Stearic acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stearic acid desaturase

Species:

Leishmania braziliensis

UniProt:

A4H6I1_LEIBR

TriTrypDb:

LbrM.11.0330 , LBRM2903_140010400

Length:

460

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0031090	organelle membrane	3	2

Expansion

Sequence features

A4H6I1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6I1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	16
GO:0006629	lipid metabolic process	3	16
GO:0006631	fatty acid metabolic process	4	16
GO:0006633	fatty acid biosynthetic process	5	16
GO:0006636	unsaturated fatty acid biosynthetic process	6	16
GO:0008152	metabolic process	1	16
GO:0008610	lipid biosynthetic process	4	16
GO:0009058	biosynthetic process	2	16
GO:0009987	cellular process	1	16
GO:0016053	organic acid biosynthetic process	4	16
GO:0019752	carboxylic acid metabolic process	5	16
GO:0032787	monocarboxylic acid metabolic process	6	16
GO:0033559	unsaturated fatty acid metabolic process	5	16
GO:0043436	oxoacid metabolic process	4	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0044249	cellular biosynthetic process	3	16
GO:0044255	cellular lipid metabolic process	3	16
GO:0044281	small molecule metabolic process	2	16
GO:0044283	small molecule biosynthetic process	3	16
GO:0046394	carboxylic acid biosynthetic process	5	16
GO:0071704	organic substance metabolic process	2	16
GO:0072330	monocarboxylic acid biosynthetic process	6	16
GO:1901576	organic substance biosynthetic process	3	16

