Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H6G2_LEIBR

TriTrypDb:

LbrM.11.0140 , LBRM2903_110006300

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6G2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	68	74	PF00089	0.633
CLV_NRD_NRD_1	153	155	PF00675	0.518
CLV_NRD_NRD_1	2	4	PF00675	0.621
CLV_NRD_NRD_1	280	282	PF00675	0.548
CLV_PCSK_KEX2_1	153	155	PF00082	0.521
CLV_PCSK_KEX2_1	2	4	PF00082	0.621
CLV_PCSK_KEX2_1	239	241	PF00082	0.473
CLV_PCSK_KEX2_1	280	282	PF00082	0.548
CLV_PCSK_KEX2_1	590	592	PF00082	0.583
CLV_PCSK_KEX2_1	609	611	PF00082	0.610
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.479
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.433
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.610
CLV_PCSK_SKI1_1	192	196	PF00082	0.530
CLV_PCSK_SKI1_1	3	7	PF00082	0.589
CLV_PCSK_SKI1_1	561	565	PF00082	0.632
CLV_PCSK_SKI1_1	591	595	PF00082	0.599
CLV_PCSK_SKI1_1	603	607	PF00082	0.420
CLV_PCSK_SKI1_1	609	613	PF00082	0.587
DEG_APCC_DBOX_1	590	598	PF00400	0.428
DEG_COP1_1	133	143	PF00400	0.515
DEG_Nend_UBRbox_1	1	4	PF02207	0.627
DEG_SPOP_SBC_1	19	23	PF00917	0.609
DEG_SPOP_SBC_1	243	247	PF00917	0.527
DEG_SPOP_SBC_1	536	540	PF00917	0.494
DOC_CKS1_1	186	191	PF01111	0.521
DOC_CKS1_1	83	88	PF01111	0.520
DOC_CYCLIN_RxL_1	588	595	PF00134	0.583
DOC_MAPK_gen_1	225	234	PF00069	0.608
DOC_MAPK_gen_1	293	303	PF00069	0.612
DOC_MAPK_MEF2A_6	104	113	PF00069	0.518
DOC_MAPK_MEF2A_6	296	305	PF00069	0.521
DOC_PP2B_LxvP_1	174	177	PF13499	0.665
DOC_PP2B_LxvP_1	555	558	PF13499	0.521
DOC_USP7_MATH_1	109	113	PF00917	0.624
DOC_USP7_MATH_1	119	123	PF00917	0.602
DOC_USP7_MATH_1	136	140	PF00917	0.476
DOC_USP7_MATH_1	179	183	PF00917	0.608
DOC_USP7_MATH_1	243	247	PF00917	0.544
DOC_USP7_MATH_1	327	331	PF00917	0.564
DOC_USP7_MATH_1	37	41	PF00917	0.562
DOC_USP7_MATH_1	429	433	PF00917	0.606
DOC_USP7_MATH_1	457	461	PF00917	0.499
DOC_USP7_MATH_1	497	501	PF00917	0.750
DOC_USP7_MATH_1	536	540	PF00917	0.637
DOC_USP7_MATH_1	565	569	PF00917	0.506
DOC_USP7_MATH_1	628	632	PF00917	0.488
DOC_WW_Pin1_4	132	137	PF00397	0.565
DOC_WW_Pin1_4	185	190	PF00397	0.752
DOC_WW_Pin1_4	206	211	PF00397	0.644
DOC_WW_Pin1_4	29	34	PF00397	0.679
DOC_WW_Pin1_4	323	328	PF00397	0.512
DOC_WW_Pin1_4	392	397	PF00397	0.702
DOC_WW_Pin1_4	422	427	PF00397	0.672
DOC_WW_Pin1_4	614	619	PF00397	0.626
DOC_WW_Pin1_4	644	649	PF00397	0.540
DOC_WW_Pin1_4	82	87	PF00397	0.575
LIG_14-3-3_CanoR_1	15	20	PF00244	0.571
LIG_14-3-3_CanoR_1	166	172	PF00244	0.523
LIG_14-3-3_CanoR_1	228	234	PF00244	0.633
LIG_14-3-3_CanoR_1	433	441	PF00244	0.566
LIG_14-3-3_CanoR_1	591	597	PF00244	0.585
LIG_14-3-3_CanoR_1	610	618	PF00244	0.549
LIG_14-3-3_CanoR_1	66	71	PF00244	0.567
LIG_Actin_WH2_2	264	282	PF00022	0.593
LIG_BRCT_BRCA1_1	630	634	PF00533	0.586
LIG_BRCT_BRCA1_1	68	72	PF00533	0.564
LIG_CaM_IQ_9	298	313	PF13499	0.567
LIG_FHA_1	135	141	PF00498	0.529
LIG_FHA_1	186	192	PF00498	0.681
LIG_FHA_1	262	268	PF00498	0.434
LIG_FHA_1	365	371	PF00498	0.637
LIG_FHA_1	373	379	PF00498	0.515
LIG_FHA_1	389	395	PF00498	0.422
LIG_FHA_1	402	408	PF00498	0.670
LIG_FHA_1	433	439	PF00498	0.646
LIG_FHA_1	51	57	PF00498	0.567
LIG_FHA_1	538	544	PF00498	0.694
LIG_FHA_1	610	616	PF00498	0.519
LIG_FHA_1	645	651	PF00498	0.645
LIG_FHA_1	72	78	PF00498	0.699
LIG_FHA_1	82	88	PF00498	0.600
LIG_FHA_2	403	409	PF00498	0.620
LIG_FHA_2	578	584	PF00498	0.655
LIG_IRF3_LxIS_1	297	304	PF10401	0.557
LIG_LIR_Gen_1	214	223	PF02991	0.587
LIG_LIR_Gen_1	255	263	PF02991	0.470
LIG_LIR_Gen_1	463	472	PF02991	0.565
LIG_LIR_Nem_3	218	223	PF02991	0.562
LIG_LIR_Nem_3	255	259	PF02991	0.485
LIG_LIR_Nem_3	463	467	PF02991	0.565
LIG_LIR_Nem_3	631	637	PF02991	0.592
LIG_NRBOX	551	557	PF00104	0.444
LIG_PCNA_PIPBox_1	272	281	PF02747	0.595
LIG_Pex14_1	151	155	PF04695	0.457
LIG_Pex14_1	216	220	PF04695	0.530
LIG_RPA_C_Fungi	428	440	PF08784	0.492
LIG_SH2_GRB2like	548	551	PF00017	0.567
LIG_SH2_STAP1	548	552	PF00017	0.408
LIG_SH2_STAP1	637	641	PF00017	0.621
LIG_SH2_STAT3	548	551	PF00017	0.458
LIG_SH2_STAT5	155	158	PF00017	0.481
LIG_SH2_STAT5	256	259	PF00017	0.566
LIG_SH2_STAT5	371	374	PF00017	0.660
LIG_SH2_STAT5	437	440	PF00017	0.622
LIG_SH3_2	61	66	PF14604	0.576
LIG_SH3_3	1	7	PF00018	0.547
LIG_SH3_3	183	189	PF00018	0.582
LIG_SH3_3	247	253	PF00018	0.590
LIG_SH3_3	55	61	PF00018	0.595
LIG_SH3_3	612	618	PF00018	0.556
LIG_SH3_3	80	86	PF00018	0.513
LIG_SH3_5	252	256	PF00018	0.565
LIG_SUMO_SIM_anti_2	264	270	PF11976	0.426
LIG_TRAF2_1	258	261	PF00917	0.553
LIG_TRAF2_1	340	343	PF00917	0.711
LIG_TRAF2_1	500	503	PF00917	0.482
LIG_TRAF2_1	568	571	PF00917	0.495
LIG_TYR_ITIM	254	259	PF00017	0.484
LIG_UBA3_1	585	590	PF00899	0.433
LIG_WRC_WIRS_1	461	466	PF05994	0.579
LIG_WW_3	293	297	PF00397	0.604
MOD_CDK_SPK_2	614	619	PF00069	0.484
MOD_CDK_SPxxK_3	185	192	PF00069	0.525
MOD_CK1_1	130	136	PF00069	0.692
MOD_CK1_1	139	145	PF00069	0.553
MOD_CK1_1	18	24	PF00069	0.607
MOD_CK1_1	182	188	PF00069	0.562
MOD_CK1_1	227	233	PF00069	0.541
MOD_CK1_1	329	335	PF00069	0.627
MOD_CK1_1	395	401	PF00069	0.686
MOD_CK1_1	414	420	PF00069	0.536
MOD_CK1_1	432	438	PF00069	0.615
MOD_CK1_1	460	466	PF00069	0.557
MOD_CK2_1	227	233	PF00069	0.537
MOD_CK2_1	422	428	PF00069	0.668
MOD_CK2_1	497	503	PF00069	0.573
MOD_CK2_1	565	571	PF00069	0.493
MOD_CK2_1	577	583	PF00069	0.469
MOD_GlcNHglycan	123	126	PF01048	0.699
MOD_GlcNHglycan	17	20	PF01048	0.586
MOD_GlcNHglycan	246	249	PF01048	0.661
MOD_GlcNHglycan	288	291	PF01048	0.738
MOD_GlcNHglycan	333	336	PF01048	0.658
MOD_GlcNHglycan	397	400	PF01048	0.579
MOD_GlcNHglycan	413	416	PF01048	0.758
MOD_GlcNHglycan	417	420	PF01048	0.770
MOD_GlcNHglycan	489	492	PF01048	0.615
MOD_GlcNHglycan	499	502	PF01048	0.566
MOD_GlcNHglycan	626	629	PF01048	0.451
MOD_GSK3_1	115	122	PF00069	0.574
MOD_GSK3_1	127	134	PF00069	0.548
MOD_GSK3_1	15	22	PF00069	0.639
MOD_GSK3_1	175	182	PF00069	0.709
MOD_GSK3_1	201	208	PF00069	0.549
MOD_GSK3_1	323	330	PF00069	0.596
MOD_GSK3_1	354	361	PF00069	0.602
MOD_GSK3_1	388	395	PF00069	0.459
MOD_GSK3_1	398	405	PF00069	0.676
MOD_GSK3_1	407	414	PF00069	0.602
MOD_GSK3_1	493	500	PF00069	0.703
MOD_GSK3_1	531	538	PF00069	0.539
MOD_GSK3_1	624	631	PF00069	0.437
MOD_GSK3_1	644	651	PF00069	0.481
MOD_GSK3_1	66	73	PF00069	0.680
MOD_GSK3_1	78	85	PF00069	0.602
MOD_N-GLC_1	198	203	PF02516	0.542
MOD_N-GLC_1	330	335	PF02516	0.709
MOD_N-GLC_1	354	359	PF02516	0.707
MOD_N-GLC_2	411	413	PF02516	0.533
MOD_NEK2_1	301	306	PF00069	0.563
MOD_NEK2_1	372	377	PF00069	0.454
MOD_NEK2_1	49	54	PF00069	0.667
MOD_NEK2_1	78	83	PF00069	0.619
MOD_NEK2_2	637	642	PF00069	0.630
MOD_PIKK_1	211	217	PF00454	0.459
MOD_PIKK_1	654	660	PF00454	0.558
MOD_PK_1	66	72	PF00069	0.643
MOD_PKA_1	609	615	PF00069	0.560
MOD_PKA_2	165	171	PF00069	0.491
MOD_PKA_2	224	230	PF00069	0.561
MOD_PKA_2	279	285	PF00069	0.577
MOD_PKA_2	432	438	PF00069	0.609
MOD_PKA_2	577	583	PF00069	0.659
MOD_PKA_2	609	615	PF00069	0.560
MOD_PKA_2	70	76	PF00069	0.633
MOD_Plk_1	402	408	PF00069	0.532
MOD_Plk_4	262	268	PF00069	0.422
MOD_Plk_4	451	457	PF00069	0.627
MOD_Plk_4	460	466	PF00069	0.584
MOD_Plk_4	523	529	PF00069	0.630
MOD_Plk_4	592	598	PF00069	0.435
MOD_Plk_4	637	643	PF00069	0.669
MOD_ProDKin_1	132	138	PF00069	0.564
MOD_ProDKin_1	185	191	PF00069	0.751
MOD_ProDKin_1	206	212	PF00069	0.638
MOD_ProDKin_1	29	35	PF00069	0.677
MOD_ProDKin_1	323	329	PF00069	0.516
MOD_ProDKin_1	392	398	PF00069	0.706
MOD_ProDKin_1	422	428	PF00069	0.668
MOD_ProDKin_1	614	620	PF00069	0.622
MOD_ProDKin_1	644	650	PF00069	0.545
MOD_ProDKin_1	82	88	PF00069	0.576
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.563
TRG_ENDOCYTIC_2	256	259	PF00928	0.481
TRG_ER_diArg_1	1	3	PF00400	0.642
TRG_ER_diArg_1	152	154	PF00400	0.606
TRG_ER_diArg_1	279	281	PF00400	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P315	Leptomonas seymouri	34%	100%
A0A3Q8I910	Leishmania donovani	75%	100%
A4HUV7	Leishmania infantum	75%	100%
E9ANJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QH34	Leishmania major	73%	99%