Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H6I2_LEIBR

TriTrypDb:

LbrM.11.0340 , LBRM2903_140010300

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6I2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	199	203	PF00656	0.646
CLV_C14_Caspase3-7	253	257	PF00656	0.680
CLV_C14_Caspase3-7	385	389	PF00656	0.685
CLV_C14_Caspase3-7	547	551	PF00656	0.524
CLV_NRD_NRD_1	148	150	PF00675	0.578
CLV_NRD_NRD_1	209	211	PF00675	0.601
CLV_NRD_NRD_1	3	5	PF00675	0.530
CLV_NRD_NRD_1	526	528	PF00675	0.463
CLV_NRD_NRD_1	641	643	PF00675	0.453
CLV_PCSK_KEX2_1	148	150	PF00082	0.578
CLV_PCSK_KEX2_1	208	210	PF00082	0.560
CLV_PCSK_KEX2_1	3	5	PF00082	0.534
CLV_PCSK_KEX2_1	641	643	PF00082	0.420
CLV_PCSK_SKI1_1	3	7	PF00082	0.528
CLV_PCSK_SKI1_1	406	410	PF00082	0.513
CLV_PCSK_SKI1_1	452	456	PF00082	0.506
CLV_Separin_Metazoa	167	171	PF03568	0.628
DEG_APCC_DBOX_1	275	283	PF00400	0.548
DEG_SCF_FBW7_1	590	596	PF00400	0.557
DEG_SPOP_SBC_1	235	239	PF00917	0.559
DEG_SPOP_SBC_1	314	318	PF00917	0.474
DEG_SPOP_SBC_1	514	518	PF00917	0.389
DOC_CKS1_1	590	595	PF01111	0.561
DOC_CYCLIN_RxL_1	393	401	PF00134	0.517
DOC_CYCLIN_RxL_1	524	535	PF00134	0.524
DOC_MAPK_MEF2A_6	280	287	PF00069	0.404
DOC_PP1_RVXF_1	394	401	PF00149	0.518
DOC_PP4_FxxP_1	498	501	PF00568	0.591
DOC_USP7_MATH_1	175	179	PF00917	0.558
DOC_USP7_MATH_1	254	258	PF00917	0.780
DOC_USP7_MATH_1	27	31	PF00917	0.528
DOC_USP7_MATH_1	315	319	PF00917	0.570
DOC_USP7_MATH_1	32	36	PF00917	0.529
DOC_USP7_MATH_1	366	370	PF00917	0.633
DOC_USP7_MATH_1	555	559	PF00917	0.649
DOC_USP7_MATH_1	593	597	PF00917	0.543
DOC_USP7_MATH_1	659	663	PF00917	0.521
DOC_USP7_UBL2_3	524	528	PF12436	0.445
DOC_WW_Pin1_4	132	137	PF00397	0.607
DOC_WW_Pin1_4	171	176	PF00397	0.713
DOC_WW_Pin1_4	178	183	PF00397	0.603
DOC_WW_Pin1_4	20	25	PF00397	0.496
DOC_WW_Pin1_4	221	226	PF00397	0.519
DOC_WW_Pin1_4	549	554	PF00397	0.596
DOC_WW_Pin1_4	567	572	PF00397	0.804
DOC_WW_Pin1_4	589	594	PF00397	0.555
LIG_14-3-3_CanoR_1	208	218	PF00244	0.608
LIG_14-3-3_CanoR_1	3	10	PF00244	0.521
LIG_14-3-3_CanoR_1	368	373	PF00244	0.527
LIG_14-3-3_CanoR_1	580	590	PF00244	0.567
LIG_Actin_WH2_2	462	479	PF00022	0.512
LIG_BIR_III_2	401	405	PF00653	0.630
LIG_BIR_III_2	550	554	PF00653	0.520
LIG_BRCT_BRCA1_1	162	166	PF00533	0.546
LIG_BRCT_BRCA1_1	396	400	PF00533	0.521
LIG_Clathr_ClatBox_1	436	440	PF01394	0.389
LIG_Dynein_DLC8_1	168	174	PF01221	0.698
LIG_FHA_1	196	202	PF00498	0.483
LIG_FHA_1	225	231	PF00498	0.634
LIG_FHA_1	239	245	PF00498	0.568
