Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6H0_LEIBR

TriTrypDb:

LbrM.11.0220 , LBRM2903_230015800

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6H0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.540
CLV_NRD_NRD_1	10	12	PF00675	0.435
CLV_NRD_NRD_1	220	222	PF00675	0.595
CLV_NRD_NRD_1	3	5	PF00675	0.566
CLV_NRD_NRD_1	362	364	PF00675	0.496
CLV_NRD_NRD_1	502	504	PF00675	0.713
CLV_NRD_NRD_1	693	695	PF00675	0.560
CLV_PCSK_KEX2_1	10	12	PF00082	0.435
CLV_PCSK_KEX2_1	160	162	PF00082	0.493
CLV_PCSK_KEX2_1	220	222	PF00082	0.595
CLV_PCSK_KEX2_1	3	5	PF00082	0.566
CLV_PCSK_KEX2_1	362	364	PF00082	0.496
CLV_PCSK_KEX2_1	502	504	PF00082	0.712
CLV_PCSK_KEX2_1	693	695	PF00082	0.560
CLV_PCSK_KEX2_1	701	703	PF00082	0.563
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.493
CLV_PCSK_PC1ET2_1	701	703	PF00082	0.563
CLV_PCSK_SKI1_1	157	161	PF00082	0.491
CLV_PCSK_SKI1_1	183	187	PF00082	0.506
CLV_PCSK_SKI1_1	424	428	PF00082	0.665
CLV_PCSK_SKI1_1	468	472	PF00082	0.573
CLV_PCSK_SKI1_1	551	555	PF00082	0.580
CLV_PCSK_SKI1_1	61	65	PF00082	0.427
DEG_APCC_DBOX_1	277	285	PF00400	0.537
DEG_SCF_FBW7_1	247	252	PF00400	0.475
DEG_SCF_FBW7_1	469	475	PF00400	0.646
DEG_SPOP_SBC_1	191	195	PF00917	0.561
DEG_SPOP_SBC_1	213	217	PF00917	0.585
DEG_SPOP_SBC_1	625	629	PF00917	0.583
DOC_CKS1_1	108	113	PF01111	0.412
DOC_CKS1_1	274	279	PF01111	0.472
DOC_CKS1_1	469	474	PF01111	0.647
DOC_CKS1_1	567	572	PF01111	0.574
DOC_CYCLIN_RxL_1	157	167	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.501
DOC_MAPK_DCC_7	506	516	PF00069	0.581
DOC_MAPK_gen_1	10	18	PF00069	0.431
DOC_MAPK_HePTP_8	8	20	PF00069	0.332
DOC_MAPK_MEF2A_6	10	18	PF00069	0.431
DOC_MAPK_MEF2A_6	526	535	PF00069	0.671
DOC_MAPK_NFAT4_5	11	19	PF00069	0.311
DOC_PP2B_LxvP_1	247	250	PF13499	0.575
DOC_PP2B_LxvP_1	32	35	PF13499	0.530
DOC_PP2B_LxvP_1	416	419	PF13499	0.691
DOC_PP2B_LxvP_1	430	433	PF13499	0.544
DOC_PP2B_LxvP_1	648	651	PF13499	0.565
DOC_USP7_MATH_1	136	140	PF00917	0.629
DOC_USP7_MATH_1	191	195	PF00917	0.590
DOC_USP7_MATH_1	251	255	PF00917	0.631
DOC_USP7_MATH_1	325	329	PF00917	0.534
DOC_USP7_MATH_1	38	42	PF00917	0.582
DOC_USP7_MATH_1	381	385	PF00917	0.599
DOC_USP7_MATH_1	422	426	PF00917	0.572
DOC_USP7_MATH_1	447	451	PF00917	0.586
DOC_USP7_MATH_1	577	581	PF00917	0.600
DOC_USP7_MATH_1	626	630	PF00917	0.581
DOC_USP7_MATH_2	542	548	PF00917	0.573
DOC_WW_Pin1_4	107	112	PF00397	0.407
DOC_WW_Pin1_4	145	150	PF00397	0.542
DOC_WW_Pin1_4	170	175	PF00397	0.493
DOC_WW_Pin1_4	207	212	PF00397	0.580
DOC_WW_Pin1_4	245	250	PF00397	0.464
DOC_WW_Pin1_4	273	278	PF00397	0.574
DOC_WW_Pin1_4	313	318	PF00397	0.568
DOC_WW_Pin1_4	410	415	PF00397	0.658
DOC_WW_Pin1_4	468	473	PF00397	0.723
DOC_WW_Pin1_4	546	551	PF00397	0.688
DOC_WW_Pin1_4	566	571	PF00397	0.505
DOC_WW_Pin1_4	642	647	PF00397	0.581
DOC_WW_Pin1_4	687	692	PF00397	0.540
LIG_14-3-3_CanoR_1	180	190	PF00244	0.526
LIG_14-3-3_CanoR_1	202	211	PF00244	0.564
LIG_14-3-3_CanoR_1	355	360	PF00244	0.531
LIG_14-3-3_CanoR_1	487	496	PF00244	0.698
LIG_14-3-3_CanoR_1	537	542	PF00244	0.649
LIG_14-3-3_CanoR_1	632	642	PF00244	0.583
LIG_14-3-3_CanoR_1	694	704	PF00244	0.559
LIG_Actin_WH2_2	57	75	PF00022	0.321
LIG_APCC_ABBA_1	14	19	PF00400	0.419
LIG_APCC_ABBA_1	522	527	PF00400	0.552
LIG_BIR_II_1	1	5	PF00653	0.498
LIG_BRCT_BRCA1_1	651	655	PF00533	0.581
LIG_CtBP_PxDLS_1	336	340	PF00389	0.492
LIG_CtBP_PxDLS_1	519	523	PF00389	0.548
LIG_eIF4E_1	313	319	PF01652	0.532
LIG_EVH1_1	32	36	PF00568	0.421
LIG_EVH1_1	660	664	PF00568	0.569
LIG_FHA_1	22	28	PF00498	0.483
LIG_FHA_1	269	275	PF00498	0.628
LIG_FHA_1	314	320	PF00498	0.560
LIG_FHA_1	328	334	PF00498	0.384
LIG_FHA_1	352	358	PF00498	0.442
LIG_FHA_1	425	431	PF00498	0.596
LIG_FHA_1	635	641	PF00498	0.617
LIG_FHA_1	643	649	PF00498	0.556
LIG_FHA_1	76	82	PF00498	0.470
LIG_FHA_2	53	59	PF00498	0.443
LIG_FXI_DFP_1	17	21	PF00024	0.319
LIG_LIR_Apic_2	48	53	PF02991	0.526
LIG_LIR_Apic_2	536	542	PF02991	0.613
LIG_LIR_Apic_2	566	570	PF02991	0.570
LIG_LIR_Apic_2	685	691	PF02991	0.545
LIG_LIR_Nem_3	82	86	PF02991	0.413
LIG_NRBOX	158	164	PF00104	0.488
LIG_Pex14_1	684	688	PF04695	0.558
LIG_Pex14_2	186	190	PF04695	0.516
LIG_SH2_CRK	152	156	PF00017	0.485
LIG_SH2_CRK	539	543	PF00017	0.566
LIG_SH2_CRK	567	571	PF00017	0.574
LIG_SH2_NCK_1	539	543	PF00017	0.566
LIG_SH2_NCK_1	567	571	PF00017	0.574
LIG_SH2_SRC	50	53	PF00017	0.499
LIG_SH2_STAT5	152	155	PF00017	0.401
LIG_SH2_STAT5	50	53	PF00017	0.499
LIG_SH2_STAT5	539	542	PF00017	0.657
LIG_SH2_STAT5	86	89	PF00017	0.443
LIG_SH3_1	593	599	PF00018	0.713
LIG_SH3_2	501	506	PF14604	0.699
LIG_SH3_3	130	136	PF00018	0.418
LIG_SH3_3	247	253	PF00018	0.525
LIG_SH3_3	30	36	PF00018	0.407
LIG_SH3_3	438	444	PF00018	0.631
LIG_SH3_3	493	499	PF00018	0.674
