Transmembrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6H3_LEIBR

TriTrypDb:

LbrM.11.0250 , LBRM2903_230016100

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 1
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H6H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6H3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006887	exocytosis	4	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0032940	secretion by cell	3	1
GO:0045055	regulated exocytosis	5	1
GO:0046903	secretion	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0140352	export from cell	2	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0019899	enzyme binding	3	6
GO:0031267	small GTPase binding	5	6
GO:0051020	GTPase binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.394
CLV_C14_Caspase3-7	228	232	PF00656	0.379
CLV_C14_Caspase3-7	35	39	PF00656	0.556
CLV_NRD_NRD_1	10	12	PF00675	0.720
CLV_NRD_NRD_1	102	104	PF00675	0.634
CLV_NRD_NRD_1	120	122	PF00675	0.651
CLV_NRD_NRD_1	80	82	PF00675	0.694
CLV_NRD_NRD_1	95	97	PF00675	0.601
CLV_PCSK_FUR_1	117	121	PF00082	0.769
CLV_PCSK_KEX2_1	102	104	PF00082	0.606
CLV_PCSK_KEX2_1	119	121	PF00082	0.663
CLV_PCSK_KEX2_1	184	186	PF00082	0.638
CLV_PCSK_KEX2_1	296	298	PF00082	0.626
CLV_PCSK_KEX2_1	443	445	PF00082	0.532
CLV_PCSK_KEX2_1	80	82	PF00082	0.708
CLV_PCSK_KEX2_1	9	11	PF00082	0.728
CLV_PCSK_KEX2_1	95	97	PF00082	0.571
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.737
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.645
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.628
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.532
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.592
CLV_PCSK_PC7_1	76	82	PF00082	0.575
CLV_PCSK_SKI1_1	102	106	PF00082	0.550
CLV_PCSK_SKI1_1	11	15	PF00082	0.727
CLV_PCSK_SKI1_1	185	189	PF00082	0.569
CLV_PCSK_SKI1_1	61	65	PF00082	0.666
DEG_APCC_DBOX_1	9	17	PF00400	0.650
DEG_Nend_UBRbox_1	1	4	PF02207	0.760
DEG_SPOP_SBC_1	225	229	PF00917	0.351
DOC_CYCLIN_RxL_1	5	18	PF00134	0.467
DOC_MAPK_gen_1	307	313	PF00069	0.425
DOC_MAPK_gen_1	85	94	PF00069	0.358
DOC_MAPK_gen_1	9	16	PF00069	0.653
DOC_MAPK_MEF2A_6	349	356	PF00069	0.390
DOC_SPAK_OSR1_1	241	245	PF12202	0.291
DOC_USP7_MATH_1	225	229	PF00917	0.477
DOC_USP7_MATH_1	40	44	PF00917	0.456
DOC_USP7_MATH_1	447	451	PF00917	0.700
DOC_USP7_MATH_1	455	459	PF00917	0.728
DOC_WW_Pin1_4	263	268	PF00397	0.465
DOC_WW_Pin1_4	465	470	PF00397	0.645
LIG_14-3-3_CanoR_1	129	136	PF00244	0.431
LIG_14-3-3_CanoR_1	154	161	PF00244	0.504
LIG_14-3-3_CanoR_1	9	14	PF00244	0.713
LIG_Clathr_ClatBox_1	400	404	PF01394	0.373
LIG_deltaCOP1_diTrp_1	382	389	PF00928	0.403
LIG_FHA_1	16	22	PF00498	0.515
LIG_FHA_1	235	241	PF00498	0.325
LIG_FHA_1	264	270	PF00498	0.449
LIG_FHA_1	323	329	PF00498	0.327
LIG_FHA_1	39	45	PF00498	0.608
LIG_FHA_2	186	192	PF00498	0.311
LIG_FHA_2	340	346	PF00498	0.255
LIG_FHA_2	52	58	PF00498	0.592
LIG_LIR_Gen_1	237	245	PF02991	0.298
LIG_LIR_Gen_1	284	293	PF02991	0.460
LIG_LIR_Gen_1	342	352	PF02991	0.255
LIG_LIR_Gen_1	382	392	PF02991	0.450
LIG_LIR_Gen_1	393	403	PF02991	0.433
LIG_LIR_Nem_3	237	242	PF02991	0.366
LIG_LIR_Nem_3	263	268	PF02991	0.443
LIG_LIR_Nem_3	284	290	PF02991	0.449
LIG_LIR_Nem_3	342	347	PF02991	0.454
LIG_LIR_Nem_3	353	358	PF02991	0.404
LIG_LIR_Nem_3	382	388	PF02991	0.448
LIG_LIR_Nem_3	393	399	PF02991	0.424
