Putative DNA ligase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative DNA ligase

Gene product:

DNA ligase, putative

Species:

Leishmania braziliensis

UniProt:

A4H6G1_LEIBR

TriTrypDb:

LbrM.11.0130 , LBRM2903_110006200

Length:

771

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6G1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003909	DNA ligase activity	4	8
GO:0003910	DNA ligase (ATP) activity	5	8
GO:0016874	ligase activity	2	11
GO:0016886	ligase activity, forming phosphoric ester bonds	3	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.674
CLV_C14_Caspase3-7	291	295	PF00656	0.481
CLV_C14_Caspase3-7	70	74	PF00656	0.505
CLV_NRD_NRD_1	188	190	PF00675	0.801
CLV_NRD_NRD_1	370	372	PF00675	0.629
CLV_NRD_NRD_1	471	473	PF00675	0.735
CLV_NRD_NRD_1	553	555	PF00675	0.532
CLV_NRD_NRD_1	6	8	PF00675	0.606
CLV_NRD_NRD_1	639	641	PF00675	0.611
CLV_PCSK_FUR_1	112	116	PF00082	0.536
CLV_PCSK_KEX2_1	111	113	PF00082	0.645
CLV_PCSK_KEX2_1	114	116	PF00082	0.645
CLV_PCSK_KEX2_1	188	190	PF00082	0.801
CLV_PCSK_KEX2_1	471	473	PF00082	0.723
CLV_PCSK_KEX2_1	553	555	PF00082	0.510
CLV_PCSK_KEX2_1	6	8	PF00082	0.606
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.645
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.645
CLV_PCSK_SKI1_1	115	119	PF00082	0.658
CLV_PCSK_SKI1_1	494	498	PF00082	0.595
CLV_PCSK_SKI1_1	554	558	PF00082	0.514
CLV_PCSK_SKI1_1	565	569	PF00082	0.453
CLV_PCSK_SKI1_1	571	575	PF00082	0.358
CLV_PCSK_SKI1_1	584	588	PF00082	0.327
CLV_PCSK_SKI1_1	63	67	PF00082	0.415
CLV_PCSK_SKI1_1	684	688	PF00082	0.384
DEG_APCC_DBOX_1	683	691	PF00400	0.339
DEG_Nend_Nbox_1	1	3	PF02207	0.530
DEG_SCF_FBW7_2	633	639	PF00400	0.563
DEG_SPOP_SBC_1	100	104	PF00917	0.694
DOC_CDC14_PxL_1	243	251	PF14671	0.434
DOC_CDC14_PxL_1	324	332	PF14671	0.405
DOC_CKS1_1	379	384	PF01111	0.485
DOC_CKS1_1	633	638	PF01111	0.668
DOC_CYCLIN_RxL_1	578	591	PF00134	0.532
DOC_MAPK_gen_1	469	476	PF00069	0.761
DOC_MAPK_gen_1	489	499	PF00069	0.624
DOC_MAPK_gen_1	595	602	PF00069	0.473
DOC_MAPK_gen_1	6	14	PF00069	0.474
DOC_MAPK_MEF2A_6	325	332	PF00069	0.315
DOC_MAPK_MEF2A_6	492	501	PF00069	0.679
DOC_MAPK_NFAT4_5	494	502	PF00069	0.677
DOC_PP1_RVXF_1	559	565	PF00149	0.421
DOC_PP1_RVXF_1	61	68	PF00149	0.416
DOC_PP2B_LxvP_1	457	460	PF13499	0.611
DOC_PP2B_LxvP_1	47	50	PF13499	0.573
DOC_PP4_FxxP_1	255	258	PF00568	0.469
DOC_PP4_FxxP_1	77	80	PF00568	0.354
DOC_USP7_MATH_1	100	104	PF00917	0.660
DOC_USP7_MATH_1	18	22	PF00917	0.446
DOC_USP7_MATH_1	391	395	PF00917	0.445
DOC_USP7_MATH_1	48	52	PF00917	0.783
DOC_USP7_MATH_1	621	625	PF00917	0.709
DOC_USP7_UBL2_3	110	114	PF12436	0.535
DOC_USP7_UBL2_3	447	451	PF12436	0.585
DOC_USP7_UBL2_3	716	720	PF12436	0.621
DOC_WW_Pin1_4	119	124	PF00397	0.572
DOC_WW_Pin1_4	258	263	PF00397	0.554
DOC_WW_Pin1_4	350	355	PF00397	0.477
DOC_WW_Pin1_4	37	42	PF00397	0.734
DOC_WW_Pin1_4	378	383	PF00397	0.725
DOC_WW_Pin1_4	508	513	PF00397	0.637
DOC_WW_Pin1_4	529	534	PF00397	0.723
DOC_WW_Pin1_4	629	634	PF00397	0.700
DOC_WW_Pin1_4	699	704	PF00397	0.718
DOC_WW_Pin1_4	76	81	PF00397	0.370
DOC_WW_Pin1_4	95	100	PF00397	0.582
LIG_14-3-3_CanoR_1	115	124	PF00244	0.671
LIG_14-3-3_CanoR_1	283	292	PF00244	0.572
LIG_14-3-3_CanoR_1	307	316	PF00244	0.385
LIG_14-3-3_CanoR_1	336	341	PF00244	0.484
LIG_14-3-3_CanoR_1	471	475	PF00244	0.672
LIG_14-3-3_CanoR_1	565	573	PF00244	0.512
LIG_14-3-3_CanoR_1	640	645	PF00244	0.822
LIG_14-3-3_CanoR_1	7	13	PF00244	0.451
LIG_14-3-3_CanoR_1	86	91	PF00244	0.380
LIG_Actin_WH2_1	309	327	PF00022	0.396
LIG_Actin_WH2_2	450	465	PF00022	0.620
LIG_Clathr_ClatBox_1	139	143	PF01394	0.452
LIG_FHA_1	269	275	PF00498	0.424
LIG_FHA_1	418	424	PF00498	0.482
LIG_FHA_1	594	600	PF00498	0.615
LIG_FHA_1	96	102	PF00498	0.620
LIG_FHA_2	167	173	PF00498	0.585
LIG_FHA_2	208	214	PF00498	0.438
LIG_FHA_2	235	241	PF00498	0.380
LIG_FHA_2	537	543	PF00498	0.696
LIG_FHA_2	572	578	PF00498	0.517
LIG_FHA_2	646	652	PF00498	0.572
LIG_FHA_2	746	752	PF00498	0.525
LIG_LIR_Apic_2	130	135	PF02991	0.393
LIG_LIR_Apic_2	378	382	PF02991	0.488
LIG_LIR_Apic_2	89	93	PF02991	0.551
LIG_LIR_Gen_1	217	226	PF02991	0.387
LIG_LIR_Gen_1	738	749	PF02991	0.404
LIG_LIR_Nem_3	126	132	PF02991	0.387
LIG_LIR_Nem_3	217	222	PF02991	0.375
LIG_LIR_Nem_3	577	583	PF02991	0.417
LIG_LIR_Nem_3	738	744	PF02991	0.397
LIG_LYPXL_yS_3	580	583	PF13949	0.473
LIG_MYND_1	581	585	PF01753	0.552
LIG_NRBOX	342	348	PF00104	0.334
LIG_NRBOX	686	692	PF00104	0.407
LIG_PCNA_PIPBox_1	683	692	PF02747	0.408
LIG_PCNA_PIPBox_1	734	743	PF02747	0.447
LIG_Pex14_2	215	219	PF04695	0.539
LIG_PTB_Apo_2	426	433	PF02174	0.298
LIG_PTB_Phospho_1	426	432	PF10480	0.300
LIG_SH2_CRK	132	136	PF00017	0.511
LIG_SH2_CRK	410	414	PF00017	0.429
LIG_SH2_CRK	741	745	PF00017	0.386
LIG_SH2_GRB2like	427	430	PF00017	0.360
LIG_SH2_NCK_1	723	727	PF00017	0.500
LIG_SH2_PTP2	90	93	PF00017	0.531
LIG_SH2_SRC	245	248	PF00017	0.432
LIG_SH2_SRC	427	430	PF00017	0.460
LIG_SH2_SRC	723	726	PF00017	0.502
LIG_SH2_SRC	90	93	PF00017	0.501
LIG_SH2_STAP1	723	727	PF00017	0.500
LIG_SH2_STAT3	659	662	PF00017	0.348
LIG_SH2_STAT5	165	168	PF00017	0.376
LIG_SH2_STAT5	245	248	PF00017	0.386
LIG_SH2_STAT5	342	345	PF00017	0.393
LIG_SH2_STAT5	427	430	PF00017	0.413
LIG_SH2_STAT5	612	615	PF00017	0.386
LIG_SH2_STAT5	90	93	PF00017	0.523
LIG_SH3_1	10	16	PF00018	0.436
LIG_SH3_2	633	638	PF14604	0.539
LIG_SH3_3	10	16	PF00018	0.439
LIG_SH3_3	179	185	PF00018	0.551
LIG_SH3_3	244	250	PF00018	0.485
LIG_SH3_3	263	269	PF00018	0.602
LIG_SH3_3	38	44	PF00018	0.502
LIG_SH3_3	524	530	PF00018	0.711
LIG_SH3_3	597	603	PF00018	0.452
LIG_SH3_3	630	636	PF00018	0.602
LIG_SH3_3	670	676	PF00018	0.363
LIG_SH3_3	69	75	PF00018	0.530
LIG_SH3_3	716	722	PF00018	0.517
LIG_SUMO_SIM_anti_2	542	547	PF11976	0.582
LIG_SUMO_SIM_par_1	497	503	PF11976	0.552
LIG_SUMO_SIM_par_1	732	738	PF11976	0.492
LIG_TRAF2_1	722	725	PF00917	0.503
LIG_TYR_ITIM	408	413	PF00017	0.380
LIG_UBA3_1	582	588	PF00899	0.412
MOD_CDC14_SPxK_1	706	709	PF00782	0.530
MOD_CDK_SPK_2	76	81	PF00069	0.361
MOD_CDK_SPxK_1	632	638	PF00069	0.537
MOD_CDK_SPxK_1	703	709	PF00069	0.528
MOD_CK1_1	234	240	PF00069	0.431
MOD_CK1_1	279	285	PF00069	0.626
MOD_CK1_1	487	493	PF00069	0.633
MOD_CK1_1	500	506	PF00069	0.649
MOD_CK1_1	51	57	PF00069	0.621
MOD_CK1_1	747	753	PF00069	0.505
MOD_CK2_1	166	172	PF00069	0.392
MOD_CK2_1	234	240	PF00069	0.351
MOD_CK2_1	536	542	PF00069	0.686
MOD_CK2_1	54	60	PF00069	0.456
MOD_CK2_1	745	751	PF00069	0.432
MOD_Cter_Amidation	551	554	PF01082	0.619
MOD_GlcNHglycan	216	219	PF01048	0.420
MOD_GlcNHglycan	222	225	PF01048	0.381
MOD_GlcNHglycan	231	234	PF01048	0.465
MOD_GlcNHglycan	278	281	PF01048	0.561
MOD_GlcNHglycan	313	316	PF01048	0.308
MOD_GlcNHglycan	393	396	PF01048	0.683
MOD_GlcNHglycan	485	489	PF01048	0.776
MOD_GlcNHglycan	558	561	PF01048	0.561
MOD_GlcNHglycan	623	626	PF01048	0.605
MOD_GlcNHglycan	691	694	PF01048	0.599
MOD_GlcNHglycan	703	706	PF01048	0.722
MOD_GSK3_1	101	108	PF00069	0.596
MOD_GSK3_1	115	122	PF00069	0.766
MOD_GSK3_1	123	130	PF00069	0.347
MOD_GSK3_1	192	199	PF00069	0.755
MOD_GSK3_1	207	214	PF00069	0.398
MOD_GSK3_1	231	238	PF00069	0.377
MOD_GSK3_1	279	286	PF00069	0.525
MOD_GSK3_1	307	314	PF00069	0.291
MOD_GSK3_1	412	419	PF00069	0.484
MOD_GSK3_1	50	57	PF00069	0.756
MOD_GSK3_1	556	563	PF00069	0.537
MOD_GSK3_1	589	596	PF00069	0.567
MOD_GSK3_1	645	652	PF00069	0.692
MOD_GSK3_1	699	706	PF00069	0.738
MOD_GSK3_1	725	732	PF00069	0.692
MOD_GSK3_1	740	747	PF00069	0.400
MOD_GSK3_1	91	98	PF00069	0.548
MOD_N-GLC_1	328	333	PF02516	0.366
MOD_N-GLC_1	645	650	PF02516	0.581
MOD_N-GLC_1	671	676	PF02516	0.431
MOD_N-GLC_1	699	704	PF02516	0.508
MOD_NEK2_1	1	6	PF00069	0.619
MOD_NEK2_1	101	106	PF00069	0.529
MOD_NEK2_1	17	22	PF00069	0.421
MOD_NEK2_1	171	176	PF00069	0.629
MOD_NEK2_1	220	225	PF00069	0.384
MOD_NEK2_1	229	234	PF00069	0.492
MOD_NEK2_1	270	275	PF00069	0.665
MOD_NEK2_1	284	289	PF00069	0.483
MOD_NEK2_1	29	34	PF00069	0.552
MOD_NEK2_1	416	421	PF00069	0.546
MOD_NEK2_1	497	502	PF00069	0.655
MOD_NEK2_1	671	676	PF00069	0.414
MOD_NEK2_1	740	745	PF00069	0.390
MOD_NEK2_1	8	13	PF00069	0.487
MOD_NEK2_2	124	129	PF00069	0.541
MOD_NEK2_2	328	333	PF00069	0.327
MOD_PIKK_1	101	107	PF00454	0.661
MOD_PIKK_1	171	177	PF00454	0.588
MOD_PIKK_1	231	237	PF00454	0.645
MOD_PIKK_1	295	301	PF00454	0.563
MOD_PIKK_1	417	423	PF00454	0.545
MOD_PK_1	756	762	PF00069	0.496
MOD_PKA_1	110	116	PF00069	0.535
MOD_PKA_1	640	646	PF00069	0.699
MOD_PKA_2	229	235	PF00069	0.505
MOD_PKA_2	370	376	PF00069	0.720
MOD_PKA_2	462	468	PF00069	0.576
MOD_PKA_2	470	476	PF00069	0.775
MOD_PKA_2	626	632	PF00069	0.697
MOD_PKA_2	729	735	PF00069	0.605
MOD_PKB_1	638	646	PF00069	0.560
MOD_PKB_1	699	707	PF00069	0.515
MOD_Plk_1	154	160	PF00069	0.529
MOD_Plk_1	328	334	PF00069	0.358
MOD_Plk_1	627	633	PF00069	0.597
MOD_Plk_1	671	677	PF00069	0.420
MOD_Plk_4	154	160	PF00069	0.453
MOD_Plk_4	328	334	PF00069	0.397
MOD_ProDKin_1	119	125	PF00069	0.560
MOD_ProDKin_1	258	264	PF00069	0.573
MOD_ProDKin_1	350	356	PF00069	0.474
MOD_ProDKin_1	37	43	PF00069	0.733
MOD_ProDKin_1	378	384	PF00069	0.722
MOD_ProDKin_1	508	514	PF00069	0.638
MOD_ProDKin_1	529	535	PF00069	0.723
MOD_ProDKin_1	629	635	PF00069	0.702
MOD_ProDKin_1	699	705	PF00069	0.722
MOD_ProDKin_1	76	82	PF00069	0.368
MOD_ProDKin_1	95	101	PF00069	0.586
TRG_DiLeu_BaEn_1	144	149	PF01217	0.313
TRG_DiLeu_BaEn_1	352	357	PF01217	0.270
TRG_DiLeu_BaEn_4	144	150	PF01217	0.316
TRG_DiLeu_BaEn_4	724	730	PF01217	0.489
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.502
TRG_DiLeu_BaLyEn_6	582	587	PF01217	0.403
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.498
TRG_DiLeu_LyEn_5	144	149	PF01217	0.392
TRG_ENDOCYTIC_2	137	140	PF00928	0.467
TRG_ENDOCYTIC_2	410	413	PF00928	0.433
TRG_ENDOCYTIC_2	580	583	PF00928	0.397
TRG_ENDOCYTIC_2	741	744	PF00928	0.379
TRG_ER_diArg_1	594	597	PF00400	0.563
TRG_ER_diArg_1	6	8	PF00400	0.596
TRG_ER_diArg_1	603	606	PF00400	0.480
TRG_ER_diArg_1	698	701	PF00400	0.493
TRG_NLS_MonoExtC_3	109	114	PF00514	0.534
TRG_NLS_MonoExtN_4	110	115	PF00514	0.537
TRG_NLS_MonoExtN_4	188	193	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	554	558	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	584	589	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	684	688	PF00026	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN9	Leptomonas seymouri	51%	100%
A0A1X0NVK9	Trypanosomatidae	34%	100%
A0A3R7NRR1	Trypanosoma rangeli	35%	100%
A0A3S7WRI1	Leishmania donovani	76%	100%
A4HUV6	Leishmania infantum	76%	100%
D0A7J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9ANJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QH35	Leishmania major	74%	98%
V5BB55	Trypanosoma cruzi	35%	100%