GP63, leishmanolysin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Download

Quick info

Protein:

Gene product:

GP63, leishmanolysin

Species:

Leishmania braziliensis

UniProt:

A4H6E8_LEIBR

TriTrypDb:

LbrM.10.1720

Length:

486

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6E8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6E8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.865
CLV_NRD_NRD_1	168	170	PF00675	0.884
CLV_NRD_NRD_1	175	177	PF00675	0.759
CLV_NRD_NRD_1	183	185	PF00675	0.612
CLV_NRD_NRD_1	187	189	PF00675	0.545
CLV_NRD_NRD_1	193	195	PF00675	0.552
CLV_NRD_NRD_1	230	232	PF00675	0.823
CLV_NRD_NRD_1	239	241	PF00675	0.688
CLV_NRD_NRD_1	263	265	PF00675	0.876
CLV_NRD_NRD_1	267	269	PF00675	0.808
CLV_NRD_NRD_1	279	281	PF00675	0.593
CLV_NRD_NRD_1	343	345	PF00675	0.853
CLV_NRD_NRD_1	359	361	PF00675	0.457
CLV_NRD_NRD_1	365	367	PF00675	0.662
CLV_NRD_NRD_1	431	433	PF00675	0.766
CLV_NRD_NRD_1	76	78	PF00675	0.840
CLV_NRD_NRD_1	9	11	PF00675	0.838
CLV_PCSK_FUR_1	184	188	PF00082	0.873
CLV_PCSK_FUR_1	228	232	PF00082	0.826
CLV_PCSK_FUR_1	429	433	PF00082	0.775
CLV_PCSK_FUR_1	74	78	PF00082	0.841
CLV_PCSK_KEX2_1	132	134	PF00082	0.865
CLV_PCSK_KEX2_1	167	169	PF00082	0.890
CLV_PCSK_KEX2_1	175	177	PF00082	0.742
CLV_PCSK_KEX2_1	183	185	PF00082	0.594
CLV_PCSK_KEX2_1	186	188	PF00082	0.543
CLV_PCSK_KEX2_1	193	195	PF00082	0.552
CLV_PCSK_KEX2_1	230	232	PF00082	0.823
CLV_PCSK_KEX2_1	239	241	PF00082	0.688
CLV_PCSK_KEX2_1	263	265	PF00082	0.876
CLV_PCSK_KEX2_1	267	269	PF00082	0.808
CLV_PCSK_KEX2_1	279	281	PF00082	0.593
CLV_PCSK_KEX2_1	343	345	PF00082	0.853
CLV_PCSK_KEX2_1	359	361	PF00082	0.457
CLV_PCSK_KEX2_1	365	367	PF00082	0.662
CLV_PCSK_KEX2_1	431	433	PF00082	0.766
CLV_PCSK_KEX2_1	76	78	PF00082	0.840
CLV_PCSK_KEX2_1	9	11	PF00082	0.838
CLV_PCSK_PC7_1	183	189	PF00082	0.875
CLV_PCSK_PC7_1	263	269	PF00082	0.877
CLV_PCSK_SKI1_1	224	228	PF00082	0.831
CLV_PCSK_SKI1_1	442	446	PF00082	0.754
DEG_APCC_DBOX_1	477	485	PF00400	0.792
DEG_Nend_UBRbox_2	1	3	PF02207	0.865
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.832
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.865
DOC_MAPK_DCC_7	461	470	PF00069	0.846
DOC_MAPK_gen_1	129	139	PF00069	0.867
DOC_MAPK_gen_1	461	470	PF00069	0.846
DOC_MAPK_MEF2A_6	267	276	PF00069	0.870
DOC_MAPK_MEF2A_6	461	470	PF00069	0.846
DOC_PP1_RVXF_1	478	484	PF00149	0.796
DOC_SPAK_OSR1_1	22	26	PF12202	0.806
DOC_USP7_MATH_1	174	178	PF00917	0.879
DOC_USP7_MATH_1	214	218	PF00917	0.864
DOC_USP7_MATH_1	275	279	PF00917	0.862
DOC_USP7_MATH_1	317	321	PF00917	0.869
DOC_WW_Pin1_4	103	108	PF00397	0.574
DOC_WW_Pin1_4	139	144	PF00397	0.855
DOC_WW_Pin1_4	167	172	PF00397	0.882
DOC_WW_Pin1_4	31	36	PF00397	0.836
DOC_WW_Pin1_4	348	353	PF00397	0.793
DOC_WW_Pin1_4	46	51	PF00397	0.596
DOC_WW_Pin1_4	89	94	PF00397	0.834
LIG_14-3-3_CanoR_1	132	139	PF00244	0.866
LIG_14-3-3_CanoR_1	30	34	PF00244	0.834
LIG_BIR_III_4	414	418	PF00653	0.865
LIG_EVH1_1	95	99	PF00568	0.805
LIG_FHA_1	132	138	PF00498	0.867
LIG_FHA_1	52	58	PF00498	0.847
LIG_FHA_1	89	95	PF00498	0.832
LIG_MYND_1	195	199	PF01753	0.864
LIG_SH3_2	349	354	PF14604	0.783
LIG_SH3_3	113	119	PF00018	0.551
LIG_SH3_3	140	146	PF00018	0.850
LIG_SH3_3	266	272	PF00018	0.873
LIG_SH3_3	346	352	PF00018	0.800
LIG_SH3_3	460	466	PF00018	0.845
LIG_SH3_3	90	96	PF00018	0.827
LIG_SH3_3	97	103	PF00018	0.679
LIG_SUMO_SIM_par_1	114	120	PF11976	0.833
LIG_TRAF2_2	199	204	PF00917	0.876
MOD_CDC14_SPxK_1	351	354	PF00782	0.764
MOD_CDK_SPxK_1	348	354	PF00069	0.787
MOD_CK1_1	108	114	PF00069	0.828
MOD_CK1_1	117	123	PF00069	0.673
MOD_CK1_1	49	55	PF00069	0.851
MOD_Cter_Amidation	181	184	PF01082	0.873
MOD_Cter_Amidation	191	194	PF01082	0.703
MOD_Cter_Amidation	7	10	PF01082	0.845
MOD_Cter_Amidation	74	77	PF01082	0.846
MOD_GlcNHglycan	176	179	PF01048	0.873
MOD_GlcNHglycan	224	227	PF01048	0.829
MOD_GlcNHglycan	319	322	PF01048	0.866
MOD_GlcNHglycan	39	42	PF01048	0.856
MOD_GlcNHglycan	470	473	PF01048	0.822
MOD_GSK3_1	117	124	PF00069	0.832
MOD_GSK3_1	127	134	PF00069	0.693
MOD_GSK3_1	25	32	PF00069	0.813
MOD_GSK3_1	94	101	PF00069	0.810
MOD_NEK2_1	1	6	PF00069	0.854
MOD_NEK2_1	468	473	PF00069	0.828
MOD_PIKK_1	1	7	PF00454	0.853
MOD_PIKK_1	131	137	PF00454	0.867
MOD_PIKK_1	25	31	PF00454	0.810
MOD_PKA_1	193	199	PF00069	0.867
MOD_PKA_2	131	137	PF00069	0.867
MOD_PKA_2	174	180	PF00069	0.876
MOD_PKA_2	193	199	PF00069	0.535
MOD_PKA_2	29	35	PF00069	0.832
MOD_PKA_2	386	392	PF00069	0.845
MOD_PKA_2	88	94	PF00069	0.835
MOD_ProDKin_1	103	109	PF00069	0.573
MOD_ProDKin_1	139	145	PF00069	0.856
MOD_ProDKin_1	167	173	PF00069	0.882
MOD_ProDKin_1	31	37	PF00069	0.838
MOD_ProDKin_1	348	354	PF00069	0.787
MOD_ProDKin_1	46	52	PF00069	0.595
MOD_ProDKin_1	89	95	PF00069	0.832
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.829
TRG_ER_diArg_1	167	169	PF00400	0.890
TRG_ER_diArg_1	183	186	PF00400	0.592
TRG_ER_diArg_1	187	189	PF00400	0.527
TRG_ER_diArg_1	193	195	PF00400	0.693
TRG_ER_diArg_1	218	221	PF00400	0.860
TRG_ER_diArg_1	227	230	PF00400	0.673
TRG_ER_diArg_1	239	241	PF00400	0.635
TRG_ER_diArg_1	263	265	PF00400	0.876
TRG_ER_diArg_1	267	269	PF00400	0.808
TRG_ER_diArg_1	288	291	PF00400	0.862
TRG_ER_diArg_1	342	344	PF00400	0.860
TRG_ER_diArg_1	359	362	PF00400	0.440
TRG_ER_diArg_1	364	366	PF00400	0.671
TRG_ER_diArg_1	420	423	PF00400	0.828
TRG_ER_diArg_1	43	46	PF00400	0.859
TRG_ER_diArg_1	431	434	PF00400	0.573
TRG_ER_diArg_1	478	481	PF00400	0.804
TRG_ER_diArg_1	74	77	PF00400	0.846
TRG_ER_diArg_1	9	12	PF00400	0.834
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.770