LIG_FHA_1	524	530	PF00498	0.418
LIG_FHA_2	229	235	PF00498	0.709
LIG_FHA_2	251	257	PF00498	0.712
LIG_FHA_2	506	512	PF00498	0.506
LIG_FHA_2	530	536	PF00498	0.459
LIG_GBD_Chelix_1	632	640	PF00786	0.518
LIG_LIR_Apic_2	497	501	PF02991	0.599
LIG_LIR_Gen_1	46	56	PF02991	0.425
LIG_LIR_Nem_3	163	169	PF02991	0.568
LIG_LIR_Nem_3	46	52	PF02991	0.452
LIG_LIR_Nem_3	627	632	PF02991	0.642
LIG_MYND_1	139	143	PF01753	0.570
LIG_NRBOX	482	488	PF00104	0.540
LIG_Pex14_2	494	498	PF04695	0.472
LIG_REV1ctd_RIR_1	117	126	PF16727	0.497
LIG_RPA_C_Fungi	351	363	PF08784	0.461
LIG_SH2_CRK	629	633	PF00017	0.517
LIG_SH2_STAP1	525	529	PF00017	0.374
LIG_SH2_STAT3	448	451	PF00017	0.478
LIG_SH2_STAT5	49	52	PF00017	0.423
LIG_SH2_STAT5	525	528	PF00017	0.522
LIG_SH2_STAT5	653	656	PF00017	0.456
LIG_SH3_2	404	409	PF14604	0.576
LIG_SH3_3	133	139	PF00018	0.562
LIG_SH3_3	282	288	PF00018	0.404
LIG_SH3_3	321	327	PF00018	0.614
LIG_SH3_3	360	366	PF00018	0.641
LIG_SH3_3	401	407	PF00018	0.634
LIG_SH3_3	420	426	PF00018	0.459
LIG_SH3_3	587	593	PF00018	0.584
LIG_SUMO_SIM_par_1	375	381	PF11976	0.522
LIG_SUMO_SIM_par_1	435	441	PF11976	0.388
LIG_TRAF2_1	470	473	PF00917	0.475
LIG_TRAF2_1	508	511	PF00917	0.506
LIG_WW_3	403	407	PF00397	0.564
MOD_CDK_SPxK_1	567	573	PF00069	0.603
MOD_CDK_SPxK_1	591	597	PF00069	0.481
MOD_CK1_1	144	150	PF00069	0.644
MOD_CK1_1	176	182	PF00069	0.699
MOD_CK1_1	240	246	PF00069	0.564
MOD_CK1_1	257	263	PF00069	0.504
MOD_CK1_1	316	322	PF00069	0.577
MOD_CK1_1	386	392	PF00069	0.537
MOD_CK1_1	447	453	PF00069	0.672
MOD_CK1_1	539	545	PF00069	0.558
MOD_CK1_1	558	564	PF00069	0.732
MOD_CK1_1	584	590	PF00069	0.587
MOD_CK1_1	75	81	PF00069	0.531
MOD_CK2_1	228	234	PF00069	0.703
MOD_CK2_1	28	34	PF00069	0.598
MOD_CK2_1	472	478	PF00069	0.407
MOD_CK2_1	505	511	PF00069	0.512
MOD_GlcNHglycan	156	160	PF01048	0.566
MOD_GlcNHglycan	175	178	PF01048	0.648
MOD_GlcNHglycan	30	33	PF01048	0.575
MOD_GlcNHglycan	34	37	PF01048	0.599
MOD_GlcNHglycan	357	361	PF01048	0.611
MOD_GlcNHglycan	372	375	PF01048	0.617
MOD_GlcNHglycan	385	388	PF01048	0.544
MOD_GlcNHglycan	389	392	PF01048	0.531
MOD_GlcNHglycan	661	664	PF01048	0.518
MOD_GlcNHglycan	80	83	PF01048	0.527
MOD_GSK3_1	137	144	PF00069	0.620
MOD_GSK3_1	15	22	PF00069	0.496
MOD_GSK3_1	151	158	PF00069	0.616
MOD_GSK3_1	169	176	PF00069	0.677
MOD_GSK3_1	224	231	PF00069	0.642
MOD_GSK3_1	234	241	PF00069	0.671
MOD_GSK3_1	248	255	PF00069	0.721
MOD_GSK3_1	28	35	PF00069	0.590
MOD_GSK3_1	314	321	PF00069	0.591
MOD_GSK3_1	366	373	PF00069	0.591
MOD_GSK3_1	383	390	PF00069	0.711
MOD_GSK3_1	468	475	PF00069	0.495
MOD_GSK3_1	539	546	PF00069	0.736
MOD_GSK3_1	563	570	PF00069	0.613
MOD_GSK3_1	572	579	PF00069	0.643
MOD_GSK3_1	581	588	PF00069	0.592
MOD_GSK3_1	589	596	PF00069	0.541
MOD_N-GLC_1	555	560	PF02516	0.606
MOD_N-GLC_2	668	670	PF02516	0.502
MOD_NEK2_1	377	382	PF00069	0.602
MOD_NEK2_1	48	53	PF00069	0.428
MOD_NEK2_1	515	520	PF00069	0.466
MOD_NEK2_1	544	549	PF00069	0.619
MOD_NEK2_1	625	630	PF00069	0.381
MOD_PIKK_1	169	175	PF00454	0.698
MOD_PIKK_1	366	372	PF00454	0.637
MOD_PIKK_1	447	453	PF00454	0.545
MOD_PIKK_1	86	92	PF00454	0.519
MOD_PKA_1	209	215	PF00069	0.615
MOD_PKA_1	3	9	PF00069	0.517
MOD_PKA_2	169	175	PF00069	0.698
MOD_PKA_2	209	215	PF00069	0.615
MOD_PKA_2	248	254	PF00069	0.654
MOD_PKA_2	3	9	PF00069	0.513
MOD_PKA_2	457	463	PF00069	0.439
MOD_PKA_2	572	578	PF00069	0.673
MOD_PKB_1	208	216	PF00069	0.483
MOD_Plk_1	472	478	PF00069	0.579
MOD_Plk_1	555	561	PF00069	0.697
MOD_Plk_2-3	252	258	PF00069	0.530
MOD_Plk_2-3	468	474	PF00069	0.393
MOD_Plk_4	106	112	PF00069	0.438
MOD_Plk_4	75	81	PF00069	0.536
MOD_ProDKin_1	132	138	PF00069	0.602
MOD_ProDKin_1	171	177	PF00069	0.713
MOD_ProDKin_1	178	184	PF00069	0.602
MOD_ProDKin_1	20	26	PF00069	0.498
MOD_ProDKin_1	221	227	PF00069	0.523
MOD_ProDKin_1	549	555	PF00069	0.594
MOD_ProDKin_1	567	573	PF00069	0.806
MOD_ProDKin_1	589	595	PF00069	0.550
MOD_SUMO_for_1	269	272	PF00179	0.549
MOD_SUMO_rev_2	185	193	PF00179	0.604
TRG_DiLeu_BaEn_1	264	269	PF01217	0.513
TRG_DiLeu_BaEn_1	278	283	PF01217	0.486
TRG_DiLeu_BaEn_1	432	437	PF01217	0.533
TRG_DiLeu_BaEn_4	261	267	PF01217	0.457
TRG_DiLeu_BaEn_4	510	516	PF01217	0.492
TRG_DiLeu_BaLyEn_6	482	487	PF01217	0.402
TRG_DiLeu_LyEn_5	432	437	PF01217	0.533
TRG_ENDOCYTIC_2	49	52	PF00928	0.423
TRG_ENDOCYTIC_2	629	632	PF00928	0.609
TRG_ER_diArg_1	208	210	PF00400	0.484
TRG_ER_diArg_1	57	60	PF00400	0.402
TRG_ER_diArg_1	640	642	PF00400	0.402
TRG_NES_CRM1_1	278	291	PF08389	0.411
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.432
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	435	440	PF00026	0.645
TRG_Pf-PMV_PEXEL_1	485	489	PF00026	0.422
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	610	614	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9D0	Leptomonas seymouri	34%	99%
A0A3S7WSW7	Leishmania donovani	61%	100%
A4HVZ2	Leishmania infantum	61%	100%
E9APP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
Q4QFT5	Leishmania major	62%	100%