LIG_LIR_Nem_3	405	411	PF02991	0.407
LIG_Pex14_1	247	251	PF04695	0.276
LIG_Pex14_1	351	355	PF04695	0.356
LIG_Pex14_1	385	389	PF04695	0.404
LIG_Pex14_2	305	309	PF04695	0.292
LIG_Pex14_2	427	431	PF04695	0.428
LIG_SH2_CRK	265	269	PF00017	0.475
LIG_SH2_CRK	408	412	PF00017	0.325
LIG_SH2_CRK	434	438	PF00017	0.602
LIG_SH2_NCK_1	280	284	PF00017	0.413
LIG_SH2_SRC	359	362	PF00017	0.363
LIG_SH2_STAP1	114	118	PF00017	0.393
LIG_SH2_STAP1	236	240	PF00017	0.375
LIG_SH2_STAP1	287	291	PF00017	0.333
LIG_SH2_STAP1	344	348	PF00017	0.503
LIG_SH2_STAT5	146	149	PF00017	0.359
LIG_SH2_STAT5	236	239	PF00017	0.389
LIG_SH2_STAT5	265	268	PF00017	0.448
LIG_SH2_STAT5	287	290	PF00017	0.331
LIG_SH2_STAT5	346	349	PF00017	0.444
LIG_SH2_STAT5	359	362	PF00017	0.234
LIG_SH2_STAT5	434	437	PF00017	0.530
LIG_SH3_3	170	176	PF00018	0.458
LIG_SH3_3	330	336	PF00018	0.395
LIG_SH3_3	41	47	PF00018	0.515
LIG_SUMO_SIM_par_1	398	405	PF11976	0.520
LIG_TRAF2_1	142	145	PF00917	0.338
LIG_TRAF2_1	379	382	PF00917	0.326
LIG_TRAF2_1	75	78	PF00917	0.375
LIG_TYR_ITIM	406	411	PF00017	0.317
LIG_UBA3_1	300	308	PF00899	0.453
MOD_CK1_1	263	269	PF00069	0.335
MOD_CK1_1	387	393	PF00069	0.338
MOD_CK1_1	456	462	PF00069	0.643
MOD_CK1_1	53	59	PF00069	0.571
MOD_CK2_1	128	134	PF00069	0.456
MOD_CK2_1	339	345	PF00069	0.255
MOD_CK2_1	40	46	PF00069	0.507
MOD_CK2_1	51	57	PF00069	0.544
MOD_Cter_Amidation	294	297	PF01082	0.628
MOD_Cter_Amidation	440	443	PF01082	0.536
MOD_GlcNHglycan	130	133	PF01048	0.622
MOD_GlcNHglycan	274	277	PF01048	0.584
MOD_GlcNHglycan	293	296	PF01048	0.635
MOD_GlcNHglycan	453	456	PF01048	0.502
MOD_GSK3_1	246	253	PF00069	0.351
MOD_GSK3_1	268	275	PF00069	0.402
MOD_GSK3_1	447	454	PF00069	0.723
MOD_GSK3_1	49	56	PF00069	0.625
MOD_GSK3_1	5	12	PF00069	0.719
MOD_N-GLC_1	390	395	PF02516	0.545
MOD_NEK2_1	250	255	PF00069	0.269
MOD_NEK2_1	261	266	PF00069	0.406
MOD_NEK2_1	322	327	PF00069	0.299
MOD_NEK2_1	448	453	PF00069	0.635
MOD_NEK2_2	369	374	PF00069	0.353
MOD_PIKK_1	219	225	PF00454	0.431
MOD_PIKK_1	234	240	PF00454	0.418
MOD_PK_1	121	127	PF00069	0.531
MOD_PK_1	384	390	PF00069	0.341
MOD_PKA_1	9	15	PF00069	0.707
MOD_PKA_2	128	134	PF00069	0.432
MOD_PKA_2	9	15	PF00069	0.707
MOD_Plk_4	15	21	PF00069	0.584
MOD_Plk_4	246	252	PF00069	0.326
MOD_Plk_4	268	274	PF00069	0.309
MOD_Plk_4	339	345	PF00069	0.279
MOD_Plk_4	384	390	PF00069	0.485
MOD_Plk_4	402	408	PF00069	0.376
MOD_ProDKin_1	263	269	PF00069	0.466
MOD_ProDKin_1	465	471	PF00069	0.645
MOD_SUMO_for_1	104	107	PF00179	0.511
TRG_ENDOCYTIC_2	236	239	PF00928	0.335
TRG_ENDOCYTIC_2	265	268	PF00928	0.403
TRG_ENDOCYTIC_2	287	290	PF00928	0.408
TRG_ENDOCYTIC_2	344	347	PF00928	0.438
TRG_ENDOCYTIC_2	408	411	PF00928	0.444
TRG_ER_diArg_1	102	104	PF00400	0.436
TRG_ER_diArg_1	120	122	PF00400	0.540
TRG_ER_diArg_1	9	11	PF00400	0.675
TRG_ER_diLys_1	479	482	PF00400	0.733
TRG_NES_CRM1_1	192	207	PF08389	0.294
TRG_NLS_Bipartite_1	80	99	PF00514	0.348
TRG_NLS_MonoExtC_3	94	100	PF00514	0.353
TRG_NLS_MonoExtN_4	440	446	PF00514	0.657
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD68	Leptomonas seymouri	44%	87%
A0A3Q8ICI9	Leishmania donovani	66%	86%
A0A422NEU3	Trypanosoma rangeli	23%	100%
A4I0B5	Leishmania infantum	66%	87%
E9AW79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	79%
Q9U0V4	Leishmania major	62%	100%
V5BFM4	Trypanosoma cruzi	21%	100%