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0004768	stearoyl-CoA 9-desaturase activity	6	16
GO:0005488	binding	1	7
GO:0016215	acyl-CoA desaturase activity	5	16
GO:0016491	oxidoreductase activity	2	16
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	16
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	16
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0005506	iron ion binding	6	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.428
CLV_NRD_NRD_1	178	180	PF00675	0.228
CLV_NRD_NRD_1	334	336	PF00675	0.320
CLV_NRD_NRD_1	356	358	PF00675	0.328
CLV_PCSK_KEX2_1	334	336	PF00082	0.289
CLV_PCSK_SKI1_1	142	146	PF00082	0.159
CLV_PCSK_SKI1_1	216	220	PF00082	0.304
CLV_PCSK_SKI1_1	395	399	PF00082	0.256
CLV_PCSK_SKI1_1	404	408	PF00082	0.268
DEG_APCC_DBOX_1	421	429	PF00400	0.392
DEG_MDM2_SWIB_1	210	217	PF02201	0.264
DEG_MDM2_SWIB_1	35	42	PF02201	0.473
DEG_Nend_Nbox_1	1	3	PF02207	0.675
DEG_SCF_FBW7_1	246	251	PF00400	0.361
DOC_CDC14_PxL_1	44	52	PF14671	0.390
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	58	64	PF00134	0.489
DOC_MAPK_DCC_7	422	430	PF00069	0.415
DOC_MAPK_MEF2A_6	170	177	PF00069	0.477
DOC_MAPK_MEF2A_6	422	430	PF00069	0.415
DOC_PP1_RVXF_1	382	388	PF00149	0.545
DOC_PP2B_LxvP_1	336	339	PF13499	0.569
DOC_PP2B_LxvP_1	58	61	PF13499	0.428
DOC_USP7_MATH_1	164	168	PF00917	0.428
DOC_USP7_MATH_1	248	252	PF00917	0.493
DOC_USP7_MATH_1	4	8	PF00917	0.530
DOC_USP7_MATH_1	439	443	PF00917	0.613
DOC_WW_Pin1_4	244	249	PF00397	0.500
DOC_WW_Pin1_4	60	65	PF00397	0.202
LIG_14-3-3_CanoR_1	240	248	PF00244	0.449
LIG_14-3-3_CanoR_1	88	95	PF00244	0.461
LIG_Clathr_ClatBox_1	359	363	PF01394	0.462
LIG_deltaCOP1_diTrp_1	204	211	PF00928	0.257
LIG_FHA_1	187	193	PF00498	0.328
LIG_FHA_1	380	386	PF00498	0.516
LIG_FHA_1	47	53	PF00498	0.338
LIG_FHA_1	75	81	PF00498	0.339
LIG_FHA_1	8	14	PF00498	0.698
LIG_FHA_2	131	137	PF00498	0.443
LIG_FHA_2	199	205	PF00498	0.264
LIG_FHA_2	245	251	PF00498	0.444
LIG_FHA_2	343	349	PF00498	0.471
LIG_LIR_Gen_1	157	166	PF02991	0.459
LIG_LIR_Gen_1	261	271	PF02991	0.438
LIG_LIR_Gen_1	286	296	PF02991	0.559
LIG_LIR_Gen_1	343	353	PF02991	0.523
LIG_LIR_Gen_1	49	58	PF02991	0.391
LIG_LIR_Gen_1	83	94	PF02991	0.246
LIG_LIR_LC3C_4	171	175	PF02991	0.428
LIG_LIR_Nem_3	147	152	PF02991	0.501
LIG_LIR_Nem_3	157	161	PF02991	0.441
LIG_LIR_Nem_3	261	266	PF02991	0.438
LIG_LIR_Nem_3	286	292	PF02991	0.488
LIG_LIR_Nem_3	294	298	PF02991	0.460
LIG_LIR_Nem_3	343	349	PF02991	0.512
LIG_LIR_Nem_3	49	54	PF02991	0.385
LIG_LIR_Nem_3	83	89	PF02991	0.265
LIG_NRBOX	49	55	PF00104	0.264
LIG_PDZ_Class_1	455	460	PF00595	0.538
LIG_Pex14_1	103	107	PF04695	0.457
LIG_Pex14_1	205	209	PF04695	0.243
LIG_Pex14_1	214	218	PF04695	0.285
LIG_Pex14_1	39	43	PF04695	0.264
LIG_Pex14_1	69	73	PF04695	0.264
LIG_Pex14_2	145	149	PF04695	0.361
LIG_Pex14_2	210	214	PF04695	0.411
LIG_Pex14_2	266	270	PF04695	0.416
LIG_Pex14_2	291	295	PF04695	0.471
LIG_Pex14_2	35	39	PF04695	0.478
LIG_SH2_CRK	86	90	PF00017	0.457
LIG_SH2_GRB2like	263	266	PF00017	0.443
LIG_SH2_PTP2	289	292	PF00017	0.404
LIG_SH2_SRC	43	46	PF00017	0.278
LIG_SH2_SRC	57	60	PF00017	0.247
LIG_SH2_STAP1	242	246	PF00017	0.361
LIG_SH2_STAT5	130	133	PF00017	0.443
LIG_SH2_STAT5	181	184	PF00017	0.527
LIG_SH2_STAT5	289	292	PF00017	0.464
LIG_SH2_STAT5	344	347	PF00017	0.450
LIG_SH2_STAT5	365	368	PF00017	0.461
LIG_SH2_STAT5	401	404	PF00017	0.433
LIG_SH2_STAT5	424	427	PF00017	0.521
LIG_SH2_STAT5	43	46	PF00017	0.404
LIG_SH2_STAT5	457	460	PF00017	0.558
LIG_SH2_STAT5	57	60	PF00017	0.399
LIG_SH3_3	15	21	PF00018	0.591
LIG_SH3_3	371	377	PF00018	0.536
LIG_SH3_3	433	439	PF00018	0.541
LIG_SH3_3	58	64	PF00018	0.233
LIG_SUMO_SIM_anti_2	250	258	PF11976	0.361
LIG_SUMO_SIM_par_1	365	370	PF11976	0.553
LIG_TRAF2_1	21	24	PF00917	0.605
LIG_WRC_WIRS_1	292	297	PF05994	0.475
MOD_CK1_1	442	448	PF00069	0.611
MOD_CK1_1	7	13	PF00069	0.591
MOD_CK2_1	198	204	PF00069	0.264
MOD_CMANNOS	211	214	PF00535	0.314
MOD_Cter_Amidation	355	358	PF01082	0.337
MOD_GlcNHglycan	441	444	PF01048	0.421
MOD_GlcNHglycan	446	449	PF01048	0.381
MOD_GlcNHglycan	83	86	PF01048	0.169
MOD_GSK3_1	226	233	PF00069	0.313
MOD_GSK3_1	236	243	PF00069	0.440
MOD_GSK3_1	244	251	PF00069	0.397
MOD_GSK3_1	338	345	PF00069	0.512
MOD_NEK2_1	101	106	PF00069	0.440
MOD_NEK2_1	113	118	PF00069	0.447
MOD_NEK2_1	144	149	PF00069	0.443
MOD_NEK2_1	226	231	PF00069	0.308
MOD_NEK2_1	236	241	PF00069	0.443
MOD_NEK2_1	291	296	PF00069	0.473
MOD_NEK2_1	9	14	PF00069	0.688
MOD_NEK2_2	130	135	PF00069	0.413
MOD_NEK2_2	4	9	PF00069	0.505
MOD_Plk_1	249	255	PF00069	0.361
MOD_Plk_1	342	348	PF00069	0.530
MOD_Plk_4	249	255	PF00069	0.449
MOD_Plk_4	291	297	PF00069	0.564
MOD_Plk_4	4	10	PF00069	0.630
MOD_Plk_4	46	52	PF00069	0.312
MOD_Plk_4	62	68	PF00069	0.212
MOD_ProDKin_1	244	250	PF00069	0.500
MOD_ProDKin_1	60	66	PF00069	0.196
MOD_SUMO_for_1	21	24	PF00179	0.591
TRG_ENDOCYTIC_2	158	161	PF00928	0.480
TRG_ENDOCYTIC_2	181	184	PF00928	0.424
TRG_ENDOCYTIC_2	263	266	PF00928	0.440
TRG_ENDOCYTIC_2	289	292	PF00928	0.462
TRG_ENDOCYTIC_2	37	40	PF00928	0.605
TRG_ENDOCYTIC_2	57	60	PF00928	0.533
TRG_ENDOCYTIC_2	86	89	PF00928	0.444
TRG_ER_diArg_1	333	335	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.343

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCI5	Leptomonas seymouri	46%	100%
A0A0S4KNP4	Bodo saltans	44%	100%
A0A1X0NW01	Trypanosomatidae	48%	100%
A0A3Q8I9W7	Leishmania donovani	84%	99%
A0A3Q8IBJ0	Leishmania donovani	46%	100%
A0A3R7MEL0	Trypanosoma rangeli	47%	100%
A4HDT6	Leishmania braziliensis	47%	100%
A4HVZ3	Leishmania infantum	84%	99%
A4I134	Leishmania infantum	46%	100%
C9ZW73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9APP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
E9AX71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
G5ED44	Caenorhabditis elegans	28%	100%
G5EGH6	Caenorhabditis elegans	30%	100%
G5EGN2	Caenorhabditis elegans	30%	100%
O94523	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	96%
P0DOW2	Anemone leveillei	28%	100%
P0DOW3	Anemone leveillei	27%	100%
P21147	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	90%
Q12618	Ajellomyces capsulatus	37%	97%
Q4QAA5	Leishmania major	45%	100%
Q4QFT4	Leishmania major	83%	100%
Q6US81	Spodoptera littoralis	32%	100%
Q95MI7	Capra hircus	30%	100%
Q9FV68	Limnanthes douglasii	27%	100%
Q9SID2	Arabidopsis thaliana	26%	100%