RNA-directed RNA polymerase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6F9_LEIBR

TriTrypDb:

LbrM.11.0110 , LBRM2903_110006000

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6F9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.409
CLV_C14_Caspase3-7	320	324	PF00656	0.464
CLV_C14_Caspase3-7	34	38	PF00656	0.698
CLV_C14_Caspase3-7	55	59	PF00656	0.506
CLV_C14_Caspase3-7	602	606	PF00656	0.548
CLV_C14_Caspase3-7	629	633	PF00656	0.702
CLV_C14_Caspase3-7	637	641	PF00656	0.547
CLV_MEL_PAP_1	253	259	PF00089	0.508
CLV_NRD_NRD_1	255	257	PF00675	0.554
CLV_NRD_NRD_1	314	316	PF00675	0.517
CLV_NRD_NRD_1	427	429	PF00675	0.388
CLV_NRD_NRD_1	480	482	PF00675	0.328
CLV_NRD_NRD_1	560	562	PF00675	0.417
CLV_PCSK_KEX2_1	255	257	PF00082	0.554
CLV_PCSK_KEX2_1	427	429	PF00082	0.385
CLV_PCSK_KEX2_1	467	469	PF00082	0.441
CLV_PCSK_KEX2_1	480	482	PF00082	0.347
CLV_PCSK_KEX2_1	559	561	PF00082	0.424
CLV_PCSK_PC1ET2_1	467	469	PF00082	0.525
CLV_PCSK_SKI1_1	282	286	PF00082	0.442
CLV_PCSK_SKI1_1	31	35	PF00082	0.641
CLV_PCSK_SKI1_1	378	382	PF00082	0.458
CLV_PCSK_SKI1_1	412	416	PF00082	0.545
CLV_PCSK_SKI1_1	429	433	PF00082	0.411
CLV_PCSK_SKI1_1	463	467	PF00082	0.401
CLV_PCSK_SKI1_1	483	487	PF00082	0.499
CLV_Separin_Metazoa	252	256	PF03568	0.399
DOC_AGCK_PIF_2	493	498	PF00069	0.351
DOC_CYCLIN_yClb5_NLxxxL_5	465	474	PF00134	0.264
DOC_MAPK_gen_1	107	114	PF00069	0.439
DOC_MAPK_gen_1	225	232	PF00069	0.489
DOC_MAPK_gen_1	399	407	PF00069	0.440
DOC_MAPK_gen_1	424	432	PF00069	0.382
DOC_MAPK_gen_1	559	567	PF00069	0.490
DOC_MAPK_HePTP_8	4	16	PF00069	0.655
DOC_MAPK_MEF2A_6	225	232	PF00069	0.505
DOC_MAPK_MEF2A_6	7	16	PF00069	0.539
DOC_PP1_RVXF_1	376	383	PF00149	0.522
DOC_PP1_RVXF_1	426	433	PF00149	0.443
DOC_PP4_FxxP_1	163	166	PF00568	0.292
DOC_PP4_FxxP_1	381	384	PF00568	0.481
DOC_USP7_MATH_1	32	36	PF00917	0.693
DOC_USP7_MATH_1	52	56	PF00917	0.738
DOC_USP7_MATH_1	88	92	PF00917	0.627
DOC_USP7_UBL2_3	448	452	PF12436	0.468
DOC_USP7_UBL2_3	463	467	PF12436	0.289
DOC_WW_Pin1_4	130	135	PF00397	0.583
DOC_WW_Pin1_4	300	305	PF00397	0.655
DOC_WW_Pin1_4	324	329	PF00397	0.343
DOC_WW_Pin1_4	497	502	PF00397	0.426
DOC_WW_Pin1_4	82	87	PF00397	0.718
LIG_14-3-3_CanoR_1	31	40	PF00244	0.728
LIG_14-3-3_CanoR_1	397	406	PF00244	0.549
LIG_14-3-3_CanoR_1	412	421	PF00244	0.390
LIG_14-3-3_CanoR_1	480	486	PF00244	0.500
LIG_14-3-3_CanoR_1	519	528	PF00244	0.450
LIG_14-3-3_CanoR_1	541	546	PF00244	0.460
LIG_BIR_II_1	1	5	PF00653	0.571
LIG_BRCT_BRCA1_1	302	306	PF00533	0.531
LIG_CtBP_PxDLS_1	190	194	PF00389	0.247
LIG_CtBP_PxDLS_1	443	447	PF00389	0.557
LIG_EVH1_2	126	130	PF00568	0.630
LIG_FHA_1	166	172	PF00498	0.429
LIG_FHA_1	354	360	PF00498	0.491
LIG_FHA_1	501	507	PF00498	0.500
LIG_FHA_1	598	604	PF00498	0.444
LIG_FHA_2	32	38	PF00498	0.705
LIG_FHA_2	492	498	PF00498	0.477
LIG_FHA_2	58	64	PF00498	0.689
LIG_FHA_2	88	94	PF00498	0.769
LIG_LIR_Apic_2	162	166	PF02991	0.221
LIG_LIR_Apic_2	497	501	PF02991	0.330
LIG_LIR_Apic_2	613	618	PF02991	0.470
LIG_LIR_Gen_1	183	193	PF02991	0.535
LIG_LIR_Gen_1	199	208	PF02991	0.195
LIG_LIR_Gen_1	274	284	PF02991	0.506
LIG_LIR_Gen_1	332	341	PF02991	0.540
LIG_LIR_LC3C_4	135	139	PF02991	0.499
LIG_LIR_Nem_3	113	118	PF02991	0.426
LIG_LIR_Nem_3	162	167	PF02991	0.356
LIG_LIR_Nem_3	183	188	PF02991	0.478
LIG_LIR_Nem_3	199	204	PF02991	0.179
LIG_LIR_Nem_3	207	211	PF02991	0.386
LIG_LIR_Nem_3	220	226	PF02991	0.260
LIG_LIR_Nem_3	237	243	PF02991	0.372
LIG_LIR_Nem_3	245	250	PF02991	0.353
LIG_LIR_Nem_3	332	336	PF02991	0.525
LIG_LIR_Nem_3	365	370	PF02991	0.407
LIG_LIR_Nem_3	484	489	PF02991	0.331
LIG_REV1ctd_RIR_1	565	572	PF16727	0.473
LIG_SH2_CRK	267	271	PF00017	0.419
LIG_SH2_CRK	498	502	PF00017	0.382
LIG_SH2_CRK	562	566	PF00017	0.367
LIG_SH2_GRB2like	185	188	PF00017	0.430
LIG_SH2_GRB2like	319	322	PF00017	0.281
LIG_SH2_GRB2like	366	369	PF00017	0.397
LIG_SH2_GRB2like	575	578	PF00017	0.354
LIG_SH2_PTP2	201	204	PF00017	0.336
LIG_SH2_SRC	185	188	PF00017	0.430
LIG_SH2_STAP1	244	248	PF00017	0.520
LIG_SH2_STAT3	275	278	PF00017	0.323
LIG_SH2_STAT3	492	495	PF00017	0.482
LIG_SH2_STAT5	177	180	PF00017	0.502
LIG_SH2_STAT5	185	188	PF00017	0.357
LIG_SH2_STAT5	201	204	PF00017	0.157
LIG_SH2_STAT5	23	26	PF00017	0.621
LIG_SH2_STAT5	275	278	PF00017	0.332
LIG_SH2_STAT5	492	495	PF00017	0.375
LIG_SH2_STAT5	566	569	PF00017	0.323
LIG_SH2_STAT5	575	578	PF00017	0.288
LIG_SH3_1	433	439	PF00018	0.473
LIG_SH3_3	121	127	PF00018	0.583
LIG_SH3_3	298	304	PF00018	0.505
LIG_SH3_3	382	388	PF00018	0.525
LIG_SH3_3	433	439	PF00018	0.413
LIG_SH3_3	506	512	PF00018	0.379
LIG_SH3_3	615	621	PF00018	0.668
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.429
LIG_SUMO_SIM_par_1	149	155	PF11976	0.419
LIG_SUMO_SIM_par_1	189	195	PF11976	0.291
LIG_TRAF2_1	406	409	PF00917	0.403
LIG_TRAF2_1	599	602	PF00917	0.649
LIG_UBA3_1	336	344	PF00899	0.270
LIG_WRC_WIRS_1	160	165	PF05994	0.227
LIG_WRC_WIRS_1	205	210	PF05994	0.423
LIG_WRC_WIRS_1	462	467	PF05994	0.307
LIG_WRC_WIRS_1	482	487	PF05994	0.410
LIG_WW_3	125	129	PF00397	0.583
MOD_CDK_SPK_2	300	305	PF00069	0.667
MOD_CDK_SPK_2	326	331	PF00069	0.398
MOD_CDK_SPxxK_3	324	331	PF00069	0.406
MOD_CK1_1	103	109	PF00069	0.663
MOD_CK1_1	326	332	PF00069	0.449
MOD_CK1_1	461	467	PF00069	0.422
MOD_CK1_1	500	506	PF00069	0.508
MOD_CK1_1	57	63	PF00069	0.631
MOD_CK1_1	604	610	PF00069	0.552
MOD_CK1_1	611	617	PF00069	0.531
MOD_CK2_1	211	217	PF00069	0.405
MOD_CK2_1	491	497	PF00069	0.483
MOD_CK2_1	57	63	PF00069	0.661
MOD_GlcNHglycan	134	137	PF01048	0.638
