356
MOD_CK1_1	60	66	PF00069	0.417
MOD_CK2_1	116	122	PF00069	0.321
MOD_CK2_1	127	133	PF00069	0.471
MOD_CK2_1	384	390	PF00069	0.346
MOD_CK2_1	8	14	PF00069	0.499
MOD_GlcNHglycan	10	13	PF01048	0.516
MOD_GlcNHglycan	14	18	PF01048	0.439
MOD_GlcNHglycan	166	169	PF01048	0.239
MOD_GlcNHglycan	324	327	PF01048	0.451
MOD_GlcNHglycan	377	380	PF01048	0.359
MOD_GlcNHglycan	451	454	PF01048	0.336
MOD_GlcNHglycan	485	488	PF01048	0.448
MOD_GSK3_1	104	111	PF00069	0.437
MOD_GSK3_1	482	489	PF00069	0.391
MOD_GSK3_1	517	524	PF00069	0.383
MOD_N-GLC_1	192	197	PF02516	0.416
MOD_N-GLC_1	350	355	PF02516	0.460
MOD_NEK2_1	175	180	PF00069	0.448
MOD_NEK2_1	226	231	PF00069	0.359
MOD_NEK2_1	322	327	PF00069	0.423
MOD_PK_1	57	63	PF00069	0.372
MOD_PKB_1	6	14	PF00069	0.506
MOD_Plk_1	13	19	PF00069	0.477
MOD_Plk_1	192	198	PF00069	0.530
MOD_Plk_1	245	251	PF00069	0.347
MOD_Plk_1	350	356	PF00069	0.461
MOD_Plk_1	57	63	PF00069	0.427
MOD_Plk_1	97	103	PF00069	0.441
MOD_Plk_2-3	133	139	PF00069	0.372
MOD_Plk_4	226	232	PF00069	0.455
MOD_Plk_4	526	532	PF00069	0.372
MOD_ProDKin_1	219	225	PF00069	0.385
MOD_ProDKin_1	469	475	PF00069	0.365
MOD_SUMO_for_1	250	253	PF00179	0.428
MOD_SUMO_for_1	439	442	PF00179	0.215
MOD_SUMO_rev_2	2	7	PF00179	0.534
MOD_SUMO_rev_2	437	441	PF00179	0.215
TRG_ENDOCYTIC_2	232	235	PF00928	0.460
TRG_ENDOCYTIC_2	260	263	PF00928	0.350
TRG_ENDOCYTIC_2	346	349	PF00928	0.372
TRG_ENDOCYTIC_2	457	460	PF00928	0.321
TRG_ENDOCYTIC_2	96	99	PF00928	0.467
TRG_ER_diArg_1	75	77	PF00400	0.215
TRG_NES_CRM1_1	205	217	PF08389	0.480
TRG_NLS_MonoExtC_3	4	10	PF00514	0.514
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.215

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E6	Leptomonas seymouri	42%	100%
A0A0N1PAS4	Leptomonas seymouri	79%	100%
A0A0S4IQ79	Bodo saltans	42%	100%
A0A1X0NWR5	Trypanosomatidae	49%	100%
A0A1X0P4M9	Trypanosomatidae	39%	100%
A0A3R7JY84	Trypanosoma rangeli	50%	100%
A0A3R7N130	Trypanosoma rangeli	41%	96%
A0A3S7WRP1	Leishmania donovani	85%	100%
A0A3S7X742	Leishmania donovani	44%	100%
A4HLW7	Leishmania braziliensis	43%	100%
A4HUX3	Leishmania infantum	85%	100%
A4I996	Leishmania infantum	44%	100%
A8EXL1	Rickettsia canadensis (strain McKiel)	31%	100%
A8GHX6	Serratia proteamaculans (strain 568)	32%	100%
A9IIK3	Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448)	29%	100%
B1LVC3	Methylobacterium radiotolerans (strain ATCC 27329 / DSM 1819 / JCM 2831 / NBRC 15690 / NCIMB 10815 / 0-1)	29%	100%
B1V932	Phytoplasma australiense	30%	100%
B2FMS4	Stenotrophomonas maltophilia (strain K279a)	31%	100%
B2J3G8	Nostoc punctiforme (strain ATCC 29133 / PCC 73102)	30%	100%
B2JET5	Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 / STM815)	28%	100%
B3PUV3	Rhizobium etli (strain CIAT 652)	32%	100%
B5ZWY7	Rhizobium leguminosarum bv. trifolii (strain WSM2304)	32%	100%
B7KCB0	Gloeothece citriformis (strain PCC 7424)	28%	100%
B8HTK3	Cyanothece sp. (strain PCC 7425 / ATCC 29141)	28%	100%
C1F4B7	Acidobacterium capsulatum (strain ATCC 51196 / DSM 11244 / BCRC 80197 / JCM 7670 / NBRC 15755 / NCIMB 13165 / 161)	31%	100%
C3M9C8	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	30%	100%
C4K346	Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT)	30%	100%
C4LA51	Tolumonas auensis (strain DSM 9187 / TA4)	31%	100%
C5CCM4	Micrococcus luteus (strain ATCC 4698 / DSM 20030 / JCM 1464 / NBRC 3333 / NCIMB 9278 / NCTC 2665 / VKM Ac-2230)	32%	100%
D0A654	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	95%
D0A7H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ANK8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9B496	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
P47707	Metamycoplasma salivarium	28%	100%
Q12AW5	Polaromonas sp. (strain JS666 / ATCC BAA-500)	31%	100%
Q143Y9	Paraburkholderia xenovorans (strain LB400)	27%	100%
Q1MIZ4	Rhizobium leguminosarum bv. viciae (strain 3841)	32%	100%
Q315M7	Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20)	28%	100%
Q3KMX6	Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13)	30%	100%
Q3M9J6	Trichormus variabilis (strain ATCC 29413 / PCC 7937)	29%	100%
Q4Q3T0	Leishmania major	43%	95%
Q4QH17	Leishmania major	85%	100%
Q5FFZ5	Ehrlichia ruminantium (strain Gardel)	29%	100%
Q5HAP2	Ehrlichia ruminantium (strain Welgevonden)	29%	100%
Q5R7G6	Pongo abelii	40%	100%
Q65SA3	Mannheimia succiniciproducens (strain MBEL55E)	31%	100%
Q68XM6	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	30%	100%
Q6MC72	Protochlamydia amoebophila (strain UWE25)	29%	100%
Q6MH10	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	30%	100%
Q6NSR8	Mus musculus	40%	100%
Q73YK2	Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)	30%	100%
Q7M8W6	Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)	30%	100%
Q7N231	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	33%	100%
Q7VGF0	Helicobacter hepaticus (strain ATCC 51449 / 3B1)	34%	100%
Q816E3	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	30%	100%
Q8NDH3	Homo sapiens	40%	100%
Q8NNJ4	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	36%	100%
Q8Z064	Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)	27%	100%
Q92QY7	Rhizobium meliloti (strain 1021)	30%	100%
Q9KTX5	Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)	32%	100%
Q9PP04	Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)	31%	100%
V5BTR1	Trypanosoma cruzi	41%	97%
V5BWE3	Trypanosoma cruzi	48%	100%