LIG_SH3_3	513	519	PF00018	0.510
LIG_SH3_3	585	591	PF00018	0.693
LIG_SH3_3	593	599	PF00018	0.657
LIG_SH3_3	648	654	PF00018	0.564
LIG_SH3_3	658	664	PF00018	0.533
LIG_SH3_4	597	604	PF00018	0.599
LIG_SUMO_SIM_anti_2	371	376	PF11976	0.519
LIG_SUMO_SIM_anti_2	55	62	PF11976	0.434
LIG_SUMO_SIM_par_1	335	340	PF11976	0.491
LIG_SUMO_SIM_par_1	354	361	PF11976	0.392
LIG_TRAF2_1	358	361	PF00917	0.446
LIG_WRC_WIRS_1	80	85	PF05994	0.423
MOD_CDC14_SPxK_1	690	693	PF00782	0.536
MOD_CDK_SPK_2	273	278	PF00069	0.487
MOD_CDK_SPK_2	410	415	PF00069	0.635
MOD_CDK_SPK_2	546	551	PF00069	0.571
MOD_CDK_SPxK_1	687	693	PF00069	0.541
MOD_CDK_SPxxK_3	410	417	PF00069	0.582
MOD_CDK_SPxxK_3	566	573	PF00069	0.622
MOD_CDK_SPxxK_3	687	694	PF00069	0.545
MOD_CK1_1	139	145	PF00069	0.630
MOD_CK1_1	195	201	PF00069	0.558
MOD_CK1_1	204	210	PF00069	0.548
MOD_CK1_1	245	251	PF00069	0.471
MOD_CK1_1	252	258	PF00069	0.582
MOD_CK1_1	298	304	PF00069	0.643
MOD_CK1_1	398	404	PF00069	0.633
MOD_CK1_1	410	416	PF00069	0.547
MOD_CK1_1	436	442	PF00069	0.802
MOD_CK1_1	488	494	PF00069	0.580
MOD_CK1_1	505	511	PF00069	0.695
MOD_CK1_1	546	552	PF00069	0.670
MOD_CK1_1	580	586	PF00069	0.602
MOD_CK1_1	74	80	PF00069	0.366
MOD_CK2_1	355	361	PF00069	0.539
MOD_CK2_1	589	595	PF00069	0.602
MOD_CK2_1	6	12	PF00069	0.389
MOD_GlcNHglycan	183	186	PF01048	0.638
MOD_GlcNHglycan	194	197	PF01048	0.561
MOD_GlcNHglycan	383	386	PF01048	0.649
MOD_GlcNHglycan	41	44	PF01048	0.586
MOD_GlcNHglycan	445	448	PF01048	0.644
MOD_GlcNHglycan	462	465	PF01048	0.781
MOD_GlcNHglycan	47	50	PF01048	0.502
MOD_GlcNHglycan	490	493	PF01048	0.693
MOD_GlcNHglycan	507	510	PF01048	0.773
MOD_GlcNHglycan	546	549	PF01048	0.596
MOD_GlcNHglycan	582	585	PF01048	0.671
MOD_GlcNHglycan	609	612	PF01048	0.620
MOD_GlcNHglycan	685	688	PF01048	0.556
MOD_GlcNHglycan	91	94	PF01048	0.498
MOD_GSK3_1	136	143	PF00069	0.611
MOD_GSK3_1	191	198	PF00069	0.587
MOD_GSK3_1	201	208	PF00069	0.549
MOD_GSK3_1	21	28	PF00069	0.482
MOD_GSK3_1	245	252	PF00069	0.478
MOD_GSK3_1	261	268	PF00069	0.699
MOD_GSK3_1	269	276	PF00069	0.697
MOD_GSK3_1	298	305	PF00069	0.597
MOD_GSK3_1	351	358	PF00069	0.385
MOD_GSK3_1	398	405	PF00069	0.691
MOD_GSK3_1	433	440	PF00069	0.719
MOD_GSK3_1	443	450	PF00069	0.607
MOD_GSK3_1	454	461	PF00069	0.582
MOD_GSK3_1	468	475	PF00069	0.734
MOD_GSK3_1	533	540	PF00069	0.587
MOD_GSK3_1	617	624	PF00069	0.593
