Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4H6H6_LEIBR

TriTrypDb:

LbrM.11.0280 , LBRM2903_110007700

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6H6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.523
CLV_C14_Caspase3-7	61	65	PF00656	0.511
CLV_PCSK_KEX2_1	190	192	PF00082	0.344
CLV_PCSK_KEX2_1	308	310	PF00082	0.287
CLV_PCSK_KEX2_1	319	321	PF00082	0.287
CLV_PCSK_KEX2_1	85	87	PF00082	0.453
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.344
CLV_PCSK_PC1ET2_1	308	310	PF00082	0.273
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.313
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.453
CLV_PCSK_SKI1_1	203	207	PF00082	0.539
CLV_PCSK_SKI1_1	235	239	PF00082	0.366
CLV_PCSK_SKI1_1	286	290	PF00082	0.277
CLV_PCSK_SKI1_1	297	301	PF00082	0.336
CLV_PCSK_SKI1_1	37	41	PF00082	0.560
CLV_PCSK_SKI1_1	541	545	PF00082	0.363
CLV_PCSK_SKI1_1	568	572	PF00082	0.472
DEG_MDM2_SWIB_1	178	186	PF02201	0.321
DEG_Nend_Nbox_1	1	3	PF02207	0.477
DEG_SPOP_SBC_1	130	134	PF00917	0.627
DOC_CKS1_1	373	378	PF01111	0.363
DOC_CYCLIN_RxL_1	34	41	PF00134	0.308
DOC_MAPK_gen_1	245	254	PF00069	0.309
DOC_MAPK_gen_1	35	42	PF00069	0.395
DOC_MAPK_MEF2A_6	103	111	PF00069	0.451
DOC_MAPK_MEF2A_6	247	256	PF00069	0.254
DOC_MAPK_MEF2A_6	522	530	PF00069	0.363
DOC_PP1_RVXF_1	233	240	PF00149	0.200
DOC_PP1_RVXF_1	491	497	PF00149	0.206
DOC_PP2B_LxvP_1	109	112	PF13499	0.529
DOC_USP7_MATH_1	130	134	PF00917	0.638
DOC_USP7_MATH_1	241	245	PF00917	0.206
DOC_USP7_MATH_1	501	505	PF00917	0.212
DOC_USP7_MATH_1	98	102	PF00917	0.464
DOC_USP7_UBL2_3	148	152	PF12436	0.663
DOC_WW_Pin1_4	158	163	PF00397	0.533
DOC_WW_Pin1_4	372	377	PF00397	0.363
DOC_WW_Pin1_4	402	407	PF00397	0.347
DOC_WW_Pin1_4	479	484	PF00397	0.320
LIG_14-3-3_CanoR_1	203	210	PF00244	0.471
LIG_14-3-3_CanoR_1	35	40	PF00244	0.385
LIG_14-3-3_CanoR_1	453	459	PF00244	0.300
LIG_14-3-3_CanoR_1	479	483	PF00244	0.238
LIG_14-3-3_CanoR_1	559	565	PF00244	0.381
LIG_Actin_WH2_2	292	310	PF00022	0.291
LIG_APCC_ABBA_1	110	115	PF00400	0.454
LIG_APCC_ABBA_1	348	353	PF00400	0.363
LIG_BRCT_BRCA1_1	513	517	PF00533	0.387
LIG_BRCT_BRCA1_1	536	540	PF00533	0.314
LIG_BRCT_BRCA1_1	562	566	PF00533	0.363
LIG_Clathr_ClatBox_1	461	465	PF01394	0.206
LIG_deltaCOP1_diTrp_1	419	428	PF00928	0.363
LIG_eIF4E_1	456	462	PF01652	0.206
LIG_FHA_1	102	108	PF00498	0.454
LIG_FHA_1	204	210	PF00498	0.441
LIG_FHA_1	215	221	PF00498	0.288
LIG_FHA_1	298	304	PF00498	0.363
LIG_FHA_1	308	314	PF00498	0.260
LIG_FHA_1	430	436	PF00498	0.287
LIG_FHA_1	511	517	PF00498	0.380
LIG_FHA_2	19	25	PF00498	0.447
LIG_FHA_2	414	420	PF00498	0.287
LIG_FHA_2	480	486	PF00498	0.324
LIG_FHA_2	82	88	PF00498	0.570
LIG_GBD_Chelix_1	252	260	PF00786	0.363
LIG_LIR_Apic_2	400	406	PF02991	0.287
LIG_LIR_Gen_1	121	130	PF02991	0.602
LIG_LIR_Gen_1	211	220	PF02991	0.427
LIG_LIR_Gen_1	26	36	PF02991	0.454
LIG_LIR_Gen_1	355	365	PF02991	0.301
LIG_LIR_Nem_3	121	126	PF02991	0.482
LIG_LIR_Nem_3	173	178	PF02991	0.560
LIG_LIR_Nem_3	211	216	PF02991	0.418
LIG_LIR_Nem_3	26	31	PF02991	0.454
LIG_LIR_Nem_3	33	39	PF02991	0.384
LIG_LIR_Nem_3	355	361	PF02991	0.301
LIG_LIR_Nem_3	366	371	PF02991	0.321
LIG_LIR_Nem_3	434	440	PF02991	0.363
LIG_LIR_Nem_3	537	543	PF02991	0.401
LIG_LYPXL_yS_3	444	447	PF13949	0.363
LIG_Pex14_2	178	182	PF04695	0.357
LIG_PTAP_UEV_1	161	166	PF05743	0.519
LIG_SH2_CRK	123	127	PF00017	0.483
LIG_SH2_CRK	36	40	PF00017	0.452
LIG_SH2_STAP1	250	254	PF00017	0.363
LIG_SH2_STAP1	290	294	PF00017	0.363
LIG_SH2_STAT3	456	459	PF00017	0.206
LIG_SH2_STAT5	193	196	PF00017	0.410
LIG_SH2_STAT5	200	203	PF00017	0.390
LIG_SH2_STAT5	274	277	PF00017	0.230
LIG_SH2_STAT5	456	459	PF00017	0.254
LIG_SH2_STAT5	476	479	PF00017	0.206
LIG_SH3_3	159	165	PF00018	0.526
LIG_SH3_3	370	376	PF00018	0.363
LIG_SH3_3	433	439	PF00018	0.320
LIG_SH3_3	480	486	PF00018	0.267
LIG_SH3_3	550	556	PF00018	0.370
LIG_SUMO_SIM_anti_2	529	535	PF11976	0.206
LIG_SUMO_SIM_par_1	230	236	PF11976	0.363
LIG_SUMO_SIM_par_1	526	532	PF11976	0.291
LIG_WRC_WIRS_1	540	545	PF05994	0.363
MOD_CK1_1	101	107	PF00069	0.727
MOD_CK1_1	118	124	PF00069	0.500
MOD_CK1_1	134	140	PF00069	0.571
MOD_CK1_1	151	157	PF00069	0.556
MOD_CK1_1	38	44	PF00069	0.372
MOD_CK1_1	393	399	PF00069	0.313
MOD_CK1_1	405	411	PF00069	0.275
MOD_CK1_1	511	517	PF00069	0.327
MOD_CK1_1	535	541	PF00069	0.298
MOD_CK1_1	57	63	PF00069	0.422
MOD_CK1_1	80	86	PF00069	0.613
MOD_CK2_1	81	87	PF00069	0.455
MOD_Cter_Amidation	188	191	PF01082	0.381
MOD_DYRK1A_RPxSP_1	479	483	PF00069	0.206
MOD_GlcNHglycan	100	103	PF01048	0.436
MOD_GlcNHglycan	136	139	PF01048	0.651
MOD_GlcNHglycan	166	169	PF01048	0.501
MOD_GlcNHglycan	187	190	PF01048	0.290
MOD_GlcNHglycan	326	329	PF01048	0.230
MOD_GlcNHglycan	352	357	PF01048	0.435
MOD_GlcNHglycan	473	476	PF01048	0.456
MOD_GlcNHglycan	498	502	PF01048	0.306
MOD_GlcNHglycan	64	67	PF01048	0.535
MOD_GlcNHglycan	7	10	PF01048	0.637
MOD_GSK3_1	130	137	PF00069	0.712
MOD_GSK3_1	148	155	PF00069	0.491
MOD_GSK3_1	160	167	PF00069	0.545
MOD_GSK3_1	216	223	PF00069	0.300
MOD_GSK3_1	295	302	PF00069	0.457
MOD_GSK3_1	393	400	PF00069	0.363
MOD_GSK3_1	419	426	PF00069	0.314
MOD_GSK3_1	471	478	PF00069	0.464
MOD_GSK3_1	497	504	PF00069	0.326
MOD_GSK3_1	535	542	PF00069	0.477
MOD_GSK3_1	56	63	PF00069	0.481
MOD_GSK3_1	77	84	PF00069	0.605
MOD_GSK3_1	97	104	PF00069	0.488
MOD_N-GLC_1	134	139	PF02516	0.648
MOD_N-GLC_1	220	225	PF02516	0.325
MOD_NEK2_1	157	162	PF00069	0.603
MOD_NEK2_1	295	300	PF00069	0.324
MOD_NEK2_1	307	312	PF00069	0.446
MOD_NEK2_1	351	356	PF00069	0.287
MOD_NEK2_1	423	428	PF00069	0.292
MOD_NEK2_1	496	501	PF00069	0.311
MOD_PIKK_1	43	49	PF00454	0.493
MOD_PIKK_1	511	517	PF00454	0.363
MOD_PKA_2	18	24	PF00069	0.417
MOD_PKA_2	478	484	PF00069	0.304
MOD_PKA_2	554	560	PF00069	0.287
MOD_Plk_1	118	124	PF00069	0.637
MOD_Plk_1	170	176	PF00069	0.570
MOD_Plk_1	235	241	PF00069	0.363
MOD_Plk_1	352	358	PF00069	0.309
MOD_Plk_1	49	55	PF00069	0.475
MOD_Plk_4	118	124	PF00069	0.627
MOD_Plk_4	170	176	PF00069	0.676
MOD_Plk_4	23	29	PF00069	0.502
MOD_Plk_4	265	271	PF00069	0.477
MOD_Plk_4	35	41	PF00069	0.349
MOD_Plk_4	390	396	PF00069	0.308
MOD_Plk_4	397	403	PF00069	0.346
MOD_Plk_4	443	449	PF00069	0.287
MOD_Plk_4	457	463	PF00069	0.287
MOD_ProDKin_1	158	164	PF00069	0.530
MOD_ProDKin_1	372	378	PF00069	0.363
MOD_ProDKin_1	402	408	PF00069	0.347
MOD_ProDKin_1	479	485	PF00069	0.320
MOD_SUMO_rev_2	379	388	PF00179	0.225
MOD_SUMO_rev_2	460	469	PF00179	0.206
MOD_SUMO_rev_2	563	573	PF00179	0.316
TRG_DiLeu_BaEn_1	334	339	PF01217	0.206
TRG_DiLeu_BaEn_2	538	544	PF01217	0.363
TRG_ENDOCYTIC_2	123	126	PF00928	0.484
TRG_ENDOCYTIC_2	28	31	PF00928	0.447
TRG_ENDOCYTIC_2	290	293	PF00928	0.394
TRG_ENDOCYTIC_2	358	361	PF00928	0.311
TRG_ENDOCYTIC_2	36	39	PF00928	0.390
TRG_ENDOCYTIC_2	444	447	PF00928	0.363
TRG_ENDOCYTIC_2	521	524	PF00928	0.287
TRG_ER_diArg_1	492	495	PF00400	0.399
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I436	Leptomonas seymouri	40%	98%
A0A3Q8IB87	Leishmania donovani	77%	100%
A4HUW6	Leishmania infantum	77%	100%
E9ANJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
G5EEN4	Caenorhabditis elegans	25%	97%
Q4QH29	Leishmania major	76%	100%