CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 47, putative

Species:

Leishmania braziliensis

UniProt:

A4H6I6_LEIBR

TriTrypDb:

LbrM.11.0380 , LBRM2903_110008600

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6I6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6I6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0005488	binding	1	7
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0046914	transition metal ion binding	5	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.552
CLV_C14_Caspase3-7	167	171	PF00656	0.728
CLV_C14_Caspase3-7	183	187	PF00656	0.764
CLV_C14_Caspase3-7	189	193	PF00656	0.797
CLV_C14_Caspase3-7	196	200	PF00656	0.651
CLV_NRD_NRD_1	123	125	PF00675	0.554
CLV_NRD_NRD_1	28	30	PF00675	0.499
CLV_NRD_NRD_1	393	395	PF00675	0.608
CLV_NRD_NRD_1	467	469	PF00675	0.732
CLV_NRD_NRD_1	489	491	PF00675	0.759
CLV_NRD_NRD_1	541	543	PF00675	0.657
CLV_NRD_NRD_1	79	81	PF00675	0.744
CLV_PCSK_KEX2_1	276	278	PF00082	0.584
CLV_PCSK_KEX2_1	28	30	PF00082	0.555
CLV_PCSK_KEX2_1	393	395	PF00082	0.629
CLV_PCSK_KEX2_1	467	469	PF00082	0.732
CLV_PCSK_KEX2_1	489	491	PF00082	0.761
CLV_PCSK_KEX2_1	541	543	PF00082	0.657
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.626
CLV_PCSK_SKI1_1	305	309	PF00082	0.709
CLV_PCSK_SKI1_1	310	314	PF00082	0.706
CLV_PCSK_SKI1_1	37	41	PF00082	0.633
CLV_PCSK_SKI1_1	54	58	PF00082	0.420
DEG_Kelch_Keap1_1	176	181	PF01344	0.586
DEG_SCF_TRCP1_1	600	605	PF00400	0.824
DEG_SPOP_SBC_1	98	102	PF00917	0.697
DOC_CKS1_1	13	18	PF01111	0.573
DOC_CKS1_1	289	294	PF01111	0.668
DOC_PIKK_1	196	204	PF02985	0.600
DOC_PP1_RVXF_1	248	254	PF00149	0.564
DOC_PP2B_LxvP_1	528	531	PF13499	0.585
DOC_USP7_MATH_1	139	143	PF00917	0.707
DOC_USP7_MATH_1	144	148	PF00917	0.592
DOC_USP7_MATH_1	219	223	PF00917	0.688
DOC_USP7_MATH_1	299	303	PF00917	0.626
DOC_USP7_MATH_1	411	415	PF00917	0.576
DOC_USP7_MATH_1	445	449	PF00917	0.815
DOC_USP7_MATH_1	524	528	PF00917	0.826
DOC_USP7_MATH_1	580	584	PF00917	0.592
DOC_USP7_MATH_1	79	83	PF00917	0.703
DOC_WW_Pin1_4	12	17	PF00397	0.590
DOC_WW_Pin1_4	153	158	PF00397	0.646
DOC_WW_Pin1_4	284	289	PF00397	0.660
DOC_WW_Pin1_4	290	295	PF00397	0.565
DOC_WW_Pin1_4	297	302	PF00397	0.478
DOC_WW_Pin1_4	349	354	PF00397	0.650
DOC_WW_Pin1_4	361	366	PF00397	0.612
DOC_WW_Pin1_4	437	442	PF00397	0.837
DOC_WW_Pin1_4	510	515	PF00397	0.834
DOC_WW_Pin1_4	522	527	PF00397	0.638
DOC_WW_Pin1_4	89	94	PF00397	0.601
LIG_14-3-3_CanoR_1	373	378	PF00244	0.572
LIG_AP2alpha_2	535	537	PF02296	0.585
LIG_CaM_IQ_9	462	478	PF13499	0.588
LIG_DCNL_PONY_1	1	4	PF03556	0.544
LIG_eIF4E_1	604	610	PF01652	0.814
LIG_FHA_1	150	156	PF00498	0.566
LIG_FHA_1	285	291	PF00498	0.752
LIG_FHA_1	337	343	PF00498	0.709
LIG_FHA_1	90	96	PF00498	0.614
LIG_FHA_2	181	187	PF00498	0.731
LIG_FHA_2	298	304	PF00498	0.699
LIG_Integrin_RGD_1	184	186	PF01839	0.606
LIG_LIR_Apic_2	242	248	PF02991	0.510
LIG_LIR_Apic_2	437	441	PF02991	0.622
LIG_LIR_Gen_1	231	240	PF02991	0.626
LIG_LIR_Gen_1	344	354	PF02991	0.774
LIG_LIR_Gen_1	447	455	PF02991	0.580
LIG_LIR_Nem_3	231	237	PF02991	0.637
LIG_LIR_Nem_3	331	335	PF02991	0.546
LIG_LIR_Nem_3	344	349	PF02991	0.662
LIG_LIR_Nem_3	366	372	PF02991	0.578
LIG_LIR_Nem_3	376	381	PF02991	0.578
LIG_LIR_Nem_3	447	452	PF02991	0.808
LIG_LIR_Nem_3	48	52	PF02991	0.505
LIG_PDZ_Class_1	605	610	PF00595	0.558
LIG_Pex14_2	132	136	PF04695	0.699
LIG_PTAP_UEV_1	223	228	PF05743	0.556
LIG_PTB_Apo_2	384	391	PF02174	0.740
LIG_PTB_Phospho_1	384	390	PF10480	0.738
LIG_SH2_CRK	234	238	PF00017	0.779
LIG_SH2_CRK	245	249	PF00017	0.470
LIG_SH2_CRK	280	284	PF00017	0.660
LIG_SH2_CRK	346	350	PF00017	0.774
LIG_SH2_CRK	438	442	PF00017	0.679
LIG_SH2_CRK	49	53	PF00017	0.341
LIG_SH2_CRK	523	527	PF00017	0.665
LIG_SH2_GRB2like	485	488	PF00017	0.836
LIG_SH2_NCK_1	234	238	PF00017	0.648
LIG_SH2_NCK_1	245	249	PF00017	0.620
LIG_SH2_NCK_1	346	350	PF00017	0.774
LIG_SH2_NCK_1	511	515	PF00017	0.707
LIG_SH2_NCK_1	523	527	PF00017	0.631
LIG_SH2_SRC	245	248	PF00017	0.686
LIG_SH2_STAP1	346	350	PF00017	0.774
LIG_SH2_STAT3	427	430	PF00017	0.606
LIG_SH2_STAT3	579	582	PF00017	0.846
LIG_SH2_STAT5	390	393	PF00017	0.745
LIG_SH3_3	151	157	PF00018	0.576
LIG_SH3_3	221	227	PF00018	0.812
LIG_SH3_3	260	266	PF00018	0.549
LIG_SH3_3	286	292	PF00018	0.646
LIG_SH3_3	312	318	PF00018	0.508
LIG_SH3_3	337	343	PF00018	0.616
LIG_SH3_3	350	356	PF00018	0.548
LIG_SUMO_SIM_par_1	338	345	PF11976	0.727
LIG_SUMO_SIM_par_1	92	97	PF11976	0.710
LIG_TYR_ITIM	47	52	PF00017	0.510
LIG_WRC_WIRS_1	204	209	PF05994	0.599
MOD_CDK_SPK_2	153	158	PF00069	0.819
MOD_CK1_1	14	20	PF00069	0.650
MOD_CK1_1	156	162	PF00069	0.611
MOD_CK1_1	222	228	PF00069	0.609
MOD_CK1_1	425	431	PF00069	0.567
MOD_CK1_1	437	443	PF00069	0.533
MOD_CK1_1	447	453	PF00069	0.738
MOD_CK1_1	556	562	PF00069	0.684
MOD_CK1_1	89	95	PF00069	0.620
MOD_CK1_1	99	105	PF00069	0.708
MOD_CK2_1	159	165	PF00069	0.579
MOD_CK2_1	255	261	PF00069	0.704
MOD_CK2_1	297	303	PF00069	0.696
MOD_CK2_1	485	491	PF00069	0.849
MOD_CK2_1	556	562	PF00069	0.788
MOD_CK2_1	58	64	PF00069	0.611
MOD_Cter_Amidation	539	542	PF01082	0.602
MOD_GlcNHglycan	116	119	PF01048	0.735
MOD_GlcNHglycan	141	144	PF01048	0.678
MOD_GlcNHglycan	16	19	PF01048	0.572
MOD_GlcNHglycan	257	260	PF01048	0.586
MOD_GlcNHglycan	417	420	PF01048	0.699
MOD_GlcNHglycan	422	425	PF01048	0.764