MOD_GlcNHglycan	144	147	PF01048	0.387
MOD_GlcNHglycan	213	216	PF01048	0.495
MOD_GlcNHglycan	295	298	PF01048	0.408
MOD_GlcNHglycan	589	592	PF01048	0.445
MOD_GlcNHglycan	610	613	PF01048	0.643
MOD_GlcNHglycan	90	93	PF01048	0.554
MOD_GSK3_1	12	19	PF00069	0.573
MOD_GSK3_1	155	162	PF00069	0.314
MOD_GSK3_1	209	216	PF00069	0.408
MOD_GSK3_1	27	34	PF00069	0.611
MOD_GSK3_1	300	307	PF00069	0.561
MOD_GSK3_1	41	48	PF00069	0.630
MOD_GSK3_1	597	604	PF00069	0.527
MOD_GSK3_1	99	106	PF00069	0.596
MOD_N-GLC_1	16	21	PF02516	0.530
MOD_N-GLC_1	520	525	PF02516	0.425
MOD_NEK2_1	12	17	PF00069	0.533
MOD_NEK2_1	204	209	PF00069	0.460
MOD_NEK2_1	211	216	PF00069	0.311
MOD_NEK2_1	41	46	PF00069	0.493
MOD_NEK2_1	608	613	PF00069	0.618
MOD_NEK2_2	458	463	PF00069	0.494
MOD_PIKK_1	397	403	PF00454	0.449
MOD_PIKK_1	491	497	PF00454	0.483
MOD_PIKK_1	597	603	PF00454	0.493
MOD_PK_1	541	547	PF00069	0.257
MOD_PKB_1	395	403	PF00069	0.450
MOD_Plk_1	209	215	PF00069	0.511
MOD_Plk_1	604	610	PF00069	0.578
MOD_Plk_4	159	165	PF00069	0.319
MOD_Plk_4	362	368	PF00069	0.267
MOD_Plk_4	386	392	PF00069	0.408
MOD_Plk_4	461	467	PF00069	0.350
MOD_Plk_4	541	547	PF00069	0.438
MOD_ProDKin_1	130	136	PF00069	0.583
MOD_ProDKin_1	300	306	PF00069	0.648
MOD_ProDKin_1	324	330	PF00069	0.340
MOD_ProDKin_1	497	503	PF00069	0.428
MOD_ProDKin_1	82	88	PF00069	0.712
TRG_DiLeu_BaEn_1	309	314	PF01217	0.505
TRG_DiLeu_BaLyEn_6	526	531	PF01217	0.487
TRG_ENDOCYTIC_2	185	188	PF00928	0.430
TRG_ENDOCYTIC_2	201	204	PF00928	0.157
TRG_ENDOCYTIC_2	205	208	PF00928	0.399
TRG_ENDOCYTIC_2	319	322	PF00928	0.410
TRG_ENDOCYTIC_2	367	370	PF00928	0.332
TRG_ENDOCYTIC_2	562	565	PF00928	0.367
TRG_ENDOCYTIC_2	566	569	PF00928	0.375
TRG_ENDOCYTIC_2	575	578	PF00928	0.391
TRG_ER_diArg_1	254	256	PF00400	0.553
TRG_ER_diArg_1	392	395	PF00400	0.396
TRG_ER_diArg_1	396	399	PF00400	0.395
TRG_ER_diArg_1	421	424	PF00400	0.385
TRG_ER_diArg_1	426	428	PF00400	0.362
TRG_ER_diArg_1	479	481	PF00400	0.334
TRG_ER_diArg_1	558	561	PF00400	0.406
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	529	533	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU37	Leptomonas seymouri	53%	79%
A0A0S4IU07	Bodo saltans	37%	89%
A0A0S4J638	Bodo saltans	32%	88%
A0A1X0NQ80	Trypanosomatidae	31%	84%
A0A1X0NVF1	Trypanosomatidae	44%	97%
A0A3S5H6I4	Leishmania donovani	85%	100%
A0A422N1P2	Trypanosoma rangeli	31%	89%
A0A422NYN8	Trypanosoma rangeli	44%	93%
A4HUV4	Leishmania infantum	85%	100%
C9ZT00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	85%
D0A7K0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
E9ANI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QH37	Leishmania major	83%	100%
V5BNE0	Trypanosoma cruzi	31%	90%
V5DSY4	Trypanosoma cruzi	50%	94%