LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H6G8_LEIBR
TriTrypDb:
LbrM.11.0200 , LBRM2903_110007200
Length:
132

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4H6G8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6G8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 128 130 PF00675 0.649
CLV_NRD_NRD_1 24 26 PF00675 0.566
CLV_NRD_NRD_1 8 10 PF00675 0.510
CLV_PCSK_KEX2_1 128 130 PF00082 0.637
CLV_PCSK_KEX2_1 24 26 PF00082 0.463
CLV_PCSK_KEX2_1 8 10 PF00082 0.515
CLV_PCSK_SKI1_1 49 53 PF00082 0.448
DEG_Nend_Nbox_1 1 3 PF02207 0.675
DOC_CYCLIN_yCln2_LP_2 52 58 PF00134 0.631
DOC_PP4_FxxP_1 56 59 PF00568 0.634
DOC_PP4_FxxP_1 82 85 PF00568 0.527
DOC_USP7_MATH_1 122 126 PF00917 0.440
DOC_WW_Pin1_4 105 110 PF00397 0.435
LIG_14-3-3_CanoR_1 24 28 PF00244 0.739
LIG_14-3-3_CanoR_1 3 7 PF00244 0.689
LIG_14-3-3_CanoR_1 66 70 PF00244 0.408
LIG_14-3-3_CanoR_1 9 15 PF00244 0.736
LIG_BRCT_BRCA1_1 67 71 PF00533 0.410
LIG_deltaCOP1_diTrp_1 61 64 PF00928 0.482
LIG_LIR_Apic_2 117 122 PF02991 0.450
LIG_LIR_Apic_2 79 85 PF02991 0.335
LIG_LIR_Nem_3 61 65 PF02991 0.482
LIG_LIR_Nem_3 68 74 PF02991 0.363
LIG_Pex14_2 56 60 PF04695 0.634
LIG_SH2_CRK 20 24 PF00017 0.671
LIG_SH2_CRK 78 82 PF00017 0.426
LIG_SH2_SRC 115 118 PF00017 0.483
LIG_SH2_STAP1 78 82 PF00017 0.335
LIG_SH2_STAT5 46 49 PF00017 0.649
LIG_SH3_3 91 97 PF00018 0.440
LIG_TYR_ITIM 76 81 PF00017 0.447
MOD_CK1_1 4 10 PF00069 0.693
MOD_CK2_1 10 16 PF00069 0.734
MOD_Cter_Amidation 126 129 PF01082 0.728
MOD_GlcNHglycan 124 127 PF01048 0.632
MOD_GlcNHglycan 9 12 PF01048 0.465
MOD_GSK3_1 34 41 PF00069 0.677
MOD_LATS_1 32 38 PF00433 0.681
MOD_N-GLC_1 122 127 PF02516 0.643
MOD_NEK2_1 1 6 PF00069 0.653
MOD_NEK2_1 45 50 PF00069 0.644
MOD_NEK2_1 64 69 PF00069 0.378
MOD_PKA_2 2 8 PF00069 0.661
MOD_PKA_2 23 29 PF00069 0.767
MOD_PKA_2 65 71 PF00069 0.378
MOD_ProDKin_1 105 111 PF00069 0.434
TRG_ENDOCYTIC_2 78 81 PF00928 0.344
TRG_ER_diArg_1 128 130 PF00400 0.462
TRG_ER_diArg_1 23 25 PF00400 0.757

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJC2 Leptomonas seymouri 91% 100%
A0A0S4JUP5 Bodo saltans 65% 100%
A0A1X0NV45 Trypanosomatidae 79% 100%
A0A3Q8I7X8 Leishmania donovani 98% 100%
A4HUW7 Leishmania infantum 98% 100%
D0A7J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 70% 100%
E9ANJ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QH30 Leishmania major 98% 100%
V5DT78 Trypanosoma cruzi 73% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS