Optic atrophy 3 protein-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Optic atrophy 3 protein (OPA3), putative

Species:

Leishmania braziliensis

UniProt:

A4H6F3_LEIBR

TriTrypDb:

LbrM.11.0050 , LBRM2903_110020900

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6F3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6F3

Function

Biological processes
Term	Name	Level	Count
GO:0019216	regulation of lipid metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	354	356	PF00675	0.739
CLV_NRD_NRD_1	70	72	PF00675	0.261
CLV_PCSK_KEX2_1	398	400	PF00082	0.606
CLV_PCSK_KEX2_1	69	71	PF00082	0.261
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.606
CLV_PCSK_SKI1_1	159	163	PF00082	0.411
CLV_PCSK_SKI1_1	32	36	PF00082	0.411
CLV_PCSK_SKI1_1	8	12	PF00082	0.372
DEG_APCC_DBOX_1	158	166	PF00400	0.411
DEG_SPOP_SBC_1	124	128	PF00917	0.367
DOC_CYCLIN_RxL_1	156	164	PF00134	0.411
DOC_PP4_FxxP_1	214	217	PF00568	0.411
DOC_PP4_FxxP_1	285	288	PF00568	0.472
DOC_USP7_MATH_1	106	110	PF00917	0.457
DOC_USP7_MATH_1	115	119	PF00917	0.411
DOC_USP7_MATH_1	124	128	PF00917	0.377
DOC_USP7_MATH_1	202	206	PF00917	0.411
DOC_USP7_MATH_1	268	272	PF00917	0.411
DOC_WW_Pin1_4	147	152	PF00397	0.499
LIG_14-3-3_CanoR_1	157	162	PF00244	0.411
LIG_14-3-3_CanoR_1	211	215	PF00244	0.443
LIG_14-3-3_CanoR_1	28	35	PF00244	0.351
LIG_14-3-3_CanoR_1	45	49	PF00244	0.357
LIG_Actin_WH2_2	285	301	PF00022	0.728
LIG_APCC_ABBA_1	215	220	PF00400	0.411
LIG_BRCT_BRCA1_1	180	184	PF00533	0.411
LIG_BRCT_BRCA1_1	281	285	PF00533	0.412
LIG_Clathr_ClatBox_1	243	247	PF01394	0.411
LIG_DLG_GKlike_1	157	165	PF00625	0.411
LIG_FHA_1	120	126	PF00498	0.261
LIG_FHA_1	180	186	PF00498	0.372
LIG_FHA_1	240	246	PF00498	0.411
LIG_FHA_1	299	305	PF00498	0.643
LIG_FHA_1	34	40	PF00498	0.482
LIG_FHA_1	368	374	PF00498	0.626
LIG_FHA_1	377	383	PF00498	0.639
LIG_FHA_2	188	194	PF00498	0.411
LIG_FHA_2	56	62	PF00498	0.411
LIG_LIR_Apic_2	213	217	PF02991	0.411
LIG_LIR_Apic_2	282	288	PF02991	0.514
LIG_LIR_Gen_1	205	215	PF02991	0.411
LIG_LIR_LC3C_4	242	246	PF02991	0.411
LIG_LIR_Nem_3	205	210	PF02991	0.387
LIG_LIR_Nem_3	283	289	PF02991	0.456
LIG_NRBOX	239	245	PF00104	0.411
LIG_PCNA_yPIPBox_3	383	391	PF02747	0.560
LIG_Pex14_2	210	214	PF04695	0.411
LIG_Pex14_2	7	11	PF04695	0.411
LIG_SH2_CRK	237	241	PF00017	0.411
LIG_SH2_CRK	363	367	PF00017	0.789
LIG_SH2_GRB2like	279	282	PF00017	0.382
LIG_SH2_SRC	363	366	PF00017	0.754
LIG_SH2_STAP1	179	183	PF00017	0.374
LIG_SH2_STAT3	167	170	PF00017	0.411
LIG_SH2_STAT5	237	240	PF00017	0.411
LIG_SH3_1	363	369	PF00018	0.678
LIG_SH3_3	14	20	PF00018	0.411
LIG_SH3_3	163	169	PF00018	0.369
LIG_SH3_3	363	369	PF00018	0.725
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.411
LIG_SUMO_SIM_par_1	241	247	PF11976	0.411
LIG_SxIP_EBH_1	148	159	PF03271	0.261
LIG_TYR_ITIM	235	240	PF00017	0.411
LIG_WW_3	364	368	PF00397	0.678
MOD_CK1_1	118	124	PF00069	0.511
MOD_CK1_1	147	153	PF00069	0.462
MOD_CK1_1	252	258	PF00069	0.411
MOD_CK1_1	27	33	PF00069	0.261
MOD_CK1_1	280	286	PF00069	0.415
MOD_CK1_1	320	326	PF00069	0.651
MOD_CK1_1	55	61	PF00069	0.290
MOD_CK2_1	187	193	PF00069	0.411
MOD_CK2_1	55	61	PF00069	0.360
MOD_GlcNHglycan	122	125	PF01048	0.493
MOD_GlcNHglycan	127	130	PF01048	0.250
MOD_GlcNHglycan	146	149	PF01048	0.187
MOD_GlcNHglycan	204	207	PF01048	0.513
MOD_GlcNHglycan	254	257	PF01048	0.513
MOD_GlcNHglycan	319	322	PF01048	0.572
MOD_GlcNHglycan	346	349	PF01048	0.706
MOD_GlcNHglycan	50	53	PF01048	0.378
MOD_GSK3_1	102	109	PF00069	0.408
MOD_GSK3_1	111	118	PF00069	0.405
MOD_GSK3_1	119	126	PF00069	0.290
MOD_GSK3_1	157	164	PF00069	0.378
MOD_GSK3_1	175	182	PF00069	0.257
MOD_GSK3_1	235	242	PF00069	0.411
MOD_GSK3_1	24	31	PF00069	0.513
MOD_GSK3_1	277	284	PF00069	0.384
MOD_GSK3_1	313	320	PF00069	0.529
MOD_GSK3_1	367	374	PF00069	0.543
MOD_GSK3_1	44	51	PF00069	0.183
MOD_N-GLC_1	280	285	PF02516	0.435
MOD_N-GLC_1	356	361	PF02516	0.683
MOD_NEK2_1	161	166	PF00069	0.411
MOD_NEK2_1	185	190	PF00069	0.429
MOD_NEK2_1	210	215	PF00069	0.411
MOD_NEK2_1	298	303	PF00069	0.720
MOD_NEK2_1	317	322	PF00069	0.433
MOD_NEK2_1	344	349	PF00069	0.676
MOD_NEK2_1	48	53	PF00069	0.411
MOD_NEK2_2	179	184	PF00069	0.353
MOD_PKA_2	106	112	PF00069	0.261
MOD_PKA_2	118	124	PF00069	0.261
MOD_PKA_2	210	216	PF00069	0.443
MOD_PKA_2	252	258	PF00069	0.411
MOD_PKA_2	27	33	PF00069	0.468
MOD_PKA_2	298	304	PF00069	0.703
MOD_PKA_2	44	50	PF00069	0.393
MOD_Plk_1	179	185	PF00069	0.384
MOD_Plk_1	280	286	PF00069	0.415
MOD_Plk_1	376	382	PF00069	0.617
MOD_Plk_4	150	156	PF00069	0.431
MOD_Plk_4	161	167	PF00069	0.400
MOD_Plk_4	179	185	PF00069	0.411
MOD_Plk_4	210	216	PF00069	0.411
MOD_Plk_4	235	241	PF00069	0.411
MOD_Plk_4	281	287	PF00069	0.428
MOD_Plk_4	313	319	PF00069	0.514
MOD_Plk_4	332	338	PF00069	0.580
MOD_Plk_4	377	383	PF00069	0.601
MOD_ProDKin_1	147	153	PF00069	0.499
TRG_DiLeu_BaEn_1	385	390	PF01217	0.556
TRG_ENDOCYTIC_2	237	240	PF00928	0.411
TRG_ER_diArg_1	156	159	PF00400	0.411
TRG_ER_diArg_1	341	344	PF00400	0.565
TRG_ER_diArg_1	69	71	PF00400	0.261
TRG_Pf-PMV_PEXEL_1	159	163	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.261

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X1	Leptomonas seymouri	56%	93%
A0A3Q8I8X5	Leishmania donovani	74%	100%
A4HUU7	Leishmania infantum	74%	100%
E9ANI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QH44	Leishmania major	73%	98%