Argonaute-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

argonaute-like protein

Species:

Leishmania braziliensis

UniProt:

A4H6I4_LEIBR

TriTrypDb:

LbrM.11.0360 , LBRM2903_110008400

Length:

898

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6I4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	671	675	PF00656	0.528
CLV_NRD_NRD_1	130	132	PF00675	0.495
CLV_NRD_NRD_1	174	176	PF00675	0.512
CLV_NRD_NRD_1	289	291	PF00675	0.343
CLV_NRD_NRD_1	300	302	PF00675	0.303
CLV_NRD_NRD_1	352	354	PF00675	0.225
CLV_NRD_NRD_1	378	380	PF00675	0.554
CLV_NRD_NRD_1	523	525	PF00675	0.393
CLV_NRD_NRD_1	688	690	PF00675	0.717
CLV_NRD_NRD_1	875	877	PF00675	0.308
CLV_PCSK_FUR_1	411	415	PF00082	0.251
CLV_PCSK_KEX2_1	138	140	PF00082	0.748
CLV_PCSK_KEX2_1	289	291	PF00082	0.316
CLV_PCSK_KEX2_1	300	302	PF00082	0.283
CLV_PCSK_KEX2_1	352	354	PF00082	0.225
CLV_PCSK_KEX2_1	378	380	PF00082	0.596
CLV_PCSK_KEX2_1	413	415	PF00082	0.319
CLV_PCSK_KEX2_1	688	690	PF00082	0.717
CLV_PCSK_KEX2_1	834	836	PF00082	0.467
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.508
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.225
CLV_PCSK_PC1ET2_1	413	415	PF00082	0.287
CLV_PCSK_PC1ET2_1	834	836	PF00082	0.398
CLV_PCSK_PC7_1	134	140	PF00082	0.484
CLV_PCSK_SKI1_1	255	259	PF00082	0.354
CLV_PCSK_SKI1_1	413	417	PF00082	0.284
CLV_PCSK_SKI1_1	496	500	PF00082	0.528
CLV_PCSK_SKI1_1	611	615	PF00082	0.430
CLV_PCSK_SKI1_1	705	709	PF00082	0.423
CLV_PCSK_SKI1_1	798	802	PF00082	0.339
CLV_PCSK_SKI1_1	882	886	PF00082	0.481
CLV_Separin_Metazoa	125	129	PF03568	0.432
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DEG_ODPH_VHL_1	158	171	PF01847	0.331
DEG_SCF_FBW7_1	806	812	PF00400	0.367
DOC_ANK_TNKS_1	16	23	PF00023	0.582
DOC_CDC14_PxL_1	397	405	PF14671	0.337
DOC_CKS1_1	806	811	PF01111	0.382
DOC_CYCLIN_yCln2_LP_2	423	429	PF00134	0.425
DOC_CYCLIN_yCln2_LP_2	862	868	PF00134	0.268
DOC_MAPK_DCC_7	858	868	PF00069	0.273
DOC_MAPK_gen_1	192	201	PF00069	0.388
DOC_MAPK_gen_1	630	638	PF00069	0.440
DOC_MAPK_gen_1	716	724	PF00069	0.337
DOC_MAPK_gen_1	834	841	PF00069	0.312
DOC_MAPK_HePTP_8	191	203	PF00069	0.334
DOC_MAPK_HePTP_8	446	458	PF00069	0.425
DOC_MAPK_JIP1_4	858	864	PF00069	0.299
DOC_MAPK_MEF2A_6	194	203	PF00069	0.506
