Putative aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MF, Family M17

Species:

Leishmania braziliensis

UniProt:

A4H6I7_LEIBR

TriTrypDb:

LbrM.11.0400 , LBRM2903_110008800

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H6I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6I7

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004177	aminopeptidase activity	5	2
GO:0005488	binding	1	2
GO:0008233	peptidase activity	3	2
GO:0008235	metalloexopeptidase activity	5	2
GO:0008237	metallopeptidase activity	4	2
GO:0008238	exopeptidase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0030145	manganese ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0070006	metalloaminopeptidase activity	6	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	76	78	PF00675	0.600
CLV_PCSK_KEX2_1	5	7	PF00082	0.823
CLV_PCSK_KEX2_1	76	78	PF00082	0.600
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.823
CLV_PCSK_SKI1_1	76	80	PF00082	0.600
DOC_MAPK_gen_1	27	34	PF00069	0.714
DOC_MAPK_gen_1	57	66	PF00069	0.600
DOC_PP4_FxxP_1	66	69	PF00568	0.600
DOC_USP7_MATH_1	106	110	PF00917	0.600
LIG_14-3-3_CanoR_1	110	114	PF00244	0.425
LIG_14-3-3_CanoR_1	157	165	PF00244	0.600
LIG_14-3-3_CanoR_1	6	13	PF00244	0.787
LIG_BIR_II_1	1	5	PF00653	0.855
LIG_BRCT_BRCA1_1	62	66	PF00533	0.600
LIG_DLG_GKlike_1	116	124	PF00625	0.600
LIG_FHA_1	134	140	PF00498	0.600
LIG_FHA_1	84	90	PF00498	0.600
LIG_FHA_2	128	134	PF00498	0.600
LIG_LIR_Apic_2	63	69	PF02991	0.600
LIG_LIR_Gen_1	175	184	PF02991	0.798
LIG_LIR_Gen_1	94	104	PF02991	0.600
LIG_LIR_Nem_3	175	181	PF02991	0.796
LIG_LIR_Nem_3	94	99	PF02991	0.600
LIG_NRBOX	179	185	PF00104	0.799
LIG_SH2_NCK_1	96	100	PF00017	0.600
LIG_SH2_STAT5	140	143	PF00017	0.600
LIG_SH2_STAT5	21	24	PF00017	0.724
LIG_SH2_STAT5	67	70	PF00017	0.600
LIG_SH2_STAT5	96	99	PF00017	0.600
LIG_SH3_3	138	144	PF00018	0.600
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.600
LIG_SUMO_SIM_par_1	179	185	PF11976	0.799
LIG_TRAF2_1	12	15	PF00917	0.740
LIG_UBA3_1	33	39	PF00899	0.702
MOD_CK1_1	109	115	PF00069	0.425
MOD_CK1_1	16	22	PF00069	0.722
MOD_CK1_1	182	188	PF00069	0.811
MOD_CK1_1	38	44	PF00069	0.689
MOD_CK1_1	60	66	PF00069	0.600
MOD_CK2_1	116	122	PF00069	0.600
MOD_CK2_1	127	133	PF00069	0.407
MOD_CK2_1	182	188	PF00069	0.811
MOD_CK2_1	8	14	PF00069	0.770
MOD_GlcNHglycan	10	13	PF01048	0.774
MOD_GlcNHglycan	14	18	PF01048	0.649
MOD_GSK3_1	104	111	PF00069	0.600
MOD_NEK2_1	159	164	PF00069	0.600
MOD_NEK2_1	179	184	PF00069	0.450
MOD_PK_1	57	63	PF00069	0.600
MOD_PKA_2	109	115	PF00069	0.425
MOD_PKB_1	6	14	PF00069	0.781
MOD_Plk_1	13	19	PF00069	0.726
MOD_Plk_1	57	63	PF00069	0.600
MOD_Plk_1	97	103	PF00069	0.600
MOD_Plk_2-3	133	139	PF00069	0.600
MOD_Plk_4	179	185	PF00069	0.799
MOD_SUMO_rev_2	2	7	PF00179	0.837
TRG_DiLeu_BaEn_2	174	180	PF01217	0.786
TRG_ENDOCYTIC_2	96	99	PF00928	0.600
TRG_ER_diArg_1	75	77	PF00400	0.600
TRG_NLS_MonoExtC_3	4	10	PF00514	0.812