Leishmanolysin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

GP63, leishmanolysin

Species:

Leishmania braziliensis

UniProt:

A4H6E5_LEIBR

TriTrypDb:

LbrM.10.1690 , LBRM2903_100011400

Length:

511

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 51

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 42, no: 10
NetGPI	no	yes: 0, no: 52

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	53
GO:0110165	cellular anatomical entity	1	53
GO:0005737	cytoplasm	2	4
GO:0018995	host cellular component	2	4
GO:0033643	host cell part	3	4
GO:0033646	host intracellular part	4	4
GO:0033647	host intracellular organelle	5	4
GO:0033648	host intracellular membrane-bounded organelle	6	4
GO:0042025	host cell nucleus	7	4

Expansion

Sequence features

A4H6E5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6E5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	53
GO:0006807	nitrogen compound metabolic process	2	53
GO:0007155	cell adhesion	2	53
GO:0008152	metabolic process	1	53
GO:0009987	cellular process	1	53
GO:0019538	protein metabolic process	3	53
GO:0043170	macromolecule metabolic process	3	53
GO:0044238	primary metabolic process	2	53
GO:0071704	organic substance metabolic process	2	53
GO:1901564	organonitrogen compound metabolic process	3	53
GO:0009966	regulation of signal transduction	4	4
GO:0010646	regulation of cell communication	4	4
GO:0010749	regulation of nitric oxide mediated signal transduction	6	4
GO:0023051	regulation of signaling	3	4
GO:0035821	modulation of process of another organism	2	4
GO:0044003	modulation by symbiont of host process	3	4
GO:0044068	modulation by symbiont of host cellular process	4	4
GO:0044081	modulation by symbiont of host nitric oxide-mediated signal transduction	5	4
GO:0044403	biological process involved in symbiotic interaction	2	4
GO:0044419	biological process involved in interspecies interaction between organisms	1	4
GO:0044501	modulation of signal transduction in another organism	3	4
GO:0048583	regulation of response to stimulus	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051701	biological process involved in interaction with host	3	4
GO:0052027	modulation by symbiont of host signal transduction pathway	4	4
GO:0065007	biological regulation	1	4
GO:0075130	modulation by symbiont of host protein kinase-mediated signal transduction	5	4
GO:1902531	regulation of intracellular signal transduction	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	53
GO:0004175	endopeptidase activity	4	53