MOD_GlcNHglycan	498	501	PF01048	0.751
MOD_GlcNHglycan	592	595	PF01048	0.785
MOD_GlcNHglycan	60	63	PF01048	0.631
MOD_GlcNHglycan	600	603	PF01048	0.701
MOD_GlcNHglycan	604	607	PF01048	0.647
MOD_GlcNHglycan	81	84	PF01048	0.711
MOD_GlcNHglycan	87	91	PF01048	0.729
MOD_GSK3_1	145	152	PF00069	0.703
MOD_GSK3_1	186	193	PF00069	0.828
MOD_GSK3_1	251	258	PF00069	0.545
MOD_GSK3_1	284	291	PF00069	0.750
MOD_GSK3_1	359	366	PF00069	0.739
MOD_GSK3_1	411	418	PF00069	0.740
MOD_GSK3_1	422	429	PF00069	0.586
MOD_GSK3_1	444	451	PF00069	0.746
MOD_GSK3_1	510	517	PF00069	0.705
MOD_GSK3_1	522	529	PF00069	0.643
MOD_GSK3_1	588	595	PF00069	0.735
MOD_GSK3_1	598	605	PF00069	0.733
MOD_GSK3_1	60	67	PF00069	0.637
MOD_GSK3_1	7	14	PF00069	0.732
MOD_GSK3_1	85	92	PF00069	0.676
MOD_GSK3_1	97	104	PF00069	0.663
MOD_N-GLC_1	415	420	PF02516	0.708
MOD_NEK2_1	116	121	PF00069	0.583
MOD_NEK2_1	132	137	PF00069	0.661
MOD_NEK2_1	149	154	PF00069	0.490
MOD_NEK2_1	269	274	PF00069	0.614
MOD_NEK2_1	335	340	PF00069	0.576
MOD_NEK2_1	348	353	PF00069	0.683
MOD_NEK2_1	415	420	PF00069	0.578
MOD_NEK2_1	422	427	PF00069	0.681
MOD_NEK2_1	516	521	PF00069	0.584
MOD_NEK2_2	127	132	PF00069	0.796
MOD_OFUCOSY	53	59	PF10250	0.654
MOD_PIKK_1	305	311	PF00454	0.725
MOD_PIKK_1	426	432	PF00454	0.781
MOD_PIKK_1	580	586	PF00454	0.798
MOD_PKA_2	556	562	PF00069	0.719
MOD_PKA_2	64	70	PF00069	0.774
MOD_PKA_2	79	85	PF00069	0.581
MOD_Plk_1	144	150	PF00069	0.559
MOD_Plk_1	335	341	PF00069	0.584
MOD_Plk_2-3	186	192	PF00069	0.765
MOD_Plk_2-3	546	552	PF00069	0.590
MOD_Plk_4	127	133	PF00069	0.695
MOD_Plk_4	150	156	PF00069	0.566
MOD_Plk_4	336	342	PF00069	0.699
MOD_Plk_4	373	379	PF00069	0.510
MOD_ProDKin_1	12	18	PF00069	0.581
MOD_ProDKin_1	153	159	PF00069	0.647
MOD_ProDKin_1	284	290	PF00069	0.661
MOD_ProDKin_1	297	303	PF00069	0.476
MOD_ProDKin_1	349	355	PF00069	0.648
MOD_ProDKin_1	361	367	PF00069	0.599
MOD_ProDKin_1	437	443	PF00069	0.837
MOD_ProDKin_1	510	516	PF00069	0.835
MOD_ProDKin_1	522	528	PF00069	0.640
MOD_ProDKin_1	89	95	PF00069	0.601
MOD_SUMO_rev_2	117	126	PF00179	0.567
MOD_SUMO_rev_2	32	39	PF00179	0.479
TRG_ENDOCYTIC_2	234	237	PF00928	0.778
TRG_ENDOCYTIC_2	332	335	PF00928	0.646
TRG_ENDOCYTIC_2	346	349	PF00928	0.540
TRG_ENDOCYTIC_2	49	52	PF00928	0.497
TRG_ER_diArg_1	227	230	PF00400	0.698
TRG_ER_diArg_1	27	29	PF00400	0.556
TRG_ER_diArg_1	531	534	PF00400	0.593
TRG_NES_CRM1_1	35	48	PF08389	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T4	Leptomonas seymouri	47%	100%
A0A3Q8I8Z7	Leishmania donovani	69%	100%
A4HUX1	Leishmania infantum	69%	100%
E9ANK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QH20	Leishmania major	70%	98%