Putative amino acid permease/transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

amino acid permease/transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4H6H7_LEIBR

TriTrypDb:

LbrM.11.0290 , LBRM2903_110007800

Length:

467

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	23
GO:0110165	cellular anatomical entity	1	23
GO:0000323	lytic vacuole	6	1
GO:0005764	lysosome	7	1
GO:0005773	vacuole	5	1
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H6H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6H7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	23
GO:0015203	polyamine transmembrane transporter activity	3	23
GO:0022857	transmembrane transporter activity	2	23
GO:0003824	catalytic activity	1	5
GO:0016787	hydrolase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	301	303	PF00675	0.200
CLV_NRD_NRD_1	455	457	PF00675	0.505
CLV_PCSK_KEX2_1	301	303	PF00082	0.297
CLV_PCSK_KEX2_1	455	457	PF00082	0.494
CLV_PCSK_SKI1_1	256	260	PF00082	0.398
CLV_PCSK_SKI1_1	429	433	PF00082	0.396
DEG_Nend_Nbox_1	1	3	PF02207	0.253
DOC_CYCLIN_yCln2_LP_2	361	367	PF00134	0.425
DOC_MAPK_gen_1	107	116	PF00069	0.289
DOC_MAPK_MEF2A_6	343	351	PF00069	0.318
DOC_MAPK_MEF2A_6	373	382	PF00069	0.514
DOC_MAPK_MEF2A_6	397	406	PF00069	0.314
DOC_PP1_RVXF_1	427	434	PF00149	0.530
DOC_PP1_RVXF_1	59	65	PF00149	0.309
DOC_PP4_FxxP_1	365	368	PF00568	0.436
DOC_USP7_MATH_1	226	230	PF00917	0.284
DOC_USP7_MATH_1	381	385	PF00917	0.328
DOC_USP7_MATH_1	438	442	PF00917	0.694
DOC_USP7_MATH_1	49	53	PF00917	0.429
DOC_USP7_MATH_1	73	77	PF00917	0.383
LIG_14-3-3_CanoR_1	205	211	PF00244	0.435
LIG_14-3-3_CanoR_1	429	434	PF00244	0.633
LIG_Actin_WH2_2	243	258	PF00022	0.251
LIG_APCC_ABBA_1	391	396	PF00400	0.295
LIG_Clathr_ClatBox_1	122	126	PF01394	0.152
LIG_Clathr_ClatBox_1	332	336	PF01394	0.325
LIG_CtBP_PxDLS_1	232	236	PF00389	0.200
LIG_deltaCOP1_diTrp_1	171	175	PF00928	0.452
LIG_FHA_1	1	7	PF00498	0.318
LIG_FHA_1	129	135	PF00498	0.299
LIG_FHA_1	171	177	PF00498	0.529
LIG_FHA_1	276	282	PF00498	0.403
LIG_FHA_1	397	403	PF00498	0.269
LIG_FHA_1	434	440	PF00498	0.578
LIG_FHA_1	452	458	PF00498	0.716
LIG_FHA_2	189	195	PF00498	0.484
LIG_LIR_Apic_2	217	221	PF02991	0.290
LIG_LIR_Gen_1	169	179	PF02991	0.469
LIG_LIR_Gen_1	240	250	PF02991	0.277
LIG_LIR_Gen_1	312	323	PF02991	0.373
LIG_LIR_Gen_1	414	421	PF02991	0.385
LIG_LIR_Gen_1	67	77	PF02991	0.259
LIG_LIR_Nem_3	169	175	PF02991	0.436
LIG_LIR_Nem_3	240	246	PF02991	0.264
LIG_LIR_Nem_3	304	309	PF02991	0.436
LIG_LIR_Nem_3	312	318	PF02991	0.335
LIG_LIR_Nem_3	320	326	PF02991	0.257
LIG_LIR_Nem_3	328	332	PF02991	0.203
LIG_LIR_Nem_3	350	354	PF02991	0.348
LIG_LIR_Nem_3	414	420	PF02991	0.281
LIG_LIR_Nem_3	76	82	PF02991	0.317
LIG_LIR_Nem_3	89	94	PF02991	0.255
LIG_LYPXL_S_1	86	90	PF13949	0.457
LIG_LYPXL_yS_3	87	90	PF13949	0.241
LIG_NRBOX	110	116	PF00104	0.329
LIG_Pex14_1	238	242	PF04695	0.237
LIG_Pex14_1	311	315	PF04695	0.232
LIG_Pex14_2	143	147	PF04695	0.260
LIG_Pex14_2	156	160	PF04695	0.444
LIG_Pex14_2	365	369	PF04695	0.469
LIG_PTB_Apo_2	81	88	PF02174	0.229
LIG_PTB_Phospho_1	81	87	PF10480	0.241
LIG_REV1ctd_RIR_1	418	427	PF16727	0.513
LIG_SH2_GRB2like	157	160	PF00017	0.448
LIG_SH2_PTP2	218	221	PF00017	0.290
LIG_SH2_PTP2	79	82	PF00017	0.200
LIG_SH2_SRC	165	168	PF00017	0.480
LIG_SH2_SRC	218	221	PF00017	0.290
LIG_SH2_STAP1	2	6	PF00017	0.302
LIG_SH2_STAT5	157	160	PF00017	0.430
LIG_SH2_STAT5	165	168	PF00017	0.437
LIG_SH2_STAT5	2	5	PF00017	0.289
LIG_SH2_STAT5	218	221	PF00017	0.271
LIG_SH2_STAT5	417	420	PF00017	0.352
LIG_SH2_STAT5	69	72	PF00017	0.269
LIG_SH2_STAT5	79	82	PF00017	0.228
LIG_SH2_STAT5	94	97	PF00017	0.215
LIG_SH3_3	155	161	PF00018	0.496
LIG_SUMO_SIM_anti_2	206	212	PF11976	0.152
LIG_SUMO_SIM_anti_2	24	30	PF11976	0.396
LIG_SUMO_SIM_anti_2	331	336	PF11976	0.332
LIG_SUMO_SIM_anti_2	396	402	PF11976	0.292
LIG_SUMO_SIM_par_1	131	139	PF11976	0.349
LIG_SUMO_SIM_par_1	21	27	PF11976	0.318
LIG_SUMO_SIM_par_1	231	236	PF11976	0.366
LIG_SUMO_SIM_par_1	331	336	PF11976	0.305
LIG_SUMO_SIM_par_1	344	350	PF11976	0.405
LIG_SUMO_SIM_par_1	386	392	PF11976	0.227
LIG_SUMO_SIM_par_1	39	45	PF11976	0.372
LIG_SxIP_EBH_1	429	443	PF03271	0.505
LIG_TYR_ITIM	77	82	PF00017	0.232
LIG_TYR_ITSM	238	245	PF00017	0.251
LIG_UBA3_1	390	397	PF00899	0.238
LIG_UBA3_1	57	61	PF00899	0.518
LIG_WRC_WIRS_1	1	6	PF05994	0.369
LIG_WRC_WIRS_1	245	250	PF05994	0.143
LIG_WRC_WIRS_1	326	331	PF05994	0.244
LIG_WRC_WIRS_1	348	353	PF05994	0.379
LIG_WRC_WIRS_1	412	417	PF05994	0.410
LIG_WRC_WIRS_1	430	435	PF05994	0.549
MOD_CK1_1	177	183	PF00069	0.450
MOD_CK1_1	199	205	PF00069	0.417
MOD_CK1_1	206	212	PF00069	0.250
MOD_CK1_1	263	269	PF00069	0.251
MOD_CK1_1	280	286	PF00069	0.495
MOD_CK1_1	328	334	PF00069	0.202
MOD_CK1_1	443	449	PF00069	0.722
MOD_CK2_1	181	187	PF00069	0.443
MOD_CK2_1	188	194	PF00069	0.412
MOD_CK2_1	461	467	PF00069	0.571
MOD_GlcNHglycan	183	186	PF01048	0.280
MOD_GlcNHglycan	265	268	PF01048	0.288
MOD_GlcNHglycan	272	275	PF01048	0.226
MOD_GlcNHglycan	282	285	PF01048	0.286
MOD_GlcNHglycan	383	386	PF01048	0.326
MOD_GlcNHglycan	47	50	PF01048	0.185
MOD_GlcNHglycan	6	9	PF01048	0.446
MOD_GSK3_1	129	136	PF00069	0.297
MOD_GSK3_1	166	173	PF00069	0.453
MOD_GSK3_1	177	184	PF00069	0.435
MOD_GSK3_1	199	206	PF00069	0.475
MOD_GSK3_1	233	240	PF00069	0.303
MOD_GSK3_1	256	263	PF00069	0.308
MOD_GSK3_1	270	277	PF00069	0.271
MOD_GSK3_1	305	312	PF00069	0.424
MOD_GSK3_1	317	324	PF00069	0.313
MOD_GSK3_1	407	414	PF00069	0.330
MOD_GSK3_1	429	436	PF00069	0.636
MOD_GSK3_1	45	52	PF00069	0.359
MOD_GSK3_1	451	458	PF00069	0.782
MOD_GSK3_1	60	67	PF00069	0.260
MOD_GSK3_1	95	102	PF00069	0.223
MOD_N-GLC_1	443	448	PF02516	0.436
MOD_NEK2_1	175	180	PF00069	0.443
MOD_NEK2_1	233	238	PF00069	0.364
MOD_NEK2_1	268	273	PF00069	0.263
MOD_NEK2_1	275	280	PF00069	0.421
MOD_NEK2_1	322	327	PF00069	0.315
MOD_NEK2_1	4	9	PF00069	0.246
MOD_NEK2_1	433	438	PF00069	0.658
MOD_NEK2_1	64	69	PF00069	0.288
MOD_NEK2_1	95	100	PF00069	0.312
MOD_PIKK_1	233	239	PF00454	0.208
MOD_PKA_1	455	461	PF00069	0.555
MOD_PKA_2	455	461	PF00069	0.650
MOD_PKA_2	99	105	PF00069	0.177
MOD_Plk_1	12	18	PF00069	0.201
MOD_Plk_1	170	176	PF00069	0.427
MOD_Plk_1	199	205	PF00069	0.360
MOD_Plk_1	233	239	PF00069	0.257
MOD_Plk_4	12	18	PF00069	0.201
MOD_Plk_4	129	135	PF00069	0.299
MOD_Plk_4	171	177	PF00069	0.370
MOD_Plk_4	188	194	PF00069	0.479
MOD_Plk_4	199	205	PF00069	0.433
MOD_Plk_4	206	212	PF00069	0.242
MOD_Plk_4	21	27	PF00069	0.274
MOD_Plk_4	260	266	PF00069	0.296
MOD_Plk_4	277	283	PF00069	0.461
MOD_Plk_4	314	320	PF00069	0.258
MOD_Plk_4	322	328	PF00069	0.294
MOD_Plk_4	386	392	PF00069	0.273
MOD_Plk_4	396	402	PF00069	0.240
MOD_Plk_4	411	417	PF00069	0.297
MOD_Plk_4	429	435	PF00069	0.637
MOD_Plk_4	73	79	PF00069	0.263
MOD_Plk_4	86	92	PF00069	0.263
MOD_SUMO_rev_2	441	451	PF00179	0.549
TRG_DiLeu_BaEn_2	170	176	PF01217	0.343
TRG_ENDOCYTIC_2	242	245	PF00928	0.216
TRG_ENDOCYTIC_2	358	361	PF00928	0.445
TRG_ENDOCYTIC_2	417	420	PF00928	0.369
TRG_ENDOCYTIC_2	69	72	PF00928	0.275
TRG_ENDOCYTIC_2	79	82	PF00928	0.231
TRG_ENDOCYTIC_2	87	90	PF00928	0.234
TRG_ER_diArg_1	455	457	PF00400	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2T0	Leptomonas seymouri	68%	81%
A0A0N1PGN1	Leptomonas seymouri	34%	89%
A0A0S4IJF6	Bodo saltans	22%	80%
A0A0S4ISA5	Bodo saltans	22%	81%
A0A0S4JBT0	Bodo saltans	27%	90%
A0A1X0NNQ0	Trypanosomatidae	30%	74%
A0A1X0NV66	Trypanosomatidae	50%	89%
A0A1X0P501	Trypanosomatidae	35%	86%
A0A3R7M6P3	Trypanosoma rangeli	31%	76%
A0A3R7N0T9	Trypanosoma rangeli	52%	92%
A0A3S5IRV3	Trypanosoma rangeli	35%	92%
A0A3S7WRN2	Leishmania donovani	84%	100%
A0A3S7XA01	Leishmania donovani	34%	90%
A2X8M8	Oryza sativa subsp. indica	27%	88%
A4HNB0	Leishmania braziliensis	36%	90%
A4HUW5	Leishmania infantum	84%	100%
A4IBY1	Leishmania infantum	35%	90%
C9ZYM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	95%
D0A7J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	92%
E9AFR8	Leishmania major	35%	100%
E9ANJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9B6X1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	90%
Q4QH28	Leishmania major	82%	100%
Q6Z8D0	Oryza sativa subsp. japonica	27%	88%
Q9C6S4	Arabidopsis thaliana	27%	97%
Q9C6S5	Arabidopsis thaliana	29%	94%
Q9FFL1	Arabidopsis thaliana	28%	95%
Q9LH39	Arabidopsis thaliana	26%	97%
Q9LHN7	Arabidopsis thaliana	24%	98%
V5BCQ1	Trypanosoma cruzi	37%	100%
V5DDZ5	Trypanosoma cruzi	30%	74%