LeishMANIAdb
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Nucleobase transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Nucleobase transporter
Gene product:
nucleobase transporter
Species:
Leishmania braziliensis
UniProt:
A4H6I0_LEIBR
TriTrypDb:
LbrM.11.0320 , LBRM2903_130016200 *
Length:
553

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 32
NetGPI no yes: 0, no: 32
Cellular components
Term Name Level Count
GO:0016020 membrane 2 33
GO:0110165 cellular anatomical entity 1 33
GO:0005886 plasma membrane 3 4

Expansion

Sequence features

A4H6I0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6I0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0015851 nucleobase transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 33
GO:0005337 nucleoside transmembrane transporter activity 4 33
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 33
GO:0022857 transmembrane transporter activity 2 33
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 33
GO:0015205 nucleobase transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 179 183 PF00656 0.184
CLV_C14_Caspase3-7 255 259 PF00656 0.633
CLV_C14_Caspase3-7 338 342 PF00656 0.815
CLV_C14_Caspase3-7 424 428 PF00656 0.300
CLV_NRD_NRD_1 239 241 PF00675 0.494
CLV_NRD_NRD_1 452 454 PF00675 0.295
CLV_NRD_NRD_1 457 459 PF00675 0.281
CLV_PCSK_FUR_1 237 241 PF00082 0.438
CLV_PCSK_KEX2_1 237 239 PF00082 0.469
CLV_PCSK_KEX2_1 452 454 PF00082 0.247
CLV_PCSK_SKI1_1 305 309 PF00082 0.421
CLV_PCSK_SKI1_1 319 323 PF00082 0.630
CLV_PCSK_SKI1_1 446 450 PF00082 0.359
CLV_PCSK_SKI1_1 459 463 PF00082 0.331
CLV_PCSK_SKI1_1 468 472 PF00082 0.351
CLV_PCSK_SKI1_1 59 63 PF00082 0.472
CLV_Separin_Metazoa 278 282 PF03568 0.598
DEG_Nend_UBRbox_2 1 3 PF02207 0.556
DEG_SCF_FBW7_1 512 518 PF00400 0.428
DOC_CDC14_PxL_1 469 477 PF14671 0.368
DOC_CKS1_1 512 517 PF01111 0.475
DOC_CYCLIN_yClb1_LxF_4 59 65 PF00134 0.325
DOC_MAPK_DCC_7 468 477 PF00069 0.365
DOC_MAPK_gen_1 396 403 PF00069 0.555
DOC_MAPK_MEF2A_6 468 477 PF00069 0.387
DOC_MIT_MIM_1 440 450 PF04212 0.249
DOC_PP1_RVXF_1 466 472 PF00149 0.422
DOC_PP2B_LxvP_1 109 112 PF13499 0.353
DOC_PP2B_LxvP_1 454 457 PF13499 0.420
DOC_USP7_MATH_1 256 260 PF00917 0.608
DOC_USP7_MATH_1 29 33 PF00917 0.390
DOC_USP7_MATH_1 422 426 PF00917 0.350
DOC_USP7_MATH_1 45 49 PF00917 0.369
DOC_USP7_MATH_1 513 517 PF00917 0.479
DOC_USP7_MATH_1 539 543 PF00917 0.455
DOC_USP7_UBL2_3 482 486 PF12436 0.228
DOC_WW_Pin1_4 319 324 PF00397 0.617
DOC_WW_Pin1_4 346 351 PF00397 0.634
DOC_WW_Pin1_4 508 513 PF00397 0.373
DOC_WW_Pin1_4 51 56 PF00397 0.427
LIG_14-3-3_CanoR_1 237 243 PF00244 0.709
LIG_14-3-3_CanoR_1 305 313 PF00244 0.582
LIG_14-3-3_CanoR_1 446 451 PF00244 0.343
LIG_14-3-3_CanoR_1 87 91 PF00244 0.517
LIG_Actin_WH2_2 161 179 PF00022 0.429
LIG_BRCT_BRCA1_1 368 372 PF00533 0.559
LIG_BRCT_BRCA1_1 498 502 PF00533 0.427
LIG_BRCT_BRCA1_1 53 57 PF00533 0.391
LIG_BRCT_BRCA1_1 88 92 PF00533 0.554
LIG_BRCT_BRCA1_2 53 59 PF00533 0.244
LIG_Clathr_ClatBox_1 91 95 PF01394 0.375
LIG_CSL_BTD_1 454 457 PF09270 0.420
LIG_EH1_1 64 72 PF00400 0.404
LIG_FHA_1 13 19 PF00498 0.371
LIG_FHA_1 154 160 PF00498 0.531
LIG_FHA_1 2 8 PF00498 0.631
LIG_FHA_1 20 26 PF00498 0.369
LIG_FHA_1 316 322 PF00498 0.607
LIG_FHA_1 368 374 PF00498 0.668
LIG_FHA_1 380 386 PF00498 0.508
LIG_FHA_1 406 412 PF00498 0.345
LIG_FHA_1 429 435 PF00498 0.359
LIG_FHA_1 478 484 PF00498 0.410
LIG_FHA_1 512 518 PF00498 0.484
LIG_FHA_1 530 536 PF00498 0.175
LIG_FHA_1 67 73 PF00498 0.381
LIG_FHA_2 306 312 PF00498 0.704
LIG_FHA_2 334 340 PF00498 0.826
LIG_FHA_2 379 385 PF00498 0.541
LIG_FHA_2 517 523 PF00498 0.511
LIG_GBD_Chelix_1 168 176 PF00786 0.404
LIG_IBAR_NPY_1 215 217 PF08397 0.518
LIG_LIR_Gen_1 142 152 PF02991 0.501
LIG_LIR_Gen_1 181 192 PF02991 0.349
LIG_LIR_Gen_1 412 421 PF02991 0.394
LIG_LIR_Gen_1 427 437 PF02991 0.342
LIG_LIR_Gen_1 63 72 PF02991 0.359
LIG_LIR_LC3C_4 15 19 PF02991 0.249
LIG_LIR_Nem_3 142 147 PF02991 0.507
LIG_LIR_Nem_3 181 187 PF02991 0.318
LIG_LIR_Nem_3 191 197 PF02991 0.355
LIG_LIR_Nem_3 39 44 PF02991 0.356
LIG_LIR_Nem_3 412 416 PF02991 0.339
LIG_LIR_Nem_3 427 433 PF02991 0.342
LIG_LIR_Nem_3 449 454 PF02991 0.312
LIG_LIR_Nem_3 63 68 PF02991 0.315
LIG_LYPXL_S_1 398 402 PF13949 0.370
LIG_LYPXL_yS_3 399 402 PF13949 0.448
LIG_NRBOX 167 173 PF00104 0.292
LIG_NRBOX 208 214 PF00104 0.264
LIG_PALB2_WD40_1 425 433 PF16756 0.228
LIG_Pex14_1 232 236 PF04695 0.601
LIG_Pex14_2 84 88 PF04695 0.528
LIG_PTB_Apo_2 138 145 PF02174 0.345
LIG_PTB_Phospho_1 138 144 PF10480 0.345
LIG_SH2_CRK 184 188 PF00017 0.325
LIG_SH2_CRK 217 221 PF00017 0.502
LIG_SH2_CRK 41 45 PF00017 0.334
LIG_SH2_CRK 65 69 PF00017 0.462
LIG_SH2_NCK_1 510 514 PF00017 0.400
LIG_SH2_NCK_1 65 69 PF00017 0.413
LIG_SH2_STAP1 184 188 PF00017 0.361
LIG_SH2_STAP1 217 221 PF00017 0.480
LIG_SH2_STAT5 130 133 PF00017 0.402
LIG_SH2_STAT5 138 141 PF00017 0.403
