LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H6H3_LEIBR
TriTrypDb:
LbrM.11.0250 , LBRM2903_230016100 *
Length:
482

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 7, no: 1
NetGPI no yes: 0, no: 8
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 8
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 8
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Expansion

Sequence features

A4H6H3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6H3

Function

Biological processes
TermNameLevelCount
GO:0006810 transport 3 1
GO:0006887 exocytosis 4 1
GO:0009987 cellular process 1 1
GO:0016192 vesicle-mediated transport 4 1
GO:0032940 secretion by cell 3 1
GO:0045055 regulated exocytosis 5 1
GO:0046903 secretion 4 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0140352 export from cell 2 1
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Molecular functions
TermNameLevelCount
GO:0005488 binding 1 6
GO:0005515 protein binding 2 6
GO:0019899 enzyme binding 3 6
GO:0031267 small GTPase binding 5 6
GO:0051020 GTPase binding 4 6
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 218 222 PF00656 0.394
CLV_C14_Caspase3-7 228 232 PF00656 0.379
CLV_C14_Caspase3-7 35 39 PF00656 0.556
CLV_NRD_NRD_1 10 12 PF00675 0.720
CLV_NRD_NRD_1 102 104 PF00675 0.634
CLV_NRD_NRD_1 120 122 PF00675 0.651
CLV_NRD_NRD_1 80 82 PF00675 0.694
CLV_NRD_NRD_1 95 97 PF00675 0.601
CLV_PCSK_FUR_1 117 121 PF00082 0.769
CLV_PCSK_KEX2_1 102 104 PF00082 0.606
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PD68 Leptomonas seymouri 44% 87%
A0A3Q8ICI9 Leishmania donovani 66% 86%
A0A422NEU3 Trypanosoma rangeli 23% 100%
A4I0B5 Leishmania infantum 66% 87%
E9AW79 Leishmania mexicana (strain MHOM/GT/2001/U1103) 62% 79%
Q9U0V4 Leishmania major 62% 100%
V5BFM4 Trypanosoma cruzi 21% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS