LeishMANIAdb
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Leishmanolysin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Leishmanolysin
Gene product:
GP63, leishmanolysin (fragment)
Species:
Leishmania braziliensis
UniProt:
A4H6E3_LEIBR
TriTrypDb:
LbrM.10.1670 , LBRM2903_100010600
Length:
574

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 51
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 41, no: 10
NetGPI no yes: 0, no: 51
Cellular components
Term Name Level Count
GO:0016020 membrane 2 52
GO:0110165 cellular anatomical entity 1 52
GO:0005737 cytoplasm 2 4
GO:0018995 host cellular component 2 4
GO:0033643 host cell part 3 4
GO:0033646 host intracellular part 4 4
GO:0033647 host intracellular organelle 5 4
GO:0033648 host intracellular membrane-bounded organelle 6 4
GO:0042025 host cell nucleus 7 4

Expansion

Sequence features

A4H6E3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6E3

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 52
GO:0006807 nitrogen compound metabolic process 2 52
GO:0007155 cell adhesion 2 52
GO:0008152 metabolic process 1 52
GO:0009987 cellular process 1 52
GO:0019538 protein metabolic process 3 52
GO:0043170 macromolecule metabolic process 3 52
GO:0044238 primary metabolic process 2 52
GO:0071704 organic substance metabolic process 2 52
GO:1901564 organonitrogen compound metabolic process 3 52
GO:0009966 regulation of signal transduction 4 4
GO:0010646 regulation of cell communication 4 4
GO:0010749 regulation of nitric oxide mediated signal transduction 6 4
GO:0023051 regulation of signaling 3 4
GO:0035821 modulation of process of another organism 2 4
GO:0044003 modulation by symbiont of host process 3 4
GO:0044068 modulation by symbiont of host cellular process 4 4
GO:0044081 modulation by symbiont of host nitric oxide-mediated signal transduction 5 4
GO:0044403 biological process involved in symbiotic interaction 2 4
GO:0044419 biological process involved in interspecies interaction between organisms 1 4
GO:0044501 modulation of signal transduction in another organism 3 4
GO:0048583 regulation of response to stimulus 3 4
GO:0050789 regulation of biological process 2 4
GO:0050794 regulation of cellular process 3 4
GO:0051701 biological process involved in interaction with host 3 4
GO:0052027 modulation by symbiont of host signal transduction pathway 4 4
GO:0065007 biological regulation 1 4
GO:0075130 modulation by symbiont of host protein kinase-mediated signal transduction 5 4
GO:1902531 regulation of intracellular signal transduction 5 4
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 52
GO:0004175 endopeptidase activity 4 52
GO:0004222 metalloendopeptidase activity 5 52
GO:0005488 binding 1 52
GO:0008233 peptidase activity 3 52
GO:0008237 metallopeptidase activity 4 52
GO:0016787 hydrolase activity 2 52
GO:0043167 ion binding 2 52
GO:0043169 cation binding 3 52
GO:0046872 metal ion binding 4 52
GO:0140096 catalytic activity, acting on a protein 2 52
GO:0008047 enzyme activator activity 3 4
GO:0008160 protein tyrosine phosphatase activator activity 6 4
GO:0019208 phosphatase regulator activity 3 4
GO:0019211 phosphatase activator activity 4 4
GO:0019888 protein phosphatase regulator activity 4 4
GO:0030234 enzyme regulator activity 2 4
GO:0072542 protein phosphatase activator activity 5 4
GO:0098772 molecular function regulator activity 1 4
GO:0140677 molecular function activator activity 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 170 172 PF00675 0.390
CLV_NRD_NRD_1 81 83 PF00675 0.410
CLV_PCSK_KEX2_1 170 172 PF00082 0.563
CLV_PCSK_KEX2_1 81 83 PF00082 0.410
CLV_PCSK_SKI1_1 128 132 PF00082 0.405
CLV_PCSK_SKI1_1 171 175 PF00082 0.541
CLV_PCSK_SKI1_1 278 282 PF00082 0.557
CLV_PCSK_SKI1_1 356 360 PF00082 0.496
CLV_PCSK_SKI1_1 414 418 PF00082 0.467
CLV_PCSK_SKI1_1 457 461 PF00082 0.409
DEG_ODPH_VHL_1 29 41 PF01847 0.556
DEG_SPOP_SBC_1 111 115 PF00917 0.258
DEG_SPOP_SBC_1 563 567 PF00917 0.195
DOC_CYCLIN_yCln2_LP_2 14 20 PF00134 0.576
DOC_MAPK_gen_1 308 316 PF00069 0.325
DOC_MAPK_MEF2A_6 9 18 PF00069 0.580
DOC_PP2B_LxvP_1 14 17 PF13499 0.581
DOC_PP2B_LxvP_1 362 365 PF13499 0.379
DOC_PP2B_LxvP_1 90 93 PF13499 0.258
DOC_PP4_FxxP_1 212 215 PF00568 0.390
DOC_USP7_MATH_1 10 14 PF00917 0.581
DOC_USP7_MATH_1 515 519 PF00917 0.287
DOC_USP7_MATH_1 93 97 PF00917 0.263
DOC_USP7_MATH_1 99 103 PF00917 0.241
DOC_USP7_UBL2_3 410 414 PF12436 0.207
DOC_WW_Pin1_4 112 117 PF00397 0.276
DOC_WW_Pin1_4 316 321 PF00397 0.253
DOC_WW_Pin1_4 511 516 PF00397 0.233
DOC_WW_Pin1_4 552 557 PF00397 0.403
LIG_14-3-3_CanoR_1 128 134 PF00244 0.372
LIG_14-3-3_CanoR_1 193 201 PF00244 0.189
LIG_14-3-3_CanoR_1 432 440 PF00244 0.271
LIG_14-3-3_CanoR_1 536 542 PF00244 0.368
LIG_14-3-3_CanoR_1 72 78 PF00244 0.363
LIG_APCC_ABBA_1 183 188 PF00400 0.390
LIG_APCC_ABBA_1 292 297 PF00400 0.225
LIG_APCC_ABBA_1 377 382 PF00400 0.378
LIG_APCC_ABBA_1 499 504 PF00400 0.403
LIG_BRCT_BRCA1_1 402 406 PF00533 0.273
LIG_BRCT_BRCA1_1 565 569 PF00533 0.403
LIG_BRCT_BRCA1_2 565 571 PF00533 0.198
LIG_FHA_1 124 130 PF00498 0.311
LIG_FHA_1 174 180 PF00498 0.256
LIG_FHA_1 196 202 PF00498 0.300
LIG_FHA_1 209 215 PF00498 0.295
LIG_FHA_1 218 224 PF00498 0.281
LIG_FHA_1 279 285 PF00498 0.324
LIG_FHA_1 374 380 PF00498 0.394
LIG_FHA_1 538 544 PF00498 0.385
LIG_FHA_1 565 571 PF00498 0.277
LIG_FHA_2 129 135 PF00498 0.222
LIG_FHA_2 200 206 PF00498 0.233
LIG_FHA_2 291 297 PF00498 0.247
LIG_FHA_2 331 337 PF00498 0.209
LIG_FHA_2 389 395 PF00498 0.238
LIG_FHA_2 493 499 PF00498 0.209
LIG_GBD_Chelix_1 284 292 PF00786 0.427
LIG_LIR_Apic_2 176 180 PF02991 0.224
LIG_LIR_Apic_2 211 215 PF02991 0.377
LIG_LIR_Apic_2 311 315 PF02991 0.294
LIG_LIR_Gen_1 293 301 PF02991 0.255
LIG_LIR_Gen_1 334 342 PF02991 0.398
LIG_LIR_Gen_1 498 506 PF02991 0.281
LIG_LIR_Nem_3 121 127 PF02991 0.282
LIG_LIR_Nem_3 140 145 PF02991 0.208
LIG_LIR_Nem_3 226 231 PF02991 0.372
LIG_LIR_Nem_3 293 298 PF02991 0.256
LIG_LIR_Nem_3 334 340 PF02991 0.363
LIG_LIR_Nem_3 468 473 PF02991 0.286
LIG_LIR_Nem_3 498 502 PF02991 0.288
LIG_Pex14_1 419 423 PF04695 0.392
LIG_PTB_Apo_2 222 229 PF02174 0.383
LIG_SH2_CRK 372 376 PF00017 0.403
LIG_SH2_CRK 473 477 PF00017 0.273
LIG_SH2_CRK 525 529 PF00017 0.359
LIG_SH2_NCK_1 480 484 PF00017 0.205
LIG_SH2_PTP2 94 97 PF00017 0.283
LIG_SH2_STAP1 272 276 PF00017 0.349
LIG_SH2_STAP1 480 484 PF00017 0.210
LIG_SH2_STAP1 541 545 PF00017 0.403
LIG_SH2_STAT3 145 148 PF00017 0.251
LIG_SH2_STAT3 541 544 PF00017 0.388
LIG_SH2_STAT5 142 145 PF00017 0.234
LIG_SH2_STAT5 177 180 PF00017 0.264
LIG_SH2_STAT5 231 234 PF00017 0.376
LIG_SH2_STAT5 337 340 PF00017 0.361
LIG_SH2_STAT5 372 375 PF00017 0.329
LIG_SH2_STAT5 455 458 PF00017 0.387
LIG_SH2_STAT5 473 476 PF00017 0.215
LIG_SH2_STAT5 551 554 PF00017 0.338
LIG_SH2_STAT5 94 97 PF00017 0.361
LIG_SH3_3 233 239 PF00018 0.253
LIG_SH3_3 258 264 PF00018 0.202
LIG_SH3_3 518 524 PF00018 0.236
LIG_SUMO_SIM_anti_2 296 303 PF11976 0.226
LIG_TYR_ITIM 335 340 PF00017 0.387
LIG_TYR_ITIM 471 476 PF00017 0.202
LIG_TYR_ITIM 92 97 PF00017 0.326
MOD_CDK_SPK_2 511 516 PF00069 0.254
MOD_CDK_SPxxK_3 552 559 PF00069 0.405
MOD_CK1_1 234 240 PF00069 0.473
MOD_CK1_1 318 324 PF00069 0.228
MOD_CK1_1 348 354 PF00069 0.421
MOD_CK1_1 490 496 PF00069 0.359
MOD_CK1_1 500 506 PF00069 0.283
MOD_CK2_1 128 134 PF00069 0.199
MOD_CK2_1 199 205 PF00069 0.250
MOD_CK2_1 290 296 PF00069 0.240
MOD_CK2_1 330 336 PF00069 0.236
MOD_CK2_1 388 394 PF00069 0.493
MOD_CK2_1 492 498 PF00069 0.267
MOD_GlcNHglycan 101 104 PF01048 0.253
MOD_GlcNHglycan 120 123 PF01048 0.286
MOD_GlcNHglycan 269 272 PF01048 0.240
MOD_GlcNHglycan 345 348 PF01048 0.414
MOD_GlcNHglycan 366 369 PF01048 0.277
MOD_GlcNHglycan 548 551 PF01048 0.424
MOD_GlcNHglycan 87 90 PF01048 0.440
MOD_GSK3_1 110 117 PF00069 0.246
MOD_GSK3_1 195 202 PF00069 0.326
MOD_GSK3_1 217 224 PF00069 0.471
MOD_GSK3_1 272 279 PF00069 0.362
MOD_GSK3_1 423 430 PF00069 0.277
MOD_GSK3_1 487 494 PF00069 0.277
MOD_GSK3_1 511 518 PF00069 0.254
MOD_N-GLC_1 414 419 PF02516 0.403
MOD_N-GLC_1 424 429 PF02516 0.331
MOD_NEK2_1 110 115 PF00069 0.243
MOD_NEK2_1 276 281 PF00069 0.365
MOD_NEK2_1 290 295 PF00069 0.396
MOD_NEK2_1 459 464 PF00069 0.305
MOD_NEK2_1 562 567 PF00069 0.225
MOD_NEK2_2 492 497 PF00069 0.202
MOD_PIKK_1 414 420 PF00454 0.382
MOD_PK_1 497 503 PF00069 0.222
MOD_PKA_2 431 437 PF00069 0.338
MOD_Plk_1 272 278 PF00069 0.193
MOD_Plk_1 290 296 PF00069 0.248
MOD_Plk_1 414 420 PF00069 0.408
MOD_Plk_1 497 503 PF00069 0.242
MOD_Plk_2-3 164 170 PF00069 0.382
MOD_Plk_4 141 147 PF00069 0.263
MOD_Plk_4 173 179 PF00069 0.288
MOD_Plk_4 272 278 PF00069 0.205
MOD_Plk_4 290 296 PF00069 0.336
MOD_Plk_4 318 324 PF00069 0.319
MOD_ProDKin_1 112 118 PF00069 0.315
MOD_ProDKin_1 316 322 PF00069 0.283
MOD_ProDKin_1 511 517 PF00069 0.256
MOD_ProDKin_1 552 558 PF00069 0.493
MOD_SUMO_for_1 358 361 PF00179 0.344
MOD_SUMO_rev_2 297 307 PF00179 0.205
TRG_DiLeu_BaEn_1 296 301 PF01217 0.212
TRG_DiLeu_BaEn_3 168 174 PF01217 0.263
TRG_ENDOCYTIC_2 337 340 PF00928 0.434
TRG_ENDOCYTIC_2 372 375 PF00928 0.493
TRG_ENDOCYTIC_2 473 476 PF00928 0.379
TRG_ENDOCYTIC_2 525 528 PF00928 0.467
TRG_ENDOCYTIC_2 94 97 PF00928 0.326
TRG_ER_diArg_1 81 83 PF00400 0.225
TRG_NES_CRM1_1 291 303 PF08389 0.259

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IL11 Leptomonas seymouri 34% 88%
A0A0S4IP65 Bodo saltans 23% 71%
A0A0S4IUT6 Bodo saltans 30% 70%
A0A0S4IUU1 Bodo saltans 31% 87%
A0A0S4IYM3 Bodo saltans 31% 79%
A0A1D5NSK0 Danio rerio 24% 92%
A0A1X0NDG7 Trypanosomatidae 30% 88%
A0A1X0NDJ3 Trypanosomatidae 30% 79%
A0A1X0NDK7 Trypanosomatidae 31% 80%
A0A1X0NDU8 Trypanosomatidae 32% 86%
A0A1X0NE71 Trypanosomatidae 29% 100%
A0A1X0NER9 Trypanosomatidae 34% 90%
A0A1X0NET7 Trypanosomatidae 33% 100%
A0A1X0NEX7 Trypanosomatidae 33% 88%
A0A1X0NF32 Trypanosomatidae 31% 100%
A0A1X0NF41 Trypanosomatidae 32% 94%
A0A1X0NFJ0 Trypanosomatidae 28% 100%
A0A1X0NFK3 Trypanosomatidae 29% 86%
A0A1X0NFS0 Trypanosomatidae 29% 66%
A0A1X0NFU4 Trypanosomatidae 30% 70%
A0A1X0NG20 Trypanosomatidae 32% 93%
A0A1X0NGP3 Trypanosomatidae 31% 67%
A0A1X0NGY3 Trypanosomatidae 30% 75%
A0A1X0NGZ3 Trypanosomatidae 32% 95%
A0A1X0NHP6 Trypanosomatidae 32% 100%
A0A1X0NHQ6 Trypanosomatidae 33% 100%
A0A1X0NI74 Trypanosomatidae 30% 77%
A0A1X0NII4 Trypanosomatidae 29% 68%
A0A1X0NIZ3 Trypanosomatidae 31% 100%
A0A1X0NJS3 Trypanosomatidae 34% 88%
A0A1X0NJU4 Trypanosomatidae 31% 67%
A0A1X0NK66 Trypanosomatidae 35% 87%
A0A1X0NKJ8 Trypanosomatidae 28% 77%
A0A1X0NKW9 Trypanosomatidae 31% 100%
A0A1X0NME2 Trypanosomatidae 31% 91%
A0A1X0NMK3 Trypanosomatidae 28% 100%
A0A1X0NMK7 Trypanosomatidae 36% 100%
A0A1X0NMV0 Trypanosomatidae 30% 78%
A0A1X0NN43 Trypanosomatidae 27% 80%
A0A1X0NNK8 Trypanosomatidae 32% 87%
A0A1X0NPW0 Trypanosomatidae 31% 89%
A0A1X0NQM4 Trypanosomatidae 35% 100%
A0A1X0NQN3 Trypanosomatidae 35% 100%
A0A1X0NQU4 Trypanosomatidae 35% 89%
A0A1X0NQW6 Trypanosomatidae 34% 100%
A0A1X0NRF3 Trypanosomatidae 34% 85%
A0A1X0NRY8 Trypanosomatidae 36% 100%
A0A1X0NU16 Trypanosomatidae 36% 96%
A0A1X0NUR2 Trypanosomatidae 34% 78%
A0A1X0NV28 Trypanosomatidae 36% 97%
A0A1X0NVC3 Trypanosomatidae 28% 84%
A0A1X0NVE0 Trypanosomatidae 28% 73%
A0A1X0NW07 Trypanosomatidae 28% 92%
A0A1X0NX98 Trypanosomatidae 32% 72%
A0A1X0NXB6 Trypanosomatidae 31% 81%
A0A1X0NXH6 Trypanosomatidae 32% 79%
A0A1X0NXQ4 Trypanosomatidae 29% 85%
A0A1X0NXR7 Trypanosomatidae 32% 76%
A0A1X0NYE7 Trypanosomatidae 32% 100%
A0A1X0NYN2 Trypanosomatidae 34% 100%
A0A1X0NYN4 Trypanosomatidae 28% 81%
A0A1X0NYS5 Trypanosomatidae 34% 96%
A0A1X0NYZ2 Trypanosomatidae 38% 100%
A0A1X0NZ46 Trypanosomatidae 29% 99%
A0A1X0NZ63 Trypanosomatidae 31% 90%
A0A1X0NZN6 Trypanosomatidae 28% 88%
A0A1X0P055 Trypanosomatidae 36% 97%
A0A1X0P154 Trypanosomatidae 29% 96%
A0A1X0P331 Trypanosomatidae 33% 100%
A0A1X0P3K0 Trypanosomatidae 30% 79%
A0A1X0P3S2 Trypanosomatidae 29% 100%
A0A1X0P4L8 Trypanosomatidae 30% 100%
A0A1X0P4Y5 Trypanosomatidae 30% 89%
A0A1X0P5J0 Trypanosomatidae 33% 84%
A0A1X0P8B4 Trypanosomatidae 32% 100%
A0A1X0P9Z4 Trypanosomatidae 32% 100%
A0A1X0PB04 Trypanosomatidae 34% 100%
A0A3Q8I8N3 Leishmania donovani 59% 96%
A0A3Q8I8P8 Leishmania donovani 61% 96%
A0A3Q8I8S6 Leishmania donovani 62% 90%
A0A3Q8I8S9 Leishmania donovani 61% 96%
A0A3Q8IAZ8 Leishmania donovani 59% 96%
A0A3Q8IC35 Leishmania donovani 59% 96%
A0A3Q8IC44 Leishmania donovani 59% 97%
A0A3Q8IH61 Leishmania donovani 60% 97%
A0A3Q8IIN4 Leishmania donovani 34% 90%
A0A3R7JT49 Trypanosoma rangeli 35% 68%
A0A3R7JTB6 Trypanosoma rangeli 32% 82%
A0A3R7K7T9 Trypanosoma rangeli 35% 96%
A0A3R7K9S1 Trypanosoma rangeli 34% 100%
A0A3R7KMY2 Trypanosoma rangeli 34% 86%
A0A3R7LFC4 Trypanosoma rangeli 36% 85%
A0A3R7LFZ4 Trypanosoma rangeli 38% 100%
A0A3R7LX11 Trypanosoma rangeli 35% 100%
A0A3R7M1R8 Trypanosoma rangeli 35% 100%
A0A3R7M574 Trypanosoma rangeli 32% 90%
A0A3R7M7N6 Trypanosoma rangeli 33% 83%
A0A3R7MTS2 Trypanosoma rangeli 39% 100%
A0A3R7MW36 Trypanosoma rangeli 33% 100%
A0A3R7MXF4 Trypanosoma rangeli 37% 94%
A0A3R7N289 Trypanosoma rangeli 33% 79%
A0A3R7N7I3 Trypanosoma rangeli 40% 100%
A0A3R7NTI8 Trypanosoma rangeli 35% 100%
A0A3R7R2J4 Trypanosoma rangeli 33% 89%
A0A3R7R5R1 Trypanosoma rangeli 36% 96%
A0A3S5H6G0 Leishmania donovani 61% 96%
A0A3S5IQY2 Trypanosoma rangeli 37% 100%
A0A3S7WR43 Leishmania donovani 59% 96%
A0A3S7WR46 Leishmania donovani 61% 96%
A0A3S7WR60 Leishmania donovani 61% 96%
A0A3S7X192 Leishmania donovani 38% 100%
A0A422MRQ6 Trypanosoma rangeli 34% 77%
A0A422MU95 Trypanosoma rangeli 33% 100%
A0A422MVS3 Trypanosoma rangeli 35% 100%
A0A422MZ47 Trypanosoma rangeli 40% 100%
A0A422MZG4 Trypanosoma rangeli 35% 98%
A0A422N361 Trypanosoma rangeli 34% 100%
A0A422N7Q6 Trypanosoma rangeli 36% 89%
A0A422NDS2 Trypanosoma rangeli 36% 99%
A0A422NDT3 Trypanosoma rangeli 30% 100%
A4H626 Leishmania braziliensis 85% 100%
A4H627 Leishmania braziliensis 73% 100%
A4H629 Leishmania braziliensis 70% 100%
A4H630 Leishmania braziliensis 72% 100%
A4H631 Leishmania braziliensis 78% 100%