MOD_GSK3_1	678	685	PF00069	0.575
MOD_GSK3_1	71	78	PF00069	0.471
MOD_N-GLC_1	25	30	PF02516	0.404
MOD_N-GLC_1	301	306	PF02516	0.623
MOD_N-GLC_1	325	330	PF02516	0.468
MOD_N-GLC_1	398	403	PF02516	0.554
MOD_N-GLC_1	459	464	PF02516	0.716
MOD_NEK2_1	144	149	PF00069	0.474
MOD_NEK2_1	150	155	PF00069	0.361
MOD_NEK2_1	179	184	PF00069	0.641
MOD_NEK2_1	190	195	PF00069	0.564
MOD_NEK2_1	205	210	PF00069	0.541
MOD_NEK2_1	214	219	PF00069	0.547
MOD_NEK2_1	300	305	PF00069	0.655
MOD_NEK2_1	368	373	PF00069	0.562
MOD_NEK2_1	39	44	PF00069	0.581
MOD_NEK2_1	437	442	PF00069	0.549
MOD_NEK2_1	533	538	PF00069	0.556
MOD_NEK2_1	614	619	PF00069	0.580
MOD_NEK2_1	683	688	PF00069	0.559
MOD_PIKK_1	403	409	PF00454	0.582
MOD_PIKK_1	568	574	PF00454	0.695
MOD_PIKK_1	615	621	PF00454	0.613
MOD_PIKK_1	627	633	PF00454	0.555
MOD_PK_1	71	77	PF00069	0.472
MOD_PKA_1	502	508	PF00069	0.596
MOD_PKA_2	179	185	PF00069	0.523
MOD_PKA_2	201	207	PF00069	0.569
MOD_PKA_2	361	367	PF00069	0.581
MOD_PKA_2	502	508	PF00069	0.619
MOD_Plk_1	139	145	PF00069	0.513
MOD_Plk_1	21	27	PF00069	0.478
MOD_Plk_1	295	301	PF00069	0.661
MOD_Plk_1	398	404	PF00069	0.557
MOD_Plk_4	129	135	PF00069	0.511
MOD_Plk_4	363	369	PF00069	0.585
MOD_Plk_4	386	392	PF00069	0.691
MOD_Plk_4	447	453	PF00069	0.679
MOD_Plk_4	520	526	PF00069	0.554
MOD_ProDKin_1	107	113	PF00069	0.412
MOD_ProDKin_1	145	151	PF00069	0.529
MOD_ProDKin_1	170	176	PF00069	0.496
MOD_ProDKin_1	207	213	PF00069	0.576
MOD_ProDKin_1	245	251	PF00069	0.475
MOD_ProDKin_1	273	279	PF00069	0.564
MOD_ProDKin_1	313	319	PF00069	0.565
MOD_ProDKin_1	410	416	PF00069	0.658
MOD_ProDKin_1	468	474	PF00069	0.719
MOD_ProDKin_1	546	552	PF00069	0.687
MOD_ProDKin_1	566	572	PF00069	0.505
MOD_ProDKin_1	642	648	PF00069	0.583
MOD_ProDKin_1	687	693	PF00069	0.541
MOD_SUMO_for_1	93	96	PF00179	0.519
MOD_SUMO_rev_2	592	599	PF00179	0.597
TRG_DiLeu_BaEn_1	104	109	PF01217	0.421
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.472
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.491
TRG_DiLeu_LyEn_5	314	319	PF01217	0.530
TRG_ENDOCYTIC_2	152	155	PF00928	0.485
TRG_ER_diArg_1	243	246	PF00400	0.484
TRG_ER_diArg_1	501	503	PF00400	0.710
TRG_ER_diArg_1	693	695	PF00400	0.560
TRG_NES_CRM1_1	520	532	PF08389	0.554
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AW76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	96%
Q4QBA2	Leishmania major	57%	100%