Methylcrotonoyl-CoA carboxylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-methylcrotonoyl-CoA carboxylase beta subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H6I5_LEIBR

TriTrypDb:

LbrM.11.0370 , LBRM2903_110008500

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1905202	methylcrotonoyl-CoA carboxylase complex	3	1

Expansion

Sequence features

A4H6I5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6I5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006520	amino acid metabolic process	3	12
GO:0006551	leucine metabolic process	5	12
GO:0006552	leucine catabolic process	6	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009063	amino acid catabolic process	4	12
GO:0009081	branched-chain amino acid metabolic process	4	12
GO:0009083	branched-chain amino acid catabolic process	5	12
GO:0009987	cellular process	1	12
GO:0016054	organic acid catabolic process	4	12
GO:0019752	carboxylic acid metabolic process	5	12
GO:0043436	oxoacid metabolic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	12
GO:0044281	small molecule metabolic process	2	12
GO:0044282	small molecule catabolic process	3	12
GO:0046395	carboxylic acid catabolic process	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12
GO:1901605	alpha-amino acid metabolic process	4	12
GO:1901606	alpha-amino acid catabolic process	5	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004485	methylcrotonoyl-CoA carboxylase activity	5	8
GO:0016421	CoA carboxylase activity	4	8
GO:0016874	ligase activity	2	12
GO:0016885	ligase activity, forming carbon-carbon bonds	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	40	44	PF00656	0.332
CLV_NRD_NRD_1	310	312	PF00675	0.236
CLV_NRD_NRD_1	422	424	PF00675	0.291
CLV_NRD_NRD_1	89	91	PF00675	0.432
CLV_PCSK_KEX2_1	310	312	PF00082	0.236
CLV_PCSK_KEX2_1	422	424	PF00082	0.162
CLV_PCSK_SKI1_1	152	156	PF00082	0.298
CLV_PCSK_SKI1_1	215	219	PF00082	0.164
CLV_PCSK_SKI1_1	488	492	PF00082	0.236
CLV_PCSK_SKI1_1	515	519	PF00082	0.382
DEG_APCC_DBOX_1	422	430	PF00400	0.162
DEG_Nend_UBRbox_1	1	4	PF02207	0.391
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.571
DOC_MAPK_gen_1	310	318	PF00069	0.298
DOC_MAPK_gen_1	422	429	PF00069	0.298
DOC_MAPK_MEF2A_6	226	235	PF00069	0.342
DOC_MAPK_MEF2A_6	389	397	PF00069	0.285
DOC_MAPK_MEF2A_6	422	429	PF00069	0.236
DOC_PP1_RVXF_1	213	219	PF00149	0.164
DOC_PP2B_PxIxI_1	462	468	PF00149	0.236
DOC_PP4_FxxP_1	491	494	PF00568	0.236
DOC_USP7_MATH_1	221	225	PF00917	0.296
DOC_USP7_MATH_1	34	38	PF00917	0.370
DOC_USP7_MATH_1	575	579	PF00917	0.376
DOC_USP7_MATH_1	76	80	PF00917	0.515
DOC_USP7_UBL2_3	531	535	PF12436	0.251
DOC_WW_Pin1_4	23	28	PF00397	0.357
LIG_14-3-3_CanoR_1	21	30	PF00244	0.501
LIG_14-3-3_CanoR_1	276	282	PF00244	0.238
LIG_14-3-3_CanoR_1	497	501	PF00244	0.251
LIG_Actin_WH2_2	505	520	PF00022	0.382
LIG_CaM_IQ_9	525	540	PF13499	0.162
LIG_EVH1_2	266	270	PF00568	0.270
LIG_FHA_1	111	117	PF00498	0.270
LIG_FHA_1	258	264	PF00498	0.245
LIG_FHA_1	298	304	PF00498	0.288
LIG_FHA_1	457	463	PF00498	0.236
LIG_FHA_1	464	470	PF00498	0.236
LIG_FHA_1	544	550	PF00498	0.236
LIG_FHA_1	558	564	PF00498	0.242
LIG_FHA_2	38	44	PF00498	0.369
LIG_LIR_Gen_1	113	122	PF02991	0.236
LIG_LIR_Gen_1	370	379	PF02991	0.286
LIG_LIR_Gen_1	486	496	PF02991	0.295
LIG_LIR_Gen_1	7	16	PF02991	0.442
LIG_LIR_Nem_3	113	118	PF02991	0.236
LIG_LIR_Nem_3	166	170	PF02991	0.249
LIG_LIR_Nem_3	210	216	PF02991	0.273
LIG_LIR_Nem_3	370	375	PF02991	0.286
LIG_LIR_Nem_3	7	11	PF02991	0.446
LIG_Pex14_2	213	217	PF04695	0.236
LIG_Pex14_2	485	489	PF04695	0.236
LIG_Rb_pABgroove_1	331	339	PF01858	0.382
LIG_SH2_CRK	8	12	PF00017	0.511
LIG_SH2_SRC	12	15	PF00017	0.440
LIG_SH2_SRC	244	247	PF00017	0.263
LIG_SH2_SRC	441	444	PF00017	0.270
LIG_SH2_SRC	61	64	PF00017	0.332
LIG_SH2_STAP1	133	137	PF00017	0.414
LIG_SH2_STAP1	405	409	PF00017	0.236
LIG_SH2_STAP1	8	12	PF00017	0.511
LIG_SH2_STAT5	191	194	PF00017	0.284
LIG_SH2_STAT5	244	247	PF00017	0.264
LIG_SH2_STAT5	307	310	PF00017	0.345
LIG_SH2_STAT5	61	64	PF00017	0.475
LIG_SH2_STAT5	8	11	PF00017	0.438
LIG_SH3_3	329	335	PF00018	0.382
LIG_SH3_3	33	39	PF00018	0.464
LIG_SH3_3	551	557	PF00018	0.236
LIG_SUMO_SIM_par_1	508	513	PF11976	0.255
LIG_SUMO_SIM_par_1	79	84	PF11976	0.314
LIG_TRAF2_1	278	281	PF00917	0.190
LIG_TRAF2_1	69	72	PF00917	0.440
LIG_TYR_ITIM	6	11	PF00017	0.382
LIG_WW_1	334	337	PF00397	0.330
MOD_CK1_1	224	230	PF00069	0.425
MOD_CK1_1	37	43	PF00069	0.451
MOD_CK2_1	275	281	PF00069	0.196
MOD_CK2_1	518	524	PF00069	0.383
MOD_CK2_1	66	72	PF00069	0.415
MOD_Cter_Amidation	437	440	PF01082	0.295
MOD_GlcNHglycan	137	140	PF01048	0.276
MOD_GlcNHglycan	194	197	PF01048	0.236
MOD_GlcNHglycan	223	226	PF01048	0.282
MOD_GlcNHglycan	291	294	PF01048	0.251
MOD_GlcNHglycan	407	410	PF01048	0.254
MOD_GlcNHglycan	520	523	PF01048	0.176
MOD_GSK3_1	19	26	PF00069	0.471
MOD_GSK3_1	501	508	PF00069	0.423
MOD_GSK3_1	538	545	PF00069	0.251
MOD_N-GLC_1	198	203	PF02516	0.323
MOD_N-GLC_1	221	226	PF02516	0.162
MOD_N-GLC_1	257	262	PF02516	0.251
MOD_N-GLC_1	430	435	PF02516	0.236
MOD_N-GLC_1	518	523	PF02516	0.298
MOD_NEK2_1	116	121	PF00069	0.236
MOD_NEK2_1	192	197	PF00069	0.257
MOD_NEK2_1	378	383	PF00069	0.382
MOD_NEK2_1	455	460	PF00069	0.286
MOD_NEK2_1	501	506	PF00069	0.287
MOD_NEK2_1	510	515	PF00069	0.201
MOD_NEK2_1	568	573	PF00069	0.295
MOD_NEK2_1	92	97	PF00069	0.330
MOD_PIKK_1	116	122	PF00454	0.236
MOD_PIKK_1	21	27	PF00454	0.429
MOD_PIKK_1	417	423	PF00454	0.330
MOD_PIKK_1	501	507	PF00454	0.298
MOD_PKA_2	20	26	PF00069	0.417
MOD_PKA_2	275	281	PF00069	0.162
MOD_PKA_2	289	295	PF00069	0.251
MOD_PKA_2	496	502	PF00069	0.251
MOD_PKA_2	568	574	PF00069	0.336
MOD_Plk_1	116	122	PF00069	0.236
MOD_Plk_1	158	164	PF00069	0.236
MOD_Plk_1	557	563	PF00069	0.386
MOD_Plk_1	6	12	PF00069	0.361
MOD_Plk_4	163	169	PF00069	0.236
MOD_Plk_4	257	263	PF00069	0.250
MOD_Plk_4	379	385	PF00069	0.268
MOD_Plk_4	505	511	PF00069	0.243
MOD_Plk_4	76	82	PF00069	0.294
MOD_ProDKin_1	23	29	PF00069	0.345
MOD_SUMO_rev_2	323	333	PF00179	0.314
MOD_SUMO_rev_2	368	378	PF00179	0.238
TRG_DiLeu_BaEn_2	340	346	PF01217	0.251
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.298
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.236
TRG_ENDOCYTIC_2	167	170	PF00928	0.236
TRG_ENDOCYTIC_2	8	11	PF00928	0.511
TRG_ER_diArg_1	422	424	PF00400	0.162
TRG_ER_diArg_1	55	58	PF00400	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K5	Leptomonas seymouri	32%	100%
A0A0N1IIF0	Leptomonas seymouri	83%	87%
A0A0S4IW40	Bodo saltans	65%	85%
A0A0S4J7G9	Bodo saltans	32%	100%
A0A1X0NV46	Trypanosomatidae	70%	93%
A0A3Q8I921	Leishmania donovani	93%	100%
A0A3R7M923	Trypanosoma rangeli	70%	93%
A0A3S7X171	Leishmania donovani	32%	100%
A4HG89	Leishmania braziliensis	33%	100%
A4HUX0	Leishmania infantum	93%	100%
D0A7I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	95%
E9ANK4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AZL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
I3R7F1	Haloferax mediterranei (strain ATCC 33500 / DSM 1411 / JCM 8866 / NBRC 14739 / NCIMB 2177 / R-4)	33%	100%
I6YDK7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	60%	100%
O31825	Bacillus subtilis (strain 168)	38%	100%
O53578	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	29%	100%
O54028	Propionigenium modestum	33%	100%
O86318	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	48%	100%
P05166	Homo sapiens	31%	100%
P07633	Rattus norvegicus	32%	100%
P34385	Caenorhabditis elegans	57%	95%
P53002	Mycobacterium leprae (strain TN)	31%	100%
P53003	Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)	34%	100%
P54541	Bacillus subtilis (strain 168)	33%	100%
P63408	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	100%
P79384	Sus scrofa	32%	100%
P9WQH4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	100%
P9WQH5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
P9WQH6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	100%
P9WQH7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
Q06101	Rhodococcus erythropolis	33%	100%
Q06700	Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4)	28%	99%
Q168G2	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	32%	100%
Q2TBR0	Bos taurus	32%	100%
Q3J4E3	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	34%	100%
Q3ULD5	Mus musculus	61%	100%
Q4Q8M1	Leishmania major	32%	100%
Q4QH21	Leishmania major	93%	100%
Q57079	Veillonella parvula	32%	100%
Q5XIT9	Rattus norvegicus	61%	100%
Q8GBW6	Propionibacterium freudenreichii subsp. shermanii	34%	100%
Q8T2J9	Dictyostelium discoideum	60%	98%
Q99MN9	Mus musculus	31%	100%
Q9HCC0	Homo sapiens	59%	100%
Q9LDD8	Arabidopsis thaliana	56%	99%
Q9V9A7	Drosophila melanogaster	59%	100%
V5BWB7	Trypanosoma cruzi	69%	94%