Putative pumillio protein 10

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumillio protein 10, putative

Species:

Leishmania braziliensis

UniProt:

A4H6G3_LEIBR

TriTrypDb:

LbrM.11.0150 , LBRM2903_110006400

Length:

743

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6G3

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	156	160	PF00656	0.731
CLV_C14_Caspase3-7	351	355	PF00656	0.299
CLV_C14_Caspase3-7	475	479	PF00656	0.441
CLV_NRD_NRD_1	113	115	PF00675	0.661
CLV_NRD_NRD_1	186	188	PF00675	0.507
CLV_NRD_NRD_1	309	311	PF00675	0.609
CLV_NRD_NRD_1	32	34	PF00675	0.604
CLV_NRD_NRD_1	356	358	PF00675	0.502
CLV_NRD_NRD_1	40	42	PF00675	0.567
CLV_NRD_NRD_1	516	518	PF00675	0.343
CLV_PCSK_FUR_1	30	34	PF00082	0.635
CLV_PCSK_FUR_1	370	374	PF00082	0.414
CLV_PCSK_KEX2_1	115	117	PF00082	0.642
CLV_PCSK_KEX2_1	186	188	PF00082	0.507
CLV_PCSK_KEX2_1	3	5	PF00082	0.718
CLV_PCSK_KEX2_1	309	311	PF00082	0.561
CLV_PCSK_KEX2_1	32	34	PF00082	0.524
CLV_PCSK_KEX2_1	356	358	PF00082	0.452
CLV_PCSK_KEX2_1	361	363	PF00082	0.402
CLV_PCSK_KEX2_1	372	374	PF00082	0.268
CLV_PCSK_KEX2_1	423	425	PF00082	0.497
CLV_PCSK_KEX2_1	516	518	PF00082	0.477
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.642
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.691
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.561
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.420
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.305
CLV_PCSK_PC1ET2_1	423	425	PF00082	0.497
CLV_PCSK_PC7_1	357	363	PF00082	0.497
CLV_PCSK_SKI1_1	13	17	PF00082	0.574
CLV_PCSK_SKI1_1	209	213	PF00082	0.436
CLV_PCSK_SKI1_1	357	361	PF00082	0.479
CLV_PCSK_SKI1_1	644	648	PF00082	0.527
DEG_APCC_DBOX_1	356	364	PF00400	0.500
DEG_SPOP_SBC_1	72	76	PF00917	0.304
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.353
DOC_MAPK_gen_1	38	48	PF00069	0.693
DOC_MAPK_gen_1	525	533	PF00069	0.269
DOC_MAPK_JIP1_4	612	618	PF00069	0.247
DOC_MAPK_MEF2A_6	525	533	PF00069	0.381
DOC_PP2B_LxvP_1	384	387	PF13499	0.370
DOC_PP2B_LxvP_1	481	484	PF13499	0.299
DOC_SPAK_OSR1_1	625	629	PF12202	0.274
DOC_USP7_MATH_1	153	157	PF00917	0.651
DOC_USP7_MATH_1	198	202	PF00917	0.516
DOC_USP7_MATH_1	387	391	PF00917	0.587
DOC_USP7_MATH_1	484	488	PF00917	0.435
DOC_USP7_MATH_1	520	524	PF00917	0.430
DOC_USP7_MATH_1	586	590	PF00917	0.382
DOC_USP7_MATH_1	72	76	PF00917	0.351
DOC_USP7_UBL2_3	38	42	PF12436	0.621
DOC_USP7_UBL2_3	482	486	PF12436	0.289
DOC_WW_Pin1_4	297	302	PF00397	0.643
DOC_WW_Pin1_4	382	387	PF00397	0.400
DOC_WW_Pin1_4	582	587	PF00397	0.466
LIG_14-3-3_CanoR_1	186	196	PF00244	0.446
LIG_14-3-3_CanoR_1	229	237	PF00244	0.456
LIG_14-3-3_CanoR_1	251	260	PF00244	0.504
LIG_14-3-3_CanoR_1	267	273	PF00244	0.294
LIG_14-3-3_CanoR_1	282	288	PF00244	0.332
LIG_14-3-3_CanoR_1	297	301	PF00244	0.595
LIG_14-3-3_CanoR_1	644	650	PF00244	0.462
LIG_14-3-3_CanoR_1	669	679	PF00244	0.483
LIG_14-3-3_CanoR_1	70	78	PF00244	0.453
LIG_14-3-3_CanoR_1	711	720	PF00244	0.504
LIG_Actin_RPEL_3	350	369	PF02755	0.503
LIG_Actin_WH2_2	470	488	PF00022	0.242
LIG_BIR_III_4	667	671	PF00653	0.440
LIG_BRCT_BRCA1_1	642	646	PF00533	0.496
LIG_EH1_1	426	434	PF00400	0.372
LIG_EH1_1	470	478	PF00400	0.333
LIG_EH1_1	499	507	PF00400	0.376
LIG_EH1_1	625	633	PF00400	0.368
LIG_FHA_1	170	176	PF00498	0.526
LIG_FHA_1	329	335	PF00498	0.477
LIG_FHA_1	364	370	PF00498	0.564
LIG_FHA_1	373	379	PF00498	0.501
LIG_FHA_1	442	448	PF00498	0.360
LIG_FHA_1	501	507	PF00498	0.521
LIG_FHA_1	524	530	PF00498	0.356
LIG_FHA_1	553	559	PF00498	0.448
LIG_FHA_1	601	607	PF00498	0.442
LIG_FHA_1	653	659	PF00498	0.343
LIG_FHA_1	97	103	PF00498	0.754
LIG_FHA_2	253	259	PF00498	0.552
LIG_FHA_2	349	355	PF00498	0.503
LIG_FHA_2	572	578	PF00498	0.311
LIG_FHA_2	671	677	PF00498	0.279
LIG_GBD_Chelix_1	188	196	PF00786	0.369
LIG_GBD_Chelix_1	428	436	PF00786	0.452
LIG_Integrin_isoDGR_2	623	625	PF01839	0.274
LIG_LIR_Gen_1	643	650	PF02991	0.411
LIG_LIR_LC3C_4	512	515	PF02991	0.311
LIG_LIR_Nem_3	10	15	PF02991	0.508
LIG_LIR_Nem_3	643	649	PF02991	0.454
LIG_NRBOX	377	383	PF00104	0.435
LIG_NRBOX	658	664	PF00104	0.414
LIG_PCNA_PIPBox_1	78	87	PF02747	0.521
LIG_PCNA_yPIPBox_3	423	433	PF02747	0.418
LIG_PCNA_yPIPBox_3	653	663	PF02747	0.357
LIG_Pex14_2	728	732	PF04695	0.348
LIG_PTB_Apo_2	540	547	PF02174	0.475
LIG_PTB_Phospho_1	540	546	PF10480	0.474
LIG_REV1ctd_RIR_1	726	735	PF16727	0.367
LIG_RPA_C_Fungi	660	672	PF08784	0.423
LIG_SH2_CRK	85	89	PF00017	0.479
LIG_SH2_NCK_1	546	550	PF00017	0.346
LIG_SH2_NCK_1	85	89	PF00017	0.479
LIG_SH2_STAP1	587	591	PF00017	0.324
LIG_SH2_STAT5	546	549	PF00017	0.407
LIG_SH2_STAT5	557	560	PF00017	0.274
LIG_SH3_3	335	341	PF00018	0.412
LIG_SH3_3	45	51	PF00018	0.681
LIG_SUMO_SIM_par_1	146	152	PF11976	0.406
LIG_SUMO_SIM_par_1	290	296	PF11976	0.497
LIG_SUMO_SIM_par_1	379	385	PF11976	0.489
LIG_SUMO_SIM_par_1	472	478	PF11976	0.396
LIG_SUMO_SIM_par_1	614	620	PF11976	0.221
LIG_UBA3_1	518	525	PF00899	0.354
LIG_UBA3_1	662	671	PF00899	0.383
MOD_CK1_1	108	114	PF00069	0.710
MOD_CK1_1	239	245	PF00069	0.516
MOD_CK1_1	293	299	PF00069	0.494
MOD_CK1_1	396	402	PF00069	0.503
MOD_CK1_1	523	529	PF00069	0.345
MOD_CK1_1	564	570	PF00069	0.475
MOD_CK1_1	617	623	PF00069	0.462
MOD_CK1_1	715	721	PF00069	0.507
MOD_CK2_1	132	138	PF00069	0.450
MOD_CK2_1	199	205	PF00069	0.494
MOD_CK2_1	23	29	PF00069	0.585
MOD_CK2_1	252	258	PF00069	0.547
MOD_CK2_1	484	490	PF00069	0.420
MOD_CK2_1	571	577	PF00069	0.330
MOD_CK2_1	670	676	PF00069	0.280
MOD_CK2_1	737	743	PF00069	0.356
MOD_Cter_Amidation	1	4	PF01082	0.533
MOD_Cter_Amidation	184	187	PF01082	0.488
MOD_DYRK1A_RPxSP_1	297	301	PF00069	0.466
MOD_GlcNHglycan	155	158	PF01048	0.713
MOD_GlcNHglycan	182	186	PF01048	0.455
MOD_GlcNHglycan	231	234	PF01048	0.463
MOD_GlcNHglycan	324	327	PF01048	0.748
MOD_GlcNHglycan	342	345	PF01048	0.288
MOD_GlcNHglycan	389	392	PF01048	0.633
MOD_GlcNHglycan	460	463	PF01048	0.464
MOD_GlcNHglycan	486	489	PF01048	0.422
MOD_GlcNHglycan	563	566	PF01048	0.502
MOD_GlcNHglycan	707	710	PF01048	0.402
MOD_GlcNHglycan	714	717	PF01048	0.363
MOD_GSK3_1	101	108	PF00069	0.737
MOD_GSK3_1	188	195	PF00069	0.407
MOD_GSK3_1	262	269	PF00069	0.499
MOD_GSK3_1	292	299	PF00069	0.474
MOD_GSK3_1	368	375	PF00069	0.474
MOD_GSK3_1	376	383	PF00069	0.468
MOD_GSK3_1	387	394	PF00069	0.612
MOD_GSK3_1	519	526	PF00069	0.449
MOD_GSK3_1	552	559	PF00069	0.472
MOD_GSK3_1	578	585	PF00069	0.474
MOD_GSK3_1	681	688	PF00069	0.315
MOD_GSK3_1	73	80	PF00069	0.497
MOD_GSK3_1	92	99	PF00069	0.672
MOD_LATS_1	507	513	PF00433	0.372
MOD_N-GLC_1	500	505	PF02516	0.447
MOD_N-GLC_1	53	58	PF02516	0.334
MOD_N-GLC_1	681	686	PF02516	0.534
MOD_N-GLC_1	95	100	PF02516	0.464
MOD_NEK2_1	132	137	PF00069	0.498
MOD_NEK2_1	140	145	PF00069	0.522
MOD_NEK2_1	192	197	PF00069	0.456
MOD_NEK2_1	23	28	PF00069	0.605
MOD_NEK2_1	276	281	PF00069	0.478
MOD_NEK2_1	292	297	PF00069	0.320
MOD_NEK2_1	305	310	PF00069	0.632
MOD_NEK2_1	348	353	PF00069	0.353
MOD_NEK2_1	368	373	PF00069	0.446
MOD_NEK2_1	552	557	PF00069	0.384
MOD_NEK2_1	561	566	PF00069	0.439
MOD_NEK2_1	60	65	PF00069	0.523
MOD_NEK2_1	616	621	PF00069	0.303
MOD_NEK2_1	675	680	PF00069	0.316
MOD_NEK2_1	7	12	PF00069	0.632
MOD_NEK2_1	71	76	PF00069	0.334
MOD_NEK2_2	520	525	PF00069	0.269
MOD_PIKK_1	140	146	PF00454	0.458
MOD_PIKK_1	376	382	PF00454	0.416
MOD_PIKK_1	53	59	PF00454	0.446
MOD_PIKK_1	60	66	PF00454	0.346
MOD_PIKK_1	652	658	PF00454	0.339
MOD_PIKK_1	737	743	PF00454	0.356
MOD_PKA_1	310	316	PF00069	0.514
MOD_PKA_1	372	378	PF00069	0.521
MOD_PKA_2	252	258	PF00069	0.509
MOD_PKA_2	266	272	PF00069	0.321
MOD_PKA_2	281	287	PF00069	0.353
MOD_PKA_2	296	302	PF00069	0.668
MOD_PKA_2	305	311	PF00069	0.493
MOD_PKA_2	372	378	PF00069	0.503
MOD_PKA_2	396	402	PF00069	0.316
MOD_PKA_2	638	644	PF00069	0.479
MOD_PKA_2	652	658	PF00069	0.455
MOD_PKB_1	251	259	PF00069	0.523
MOD_Plk_1	169	175	PF00069	0.628
MOD_Plk_1	675	681	PF00069	0.432
MOD_Plk_4	171	177	PF00069	0.426
MOD_Plk_4	188	194	PF00069	0.469
MOD_Plk_4	472	478	PF00069	0.396
MOD_Plk_4	509	515	PF00069	0.351
MOD_Plk_4	564	570	PF00069	0.512
MOD_Plk_4	602	608	PF00069	0.497
MOD_Plk_4	675	681	PF00069	0.508
MOD_Plk_4	690	696	PF00069	0.225
MOD_Plk_4	702	708	PF00069	0.325
MOD_Plk_4	715	721	PF00069	0.479
MOD_Plk_4	77	83	PF00069	0.308
MOD_ProDKin_1	297	303	PF00069	0.648
MOD_ProDKin_1	382	388	PF00069	0.413
MOD_ProDKin_1	582	588	PF00069	0.460
MOD_SUMO_rev_2	37	43	PF00179	0.722
TRG_DiLeu_BaEn_1	548	553	PF01217	0.459
TRG_DiLeu_BaEn_4	216	222	PF01217	0.407
TRG_ENDOCYTIC_2	85	88	PF00928	0.546
TRG_ER_diArg_1	186	188	PF00400	0.511
TRG_ER_diArg_1	250	253	PF00400	0.485
TRG_ER_diArg_1	515	517	PF00400	0.482
TRG_ER_diArg_1	9	12	PF00400	0.672
TRG_NES_CRM1_1	410	422	PF08389	0.456
TRG_NES_CRM1_1	723	738	PF08389	0.476
TRG_NLS_MonoCore_2	113	118	PF00514	0.767
TRG_NLS_MonoExtC_3	113	118	PF00514	0.658
TRG_NLS_MonoExtN_4	306	313	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	625	629	PF00026	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F3	Leptomonas seymouri	68%	100%
A0A0S4IWW4	Bodo saltans	34%	100%
A0A1X0NV47	Trypanosomatidae	37%	100%
A0A3Q8I8Y6	Leishmania donovani	84%	100%
A0A3R7MZX0	Trypanosoma rangeli	37%	100%
A4HUV8	Leishmania infantum	84%	100%
D0A7J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ANJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QH33	Leishmania major	85%	100%
V5DSY9	Trypanosoma cruzi	38%	100%