DOC_MAPK_MEF2A_6	449	458	PF00069	0.425
DOC_MAPK_MEF2A_6	630	638	PF00069	0.440
DOC_MAPK_MEF2A_6	74	83	PF00069	0.358
DOC_MAPK_MEF2A_6	858	866	PF00069	0.289
DOC_PP1_RVXF_1	210	217	PF00149	0.424
DOC_PP1_RVXF_1	323	330	PF00149	0.425
DOC_PP2B_LxvP_1	201	204	PF13499	0.314
DOC_PP2B_LxvP_1	451	454	PF13499	0.425
DOC_PP2B_LxvP_1	862	865	PF13499	0.296
DOC_PP4_FxxP_1	316	319	PF00568	0.425
DOC_USP7_MATH_1	383	387	PF00917	0.306
DOC_USP7_MATH_1	563	567	PF00917	0.326
DOC_USP7_MATH_1	604	608	PF00917	0.490
DOC_USP7_MATH_1	675	679	PF00917	0.614
DOC_USP7_MATH_1	809	813	PF00917	0.395
DOC_USP7_MATH_2	775	781	PF00917	0.424
DOC_USP7_UBL2_3	277	281	PF12436	0.350
DOC_USP7_UBL2_3	546	550	PF12436	0.512
DOC_USP7_UBL2_3	712	716	PF12436	0.387
DOC_WW_Pin1_4	332	337	PF00397	0.425
DOC_WW_Pin1_4	422	427	PF00397	0.425
DOC_WW_Pin1_4	519	524	PF00397	0.536
DOC_WW_Pin1_4	805	810	PF00397	0.537
LIG_14-3-3_CanoR_1	139	149	PF00244	0.666
LIG_14-3-3_CanoR_1	181	189	PF00244	0.441
LIG_14-3-3_CanoR_1	524	529	PF00244	0.545
LIG_14-3-3_CanoR_1	534	542	PF00244	0.439
LIG_14-3-3_CanoR_1	561	571	PF00244	0.299
LIG_14-3-3_CanoR_1	726	736	PF00244	0.331
LIG_14-3-3_CanoR_1	790	800	PF00244	0.395
LIG_Actin_WH2_2	113	130	PF00022	0.361
LIG_Actin_WH2_2	242	257	PF00022	0.310
LIG_BIR_III_2	860	864	PF00653	0.323
LIG_BRCT_BRCA1_1	102	106	PF00533	0.369
LIG_Clathr_ClatBox_1	243	247	PF01394	0.312
LIG_CtBP_PxDLS_1	89	93	PF00389	0.319
LIG_DCNL_PONY_1	1	4	PF03556	0.538
LIG_eIF4E_1	382	388	PF01652	0.311
LIG_FHA_1	453	459	PF00498	0.425
LIG_FHA_1	508	514	PF00498	0.458
LIG_FHA_1	575	581	PF00498	0.458
LIG_FHA_1	583	589	PF00498	0.436
LIG_FHA_1	682	688	PF00498	0.669
LIG_FHA_1	719	725	PF00498	0.406
LIG_FHA_1	751	757	PF00498	0.472
LIG_FHA_1	826	832	PF00498	0.315
LIG_FHA_2	140	146	PF00498	0.559
LIG_FHA_2	172	178	PF00498	0.400
LIG_FHA_2	219	225	PF00498	0.542
LIG_FHA_2	339	345	PF00498	0.574
LIG_FHA_2	524	530	PF00498	0.616
LIG_FHA_2	624	630	PF00498	0.387
LIG_FHA_2	728	734	PF00498	0.351
LIG_FHA_2	806	812	PF00498	0.367
LIG_Integrin_RGD_1	19	21	PF01839	0.588
LIG_LIR_Apic_2	313	319	PF02991	0.425
LIG_LIR_Gen_1	103	110	PF02991	0.489
LIG_LIR_Gen_1	228	237	PF02991	0.540
LIG_LIR_Gen_1	318	329	PF02991	0.514
LIG_LIR_Gen_1	541	547	PF02991	0.469
LIG_LIR_Gen_1	640	648	PF02991	0.290
LIG_LIR_Nem_3	103	107	PF02991	0.393
LIG_LIR_Nem_3	318	324	PF02991	0.473
LIG_LIR_Nem_3	328	332	PF02991	0.411
LIG_LIR_Nem_3	344	350	PF02991	0.375
LIG_LIR_Nem_3	494	498	PF02991	0.468
LIG_LIR_Nem_3	541	545	PF02991	0.363
LIG_LIR_Nem_3	629	634	PF02991	0.438
LIG_LIR_Nem_3	640	646	PF02991	0.218
LIG_LIR_Nem_3	652	656	PF02991	0.276
LIG_LIR_Nem_3	780	785	PF02991	0.390
LIG_LIR_Nem_3	804	810	PF02991	0.425
LIG_LIR_Nem_3	828	832	PF02991	0.286
LIG_LIR_Nem_3	94	100	PF02991	0.374
LIG_LYPXL_L_2	406	415	PF13949	0.334
LIG_PCNA_yPIPBox_3	506	515	PF02747	0.296
LIG_Pex14_1	512	516	PF04695	0.314
LIG_Pex14_2	347	351	PF04695	0.446
LIG_Pex14_2	558	562	PF04695	0.496
LIG_Pex14_2	764	768	PF04695	0.295
LIG_PTB_Apo_2	694	701	PF02174	0.336
LIG_SH2_CRK	355	359	PF00017	0.425
LIG_SH2_CRK	631	635	PF00017	0.346
LIG_SH2_CRK	782	786	PF00017	0.349
LIG_SH2_CRK	853	857	PF00017	0.283
LIG_SH2_CRK	878	882	PF00017	0.350
LIG_SH2_NCK_1	807	811	PF00017	0.380
LIG_SH2_SRC	457	460	PF00017	0.295
LIG_SH2_SRC	670	673	PF00017	0.515
LIG_SH2_SRC	872	875	PF00017	0.277
LIG_SH2_STAP1	222	226	PF00017	0.434
LIG_SH2_STAP1	355	359	PF00017	0.425
LIG_SH2_STAP1	639	643	PF00017	0.298
LIG_SH2_STAP1	874	878	PF00017	0.294
LIG_SH2_STAT3	473	476	PF00017	0.355
LIG_SH2_STAT3	830	833	PF00017	0.288
LIG_SH2_STAT5	100	103	PF00017	0.342
LIG_SH2_STAT5	230	233	PF00017	0.422
LIG_SH2_STAT5	350	353	PF00017	0.418
LIG_SH2_STAT5	367	370	PF00017	0.497
LIG_SH2_STAT5	457	460	PF00017	0.426
LIG_SH2_STAT5	473	476	PF00017	0.433
LIG_SH2_STAT5	503	506	PF00017	0.410
LIG_SH2_STAT5	639	642	PF00017	0.399
LIG_SH2_STAT5	656	659	PF00017	0.249
LIG_SH2_STAT5	807	810	PF00017	0.518
LIG_SH2_STAT5	814	817	PF00017	0.290
LIG_SH2_STAT5	830	833	PF00017	0.229
LIG_SH3_1	853	859	PF00018	0.291
LIG_SH3_3	358	364	PF00018	0.487
LIG_SH3_3	456	462	PF00018	0.564
LIG_SH3_3	486	492	PF00018	0.346
LIG_SH3_3	515	521	PF00018	0.540
LIG_SH3_3	754	760	PF00018	0.296
LIG_SH3_3	76	82	PF00018	0.356
LIG_SH3_3	803	809	PF00018	0.440
LIG_SH3_3	853	859	PF00018	0.378
LIG_SUMO_SIM_anti_2	838	843	PF11976	0.295
LIG_SUMO_SIM_par_1	425	430	PF11976	0.425
LIG_SUMO_SIM_par_1	572	577	PF11976	0.339
LIG_SUMO_SIM_par_1	88	94	PF11976	0.406
LIG_UBA3_1	126	132	PF00899	0.343
LIG_UBA3_1	841	846	PF00899	0.381
LIG_WRC_WIRS_1	101	106	PF05994	0.338
LIG_WRC_WIRS_1	810	815	PF05994	0.294
LIG_WRPW_2	653	656	PF00400	0.299
MOD_CDC14_SPxK_1	522	525	PF00782	0.468
MOD_CDK_SPK_2	519	524	PF00069	0.334
MOD_CDK_SPxK_1	519	525	PF00069	0.446
MOD_CK1_1	260	266	PF00069	0.617
MOD_CK1_1	279	285	PF00069	0.277
MOD_CK1_1	311	317	PF00069	0.471
MOD_CK1_1	334	340	PF00069	0.606
MOD_CK1_1	527	533	PF00069	0.536
MOD_CK1_1	566	572	PF00069	0.430
MOD_CK1_1	678	684	PF00069	0.667
MOD_CK1_1	718	724	PF00069	0.495
MOD_CK1_1	880	886	PF00069	0.406
MOD_CK2_1	139	145	PF00069	0.675
MOD_CK2_1	171	177	PF00069	0.382
MOD_CK2_1	218	224	PF00069	0.532
MOD_CK2_1	232	238	PF00069	0.559
MOD_CK2_1	338	344	PF00069	0.463
MOD_CK2_1	623	629	PF00069	0.371
MOD_CK2_1	727	733	PF00069	0.375
MOD_CK2_1	880	886	PF00069	0.345
MOD_GlcNHglycan	142	145	PF01048	0.503
MOD_GlcNHglycan	259	262	PF01048	0.439
MOD_GlcNHglycan	446	449	PF01048	0.269
MOD_GlcNHglycan	459	462	PF01048	0.314
MOD_GlcNHglycan	529	532	PF01048	0.542
MOD_GlcNHglycan	66	69	PF01048	0.550
MOD_GlcNHglycan	779	782	PF01048	0.535
MOD_GlcNHglycan	815	818	PF01048	0.439
MOD_GSK3_1	167	174	PF00069	0.444
MOD_GSK3_1	177	184	PF00069	0.424
MOD_GSK3_1	257	264	PF00069	0.505
MOD_GSK3_1	272	279	PF00069	0.318
MOD_GSK3_1	334	341	PF00069	0.514
MOD_GSK3_1	467	474	PF00069	0.350
MOD_GSK3_1	519	526	PF00069	0.434
MOD_GSK3_1	562	569	PF00069	0.346
MOD_GSK3_1	60	67	PF00069	0.530
MOD_GSK3_1	619	626	PF00069	0.569
MOD_GSK3_1	670	677	PF00069	0.444
MOD_GSK3_1	679	686	PF00069	0.504
MOD_GSK3_1	801	808	PF00069	0.529
MOD_GSK3_1	809	816	PF00069	0.528
MOD_N-GLC_1	108	113	PF02516	0.396
MOD_N-GLC_1	132	137	PF02516	0.451
MOD_N-GLC_1	181	186	PF02516	0.611
MOD_N-GLC_1	507	512	PF02516	0.349
MOD_N-GLC_1	818	823	PF02516	0.337
MOD_N-GLC_2	850	852	PF02516	0.267
MOD_NEK2_1	126	131	PF00069	0.425
MOD_NEK2_1	218	223	PF00069	0.534
MOD_NEK2_1	272	277	PF00069	0.394
MOD_NEK2_1	338	343	PF00069	0.425
MOD_NEK2_1	427	432	PF00069	0.501
MOD_NEK2_1	562	567	PF00069	0.341
MOD_NEK2_1	680	685	PF00069	0.530
MOD_NEK2_1	813	818	PF00069	0.289
MOD_NEK2_2	197	202	PF00069	0.464
MOD_NEK2_2	809	814	PF00069	0.487
MOD_PIKK_1	487	493	PF00454	0.503
MOD_PIKK_1	5	11	PF00454	0.679
MOD_PIKK_1	566	572	PF00454	0.282
MOD_PIKK_1	582	588	PF00454	0.265