GO:0004222	metalloendopeptidase activity	5	53
GO:0005488	binding	1	53
GO:0008233	peptidase activity	3	53
GO:0008237	metallopeptidase activity	4	53
GO:0016787	hydrolase activity	2	53
GO:0043167	ion binding	2	53
GO:0043169	cation binding	3	53
GO:0046872	metal ion binding	4	53
GO:0140096	catalytic activity, acting on a protein	2	53
GO:0008047	enzyme activator activity	3	4
GO:0008160	protein tyrosine phosphatase activator activity	6	4
GO:0019208	phosphatase regulator activity	3	4
GO:0019211	phosphatase activator activity	4	4
GO:0019888	protein phosphatase regulator activity	4	4
GO:0030234	enzyme regulator activity	2	4
GO:0072542	protein phosphatase activator activity	5	4
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	35	41	PF00089	0.459
CLV_NRD_NRD_1	19	21	PF00675	0.370
CLV_NRD_NRD_1	2	4	PF00675	0.590
CLV_NRD_NRD_1	490	492	PF00675	0.583
CLV_PCSK_KEX2_1	1	3	PF00082	0.599
CLV_PCSK_KEX2_1	19	21	PF00082	0.370
CLV_PCSK_KEX2_1	490	492	PF00082	0.583
CLV_PCSK_KEX2_1	59	61	PF00082	0.533
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.530
CLV_PCSK_SKI1_1	167	171	PF00082	0.602
CLV_PCSK_SKI1_1	19	23	PF00082	0.389
CLV_PCSK_SKI1_1	245	249	PF00082	0.508
CLV_PCSK_SKI1_1	60	64	PF00082	0.525
DEG_APCC_DBOX_1	18	26	PF00400	0.339
DEG_Nend_UBRbox_1	1	3	PF02207	0.542
DEG_SCF_FBW7_1	441	448	PF00400	0.289
DOC_CKS1_1	338	343	PF01111	0.267
DOC_CYCLIN_RxL_1	15	26	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.349
DOC_PP2B_LxvP_1	251	254	PF13499	0.430
DOC_PP4_FxxP_1	101	104	PF00568	0.411
DOC_PP4_FxxP_1	201	204	PF00568	0.337
DOC_USP7_MATH_1	110	114	PF00917	0.261
DOC_USP7_MATH_1	4	8	PF00917	0.586
DOC_USP7_MATH_1	445	449	PF00917	0.300
DOC_USP7_MATH_1	480	484	PF00917	0.387
DOC_WW_Pin1_4	337	342	PF00397	0.273
DOC_WW_Pin1_4	441	446	PF00397	0.449
LIG_14-3-3_CanoR_1	289	296	PF00244	0.279
LIG_14-3-3_CanoR_1	322	330	PF00244	0.319
LIG_14-3-3_CanoR_1	336	341	PF00244	0.308
LIG_14-3-3_CanoR_1	404	412	PF00244	0.334
LIG_14-3-3_CanoR_1	428	433	PF00244	0.432
LIG_14-3-3_CanoR_1	494	502	PF00244	0.582
LIG_APCC_ABBA_1	266	271	PF00400	0.424
LIG_APCC_ABBA_1	389	394	PF00400	0.449
LIG_APCC_ABBA_1	72	77	PF00400	0.342
LIG_BRCT_BRCA1_1	179	183	PF00533	0.374
LIG_BRCT_BRCA1_1	291	295	PF00533	0.321
LIG_BRCT_BRCA1_1	454	458	PF00533	0.449
LIG_FHA_1	107	113	PF00498	0.326
LIG_FHA_1	134	140	PF00498	0.344
LIG_FHA_1	164	170	PF00498	0.399
LIG_FHA_1	185	191	PF00498	0.269
LIG_FHA_1	263	269	PF00498	0.441
LIG_FHA_1	323	329	PF00498	0.417
LIG_FHA_1	427	433	PF00498	0.432
LIG_FHA_1	496	502	PF00498	0.561
LIG_FHA_1	92	98	PF00498	0.311
LIG_FHA_2	313	319	PF00498	0.244
LIG_FHA_2	405	411	PF00498	0.252
LIG_FHA_2	442	448	PF00498	0.308
LIG_FHA_2	48	54	PF00498	0.366
LIG_LIR_Apic_2	100	104	PF02991	0.341
LIG_LIR_Apic_2	217	222	PF02991	0.275
LIG_LIR_Apic_2	337	341	PF02991	0.258
LIG_LIR_Gen_1	223	231	PF02991	0.448
LIG_LIR_Gen_1	344	354	PF02991	0.336
LIG_LIR_Nem_3	116	120	PF02991	0.344
LIG_LIR_Nem_3	223	229	PF02991	0.413
LIG_LIR_Nem_3	344	349	PF02991	0.374
LIG_LIR_Nem_3	358	363	PF02991	0.334
LIG_MLH1_MIPbox_1	180	184	PF16413	0.267
LIG_Pex14_1	308	312	PF04695	0.439
LIG_Pex14_2	179	183	PF04695	0.387
LIG_PTB_Apo_2	111	118	PF02174	0.430
LIG_PTB_Apo_2	457	464	PF02174	0.253
LIG_PTB_Phospho_1	457	463	PF10480	0.253
LIG_SH2_CRK	219	223	PF00017	0.275
LIG_SH2_CRK	261	265	PF00017	0.344
LIG_SH2_CRK	338	342	PF00017	0.285
LIG_SH2_GRB2like	261	264	PF00017	0.264
LIG_SH2_GRB2like	370	373	PF00017	0.269
LIG_SH2_PTP2	469	472	PF00017	0.446
LIG_SH2_SRC	226	229	PF00017	0.339
LIG_SH2_SRC	469	472	PF00017	0.446
LIG_SH2_SRC	66	69	PF00017	0.289
LIG_SH2_STAP1	430	434	PF00017	0.449
LIG_SH2_STAT3	430	433	PF00017	0.435
LIG_SH2_STAT5	120	123	PF00017	0.426
LIG_SH2_STAT5	226	229	PF00017	0.412
LIG_SH2_STAT5	261	264	PF00017	0.320
LIG_SH2_STAT5	345	348	PF00017	0.350
LIG_SH2_STAT5	363	366	PF00017	0.313
LIG_SH2_STAT5	440	443	PF00017	0.385
LIG_SH2_STAT5	463	466	PF00017	0.446
LIG_SH2_STAT5	469	472	PF00017	0.380
LIG_SH2_STAT5	66	69	PF00017	0.312
LIG_SH3_3	122	128	PF00018	0.305
LIG_SH3_3	5	11	PF00018	0.623
LIG_Sin3_3	497	504	PF02671	0.576
LIG_TYR_ITIM	224	229	PF00017	0.439
MOD_CK1_1	123	129	PF00069	0.524
MOD_CK1_1	237	243	PF00069	0.467
MOD_CK1_1	390	396	PF00069	0.331
MOD_CK1_1	462	468	PF00069	0.355
MOD_CK2_1	277	283	PF00069	0.538
MOD_CK2_1	312	318	PF00069	0.251
MOD_CK2_1	404	410	PF00069	0.244
MOD_CK2_1	441	447	PF00069	0.351
MOD_Cter_Amidation	488	491	PF01082	0.570
MOD_GlcNHglycan	234	237	PF01048	0.435
MOD_GlcNHglycan	255	258	PF01048	0.352
MOD_GlcNHglycan	357	360	PF01048	0.394
MOD_GlcNHglycan	437	440	PF01048	0.470
MOD_GlcNHglycan	454	457	PF01048	0.283
MOD_GlcNHglycan	482	485	PF01048	0.435
MOD_GSK3_1	106	113	PF00069	0.406
MOD_GSK3_1	163	170	PF00069	0.414
MOD_GSK3_1	337	344	PF00069	0.327
MOD_GSK3_1	364	371	PF00069	0.279
MOD_GSK3_1	422	429	PF00069	0.384
MOD_GSK3_1	441	448	PF00069	0.305
MOD_GSK3_1	84	91	PF00069	0.379
MOD_N-GLC_1	206	211	PF02516	0.414
MOD_N-GLC_1	262	267	PF02516	0.279
MOD_N-GLC_1	289	294	PF02516	0.341
MOD_N-GLC_1	303	308	PF02516	0.450
MOD_N-GLC_1	313	318	PF02516	0.379
MOD_N-GLC_1	350	355	PF02516	0.281
MOD_N-GLC_1	459	464	PF02516	0.295
MOD_NEK2_1	177	182	PF00069	0.471
MOD_NEK2_1	183	188	PF00069	0.382
MOD_NEK2_1	191	196	PF00069	0.328
MOD_NEK2_1	368	373	PF00069	0.236
MOD_NEK2_2	178	183	PF00069	0.284
MOD_PIKK_1	303	309	PF00454	0.429
MOD_PK_1	387	393	PF00069	0.271
MOD_PK_1	428	434	PF00069	0.416
MOD_PKA_2	321	327	PF00069	0.542
MOD_PKA_2	37	43	PF00069	0.304
MOD_PKA_2	403	409	PF00069	0.279
MOD_PKA_2	434	440	PF00069	0.359
MOD_PKA_2	88	94	PF00069	0.252
MOD_Plk_1	206	212	PF00069	0.315
MOD_Plk_1	262	268	PF00069	0.503
MOD_Plk_1	277	283	PF00069	0.295
MOD_Plk_1	303	309	PF00069	0.454
MOD_Plk_1	350	356	PF00069	0.299
MOD_Plk_1	387	393	PF00069	0.290
MOD_Plk_1	410	416	PF00069	0.239
MOD_Plk_1	426	432	PF00069	0.229
MOD_Plk_1	99	105	PF00069	0.251
MOD_Plk_2-3	53	59	PF00069	0.429
MOD_Plk_4	178	184	PF00069	0.382
MOD_Plk_4	207	213	PF00069	0.368
MOD_Plk_4	341	347	PF00069	0.382
MOD_Plk_4	459	465	PF00069	0.335
MOD_ProDKin_1	337	343	PF00069	0.292
MOD_ProDKin_1	441	447	PF00069	0.538
MOD_SUMO_for_1	247	250	PF00179	0.340
TRG_DiLeu_BaEn_3	57	63	PF01217	0.311
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.364
TRG_ENDOCYTIC_2	226	229	PF00928	0.485
TRG_ENDOCYTIC_2	261	264	PF00928	0.391
TRG_ENDOCYTIC_2	363	366	PF00928	0.523
TRG_ENDOCYTIC_2	414	417	PF00928	0.513
TRG_ENDOCYTIC_2	469	472	PF00928	0.390
TRG_ER_diArg_1	1	3	PF00400	0.606
TRG_ER_diArg_1	19	21	PF00400	0.370
TRG_ER_diArg_1	327	330	PF00400	0.307
TRG_ER_diArg_1	78	81	PF00400	0.279
TRG_Pf-PMV_PEXEL_1	19	24	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL11	Leptomonas seymouri	37%	78%
A0A0S4IS53	Bodo saltans	39%	100%
A0A0S4IUU1	Bodo saltans	34%	78%
A0A0S4IYM3	Bodo saltans	33%	70%
A0A1D5NSK0	Danio rerio	24%	82%
A0A1L8HYT7	Xenopus laevis	24%	71%
A0A1X0NDG7	Trypanosomatidae	30%	78%
A0A1X0NDJ3	Trypanosomatidae	29%	71%
A0A1X0NDK2	Trypanosomatidae	33%	89%
A0A1X0NDK7	Trypanosomatidae	31%	72%
A0A1X0NDK9	Trypanosomatidae	29%	100%
A0A1X0NDM7	Trypanosomatidae	30%	79%
A0A1X0NDU8	Trypanosomatidae	29%	77%
A0A1X0NE71	Trypanosomatidae	31%	100%
A0A1X0NER9	Trypanosomatidae	33%	80%
A0A1X0NET7	Trypanosomatidae	34%	99%
A0A1X0NEX7	Trypanosomatidae	32%	78%
A0A1X0NEZ6	Trypanosomatidae	30%	78%
A0A1X0NF32	Trypanosomatidae	32%	100%
A0A1X0NF41	Trypanosomatidae	31%	83%
A0A1X0NFJ0	Trypanosomatidae	31%	97%
A0A1X0NFK3	Trypanosomatidae	30%	76%
A0A1X0NFZ9	Trypanosomatidae	34%	100%
A0A1X0NG20	Trypanosomatidae	34%	82%
A0A1X0NGN3	Trypanosomatidae	36%	100%
A0A1X0NGY3	Trypanosomatidae	32%	67%
A0A1X0NGZ3	Trypanosomatidae	33%	85%
A0A1X0NHP6	Trypanosomatidae	32%	97%
A0A1X0NHQ6	Trypanosomatidae	32%	99%
A0A1X0NI74	Trypanosomatidae	31%	68%
A0A1X0NIZ3	Trypanosomatidae	32%	91%
A0A1X0NJC6	Trypanosomatidae	35%	100%
A0A1X0NJS3	Trypanosomatidae	30%	78%
A0A1X0NK66	Trypanosomatidae	33%	77%
A0A1X0NKJ8	Trypanosomatidae	29%	68%
A0A1X0NKW9	Trypanosomatidae	30%	100%
A0A1X0NME2	Trypanosomatidae	33%	81%
A0A1X0NMK3	Trypanosomatidae	29%	99%
A0A1X0NMK7	Trypanosomatidae	39%	98%
A0A1X0NMV0	Trypanosomatidae	32%	69%
A0A1X0NN43	Trypanosomatidae	33%	71%
A0A1X0NNK8	Trypanosomatidae	30%	78%
A0A1X0NPW0	Trypanosomatidae	32%	79%
A0A1X0NQJ5	Trypanosomatidae	37%	100%
A0A1X0NQM4	Trypanosomatidae	35%	100%
A0A1X0NQN3	Trypanosomatidae	36%	100%
A0A1X0NQU4	Trypanosomatidae	37%	79%
A0A1X0NQW6	Trypanosomatidae	34%	89%
A0A1X0NRF3	Trypanosomatidae	32%	76%
A0A1X0NRY8	Trypanosomatidae	38%	94%
A0A1X0NU16	Trypanosomatidae	35%	85%
A0A1X0NUR2	Trypanosomatidae	35%	69%
A0A1X0NV28	Trypanosomatidae	36%	87%
A0A1X0NVC3	Trypanosomatidae	34%	75%
A0A1X0NW07	Trypanosomatidae	27%	82%
A0A1X0NX94	Trypanosomatidae	32%	79%
A0A1X0NXB6	Trypanosomatidae	32%	72%
A0A1X0NXH6	Trypanosomatidae	34%	70%
A0A1X0NXQ4	Trypanosomatidae	29%	75%
A0A1X0NXR7	Trypanosomatidae	35%	68%
A0A1X0NY94	Trypanosomatidae	39%	100%
A0A1X0NYE3	Trypanosomatidae	33%	82%
A0A1X0NYE7	Trypanosomatidae	32%	100%
A0A1X0NYN2	Trypanosomatidae	35%	97%
A0A1X0NYN4	Trypanosomatidae	28%	72%
A0A1X0NYS5	Trypanosomatidae	35%	85%
A0A1X0NYZ2	Trypanosomatidae	37%	91%
A0A1X0NZ46	Trypanosomatidae	28%	88%
A0A1X0NZ63	Trypanosomatidae	31%	80%
A0A1X0NZN6	Trypanosomatidae	27%	78%
A0A1X0P055	Trypanosomatidae	37%	86%
A0A1X0P0C4	Trypanosomatidae	31%	100%
A0A1X0P154	Trypanosomatidae	28%	85%
A0A1X0P331	Trypanosomatidae	34%	90%
A0A1X0P3K0	Trypanosomatidae	27%	70%
A0A1X0P3S2	Trypanosomatidae	27%	92%
A0A1X0P4L8	Trypanosomatidae	33%	99%
A0A1X0P4Y5	Trypanosomatidae	28%	80%
A0A1X0P544	Trypanosomatidae	31%	80%
A0A1X0P5J0	Trypanosomatidae	33%	74%
A0A1X0P7R3	Trypanosomatidae	37%	90%
A0A1X0P8B4	Trypanosomatidae	33%	100%
A0A1X0P9Z4	Trypanosomatidae	30%	93%
A0A1X0PB04	Trypanosomatidae	33%	100%
A0A286YEC0	Mus musculus	25%	73%
A0A3Q8I8N3	Leishmania donovani	68%	85%
A0A3Q8I8P8	Leishmania donovani	69%	85%
A0A3Q8I8S6	Leishmania donovani	72%	80%
A0A3Q8I8S9	Leishmania donovani	69%	85%
A0A3Q8IAZ8	Leishmania donovani	68%	85%
A0A3Q8IC35	Leishmania donovani	68%	85%
A0A3Q8IC44	Leishmania donovani	68%	87%
A0A3Q8IH61	Leishmania donovani	69%	87%
A0A3Q8IIN4	Leishmania donovani	40%	80%
A0A3R7JTB6	Trypanosoma rangeli	33%	73%
A0A3R7JUH9	Trypanosoma rangeli	39%	100%
A0A3R7JUS0	Trypanosoma rangeli	33%	100%
A0A3R7JV87	Trypanosoma rangeli	36%	96%
A0A3R7K7T9	Trypanosoma rangeli	34%	85%
A0A3R7K9S1	Trypanosoma rangeli	36%	98%
A0A3R7KLR6	Trypanosoma rangeli	35%	80%
A0A3R7KMY2	Trypanosoma rangeli	36%	76%
A0A3R7LFC4	Trypanosoma rangeli	37%	76%
A0A3R7LFZ4	Trypanosoma rangeli	37%	93%
A0A3R7LWG1	Trypanosoma rangeli	34%	90%
A0A3R7LX11	Trypanosoma rangeli	39%	91%
A0A3R7M1R8	Trypanosoma rangeli	36%	89%
A0A3R7M574	Trypanosoma rangeli	36%	80%
A0A3R7M7N6	Trypanosoma rangeli	37%	74%
A0A3R7MTS2	Trypanosoma rangeli	38%	100%
A0A3R7MW36	Trypanosoma rangeli	36%	96%
A0A3R7MXF4	Trypanosoma rangeli	37%	83%
A0A3R7N1W7	Trypanosoma rangeli	33%	87%
A0A3R7N289	Trypanosoma rangeli	34%	70%
A0A3R7NTI8	Trypanosoma rangeli	37%	89%
A0A3R7R2J4	Trypanosoma rangeli	36%	79%
A0A3R7R5R1	Trypanosoma rangeli	35%	85%
A0A3R7R818	Trypanosoma rangeli	32%	97%
A0A3S5H6G0	Leishmania donovani	69%	85%
A0A3S5IQY2	Trypanosoma rangeli	41%	99%
A0A3S7WR43	Leishmania donovani	68%	85%
A0A3S7WR46	Leishmania donovani	69%	85%
A0A3S7WR60	Leishmania donovani	70%	85%
A0A3S7X192	Leishmania donovani	40%	90%
A0A422MP17	Trypanosoma rangeli	39%	100%
A0A422MRQ6	Trypanosoma rangeli	38%	68%
A0A422MTA9	Trypanosoma rangeli	35%	70%
A0A422MTE4	Trypanosoma rangeli	33%	100%
A0A422MU95	Trypanosoma rangeli	37%	89%
A0A422MUP1	Trypanosoma rangeli	39%	100%
A0A422MUY8	Trypanosoma rangeli	40%	91%
A0A422MVF5	Trypanosoma rangeli	34%	91%
A0A422MVS3	Trypanosoma rangeli	34%	99%
A0A422MW99	Trypanosoma rangeli	32%	69%
A0A422MZ47	Trypanosoma rangeli	38%	90%
A0A422MZG4	Trypanosoma rangeli	37%	87%
A0A422N361	Trypanosoma rangeli	36%	92%
A0A422N7Q6	Trypanosoma rangeli	36%	79%
A0A422NDS2	Trypanosoma rangeli	33%	88%
A0A422NDT3	Trypanosoma rangeli	33%	89%
A0A422NP82	Trypanosoma rangeli	38%	89%
A4H626	Leishmania braziliensis	67%	100%
A4H627	Leishmania braziliensis	65%	100%
A4H629	Leishmania braziliensis	91%	100%
A4H630	Leishmania braziliensis	88%	100%
A4H631	Leishmania braziliensis	67%	100%
A4H632	Leishmania braziliensis	76%	100%
A4H633	Leishmania braziliensis	65%	100%
A4H634	Leishmania braziliensis	87%	100%
A4H635	Leishmania braziliensis	89%	100%
A4H636	Leishmania braziliensis	65%	100%
A4H637	Leishmania braziliensis	86%	100%
A4H638	Leishmania braziliensis	87%	100%
A4H639	Leishmania braziliensis	84%	100%
A4H640	Leishmania braziliensis	86%	100%
A4H6D2	Leishmania braziliensis	66%	100%
A4H6D3	Leishmania braziliensis	66%	100%
A4H6D5	Leishmania braziliensis	68%	72%
A4H6D7	Leishmania braziliensis	64%	100%
A4H6D8	Leishmania braziliensis	65%	100%
A4H6D9	Leishmania braziliensis	63%	100%
A4H6E0	Leishmania braziliensis	66%	100%
A4H6E1	Leishmania braziliensis	66%	100%
A4H6E2	Leishmania braziliensis	67%	100%
A4H6E3	Leishmania braziliensis	69%	100%
A4H6E4	Leishmania braziliensis	68%	100%
A4HJI2	Leishmania braziliensis	38%	79%
A4HUF6	Leishmania infantum	69%	85%
A4HUF8	Leishmania infantum	69%	85%
A4HUF9	Leishmania infantum	73%	80%
A4HUG0	Leishmania infantum	68%	67%
A4I6X5	Leishmania infantum	40%	80%
C9ZUT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	88%
D0A1R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	86%
D0A7S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	76%
D0A7W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A855	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	83%
E9AHH5	Leishmania infantum	40%	90%
E9AN53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	78%
E9AN54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	85%
E9AN55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	79%
E9AN56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	79%
E9AN57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	85%
E9AZL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	90%
E9B1Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	80%
O62446	Caenorhabditis elegans	26%	77%
P08148	Leishmania major	71%	85%
P15706	Leishmania chagasi	69%	85%
P23223	Leishmania donovani	70%	87%
P43150	Leishmania mexicana	68%	79%
Q00689	Leishmania guyanensis	83%	82%
Q06031	Crithidia fasciculata	56%	78%
Q27673	Leishmania amazonensis	67%	86%
Q29AK2	Drosophila pseudoobscura pseudoobscura	24%	75%
Q4Q662	Leishmania major	40%	100%
Q4Q8L3	Leishmania major	39%	100%
Q4QHG9	Leishmania major	71%	100%
Q4QHH0	Leishmania major	73%	100%
Q4QHH1	Leishmania major	71%	100%
Q4QHH2	Leishmania major	71%	100%
Q61YG1	Caenorhabditis briggsae	26%	77%
Q6LA77	Leishmania infantum	69%	85%
Q8BMN4	Mus musculus	28%	75%
Q8MNZ1	Leishmania tropica	71%	78%
Q96KR4	Homo sapiens	25%	78%
Q9VH19	Drosophila melanogaster	23%	75%
V5A303	Trypanosoma cruzi	40%	100%
V5A359	Trypanosoma cruzi	41%	94%
V5AII7	Trypanosoma cruzi	42%	94%
V5AJE7	Trypanosoma cruzi	35%	98%
V5AMH8	Trypanosoma cruzi	36%	100%
V5AN34	Trypanosoma cruzi	39%	100%
V5AX72	Trypanosoma cruzi	37%	69%
V5B5M0	Trypanosoma cruzi	36%	69%
V5B9W5	Trypanosoma cruzi	35%	76%
V5BAL3	Trypanosoma cruzi	40%	100%
V5BD39	Trypanosoma cruzi	45%	100%
V5BLT3	Trypanosoma cruzi	32%	81%
V5CI97	Trypanosoma cruzi	32%	80%
V5CIA7	Trypanosoma cruzi	33%	100%