Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6G0_LEIBR

TriTrypDb:

LbrM.11.0120 , LBRM2903_110006100

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H6G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6G0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.286
CLV_NRD_NRD_1	180	182	PF00675	0.470
CLV_NRD_NRD_1	183	185	PF00675	0.444
CLV_NRD_NRD_1	292	294	PF00675	0.565
CLV_NRD_NRD_1	341	343	PF00675	0.668
CLV_NRD_NRD_1	439	441	PF00675	0.506
CLV_NRD_NRD_1	445	447	PF00675	0.533
CLV_NRD_NRD_1	463	465	PF00675	0.502
CLV_NRD_NRD_1	586	588	PF00675	0.634
CLV_NRD_NRD_1	7	9	PF00675	0.442
CLV_PCSK_FUR_1	181	185	PF00082	0.375
CLV_PCSK_KEX2_1	182	184	PF00082	0.465
CLV_PCSK_KEX2_1	292	294	PF00082	0.565
CLV_PCSK_KEX2_1	341	343	PF00082	0.644
CLV_PCSK_KEX2_1	439	441	PF00082	0.506
CLV_PCSK_KEX2_1	586	588	PF00082	0.555
CLV_PCSK_KEX2_1	7	9	PF00082	0.443
CLV_PCSK_PC1ET2_1	182	184	PF00082	0.465
CLV_PCSK_PC7_1	435	441	PF00082	0.469
CLV_PCSK_SKI1_1	183	187	PF00082	0.460
CLV_PCSK_SKI1_1	189	193	PF00082	0.475
DEG_APCC_DBOX_1	445	453	PF00400	0.532
DEG_APCC_DBOX_1	556	564	PF00400	0.540
DEG_Nend_UBRbox_3	1	3	PF02207	0.409
DEG_SPOP_SBC_1	221	225	PF00917	0.643
DEG_SPOP_SBC_1	317	321	PF00917	0.671
DOC_CDC14_PxL_1	162	170	PF14671	0.304
DOC_CKS1_1	259	264	PF01111	0.549
DOC_CYCLIN_RxL_1	183	194	PF00134	0.455
DOC_CYCLIN_RxL_1	29	40	PF00134	0.374
DOC_CYCLIN_yClb5_NLxxxL_5	419	428	PF00134	0.438
DOC_MAPK_gen_1	127	137	PF00069	0.451
DOC_MAPK_gen_1	181	190	PF00069	0.464
DOC_MAPK_gen_1	439	445	PF00069	0.510
DOC_MAPK_HePTP_8	180	192	PF00069	0.461
DOC_MAPK_MEF2A_6	183	192	PF00069	0.458
DOC_MAPK_MEF2A_6	421	428	PF00069	0.432
DOC_MAPK_MEF2A_6	557	566	PF00069	0.543
DOC_MAPK_RevD_3	166	182	PF00069	0.313
DOC_PP2B_LxvP_1	190	193	PF13499	0.469
DOC_PP2B_LxvP_1	544	547	PF13499	0.536
DOC_PP2B_LxvP_1	566	569	PF13499	0.557
DOC_PP4_FxxP_1	389	392	PF00568	0.633
DOC_USP7_MATH_1	221	225	PF00917	0.622
DOC_USP7_MATH_1	235	239	PF00917	0.599
DOC_USP7_MATH_1	309	313	PF00917	0.613
DOC_USP7_MATH_1	357	361	PF00917	0.576
DOC_USP7_MATH_1	374	378	PF00917	0.660
DOC_USP7_MATH_1	493	497	PF00917	0.586
DOC_USP7_MATH_1	522	526	PF00917	0.681
DOC_USP7_MATH_1	556	560	PF00917	0.593
DOC_USP7_MATH_1	569	573	PF00917	0.609
DOC_WW_Pin1_4	258	263	PF00397	0.551
DOC_WW_Pin1_4	333	338	PF00397	0.619
DOC_WW_Pin1_4	350	355	PF00397	0.792
DOC_WW_Pin1_4	359	364	PF00397	0.695
DOC_WW_Pin1_4	368	373	PF00397	0.704
DOC_WW_Pin1_4	391	396	PF00397	0.745
DOC_WW_Pin1_4	498	503	PF00397	0.564
DOC_WW_Pin1_4	507	512	PF00397	0.635
DOC_WW_Pin1_4	532	537	PF00397	0.704
DOC_WW_Pin1_4	558	563	PF00397	0.539
LIG_14-3-3_CanoR_1	120	124	PF00244	0.363
LIG_14-3-3_CanoR_1	130	135	PF00244	0.321
LIG_14-3-3_CanoR_1	183	192	PF00244	0.530
LIG_14-3-3_CanoR_1	211	220	PF00244	0.628
LIG_14-3-3_CanoR_1	430	438	PF00244	0.549
LIG_14-3-3_CanoR_1	474	484	PF00244	0.530
LIG_14-3-3_CanoR_1	555	561	PF00244	0.543
LIG_14-3-3_CanoR_1	8	14	PF00244	0.422
LIG_Actin_WH2_2	139	156	PF00022	0.358
LIG_BRCT_BRCA1_1	168	172	PF00533	0.438
LIG_BRCT_BRCA1_1	309	313	PF00533	0.537
LIG_Clathr_ClatBox_1	134	138	PF01394	0.460
LIG_FHA_1	116	122	PF00498	0.468
LIG_FHA_1	221	227	PF00498	0.620
LIG_FHA_1	325	331	PF00498	0.735
LIG_FHA_2	120	126	PF00498	0.454
LIG_FHA_2	575	581	PF00498	0.552
LIG_FHA_2	71	77	PF00498	0.401
LIG_IRF3_LxIS_1	53	59	PF10401	0.294
LIG_LIR_Apic_2	387	392	PF02991	0.533
LIG_LIR_Gen_1	104	111	PF02991	0.371
LIG_LIR_Nem_3	104	108	PF02991	0.398
LIG_NRBOX	24	30	PF00104	0.429
LIG_SH2_SRC	123	126	PF00017	0.362
LIG_SH2_SRC	285	288	PF00017	0.564
LIG_SH2_STAT5	123	126	PF00017	0.362
LIG_SH2_STAT5	285	288	PF00017	0.564
LIG_SH3_2	337	342	PF14604	0.545
LIG_SH3_3	215	221	PF00018	0.552
LIG_SH3_3	334	340	PF00018	0.590
LIG_SH3_3	389	395	PF00018	0.686
LIG_SH3_3	400	406	PF00018	0.742
LIG_SH3_3	533	539	PF00018	0.697
LIG_SH3_3	559	565	PF00018	0.541
LIG_SUMO_SIM_anti_2	51	57	PF11976	0.386
LIG_SUMO_SIM_par_1	514	519	PF11976	0.625
LIG_SUMO_SIM_par_1	70	76	PF11976	0.406
LIG_WRC_WIRS_1	10	15	PF05994	0.422
MOD_CDK_SPxxK_3	507	514	PF00069	0.700
MOD_CK1_1	209	215	PF00069	0.637
MOD_CK1_1	225	231	PF00069	0.614
MOD_CK1_1	248	254	PF00069	0.555
MOD_CK1_1	288	294	PF00069	0.604
MOD_CK1_1	358	364	PF00069	0.692
MOD_CK1_1	37	43	PF00069	0.387
MOD_CK1_1	377	383	PF00069	0.670
MOD_CK1_1	414	420	PF00069	0.576
MOD_CK1_1	521	527	PF00069	0.650
MOD_CK1_1	572	578	PF00069	0.641
MOD_CK1_1	80	86	PF00069	0.410
MOD_CK2_1	191	197	PF00069	0.569
MOD_CK2_1	233	239	PF00069	0.671
MOD_CK2_1	70	76	PF00069	0.448
MOD_GlcNHglycan	168	171	PF01048	0.437
MOD_GlcNHglycan	173	176	PF01048	0.406
MOD_GlcNHglycan	247	250	PF01048	0.786
MOD_GlcNHglycan	255	258	PF01048	0.584
MOD_GlcNHglycan	273	277	PF01048	0.623
MOD_GlcNHglycan	288	291	PF01048	0.556
MOD_GlcNHglycan	477	480	PF01048	0.728
MOD_GlcNHglycan	519	523	PF01048	0.623
MOD_GlcNHglycan	599	602	PF01048	0.476
MOD_GSK3_1	115	122	PF00069	0.430
MOD_GSK3_1	125	132	PF00069	0.372
MOD_GSK3_1	138	145	PF00069	0.360
MOD_GSK3_1	201	208	PF00069	0.604
MOD_GSK3_1	216	223	PF00069	0.619
MOD_GSK3_1	225	232	PF00069	0.613
MOD_GSK3_1	245	252	PF00069	0.508
MOD_GSK3_1	268	275	PF00069	0.717
MOD_GSK3_1	317	324	PF00069	0.572
MOD_GSK3_1	331	338	PF00069	0.645
MOD_GSK3_1	353	360	PF00069	0.838
MOD_GSK3_1	380	387	PF00069	0.615
MOD_GSK3_1	518	525	PF00069	0.647
MOD_GSK3_1	569	576	PF00069	0.567
MOD_GSK3_1	597	604	PF00069	0.633
MOD_GSK3_1	97	104	PF00069	0.354
MOD_N-GLC_1	101	106	PF02516	0.345
MOD_N-GLC_1	56	61	PF02516	0.337
MOD_NEK2_1	210	215	PF00069	0.778
MOD_NEK2_1	229	234	PF00069	0.587
MOD_NEK2_1	34	39	PF00069	0.373
MOD_NEK2_1	384	389	PF00069	0.769
MOD_NEK2_1	56	61	PF00069	0.368
MOD_NEK2_1	579	584	PF00069	0.770
MOD_NEK2_1	597	602	PF00069	0.501
MOD_NEK2_1	77	82	PF00069	0.394
MOD_NEK2_1	97	102	PF00069	0.235
MOD_PIKK_1	138	144	PF00454	0.335
MOD_PIKK_1	183	189	PF00454	0.527
MOD_PIKK_1	249	255	PF00454	0.605
MOD_PKA_1	183	189	PF00069	0.375
MOD_PKA_2	119	125	PF00069	0.356
MOD_PKA_2	129	135	PF00069	0.292
MOD_PKA_2	183	189	PF00069	0.375
MOD_PKA_2	210	216	PF00069	0.639
MOD_PKA_2	271	277	PF00069	0.633
MOD_PKA_2	377	383	PF00069	0.592
MOD_PKA_2	414	420	PF00069	0.607
MOD_PKA_2	429	435	PF00069	0.506
MOD_PKA_2	556	562	PF00069	0.532
MOD_PKB_1	181	189	PF00069	0.530
MOD_Plk_1	101	107	PF00069	0.350
MOD_Plk_1	221	227	PF00069	0.620
MOD_Plk_1	229	235	PF00069	0.606
MOD_Plk_1	272	278	PF00069	0.584
MOD_Plk_4	119	125	PF00069	0.395
MOD_Plk_4	130	136	PF00069	0.384
MOD_Plk_4	384	390	PF00069	0.637
MOD_Plk_4	398	404	PF00069	0.732
MOD_Plk_4	51	57	PF00069	0.433
MOD_Plk_4	80	86	PF00069	0.298
MOD_ProDKin_1	258	264	PF00069	0.551
MOD_ProDKin_1	333	339	PF00069	0.620
MOD_ProDKin_1	350	356	PF00069	0.794
MOD_ProDKin_1	359	365	PF00069	0.697
MOD_ProDKin_1	368	374	PF00069	0.698
MOD_ProDKin_1	391	397	PF00069	0.750
MOD_ProDKin_1	498	504	PF00069	0.564
MOD_ProDKin_1	507	513	PF00069	0.635
MOD_ProDKin_1	532	538	PF00069	0.703
MOD_ProDKin_1	558	564	PF00069	0.539
TRG_DiLeu_BaEn_1	23	28	PF01217	0.437
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.420
TRG_DiLeu_BaLyEn_6	174	179	PF01217	0.380
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.470
TRG_DiLeu_BaLyEn_6	559	564	PF01217	0.540
TRG_ENDOCYTIC_2	300	303	PF00928	0.534
TRG_ER_diArg_1	180	183	PF00400	0.476
TRG_ER_diArg_1	340	342	PF00400	0.639
TRG_ER_diArg_1	438	440	PF00400	0.519
TRG_NLS_MonoCore_2	180	185	PF00514	0.377
TRG_NLS_MonoExtN_4	181	186	PF00514	0.379
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	342	347	PF00026	0.632
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	514	519	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBI0	Leptomonas seymouri	48%	96%
A0A3Q8I916	Leishmania donovani	70%	100%
A4HUV5	Leishmania infantum	70%	100%
E9ANJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
Q4QH36	Leishmania major	69%	96%