LIG_SH2_STAT5 194 197 PF00017 0.325
LIG_SH2_STAT5 221 224 PF00017 0.540
LIG_SH2_STAT5 364 367 PF00017 0.569
LIG_SH2_STAT5 413 416 PF00017 0.302
LIG_SH2_STAT5 43 46 PF00017 0.350
LIG_SH2_STAT5 490 493 PF00017 0.383
LIG_SH2_STAT5 65 68 PF00017 0.341
LIG_SH3_3 146 152 PF00018 0.497
LIG_SH3_3 354 360 PF00018 0.613
LIG_SH3_3 49 55 PF00018 0.327
LIG_SH3_3 509 515 PF00018 0.488
LIG_SH3_5 360 364 PF00018 0.582
LIG_SUMO_SIM_anti_2 104 110 PF11976 0.333
LIG_SUMO_SIM_anti_2 66 72 PF11976 0.366
LIG_SUMO_SIM_par_1 151 156 PF11976 0.438
LIG_SUMO_SIM_par_1 200 205 PF11976 0.350
LIG_SUMO_SIM_par_1 419 425 PF11976 0.362
LIG_SUMO_SIM_par_1 97 104 PF11976 0.221
LIG_TYR_ITIM 192 197 PF00017 0.404
LIG_UBA3_1 171 177 PF00899 0.448
LIG_UBA3_1 474 482 PF00899 0.289
LIG_WRC_WIRS_1 406 411 PF05994 0.345
LIG_WRC_WIRS_1 61 66 PF05994 0.364
LIG_WRC_WIRS_1 81 86 PF05994 0.480
LIG_WW_3 455 459 PF00397 0.438
MOD_CK1_1 32 38 PF00069 0.314
MOD_CK1_1 511 517 PF00069 0.489
MOD_CK1_1 63 69 PF00069 0.379
MOD_CK2_1 305 311 PF00069 0.695
MOD_CK2_1 333 339 PF00069 0.694
MOD_CK2_1 346 352 PF00069 0.742
MOD_CK2_1 378 384 PF00069 0.637
MOD_CK2_1 516 522 PF00069 0.485
MOD_DYRK1A_RPxSP_1 319 323 PF00069 0.612
MOD_GlcNHglycan 161 164 PF01048 0.368
MOD_GlcNHglycan 184 187 PF01048 0.400
MOD_GlcNHglycan 204 207 PF01048 0.292
MOD_GlcNHglycan 253 257 PF01048 0.490
MOD_GlcNHglycan 289 292 PF01048 0.511
MOD_GlcNHglycan 31 34 PF01048 0.591
MOD_GlcNHglycan 424 427 PF01048 0.570
MOD_GlcNHglycan 47 50 PF01048 0.576
MOD_GSK3_1 176 183 PF00069 0.306
MOD_GSK3_1 252 259 PF00069 0.597
MOD_GSK3_1 315 322 PF00069 0.601
MOD_GSK3_1 331 338 PF00069 0.827
MOD_GSK3_1 405 412 PF00069 0.403
MOD_GSK3_1 504 511 PF00069 0.310
MOD_GSK3_1 76 83 PF00069 0.330
MOD_N-GLC_1 79 84 PF02516 0.405
MOD_NEK2_1 1 6 PF00069 0.686
MOD_NEK2_1 12 17 PF00069 0.315
MOD_NEK2_1 139 144 PF00069 0.502
MOD_NEK2_1 159 164 PF00069 0.323
MOD_NEK2_1 176 181 PF00069 0.265
MOD_NEK2_1 188 193 PF00069 0.270
MOD_NEK2_1 225 230 PF00069 0.631
MOD_NEK2_1 365 370 PF00069 0.725
MOD_NEK2_1 409 414 PF00069 0.370
MOD_NEK2_1 44 49 PF00069 0.332
MOD_NEK2_1 462 467 PF00069 0.332
MOD_NEK2_1 477 482 PF00069 0.433
MOD_NEK2_1 496 501 PF00069 0.366
MOD_NEK2_1 529 534 PF00069 0.378
MOD_NEK2_1 94 99 PF00069 0.345
MOD_PIKK_1 186 192 PF00454 0.272
MOD_PIKK_1 333 339 PF00454 0.621
MOD_PK_1 238 244 PF00069 0.552
MOD_PKA_1 238 244 PF00069 0.736
MOD_PKA_2 225 231 PF00069 0.527
MOD_PKA_2 238 244 PF00069 0.564
MOD_PKA_2 280 286 PF00069 0.624
MOD_PKA_2 86 92 PF00069 0.497
MOD_Plk_1 79 85 PF00069 0.403
MOD_Plk_1 94 100 PF00069 0.345
MOD_Plk_2-3 270 276 PF00069 0.639
MOD_Plk_4 13 19 PF00069 0.332
MOD_Plk_4 167 173 PF00069 0.336
MOD_Plk_4 188 194 PF00069 0.332
MOD_Plk_4 32 38 PF00069 0.323
MOD_Plk_4 409 415 PF00069 0.317
MOD_Plk_4 429 435 PF00069 0.306
MOD_Plk_4 446 452 PF00069 0.315
MOD_Plk_4 504 510 PF00069 0.360
MOD_Plk_4 539 545 PF00069 0.363
MOD_Plk_4 60 66 PF00069 0.323
MOD_Plk_4 80 86 PF00069 0.430
MOD_ProDKin_1 319 325 PF00069 0.617
MOD_ProDKin_1 346 352 PF00069 0.633
MOD_ProDKin_1 508 514 PF00069 0.373
MOD_ProDKin_1 51 57 PF00069 0.422
MOD_SUMO_for_1 353 356 PF00179 0.661
MOD_SUMO_rev_2 253 262 PF00179 0.633
TRG_DiLeu_BaLyEn_6 443 448 PF01217 0.420
TRG_DiLeu_BaLyEn_6 470 475 PF01217 0.398
TRG_ENDOCYTIC_2 144 147 PF00928 0.500
TRG_ENDOCYTIC_2 184 187 PF00928 0.321
TRG_ENDOCYTIC_2 194 197 PF00928 0.341
TRG_ENDOCYTIC_2 217 220 PF00928 0.550
TRG_ENDOCYTIC_2 399 402 PF00928 0.448
TRG_ENDOCYTIC_2 41 44 PF00928 0.324
TRG_ENDOCYTIC_2 413 416 PF00928 0.307
TRG_ENDOCYTIC_2 65 68 PF00928 0.331
TRG_ER_diArg_1 236 239 PF00400 0.668
TRG_ER_diArg_1 451 453 PF00400 0.503

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 47% 100%
A0A0N0P6Z5 Leptomonas seymouri 29% 100%
A0A0N1I1J0 Leptomonas seymouri 58% 100%
A0A0N1I8E8 Leptomonas seymouri 25% 100%
A0A0N1PBQ1 Leptomonas seymouri 36% 100%
A0A3Q8ICX7 Leishmania donovani 35% 100%
A0A3S7WTL0 Leishmania donovani 29% 100%
A0A3S7XAS5 Leishmania donovani 31% 100%
A0A422N8M2 Trypanosoma rangeli 28% 100%
A0A422NHH9 Trypanosoma rangeli 29% 100%
A4H7A5 Leishmania braziliensis 35% 100%
A4HG96 Leishmania braziliensis 22% 100%
A4HP60 Leishmania braziliensis 32% 100%
A4HUW2 Leishmania infantum 75% 100%
A4HVP9 Leishmania infantum 35% 100%
A4HWK9 Leishmania infantum 29% 100%
A4IDG6 Leishmania infantum 31% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
E9AGM5 Leishmania infantum 29% 100%
E9AGM6 Leishmania infantum 29% 100%
E9AGM7 Leishmania infantum 29% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 91%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 91%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
O76343 Leishmania donovani 29% 100%
Q4Q1M9 Leishmania major 31% 93%
Q4QF58 Leishmania major 28% 91%
Q4QG33 Leishmania major 34% 91%
Q4QH25 Leishmania major 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS