Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6F4_LEIBR

TriTrypDb:

LbrM.11.0060 , LBRM2903_110020700 , LBRM2903_110020800

Length:

615

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H6F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6F4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	491	495	PF00656	0.615
CLV_NRD_NRD_1	105	107	PF00675	0.412
CLV_NRD_NRD_1	458	460	PF00675	0.497
CLV_NRD_NRD_1	506	508	PF00675	0.495
CLV_NRD_NRD_1	563	565	PF00675	0.424
CLV_NRD_NRD_1	588	590	PF00675	0.503
CLV_NRD_NRD_1	591	593	PF00675	0.460
CLV_PCSK_FUR_1	589	593	PF00082	0.481
CLV_PCSK_KEX2_1	104	106	PF00082	0.427
CLV_PCSK_KEX2_1	20	22	PF00082	0.281
CLV_PCSK_KEX2_1	506	508	PF00082	0.523
CLV_PCSK_KEX2_1	562	564	PF00082	0.409
CLV_PCSK_KEX2_1	588	590	PF00082	0.503
CLV_PCSK_KEX2_1	591	593	PF00082	0.460
CLV_PCSK_PC1ET2_1	104	106	PF00082	0.438
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.281
CLV_PCSK_SKI1_1	292	296	PF00082	0.427
CLV_PCSK_SKI1_1	460	464	PF00082	0.400
CLV_PCSK_SKI1_1	592	596	PF00082	0.287
DEG_APCC_DBOX_1	22	30	PF00400	0.591
DEG_APCC_DBOX_1	87	95	PF00400	0.639
DEG_Nend_UBRbox_2	1	3	PF02207	0.518
DOC_CKS1_1	185	190	PF01111	0.608
DOC_MAPK_DCC_7	531	541	PF00069	0.529
DOC_MAPK_gen_1	18	28	PF00069	0.666
DOC_MAPK_gen_1	588	599	PF00069	0.516
DOC_MAPK_gen_1	88	97	PF00069	0.645
DOC_MAPK_MEF2A_6	591	599	PF00069	0.435
DOC_MAPK_MEF2A_6	90	99	PF00069	0.640
DOC_MAPK_NFAT4_5	92	100	PF00069	0.633
DOC_MIT_MIM_1	136	145	PF04212	0.548
DOC_PP2B_LxvP_1	565	568	PF13499	0.678
DOC_USP7_MATH_1	119	123	PF00917	0.501
DOC_USP7_MATH_1	301	305	PF00917	0.582
DOC_USP7_MATH_1	401	405	PF00917	0.779
DOC_USP7_MATH_1	406	410	PF00917	0.771
DOC_USP7_MATH_1	419	423	PF00917	0.733
DOC_USP7_MATH_1	429	433	PF00917	0.729
DOC_USP7_UBL2_3	100	104	PF12436	0.479
DOC_WW_Pin1_4	184	189	PF00397	0.668
DOC_WW_Pin1_4	392	397	PF00397	0.581
DOC_WW_Pin1_4	432	437	PF00397	0.676
DOC_WW_Pin1_4	534	539	PF00397	0.643
LIG_14-3-3_CanoR_1	332	338	PF00244	0.588
LIG_14-3-3_CanoR_1	475	479	PF00244	0.595
LIG_BIR_III_4	418	422	PF00653	0.603
LIG_BRCT_BRCA1_1	511	515	PF00533	0.763
LIG_CaM_IQ_9	317	332	PF13499	0.538
LIG_FHA_1	164	170	PF00498	0.757
LIG_FHA_1	249	255	PF00498	0.603
LIG_FHA_1	318	324	PF00498	0.485
LIG_FHA_1	596	602	PF00498	0.356
LIG_FHA_1	64	70	PF00498	0.553
LIG_FHA_1	7	13	PF00498	0.597
LIG_FHA_2	145	151	PF00498	0.561
LIG_FHA_2	177	183	PF00498	0.807
LIG_FHA_2	338	344	PF00498	0.631
LIG_FHA_2	77	83	PF00498	0.537
LIG_Integrin_RGD_1	507	509	PF01839	0.388
LIG_LIR_Gen_1	147	156	PF02991	0.650
LIG_LIR_Gen_1	349	357	PF02991	0.564
LIG_LIR_Nem_3	147	152	PF02991	0.543
LIG_LIR_Nem_3	349	355	PF02991	0.559
LIG_PCNA_yPIPBox_3	588	600	PF02747	0.375
LIG_Pex14_1	382	386	PF04695	0.570
LIG_PTB_Apo_2	275	282	PF02174	0.545
LIG_PTB_Phospho_1	275	281	PF10480	0.543
LIG_RPA_C_Fungi	454	466	PF08784	0.506
LIG_SH2_CRK	387	391	PF00017	0.565
LIG_SH2_NCK_1	387	391	PF00017	0.565
LIG_SH2_STAP1	149	153	PF00017	0.563
LIG_SH2_STAP1	299	303	PF00017	0.533
LIG_SH2_STAP1	574	578	PF00017	0.424
LIG_SH3_3	182	188	PF00018	0.510
LIG_SH3_3	405	411	PF00018	0.504
LIG_SH3_3	497	503	PF00018	0.723
LIG_Sin3_3	602	609	PF02671	0.186
LIG_SUMO_SIM_par_1	604	610	PF11976	0.186
LIG_TRAF2_1	242	245	PF00917	0.544
LIG_TRAF2_1	340	343	PF00917	0.457
LIG_TRAF2_1	79	82	PF00917	0.455
LIG_UBA3_1	94	100	PF00899	0.331
MOD_CK1_1	160	166	PF00069	0.596
MOD_CK1_1	304	310	PF00069	0.474
MOD_CK1_1	432	438	PF00069	0.525
MOD_CK1_1	488	494	PF00069	0.596
MOD_CK1_1	534	540	PF00069	0.492
MOD_CK2_1	119	125	PF00069	0.444
MOD_CK2_1	176	182	PF00069	0.794
MOD_CK2_1	337	343	PF00069	0.454
MOD_CK2_1	76	82	PF00069	0.501
MOD_Cter_Amidation	504	507	PF01082	0.707
MOD_GlcNHglycan	121	124	PF01048	0.362
MOD_GlcNHglycan	159	162	PF01048	0.524
MOD_GlcNHglycan	176	179	PF01048	0.660
MOD_GlcNHglycan	195	198	PF01048	0.683
MOD_GlcNHglycan	204	207	PF01048	0.555
MOD_GlcNHglycan	303	306	PF01048	0.471
MOD_GlcNHglycan	34	37	PF01048	0.421
MOD_GlcNHglycan	412	415	PF01048	0.788
MOD_GlcNHglycan	421	424	PF01048	0.697
MOD_GlcNHglycan	425	428	PF01048	0.755
MOD_GlcNHglycan	430	434	PF01048	0.547
MOD_GlcNHglycan	490	493	PF01048	0.564
MOD_GlcNHglycan	548	551	PF01048	0.498
MOD_GlcNHglycan	578	581	PF01048	0.661
MOD_GlcNHglycan	611	614	PF01048	0.359
MOD_GSK3_1	119	126	PF00069	0.459
MOD_GSK3_1	157	164	PF00069	0.510
MOD_GSK3_1	193	200	PF00069	0.628
MOD_GSK3_1	386	393	PF00069	0.563
MOD_GSK3_1	406	413	PF00069	0.750
MOD_GSK3_1	419	426	PF00069	0.609
MOD_GSK3_1	542	549	PF00069	0.578
MOD_GSK3_1	576	583	PF00069	0.697
MOD_N-GLC_1	201	206	PF02516	0.686
MOD_NEK2_1	276	281	PF00069	0.323
MOD_NEK2_1	331	336	PF00069	0.601
MOD_NEK2_1	474	479	PF00069	0.453
MOD_NEK2_1	485	490	PF00069	0.609
MOD_NEK2_1	539	544	PF00069	0.651
MOD_NEK2_1	551	556	PF00069	0.597
MOD_NEK2_1	595	600	PF00069	0.328
MOD_NEK2_1	607	612	PF00069	0.462
MOD_NEK2_1	84	89	PF00069	0.471
MOD_PIKK_1	112	118	PF00454	0.596
MOD_PIKK_1	144	150	PF00454	0.480
MOD_PIKK_1	248	254	PF00454	0.517
MOD_PIKK_1	304	310	PF00454	0.500
MOD_PIKK_1	317	323	PF00454	0.388
MOD_PIKK_1	331	337	PF00454	0.596
MOD_PIKK_1	401	407	PF00454	0.677
MOD_PIKK_1	449	455	PF00454	0.499
MOD_PIKK_1	7	13	PF00454	0.496
MOD_PKA_2	119	125	PF00069	0.364
MOD_PKA_2	331	337	PF00069	0.505
MOD_PKA_2	474	480	PF00069	0.592
MOD_PKA_2	520	526	PF00069	0.494
MOD_PKB_1	529	537	PF00069	0.419
MOD_Plk_1	112	118	PF00069	0.551
MOD_Plk_1	248	254	PF00069	0.511
MOD_Plk_1	276	282	PF00069	0.483
MOD_Plk_1	317	323	PF00069	0.445
MOD_Plk_1	342	348	PF00069	0.510
MOD_Plk_1	49	55	PF00069	0.454
MOD_Plk_2-3	343	349	PF00069	0.505
MOD_Plk_2-3	520	526	PF00069	0.466
MOD_Plk_4	151	157	PF00069	0.508
MOD_Plk_4	266	272	PF00069	0.435
MOD_Plk_4	480	486	PF00069	0.534
MOD_Plk_4	520	526	PF00069	0.644
MOD_Plk_4	542	548	PF00069	0.524
MOD_ProDKin_1	184	190	PF00069	0.599
MOD_ProDKin_1	392	398	PF00069	0.478
MOD_ProDKin_1	432	438	PF00069	0.600
MOD_ProDKin_1	534	540	PF00069	0.553
MOD_SUMO_for_1	224	227	PF00179	0.455
MOD_SUMO_for_1	242	245	PF00179	0.619
MOD_SUMO_for_1	99	102	PF00179	0.327
MOD_SUMO_rev_2	170	177	PF00179	0.506
MOD_SUMO_rev_2	25	35	PF00179	0.426
MOD_SUMO_rev_2	261	267	PF00179	0.545
MOD_SUMO_rev_2	358	364	PF00179	0.593
MOD_SUMO_rev_2	377	384	PF00179	0.567
MOD_SUMO_rev_2	71	76	PF00179	0.539
MOD_SUMO_rev_2	93	101	PF00179	0.539
TRG_DiLeu_BaEn_1	24	29	PF01217	0.482
TRG_DiLeu_BaEn_1	249	254	PF01217	0.482
TRG_DiLeu_BaEn_4	24	30	PF01217	0.484
TRG_DiLeu_BaLyEn_6	535	540	PF01217	0.677
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.382
TRG_DiLeu_LyEn_5	24	29	PF01217	0.482
TRG_ENDOCYTIC_2	149	152	PF00928	0.431
TRG_ENDOCYTIC_2	387	390	PF00928	0.563
TRG_ER_diArg_1	562	564	PF00400	0.487
TRG_ER_diArg_1	588	591	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	556	561	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW2	Leptomonas seymouri	57%	96%
A0A1X0NWL4	Trypanosomatidae	34%	100%
A0A3R7KMY4	Trypanosoma rangeli	34%	100%
A0A3S5H6I2	Leishmania donovani	75%	99%
A4HUU8	Leishmania infantum	76%	100%
D0A7K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9ANI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QH43	Leishmania major	76%	100%
V5BB44	Trypanosoma cruzi	33%	100%