MOD_PK_1	630	636	PF00069	0.356
MOD_PK_1	835	841	PF00069	0.310
MOD_PKA_1	524	530	PF00069	0.380
MOD_PKA_2	140	146	PF00069	0.458
MOD_PKA_2	523	529	PF00069	0.364
MOD_PKA_2	533	539	PF00069	0.321
MOD_PKA_2	563	569	PF00069	0.507
MOD_PKA_2	60	66	PF00069	0.461
MOD_PKA_2	891	897	PF00069	0.326
MOD_Plk_1	197	203	PF00069	0.458
MOD_Plk_1	343	349	PF00069	0.446
MOD_Plk_1	507	513	PF00069	0.358
MOD_Plk_1	818	824	PF00069	0.337
MOD_Plk_2-3	167	173	PF00069	0.347
MOD_Plk_2-3	242	248	PF00069	0.319
MOD_Plk_4	311	317	PF00069	0.415
MOD_Plk_4	334	340	PF00069	0.556
MOD_Plk_4	343	349	PF00069	0.405
MOD_Plk_4	383	389	PF00069	0.308
MOD_Plk_4	402	408	PF00069	0.316
MOD_Plk_4	452	458	PF00069	0.425
MOD_Plk_4	494	500	PF00069	0.423
MOD_Plk_4	563	569	PF00069	0.405
MOD_Plk_4	623	629	PF00069	0.396
MOD_Plk_4	718	724	PF00069	0.563
MOD_Plk_4	752	758	PF00069	0.336
MOD_Plk_4	769	775	PF00069	0.445
MOD_Plk_4	809	815	PF00069	0.374
MOD_Plk_4	825	831	PF00069	0.274
MOD_ProDKin_1	332	338	PF00069	0.425
MOD_ProDKin_1	422	428	PF00069	0.425
MOD_ProDKin_1	519	525	PF00069	0.542
MOD_ProDKin_1	805	811	PF00069	0.528
MOD_SUMO_for_1	662	665	PF00179	0.369
MOD_SUMO_rev_2	228	236	PF00179	0.356
MOD_SUMO_rev_2	490	498	PF00179	0.445
TRG_DiLeu_BaEn_1	494	499	PF01217	0.325
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.426
TRG_ENDOCYTIC_2	230	233	PF00928	0.486
TRG_ENDOCYTIC_2	355	358	PF00928	0.505
TRG_ENDOCYTIC_2	367	370	PF00928	0.425
TRG_ENDOCYTIC_2	555	558	PF00928	0.360
TRG_ENDOCYTIC_2	631	634	PF00928	0.349
TRG_ENDOCYTIC_2	782	785	PF00928	0.363
TRG_ENDOCYTIC_2	807	810	PF00928	0.432
TRG_ENDOCYTIC_2	829	832	PF00928	0.323
TRG_ENDOCYTIC_2	878	881	PF00928	0.338
TRG_ER_diArg_1	189	192	PF00400	0.343
TRG_ER_diArg_1	288	290	PF00400	0.574
TRG_ER_diArg_1	299	301	PF00400	0.543
TRG_ER_diArg_1	378	380	PF00400	0.570
TRG_ER_diArg_1	687	689	PF00400	0.738
TRG_ER_diArg_1	890	893	PF00400	0.304
TRG_NLS_MonoExtN_4	128	135	PF00514	0.398
TRG_NLS_MonoExtN_4	411	417	PF00514	0.487
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IW34	Bodo saltans	29%	80%
A0A1B2LUL5	Trypanosoma rangeli	32%	100%
A0A1X0P0P6	Trypanosomatidae	30%	100%
D0A4M3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	98%
G8XR08	Leishmania braziliensis	100%	100%