A4H632 Leishmania braziliensis 66% 100%
A4H633 Leishmania braziliensis 76% 100%
A4H634 Leishmania braziliensis 72% 100%
A4H635 Leishmania braziliensis 72% 100%
A4H636 Leishmania braziliensis 69% 100%
A4H637 Leishmania braziliensis 72% 100%
A4H638 Leishmania braziliensis 64% 100%
A4H639 Leishmania braziliensis 67% 100%
A4H640 Leishmania braziliensis 72% 100%
A4H6D3 Leishmania braziliensis 78% 100%
A4H6D5 Leishmania braziliensis 84% 100%
A4H6D7 Leishmania braziliensis 72% 100%
A4H6D8 Leishmania braziliensis 85% 100%
A4H6D9 Leishmania braziliensis 84% 100%
A4H6E0 Leishmania braziliensis 83% 100%
A4H6E1 Leishmania braziliensis 76% 100%
A4H6E2 Leishmania braziliensis 77% 100%
A4H6E4 Leishmania braziliensis 81% 100%
A4H6E5 Leishmania braziliensis 69% 100%
A4HJI2 Leishmania braziliensis 37% 89%
A4HUF6 Leishmania infantum 59% 96%
A4HUF8 Leishmania infantum 61% 96%
A4HUF9 Leishmania infantum 62% 90%
A4HUG0 Leishmania infantum 61% 75%
A4I6X5 Leishmania infantum 36% 90%
C9ZUT5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 99%
D0A1R8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 97%
D0A7S8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 85%
D0A855 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 93%
E9AHH5 Leishmania infantum 38% 100%
E9AN53 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 88%
E9AN54 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 95%
E9AN55 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 89%
E9AN56 Leishmania mexicana (strain MHOM/GT/2001/U1103) 63% 89%
E9AN57 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 95%
E9AZL8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B1Z9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 90%
O62446 Caenorhabditis elegans 26% 87%
P08148 Leishmania major 61% 95%
P15706 Leishmania chagasi 61% 96%
P23223 Leishmania donovani 59% 97%
P43150 Leishmania mexicana 62% 89%
Q00689 Leishmania guyanensis 72% 92%
Q06031 Crithidia fasciculata 51% 88%
Q27673 Leishmania amazonensis 59% 96%
Q29AK2 Drosophila pseudoobscura pseudoobscura 25% 84%
Q4Q662 Leishmania major 36% 100%
Q4Q8L3 Leishmania major 39% 100%
Q4QHG9 Leishmania major 61% 100%
Q4QHH0 Leishmania major 62% 100%
Q4QHH1 Leishmania major 61% 100%
Q4QHH2 Leishmania major 61% 100%
Q61YG1 Caenorhabditis briggsae 25% 87%
Q6LA77 Leishmania infantum 61% 96%
Q8MNZ1 Leishmania tropica 62% 87%
Q9VH19 Drosophila melanogaster 23% 84%
V5A359 Trypanosoma cruzi 38% 100%
V5A488 Trypanosoma cruzi 32% 71%
V5AII7 Trypanosoma cruzi 38% 100%
V5APQ4 Trypanosoma cruzi 32% 72%
V5AX72 Trypanosoma cruzi 36% 78%
V5B5M0 Trypanosoma cruzi 35% 78%
V5BAN1 Trypanosoma cruzi 34% 73%
V5BD39 Trypanosoma cruzi 40% 100%
V5BLT3 Trypanosoma cruzi 31% 91%
V5D358 Trypanosoma cruzi 34% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS