Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF563), putative

Species:

Leishmania braziliensis

UniProt:

A4H6H9_LEIBR

TriTrypDb:

LbrM.11.0310 , LBRM2903_110008000

Length:

654

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H6H9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6H9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	10
GO:0016757	glycosyltransferase activity	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.541
CLV_MEL_PAP_1	592	598	PF00089	0.654
CLV_NRD_NRD_1	47	49	PF00675	0.502
CLV_NRD_NRD_1	51	53	PF00675	0.502
CLV_NRD_NRD_1	6	8	PF00675	0.546
CLV_PCSK_FUR_1	45	49	PF00082	0.516
CLV_PCSK_FUR_1	636	640	PF00082	0.574
CLV_PCSK_KEX2_1	118	120	PF00082	0.750
CLV_PCSK_KEX2_1	421	423	PF00082	0.478
CLV_PCSK_KEX2_1	47	49	PF00082	0.465
CLV_PCSK_KEX2_1	51	53	PF00082	0.458
CLV_PCSK_KEX2_1	638	640	PF00082	0.604
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.747
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.411
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.580
CLV_PCSK_PC7_1	47	53	PF00082	0.488
CLV_PCSK_SKI1_1	422	426	PF00082	0.591
CLV_PCSK_SKI1_1	484	488	PF00082	0.518
CLV_PCSK_SKI1_1	607	611	PF00082	0.642
DEG_APCC_DBOX_1	421	429	PF00400	0.391
DEG_SPOP_SBC_1	21	25	PF00917	0.595
DOC_CYCLIN_RxL_1	481	491	PF00134	0.324
DOC_MAPK_FxFP_2	620	623	PF00069	0.456
DOC_MAPK_gen_1	106	115	PF00069	0.368
DOC_MAPK_gen_1	368	377	PF00069	0.382
DOC_MAPK_gen_1	555	562	PF00069	0.423
DOC_MAPK_JIP1_4	482	488	PF00069	0.290
DOC_MAPK_MEF2A_6	269	278	PF00069	0.414
DOC_MAPK_MEF2A_6	530	538	PF00069	0.361
DOC_PP2B_LxvP_1	256	259	PF13499	0.326
DOC_PP2B_LxvP_1	311	314	PF13499	0.523
DOC_PP4_FxxP_1	348	351	PF00568	0.427
DOC_PP4_FxxP_1	620	623	PF00568	0.456
DOC_USP7_MATH_1	191	195	PF00917	0.493
DOC_USP7_MATH_1	209	213	PF00917	0.309
DOC_USP7_MATH_1	22	26	PF00917	0.729
DOC_USP7_MATH_1	297	301	PF00917	0.486
DOC_USP7_MATH_1	358	362	PF00917	0.558
DOC_USP7_MATH_1	394	398	PF00917	0.567
DOC_USP7_MATH_1	496	500	PF00917	0.391
DOC_WW_Pin1_4	11	16	PF00397	0.726
DOC_WW_Pin1_4	137	142	PF00397	0.473
DOC_WW_Pin1_4	201	206	PF00397	0.494
DOC_WW_Pin1_4	215	220	PF00397	0.380
DOC_WW_Pin1_4	254	259	PF00397	0.322
DOC_WW_Pin1_4	347	352	PF00397	0.500
DOC_WW_Pin1_4	354	359	PF00397	0.521
DOC_WW_Pin1_4	389	394	PF00397	0.550
DOC_WW_Pin1_4	436	441	PF00397	0.342
DOC_WW_Pin1_4	472	477	PF00397	0.345
DOC_WW_Pin1_4	549	554	PF00397	0.530
LIG_14-3-3_CanoR_1	106	115	PF00244	0.535
LIG_14-3-3_CanoR_1	162	167	PF00244	0.424
LIG_14-3-3_CanoR_1	184	189	PF00244	0.476
LIG_14-3-3_CanoR_1	226	234	PF00244	0.443
LIG_14-3-3_CanoR_1	51	57	PF00244	0.670
LIG_14-3-3_CanoR_1	555	560	PF00244	0.340
LIG_Actin_WH2_2	263	281	PF00022	0.310
LIG_APCC_ABBA_1	629	634	PF00400	0.406
LIG_deltaCOP1_diTrp_1	430	436	PF00928	0.361
LIG_deltaCOP1_diTrp_1	503	510	PF00928	0.211
LIG_eIF4E_1	359	365	PF01652	0.533
LIG_eIF4E_1	481	487	PF01652	0.308
LIG_FHA_1	108	114	PF00498	0.530
LIG_FHA_1	250	256	PF00498	0.413
LIG_FHA_1	290	296	PF00498	0.439
LIG_FHA_1	313	319	PF00498	0.485
LIG_FHA_1	378	384	PF00498	0.545
LIG_FHA_1	412	418	PF00498	0.480
LIG_FHA_1	461	467	PF00498	0.295
LIG_FHA_1	489	495	PF00498	0.340
LIG_FHA_1	570	576	PF00498	0.487
LIG_FHA_1	624	630	PF00498	0.407
LIG_FHA_2	302	308	PF00498	0.500
LIG_FHA_2	556	562	PF00498	0.317
LIG_KLC1_Yacidic_2	513	518	PF13176	0.391
LIG_LIR_Gen_1	126	133	PF02991	0.532
LIG_LIR_Gen_1	150	158	PF02991	0.366
LIG_LIR_Gen_1	285	295	PF02991	0.453
LIG_LIR_Nem_3	150	154	PF02991	0.472
LIG_LIR_Nem_3	285	291	PF02991	0.436
LIG_Pex14_2	147	151	PF04695	0.382
LIG_PTB_Apo_2	207	214	PF02174	0.490
LIG_PTB_Phospho_1	207	213	PF10480	0.493
LIG_SH2_CRK	584	588	PF00017	0.445
LIG_SH2_SRC	531	534	PF00017	0.331
LIG_SH2_STAP1	129	133	PF00017	0.360
LIG_SH2_STAP1	501	505	PF00017	0.278
LIG_SH2_STAP1	531	535	PF00017	0.353
LIG_SH2_STAT3	426	429	PF00017	0.361
LIG_SH2_STAT5	172	175	PF00017	0.470
LIG_SH2_STAT5	207	210	PF00017	0.515
LIG_SH2_STAT5	213	216	PF00017	0.418
LIG_SH2_STAT5	228	231	PF00017	0.383
LIG_SH2_STAT5	516	519	PF00017	0.354
LIG_SH3_3	12	18	PF00018	0.728
LIG_SH3_3	138	144	PF00018	0.587
LIG_SH3_3	473	479	PF00018	0.287
LIG_SH3_3	568	574	PF00018	0.470
LIG_SH3_3	584	590	PF00018	0.412
LIG_SH3_3	597	603	PF00018	0.398
LIG_SUMO_SIM_anti_2	245	250	PF11976	0.374
LIG_SUMO_SIM_par_1	572	579	PF11976	0.479
LIG_TRAF2_1	446	449	PF00917	0.365
LIG_TRAF2_1	603	606	PF00917	0.454
LIG_WRC_WIRS_1	622	627	PF05994	0.405
LIG_WRPW_2	562	565	PF00400	0.404
LIG_WW_3	392	396	PF00397	0.546
LIG_WW_3	552	556	PF00397	0.481
MOD_CDC14_SPxK_1	552	555	PF00782	0.524
MOD_CDK_SPK_2	201	206	PF00069	0.504
MOD_CDK_SPxK_1	389	395	PF00069	0.433
MOD_CDK_SPxK_1	549	555	PF00069	0.520
MOD_CDK_SPxxK_3	475	482	PF00069	0.211
MOD_CK1_1	136	142	PF00069	0.431
MOD_CK1_1	182	188	PF00069	0.479
MOD_CK1_1	194	200	PF00069	0.408
MOD_CK1_1	23	29	PF00069	0.682
MOD_CK1_1	257	263	PF00069	0.526
MOD_CK1_1	35	41	PF00069	0.733
MOD_CK1_1	389	395	PF00069	0.542
MOD_CK1_1	397	403	PF00069	0.518
MOD_CK1_1	461	467	PF00069	0.346
MOD_CK1_1	475	481	PF00069	0.354
MOD_CK1_1	569	575	PF00069	0.483
MOD_CK2_1	346	352	PF00069	0.532
MOD_CK2_1	443	449	PF00069	0.327
MOD_CK2_1	555	561	PF00069	0.329
MOD_GlcNHglycan	115	118	PF01048	0.720
MOD_GlcNHglycan	136	139	PF01048	0.743
MOD_GlcNHglycan	169	172	PF01048	0.653
MOD_GlcNHglycan	191	194	PF01048	0.700
MOD_GlcNHglycan	196	199	PF01048	0.692
MOD_GlcNHglycan	223	226	PF01048	0.520
MOD_GlcNHglycan	26	29	PF01048	0.567
MOD_GlcNHglycan	339	343	PF01048	0.706
MOD_GlcNHglycan	611	614	PF01048	0.703
MOD_GSK3_1	132	139	PF00069	0.475
MOD_GSK3_1	189	196	PF00069	0.512
MOD_GSK3_1	197	204	PF00069	0.435
MOD_GSK3_1	20	27	PF00069	0.666
MOD_GSK3_1	209	216	PF00069	0.429
MOD_GSK3_1	254	261	PF00069	0.500
MOD_GSK3_1	297	304	PF00069	0.497
MOD_GSK3_1	354	361	PF00069	0.513
MOD_GSK3_1	456	463	PF00069	0.359
MOD_N-GLC_1	194	199	PF02516	0.683
MOD_N-GLC_1	209	214	PF02516	0.703
MOD_N-GLC_1	359	364	PF02516	0.761
MOD_N-GLC_1	377	382	PF02516	0.564
MOD_N-GLC_1	443	448	PF02516	0.565
MOD_N-GLC_1	496	501	PF02516	0.591
MOD_N-GLC_1	518	523	PF02516	0.504
MOD_NEK2_1	113	118	PF00069	0.568
MOD_NEK2_1	132	137	PF00069	0.417
MOD_NEK2_1	199	204	PF00069	0.426
MOD_NEK2_1	298	303	PF00069	0.444
MOD_NEK2_1	338	343	PF00069	0.490
MOD_NEK2_1	364	369	PF00069	0.565
MOD_NEK2_1	410	415	PF00069	0.423
MOD_NEK2_1	460	465	PF00069	0.398
MOD_NEK2_1	609	614	PF00069	0.490
MOD_NEK2_1	74	79	PF00069	0.575
MOD_PIKK_1	139	145	PF00454	0.532
MOD_PIKK_1	312	318	PF00454	0.435
MOD_PIKK_1	569	575	PF00454	0.493
MOD_PIKK_1	72	78	PF00454	0.619
MOD_PK_1	162	168	PF00069	0.373
MOD_PKA_2	167	173	PF00069	0.331
MOD_PKA_2	179	185	PF00069	0.414
MOD_PKA_2	394	400	PF00069	0.584
MOD_PKA_2	489	495	PF00069	0.347
MOD_PKB_1	52	60	PF00069	0.597
MOD_Plk_1	194	200	PF00069	0.503
MOD_Plk_1	209	215	PF00069	0.336
MOD_Plk_1	359	365	PF00069	0.563
MOD_Plk_1	443	449	PF00069	0.391
MOD_Plk_1	496	502	PF00069	0.391
MOD_Plk_4	314	320	PF00069	0.466
MOD_Plk_4	359	365	PF00069	0.533
MOD_Plk_4	462	468	PF00069	0.365
MOD_ProDKin_1	11	17	PF00069	0.726
MOD_ProDKin_1	137	143	PF00069	0.475
MOD_ProDKin_1	201	207	PF00069	0.495
MOD_ProDKin_1	215	221	PF00069	0.377
MOD_ProDKin_1	254	260	PF00069	0.331
MOD_ProDKin_1	347	353	PF00069	0.501
MOD_ProDKin_1	354	360	PF00069	0.524
MOD_ProDKin_1	389	395	PF00069	0.551
MOD_ProDKin_1	436	442	PF00069	0.342
MOD_ProDKin_1	472	478	PF00069	0.345
MOD_ProDKin_1	549	555	PF00069	0.531
TRG_DiLeu_BaEn_1	605	610	PF01217	0.439
TRG_DiLeu_BaLyEn_6	490	495	PF01217	0.242
TRG_ENDOCYTIC_2	129	132	PF00928	0.543
TRG_ENDOCYTIC_2	531	534	PF00928	0.353
TRG_ENDOCYTIC_2	584	587	PF00928	0.383
TRG_ENDOCYTIC_2	622	625	PF00928	0.383
TRG_ER_diArg_1	44	47	PF00400	0.679
TRG_ER_diArg_1	452	455	PF00400	0.310
TRG_ER_diArg_1	481	484	PF00400	0.229
TRG_ER_diArg_1	50	52	PF00400	0.665
TRG_ER_diArg_1	554	557	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	639	643	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBV1	Leptomonas seymouri	26%	100%
A0A0N1PD55	Leptomonas seymouri	45%	100%
A0A1X0NW39	Trypanosomatidae	23%	100%
A0A3Q8IHF7	Leishmania donovani	79%	100%
A4HUW3	Leishmania infantum	79%	100%
E9ANK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QH26	Leishmania major	80%	99%
V5BJI5	Trypanosoma cruzi	23%	100%