Putative chromatin binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulator of chromatin condensation, putative

Species:

Leishmania braziliensis

UniProt:

A4H6F8_LEIBR

TriTrypDb:

LbrM.11.0100 , LBRM2903_110005900

Length:

732

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6F8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	460	464	PF00656	0.519
CLV_NRD_NRD_1	323	325	PF00675	0.523
CLV_NRD_NRD_1	375	377	PF00675	0.338
CLV_PCSK_KEX2_1	323	325	PF00082	0.523
CLV_PCSK_SKI1_1	286	290	PF00082	0.577
CLV_PCSK_SKI1_1	381	385	PF00082	0.511
CLV_PCSK_SKI1_1	455	459	PF00082	0.551
CLV_PCSK_SKI1_1	643	647	PF00082	0.590
CLV_PCSK_SKI1_1	714	718	PF00082	0.553
DEG_MDM2_SWIB_1	546	553	PF02201	0.556
DEG_SCF_FBW7_1	723	730	PF00400	0.503
DEG_SPOP_SBC_1	35	39	PF00917	0.313
DEG_SPOP_SBC_1	390	394	PF00917	0.489
DEG_SPOP_SBC_1	606	610	PF00917	0.609
DOC_CDC14_PxL_1	246	254	PF14671	0.427
DOC_CKS1_1	57	62	PF01111	0.378
DOC_PP1_RVXF_1	309	315	PF00149	0.468
DOC_PP2B_LxvP_1	387	390	PF13499	0.476
DOC_PP2B_LxvP_1	623	626	PF13499	0.471
DOC_PP2B_LxvP_1	89	92	PF13499	0.311
DOC_USP7_MATH_1	117	121	PF00917	0.414
DOC_USP7_MATH_1	170	174	PF00917	0.689
DOC_USP7_MATH_1	178	182	PF00917	0.549
DOC_USP7_MATH_1	284	288	PF00917	0.618
DOC_USP7_MATH_1	326	330	PF00917	0.530
DOC_USP7_MATH_1	391	395	PF00917	0.664
DOC_USP7_MATH_1	449	453	PF00917	0.555
DOC_USP7_MATH_1	605	609	PF00917	0.645
DOC_USP7_MATH_1	66	70	PF00917	0.522
DOC_USP7_MATH_1	678	682	PF00917	0.577
DOC_USP7_MATH_1	704	708	PF00917	0.452
DOC_USP7_MATH_1	715	719	PF00917	0.599
DOC_USP7_MATH_1	721	725	PF00917	0.659
DOC_USP7_UBL2_3	311	315	PF12436	0.660
DOC_WW_Pin1_4	174	179	PF00397	0.596
DOC_WW_Pin1_4	227	232	PF00397	0.619
DOC_WW_Pin1_4	515	520	PF00397	0.655
DOC_WW_Pin1_4	56	61	PF00397	0.411
DOC_WW_Pin1_4	585	590	PF00397	0.724
DOC_WW_Pin1_4	723	728	PF00397	0.693
LIG_14-3-3_CanoR_1	381	390	PF00244	0.487
LIG_14-3-3_CanoR_1	493	503	PF00244	0.592
LIG_14-3-3_CanoR_1	705	709	PF00244	0.378
LIG_14-3-3_CanoR_1	714	723	PF00244	0.544
LIG_APCC_ABBA_1	688	693	PF00400	0.412
LIG_BIR_II_1	1	5	PF00653	0.384
LIG_BRCT_BRCA1_1	328	332	PF00533	0.428
LIG_BRCT_BRCA1_1	609	613	PF00533	0.512
LIG_BRCT_BRCA1_1	680	684	PF00533	0.496
LIG_deltaCOP1_diTrp_1	549	555	PF00928	0.346
LIG_eIF4E_1	248	254	PF01652	0.248
LIG_FHA_1	123	129	PF00498	0.424
LIG_FHA_1	142	148	PF00498	0.279
LIG_FHA_1	268	274	PF00498	0.536
LIG_FHA_1	307	313	PF00498	0.464
LIG_FHA_1	31	37	PF00498	0.321
LIG_FHA_1	382	388	PF00498	0.710
LIG_FHA_1	391	397	PF00498	0.617
LIG_FHA_1	472	478	PF00498	0.419
LIG_FHA_1	683	689	PF00498	0.716
LIG_FHA_2	159	165	PF00498	0.690
LIG_FHA_2	17	23	PF00498	0.424
LIG_FHA_2	328	334	PF00498	0.363
LIG_FHA_2	349	355	PF00498	0.625
LIG_FHA_2	364	370	PF00498	0.518
LIG_FHA_2	380	386	PF00498	0.466
LIG_FHA_2	631	637	PF00498	0.740
LIG_FHA_2	81	87	PF00498	0.569
LIG_Integrin_RGD_1	258	260	PF01839	0.513
