BING4CT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat/BING4CT (NUC141) domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H6H1_LEIBR

TriTrypDb:

LbrM.11.0230 , LBRM2903_230015900

Length:

680

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H6H1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6H1

Function

Biological processes
Term	Name	Level	Count
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0030490	maturation of SSU-rRNA	9	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	547	551	PF00656	0.477
CLV_C14_Caspase3-7	586	590	PF00656	0.389
CLV_NRD_NRD_1	21	23	PF00675	0.726
CLV_NRD_NRD_1	440	442	PF00675	0.262
CLV_NRD_NRD_1	482	484	PF00675	0.490
CLV_NRD_NRD_1	494	496	PF00675	0.493
CLV_NRD_NRD_1	540	542	PF00675	0.475
CLV_NRD_NRD_1	606	608	PF00675	0.535
CLV_NRD_NRD_1	642	644	PF00675	0.724
CLV_NRD_NRD_1	676	678	PF00675	0.473
CLV_PCSK_KEX2_1	129	131	PF00082	0.464
CLV_PCSK_KEX2_1	21	23	PF00082	0.487
CLV_PCSK_KEX2_1	39	41	PF00082	0.498
CLV_PCSK_KEX2_1	470	472	PF00082	0.585
CLV_PCSK_KEX2_1	494	496	PF00082	0.507
CLV_PCSK_KEX2_1	608	610	PF00082	0.382
CLV_PCSK_KEX2_1	641	643	PF00082	0.721
CLV_PCSK_KEX2_1	676	678	PF00082	0.561
CLV_PCSK_KEX2_1	84	86	PF00082	0.414
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.464
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.520
CLV_PCSK_PC1ET2_1	470	472	PF00082	0.598
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.382
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.474
CLV_PCSK_PC7_1	80	86	PF00082	0.360
CLV_PCSK_SKI1_1	228	232	PF00082	0.298
CLV_PCSK_SKI1_1	317	321	PF00082	0.312
CLV_PCSK_SKI1_1	371	375	PF00082	0.382
CLV_PCSK_SKI1_1	412	416	PF00082	0.340
CLV_PCSK_SKI1_1	529	533	PF00082	0.513
CLV_PCSK_SKI1_1	542	546	PF00082	0.505
CLV_PCSK_SKI1_1	59	63	PF00082	0.454
CLV_PCSK_SKI1_1	676	680	PF00082	0.641
CLV_PCSK_SKI1_1	75	79	PF00082	0.487
CLV_PCSK_SKI1_1	85	89	PF00082	0.524
DEG_SPOP_SBC_1	2	6	PF00917	0.681
DEG_SPOP_SBC_1	233	237	PF00917	0.385
DOC_MAPK_gen_1	129	135	PF00069	0.350
DOC_MAPK_gen_1	178	187	PF00069	0.400
DOC_MAPK_gen_1	206	213	PF00069	0.261
DOC_PP1_RVXF_1	140	146	PF00149	0.293
DOC_PP2B_LxvP_1	417	420	PF13499	0.284
DOC_PP4_FxxP_1	288	291	PF00568	0.366
DOC_USP7_MATH_1	233	237	PF00917	0.363
DOC_USP7_MATH_1	3	7	PF00917	0.785
DOC_USP7_MATH_1	377	381	PF00917	0.477
DOC_USP7_MATH_1	496	500	PF00917	0.545
DOC_USP7_MATH_1	597	601	PF00917	0.651
DOC_USP7_UBL2_3	39	43	PF12436	0.332
DOC_USP7_UBL2_3	523	527	PF12436	0.587
DOC_USP7_UBL2_3	545	549	PF12436	0.509
DOC_USP7_UBL2_3	554	558	PF12436	0.492
DOC_USP7_UBL2_3	604	608	PF12436	0.605
DOC_USP7_UBL2_3	84	88	PF12436	0.513
DOC_WW_Pin1_4	287	292	PF00397	0.299
DOC_WW_Pin1_4	378	383	PF00397	0.443
DOC_WW_Pin1_4	5	10	PF00397	0.592
LIG_14-3-3_CanoR_1	112	119	PF00244	0.373
LIG_14-3-3_CanoR_1	130	134	PF00244	0.353
LIG_14-3-3_CanoR_1	180	188	PF00244	0.464
LIG_14-3-3_CanoR_1	317	323	PF00244	0.438
LIG_14-3-3_CanoR_1	334	340	PF00244	0.394
LIG_14-3-3_CanoR_1	412	418	PF00244	0.290
LIG_14-3-3_CanoR_1	495	501	PF00244	0.630
LIG_14-3-3_CanoR_1	556	562	PF00244	0.485
LIG_14-3-3_CanoR_1	59	67	PF00244	0.453
LIG_14-3-3_CanoR_1	660	665	PF00244	0.628
LIG_APCC_ABBA_1	399	404	PF00400	0.262
LIG_APCC_ABBAyCdc20_2	579	585	PF00400	0.585
LIG_BRCT_BRCA1_1	410	414	PF00533	0.262
LIG_CSL_BTD_1	288	291	PF09270	0.288
LIG_FHA_1	148	154	PF00498	0.319
LIG_FHA_1	233	239	PF00498	0.252
LIG_FHA_1	263	269	PF00498	0.444
LIG_FHA_1	277	283	PF00498	0.262
LIG_FHA_1	348	354	PF00498	0.299
LIG_FHA_1	413	419	PF00498	0.340
LIG_FHA_1	504	510	PF00498	0.631
LIG_FHA_1	526	532	PF00498	0.506
LIG_FHA_1	62	68	PF00498	0.572
LIG_FHA_1	98	104	PF00498	0.551
LIG_FHA_2	247	253	PF00498	0.361
LIG_FHA_2	336	342	PF00498	0.469
LIG_GBD_Chelix_1	445	453	PF00786	0.262
LIG_Integrin_isoDGR_2	315	317	PF01839	0.220
LIG_IRF3_LxIS_1	348	354	PF10401	0.402
LIG_LIR_Apic_2	428	434	PF02991	0.281
LIG_LIR_Gen_1	236	247	PF02991	0.317
LIG_LIR_Gen_1	345	353	PF02991	0.324
LIG_LIR_Gen_1	380	390	PF02991	0.342
LIG_LIR_Gen_1	411	420	PF02991	0.262
LIG_LIR_Nem_3	241	247	PF02991	0.427
LIG_LIR_Nem_3	345	351	PF02991	0.352
LIG_LIR_Nem_3	380	386	PF02991	0.342
LIG_LIR_Nem_3	411	417	PF02991	0.294
LIG_NRP_CendR_1	677	680	PF00754	0.639
LIG_PCNA_yPIPBox_3	670	679	PF02747	0.514
LIG_Pex14_1	370	374	PF04695	0.342
LIG_PTB_Apo_2	423	430	PF02174	0.262
LIG_SH2_CRK	131	135	PF00017	0.478
LIG_SH2_CRK	390	394	PF00017	0.262
LIG_SH2_CRK	431	435	PF00017	0.281
LIG_SH2_GRB2like	431	434	PF00017	0.281
LIG_SH2_SRC	244	247	PF00017	0.382
LIG_SH2_SRC	431	434	PF00017	0.281
LIG_SH2_STAP1	131	135	PF00017	0.369
LIG_SH2_STAP1	342	346	PF00017	0.368
LIG_SH2_STAP1	583	587	PF00017	0.593
LIG_SH2_STAP1	631	635	PF00017	0.668
LIG_SH2_STAT5	204	207	PF00017	0.334
LIG_SH2_STAT5	225	228	PF00017	0.319
LIG_SH2_STAT5	244	247	PF00017	0.382
LIG_SH3_3	290	296	PF00018	0.337
LIG_SH3_3	376	382	PF00018	0.400
LIG_TRAF2_1	249	252	PF00917	0.392
LIG_TRAF2_1	338	341	PF00917	0.363
LIG_TRAF2_1	533	536	PF00917	0.627
LIG_TRAF2_1	610	613	PF00917	0.385
LIG_TYR_ITIM	388	393	PF00017	0.262
LIG_UBA3_1	297	304	PF00899	0.512
MOD_CDK_SPK_2	5	10	PF00069	0.511
MOD_CDK_SPxxK_3	378	385	PF00069	0.426
MOD_CK1_1	237	243	PF00069	0.392
MOD_CK1_1	347	353	PF00069	0.445
MOD_CK1_1	5	11	PF00069	0.702
MOD_CK1_1	557	563	PF00069	0.498
MOD_CK2_1	246	252	PF00069	0.353
MOD_CK2_1	26	32	PF00069	0.581
MOD_CK2_1	335	341	PF00069	0.468
MOD_CK2_1	496	502	PF00069	0.612
MOD_CK2_1	530	536	PF00069	0.506
MOD_CK2_1	597	603	PF00069	0.614
MOD_CK2_1	653	659	PF00069	0.599
MOD_CK2_1	660	666	PF00069	0.670
MOD_GlcNHglycan	119	122	PF01048	0.536
MOD_GlcNHglycan	355	358	PF01048	0.320
MOD_GlcNHglycan	421	424	PF01048	0.323
MOD_GlcNHglycan	550	553	PF01048	0.507
MOD_GlcNHglycan	648	652	PF01048	0.544
MOD_GlcNHglycan	655	658	PF01048	0.606
MOD_GSK3_1	1	8	PF00069	0.687
MOD_GSK3_1	143	150	PF00069	0.324
MOD_GSK3_1	202	209	PF00069	0.394
MOD_GSK3_1	233	240	PF00069	0.328
MOD_GSK3_1	270	277	PF00069	0.408
MOD_GSK3_1	347	354	PF00069	0.325
MOD_GSK3_1	408	415	PF00069	0.360
MOD_GSK3_1	496	503	PF00069	0.447
MOD_GSK3_1	557	564	PF00069	0.502
MOD_GSK3_1	643	650	PF00069	0.739
MOD_LATS_1	410	416	PF00433	0.340
MOD_N-GLC_1	147	152	PF02516	0.304
MOD_N-GLC_1	351	356	PF02516	0.222
MOD_NEK2_1	147	152	PF00069	0.335
MOD_NEK2_1	232	237	PF00069	0.417
MOD_NEK2_1	245	250	PF00069	0.361
MOD_NEK2_1	318	323	PF00069	0.420
MOD_NEK2_1	351	356	PF00069	0.431
MOD_NEK2_1	500	505	PF00069	0.439
MOD_NEK2_1	561	566	PF00069	0.488
MOD_NEK2_2	234	239	PF00069	0.232
MOD_PIKK_1	111	117	PF00454	0.388
MOD_PIKK_1	123	129	PF00454	0.362
MOD_PIKK_1	172	178	PF00454	0.368
MOD_PKA_1	129	135	PF00069	0.476
MOD_PKA_1	206	212	PF00069	0.259
MOD_PKA_1	548	554	PF00069	0.487
MOD_PKA_2	111	117	PF00069	0.388
MOD_PKA_2	129	135	PF00069	0.348
MOD_PKA_2	179	185	PF00069	0.445
MOD_PKA_2	561	567	PF00069	0.486
MOD_PKA_2	659	665	PF00069	0.669
MOD_PKB_1	641	649	PF00069	0.522
MOD_PKB_1	658	666	PF00069	0.513
MOD_Plk_1	143	149	PF00069	0.341
MOD_Plk_1	188	194	PF00069	0.314
MOD_Plk_1	45	51	PF00069	0.449
MOD_Plk_2-3	456	462	PF00069	0.262
MOD_Plk_4	129	135	PF00069	0.486
MOD_Plk_4	234	240	PF00069	0.316
MOD_Plk_4	413	419	PF00069	0.262
MOD_ProDKin_1	287	293	PF00069	0.307
MOD_ProDKin_1	378	384	PF00069	0.437
MOD_ProDKin_1	5	11	PF00069	0.593
MOD_SUMO_for_1	44	47	PF00179	0.512
MOD_SUMO_rev_2	46	56	PF00179	0.565
MOD_SUMO_rev_2	524	533	PF00179	0.510
MOD_SUMO_rev_2	536	544	PF00179	0.473
TRG_DiLeu_BaEn_1	32	37	PF01217	0.508
TRG_DiLeu_BaEn_4	591	597	PF01217	0.591
TRG_DiLeu_BaLyEn_6	293	298	PF01217	0.478
TRG_ENDOCYTIC_2	131	134	PF00928	0.373
TRG_ENDOCYTIC_2	239	242	PF00928	0.327
TRG_ENDOCYTIC_2	244	247	PF00928	0.298
TRG_ENDOCYTIC_2	383	386	PF00928	0.268
TRG_ENDOCYTIC_2	390	393	PF00928	0.253
TRG_ENDOCYTIC_2	92	95	PF00928	0.555
TRG_ER_diArg_1	20	22	PF00400	0.494
TRG_ER_diArg_1	493	495	PF00400	0.586
TRG_ER_diArg_1	569	572	PF00400	0.475
TRG_ER_diArg_1	641	643	PF00400	0.741
TRG_ER_diArg_1	67	70	PF00400	0.479
TRG_ER_diArg_1	675	677	PF00400	0.470
TRG_NES_CRM1_1	176	189	PF08389	0.235
TRG_NLS_Bipartite_1	470	487	PF00514	0.567
TRG_NLS_MonoExtC_3	606	611	PF00514	0.412
TRG_NLS_MonoExtN_4	480	487	PF00514	0.450
TRG_NLS_MonoExtN_4	604	611	PF00514	0.535
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILJ4	Leptomonas seymouri	81%	100%
A0A0S4IXY1	Bodo saltans	65%	100%
A0A1X0NYJ7	Trypanosomatidae	65%	100%
A0A3Q8IM25	Leishmania donovani	89%	100%
A0A3S5IR25	Trypanosoma rangeli	64%	100%
A4I0B3	Leishmania infantum	89%	100%
C9ZV23	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AW77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q5TJE7	Canis lupus familiaris	33%	100%
Q9NF84	Leishmania major	88%	100%