Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H6F1_LEIBR

TriTrypDb:

LbrM.11.0030 , LBRM2903_110021100

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6F1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.532
CLV_C14_Caspase3-7	205	209	PF00656	0.404
CLV_C14_Caspase3-7	84	88	PF00656	0.527
CLV_NRD_NRD_1	16	18	PF00675	0.530
CLV_NRD_NRD_1	386	388	PF00675	0.627
CLV_NRD_NRD_1	396	398	PF00675	0.577
CLV_PCSK_FUR_1	394	398	PF00082	0.565
CLV_PCSK_KEX2_1	386	388	PF00082	0.714
CLV_PCSK_KEX2_1	393	395	PF00082	0.605
CLV_PCSK_KEX2_1	396	398	PF00082	0.581
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.696
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.624
CLV_PCSK_SKI1_1	390	394	PF00082	0.631
DEG_SPOP_SBC_1	236	240	PF00917	0.685
DEG_SPOP_SBC_1	413	417	PF00917	0.561
DOC_ANK_TNKS_1	169	176	PF00023	0.537
DOC_CKS1_1	131	136	PF01111	0.684
DOC_PP2B_LxvP_1	233	236	PF13499	0.557
DOC_PP2B_LxvP_1	382	385	PF13499	0.642
DOC_PP4_FxxP_1	346	349	PF00568	0.405
DOC_USP7_MATH_1	112	116	PF00917	0.743
DOC_USP7_MATH_1	237	241	PF00917	0.534
DOC_USP7_MATH_1	295	299	PF00917	0.686
DOC_USP7_MATH_1	357	361	PF00917	0.690
DOC_USP7_MATH_1	81	85	PF00917	0.521
DOC_USP7_UBL2_3	386	390	PF12436	0.590
DOC_USP7_UBL2_3	6	10	PF12436	0.649
DOC_WW_Pin1_4	130	135	PF00397	0.686
DOC_WW_Pin1_4	162	167	PF00397	0.672
DOC_WW_Pin1_4	217	222	PF00397	0.596
DOC_WW_Pin1_4	223	228	PF00397	0.590
DOC_WW_Pin1_4	373	378	PF00397	0.618
DOC_WW_Pin1_4	397	402	PF00397	0.813
DOC_WW_Pin1_4	423	428	PF00397	0.646
DOC_WW_Pin1_4	461	466	PF00397	0.637
DOC_WW_Pin1_4	481	486	PF00397	0.473
LIG_14-3-3_CanoR_1	118	127	PF00244	0.544
LIG_14-3-3_CanoR_1	139	143	PF00244	0.689
LIG_14-3-3_CanoR_1	473	478	PF00244	0.523
LIG_Actin_WH2_2	193	209	PF00022	0.595
LIG_Actin_WH2_2	309	326	PF00022	0.550
LIG_Actin_WH2_2	431	448	PF00022	0.521
LIG_BIR_III_4	253	257	PF00653	0.483
LIG_Clathr_ClatBox_1	266	270	PF01394	0.667
LIG_FHA_1	121	127	PF00498	0.716
LIG_FHA_1	193	199	PF00498	0.446
LIG_FHA_1	243	249	PF00498	0.625
LIG_FHA_1	323	329	PF00498	0.446
LIG_FHA_1	335	341	PF00498	0.461
LIG_FHA_1	362	368	PF00498	0.643
LIG_FHA_1	377	383	PF00498	0.572
LIG_FHA_1	462	468	PF00498	0.614
LIG_FHA_2	112	118	PF00498	0.574
LIG_FHA_2	131	137	PF00498	0.608
LIG_FHA_2	287	293	PF00498	0.532
LIG_GBD_Chelix_1	182	190	PF00786	0.585
LIG_HP1_1	465	469	PF01393	0.696
LIG_LIR_Apic_2	300	306	PF02991	0.623
LIG_LIR_Gen_1	136	143	PF02991	0.516
LIG_LIR_Gen_1	311	319	PF02991	0.448
LIG_LIR_Gen_1	425	436	PF02991	0.494
LIG_LIR_Nem_3	136	140	PF02991	0.523
LIG_LIR_Nem_3	178	184	PF02991	0.609
LIG_LIR_Nem_3	199	204	PF02991	0.574
LIG_LIR_Nem_3	300	305	PF02991	0.628
LIG_LIR_Nem_3	311	317	PF02991	0.371
LIG_LIR_Nem_3	425	431	PF02991	0.505
LIG_SH2_CRK	128	132	PF00017	0.737
LIG_SH2_NCK_1	128	132	PF00017	0.696
LIG_SH2_SRC	430	433	PF00017	0.482
LIG_SH2_STAT5	181	184	PF00017	0.505
LIG_SH2_STAT5	430	433	PF00017	0.572
LIG_SH2_STAT5	434	437	PF00017	0.577
LIG_SH2_STAT5	49	52	PF00017	0.603
LIG_SH3_1	128	134	PF00018	0.692
LIG_SH3_3	128	134	PF00018	0.692
LIG_SH3_3	156	162	PF00018	0.719