LIG_LIR_Gen_1	149	158	PF02991	0.419
LIG_LIR_Gen_1	269	278	PF02991	0.446
LIG_LIR_Gen_1	329	340	PF02991	0.487
LIG_LIR_Gen_1	456	465	PF02991	0.528
LIG_LIR_Gen_1	547	554	PF02991	0.521
LIG_LIR_Nem_3	149	153	PF02991	0.396
LIG_LIR_Nem_3	260	264	PF02991	0.377
LIG_LIR_Nem_3	269	274	PF02991	0.475
LIG_LIR_Nem_3	329	335	PF02991	0.429
LIG_LIR_Nem_3	456	461	PF02991	0.480
LIG_LIR_Nem_3	468	472	PF02991	0.447
LIG_LIR_Nem_3	547	553	PF02991	0.433
LIG_LYPXL_yS_3	249	252	PF13949	0.395
LIG_MLH1_MIPbox_1	328	332	PF16413	0.502
LIG_PCNA_yPIPBox_3	565	574	PF02747	0.515
LIG_Pex14_1	438	442	PF04695	0.382
LIG_Pex14_2	10	14	PF04695	0.545
LIG_Pex14_2	327	331	PF04695	0.564
LIG_Pex14_2	546	550	PF04695	0.477
LIG_SH2_CRK	200	204	PF00017	0.481
LIG_SH2_CRK	31	35	PF00017	0.377
LIG_SH2_CRK	469	473	PF00017	0.422
LIG_SH2_CRK	481	485	PF00017	0.402
LIG_SH2_NCK_1	692	696	PF00017	0.479
LIG_SH2_STAP1	692	696	PF00017	0.505
LIG_SH2_STAT5	129	132	PF00017	0.461
LIG_SH2_STAT5	148	151	PF00017	0.502
LIG_SH2_STAT5	442	445	PF00017	0.450
LIG_SH2_STAT5	577	580	PF00017	0.452
LIG_SH3_3	152	158	PF00018	0.499
LIG_SH3_3	225	231	PF00018	0.617
LIG_SH3_3	244	250	PF00018	0.310
LIG_SH3_3	343	349	PF00018	0.505
LIG_SH3_3	497	503	PF00018	0.623
LIG_SH3_3	54	60	PF00018	0.375
LIG_SH3_3	583	589	PF00018	0.489
LIG_SH3_3	636	642	PF00018	0.509
LIG_SH3_3	76	82	PF00018	0.680
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.513
LIG_SUMO_SIM_anti_2	336	344	PF11976	0.326
LIG_SUMO_SIM_par_1	104	112	PF11976	0.574
LIG_SUMO_SIM_par_1	32	39	PF11976	0.424
LIG_TRAF2_1	486	489	PF00917	0.473
LIG_TRAF2_1	510	513	PF00917	0.574
LIG_TYR_ITIM	198	203	PF00017	0.512
LIG_TYR_ITIM	247	252	PF00017	0.478
LIG_TYR_ITIM	690	695	PF00017	0.433
LIG_WRC_WIRS_1	11	16	PF05994	0.558
LIG_WW_3	157	161	PF00397	0.421
MOD_CK1_1	182	188	PF00069	0.564
MOD_CK1_1	230	236	PF00069	0.725
MOD_CK1_1	344	350	PF00069	0.354
MOD_CK1_1	418	424	PF00069	0.488
MOD_CK1_1	58	64	PF00069	0.633
MOD_CK1_1	631	637	PF00069	0.701
MOD_CK2_1	158	164	PF00069	0.523
MOD_CK2_1	16	22	PF00069	0.410
MOD_CK2_1	327	333	PF00069	0.367
MOD_CK2_1	348	354	PF00069	0.615
MOD_CK2_1	363	369	PF00069	0.532
MOD_CK2_1	401	407	PF00069	0.652
MOD_CK2_1	441	447	PF00069	0.569
MOD_CK2_1	498	504	PF00069	0.543
MOD_DYRK1A_RPxSP_1	174	178	PF00069	0.602
MOD_DYRK1A_RPxSP_1	56	60	PF00069	0.363
MOD_GlcNHglycan	184	187	PF01048	0.627
MOD_GlcNHglycan	286	289	PF01048	0.446
MOD_GlcNHglycan	342	346	PF01048	0.587
MOD_GlcNHglycan	357	360	PF01048	0.497
MOD_GlcNHglycan	393	396	PF01048	0.718
MOD_GlcNHglycan	399	402	PF01048	0.664
MOD_GlcNHglycan	417	420	PF01048	0.263
MOD_GlcNHglycan	534	537	PF01048	0.463
MOD_GlcNHglycan	592	596	PF01048	0.656
MOD_GlcNHglycan	60	63	PF01048	0.558
MOD_GlcNHglycan	633	636	PF01048	0.610
MOD_GlcNHglycan	67	71	PF01048	0.438
MOD_GlcNHglycan	674	677	PF01048	0.695
MOD_GlcNHglycan	717	720	PF01048	0.612
MOD_GlcNHglycan	723	726	PF01048	0.668
MOD_GSK3_1	117	124	PF00069	0.323
MOD_GSK3_1	166	173	PF00069	0.718
MOD_GSK3_1	174	181	PF00069	0.602
MOD_GSK3_1	30	37	PF00069	0.377
MOD_GSK3_1	344	351	PF00069	0.399
MOD_GSK3_1	391	398	PF00069	0.720
MOD_GSK3_1	494	501	PF00069	0.583
MOD_GSK3_1	544	551	PF00069	0.447
MOD_GSK3_1	658	665	PF00069	0.608
MOD_GSK3_1	678	685	PF00069	0.673
MOD_GSK3_1	715	722	PF00069	0.515
MOD_GSK3_1	723	730	PF00069	0.579
MOD_LATS_1	379	385	PF00433	0.496
MOD_N-GLC_1	166	171	PF02516	0.536
MOD_N-GLC_1	327	332	PF02516	0.331
MOD_N-GLC_1	631	636	PF02516	0.559
MOD_N-GLC_2	134	136	PF02516	0.506
MOD_NEK2_1	121	126	PF00069	0.383
MOD_NEK2_1	16	21	PF00069	0.401
MOD_NEK2_1	179	184	PF00069	0.435
MOD_NEK2_1	327	332	PF00069	0.462
MOD_NEK2_1	34	39	PF00069	0.332
MOD_NEK2_1	341	346	PF00069	0.560
MOD_NEK2_1	396	401	PF00069	0.752
MOD_NEK2_1	492	497	PF00069	0.393
MOD_NEK2_1	578	583	PF00069	0.474
MOD_NEK2_1	628	633	PF00069	0.739
MOD_NEK2_1	662	667	PF00069	0.500
MOD_NEK2_2	494	499	PF00069	0.404
MOD_NEK2_2	564	569	PF00069	0.479
MOD_NEK2_2	704	709	PF00069	0.500
MOD_PIKK_1	230	236	PF00454	0.704
MOD_PIKK_1	298	304	PF00454	0.609
MOD_PIKK_1	522	528	PF00454	0.424
MOD_PKA_2	201	207	PF00069	0.453
MOD_PKA_2	492	498	PF00069	0.500
MOD_PKA_2	55	61	PF00069	0.521
MOD_PKA_2	662	668	PF00069	0.512
MOD_PKA_2	704	710	PF00069	0.379
MOD_Plk_1	117	123	PF00069	0.457
MOD_Plk_1	327	333	PF00069	0.377
MOD_Plk_1	341	347	PF00069	0.477
MOD_Plk_1	487	493	PF00069	0.418
MOD_Plk_1	542	548	PF00069	0.496
MOD_Plk_4	106	112	PF00069	0.573
MOD_Plk_4	117	123	PF00069	0.444
MOD_Plk_4	210	216	PF00069	0.353
MOD_Plk_4	248	254	PF00069	0.538
MOD_Plk_4	30	36	PF00069	0.381
MOD_Plk_4	327	333	PF00069	0.575
MOD_Plk_4	487	493	PF00069	0.410
MOD_Plk_4	567	573	PF00069	0.515
MOD_Plk_4	704	710	PF00069	0.403
MOD_ProDKin_1	174	180	PF00069	0.591
MOD_ProDKin_1	227	233	PF00069	0.619
MOD_ProDKin_1	515	521	PF00069	0.654
MOD_ProDKin_1	56	62	PF00069	0.416
MOD_ProDKin_1	585	591	PF00069	0.727
MOD_ProDKin_1	723	729	PF00069	0.693
TRG_DiLeu_BaEn_1	430	435	PF01217	0.327
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.544
TRG_ENDOCYTIC_2	200	203	PF00928	0.483
TRG_ENDOCYTIC_2	249	252	PF00928	0.370
TRG_ENDOCYTIC_2	31	34	PF00928	0.283
TRG_ENDOCYTIC_2	469	472	PF00928	0.419
TRG_ENDOCYTIC_2	481	484	PF00928	0.248
TRG_ENDOCYTIC_2	692	695	PF00928	0.536
TRG_ER_diArg_1	323	325	PF00400	0.566
TRG_ER_diArg_1	422	425	PF00400	0.631

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q9	Leptomonas seymouri	42%	100%
A0A0S4IQ49	Bodo saltans	26%	100%
A0A1X0NV79	Trypanosomatidae	29%	100%
A0A3Q8IHE4	Leishmania donovani	77%	94%
A0A3S5ISC4	Trypanosoma rangeli	31%	100%
A4HUV3	Leishmania infantum	77%	94%
D0A7K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ANI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	95%
Q4QH38	Leishmania major	76%	100%
V5BB49	Trypanosoma cruzi	29%	100%