LIG_SH3_3	163	169	PF00018	0.629
LIG_SH3_3	435	441	PF00018	0.521
LIG_SH3_3	479	485	PF00018	0.534
LIG_SUMO_SIM_anti_2	464	470	PF11976	0.612
LIG_TRFH_1	259	263	PF08558	0.494
LIG_TRFH_1	302	306	PF08558	0.518
MOD_CDK_SPK_2	165	170	PF00069	0.540
MOD_CDK_SPK_2	397	402	PF00069	0.742
MOD_CDK_SPK_2	481	486	PF00069	0.527
MOD_CK1_1	121	127	PF00069	0.716
MOD_CK1_1	168	174	PF00069	0.544
MOD_CK1_1	191	197	PF00069	0.727
MOD_CK1_1	226	232	PF00069	0.640
MOD_CK1_1	265	271	PF00069	0.570
MOD_CK1_1	282	288	PF00069	0.697
MOD_CK1_1	356	362	PF00069	0.538
MOD_CK1_1	376	382	PF00069	0.629
MOD_CK1_1	411	417	PF00069	0.606
MOD_CK1_1	56	62	PF00069	0.684
MOD_CK2_1	356	362	PF00069	0.553
MOD_GlcNHglycan	114	117	PF01048	0.742
MOD_GlcNHglycan	122	126	PF01048	0.626
MOD_GlcNHglycan	128	131	PF01048	0.542
MOD_GlcNHglycan	170	173	PF01048	0.577
MOD_GlcNHglycan	270	274	PF01048	0.503
MOD_GlcNHglycan	297	300	PF01048	0.653
MOD_GlcNHglycan	355	358	PF01048	0.711
MOD_GlcNHglycan	359	362	PF01048	0.644
MOD_GlcNHglycan	416	419	PF01048	0.638
MOD_GlcNHglycan	43	46	PF01048	0.548
MOD_GlcNHglycan	454	457	PF01048	0.746
MOD_GSK3_1	112	119	PF00069	0.615
MOD_GSK3_1	126	133	PF00069	0.660
MOD_GSK3_1	184	191	PF00069	0.641
MOD_GSK3_1	192	199	PF00069	0.474
MOD_GSK3_1	261	268	PF00069	0.536
MOD_GSK3_1	282	289	PF00069	0.646
MOD_GSK3_1	330	337	PF00069	0.706
MOD_GSK3_1	349	356	PF00069	0.475
MOD_GSK3_1	357	364	PF00069	0.584
MOD_GSK3_1	372	379	PF00069	0.507
MOD_GSK3_1	408	415	PF00069	0.630
MOD_GSK3_1	419	426	PF00069	0.746
MOD_GSK3_1	448	455	PF00069	0.583
MOD_GSK3_1	52	59	PF00069	0.689
MOD_N-GLC_1	191	196	PF02516	0.735
MOD_N-GLC_1	419	424	PF02516	0.540
MOD_NEK2_1	126	131	PF00069	0.706
MOD_NEK2_1	153	158	PF00069	0.647
MOD_NEK2_1	269	274	PF00069	0.577
MOD_NEK2_1	309	314	PF00069	0.540
MOD_NEK2_1	54	59	PF00069	0.620
MOD_NEK2_1	63	68	PF00069	0.542
MOD_NEK2_2	202	207	PF00069	0.572
MOD_PK_1	10	16	PF00069	0.467
MOD_PKA_1	386	392	PF00069	0.562
MOD_PKA_2	138	144	PF00069	0.693
MOD_PKA_2	386	392	PF00069	0.626
MOD_Plk_1	361	367	PF00069	0.540
MOD_Plk_4	148	154	PF00069	0.677
MOD_Plk_4	196	202	PF00069	0.654
MOD_Plk_4	262	268	PF00069	0.567
MOD_Plk_4	304	310	PF00069	0.486
MOD_Plk_4	31	37	PF00069	0.482
MOD_ProDKin_1	130	136	PF00069	0.685
MOD_ProDKin_1	162	168	PF00069	0.674
MOD_ProDKin_1	217	223	PF00069	0.602
MOD_ProDKin_1	373	379	PF00069	0.621
MOD_ProDKin_1	397	403	PF00069	0.815
MOD_ProDKin_1	423	429	PF00069	0.647
MOD_ProDKin_1	461	467	PF00069	0.636
MOD_ProDKin_1	481	487	PF00069	0.475
MOD_SUMO_for_1	392	395	PF00179	0.562
TRG_AP2beta_CARGO_1	311	320	PF09066	0.356
TRG_ENDOCYTIC_2	302	305	PF00928	0.524
TRG_NLS_MonoExtC_3	385	390	PF00514	0.647
TRG_NLS_MonoExtN_4	383	390	PF00514	0.625
TRG_NLS_MonoExtN_4	6	13	PF00514	0.632
TRG_Pf-PMV_PEXEL_1	338	343	PF00026	0.465
TRG_PTS1	484	487	PF00515	0.528

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBY1	Leptomonas seymouri	34%	100%
A0A3Q8I8Z9	Leishmania donovani	65%	100%
A4HUU5	Leishmania infantum	64%	100%
E9ANI0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	97%
Q4QH46	Leishmania major	65%	100%