Leishmanolysin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

GP63, leishmanolysin

Species:

Leishmania braziliensis

UniProt:

A4H6E2_LEIBR

TriTrypDb:

LbrM.10.1660 , LBRM2903_100010600

Length:

577

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 51

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 41, no: 11
NetGPI	no	yes: 0, no: 52

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	53
GO:0110165	cellular anatomical entity	1	53
GO:0005737	cytoplasm	2	4
GO:0018995	host cellular component	2	4
GO:0033643	host cell part	3	4
GO:0033646	host intracellular part	4	4
GO:0033647	host intracellular organelle	5	4
GO:0033648	host intracellular membrane-bounded organelle	6	4
GO:0042025	host cell nucleus	7	4

Expansion

Sequence features

A4H6E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6E2

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	53
GO:0006807	nitrogen compound metabolic process	2	53
GO:0007155	cell adhesion	2	53
GO:0008152	metabolic process	1	53
GO:0009987	cellular process	1	53
GO:0019538	protein metabolic process	3	53
GO:0043170	macromolecule metabolic process	3	53
GO:0044238	primary metabolic process	2	53
GO:0071704	organic substance metabolic process	2	53
GO:1901564	organonitrogen compound metabolic process	3	53
GO:0009966	regulation of signal transduction	4	4
GO:0010646	regulation of cell communication	4	4
GO:0010749	regulation of nitric oxide mediated signal transduction	6	4
GO:0023051	regulation of signaling	3	4
GO:0035821	modulation of process of another organism	2	4
GO:0044003	modulation by symbiont of host process	3	4
GO:0044068	modulation by symbiont of host cellular process	4	4
GO:0044081	modulation by symbiont of host nitric oxide-mediated signal transduction	5	4
GO:0044403	biological process involved in symbiotic interaction	2	4
GO:0044419	biological process involved in interspecies interaction between organisms	1	4
GO:0044501	modulation of signal transduction in another organism	3	4
GO:0048583	regulation of response to stimulus	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051701	biological process involved in interaction with host	3	4
GO:0052027	modulation by symbiont of host signal transduction pathway	4	4
GO:0065007	biological regulation	1	4
GO:0075130	modulation by symbiont of host protein kinase-mediated signal transduction	5	4
GO:1902531	regulation of intracellular signal transduction	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	53
GO:0004175	endopeptidase activity	4	53
GO:0004222	metalloendopeptidase activity	5	53
GO:0005488	binding	1	53
GO:0008233	peptidase activity	3	53
GO:0008237	metallopeptidase activity	4	53
GO:0016787	hydrolase activity	2	53
GO:0043167	ion binding	2	53
GO:0043169	cation binding	3	53
GO:0046872	metal ion binding	4	53
GO:0140096	catalytic activity, acting on a protein	2	53
GO:0008047	enzyme activator activity	3	4
GO:0008160	protein tyrosine phosphatase activator activity	6	4
GO:0019208	phosphatase regulator activity	3	4
GO:0019211	phosphatase activator activity	4	4
GO:0019888	protein phosphatase regulator activity	4	4
GO:0030234	enzyme regulator activity	2	4
GO:0072542	protein phosphatase activator activity	5	4
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	537	541	PF00656	0.217
CLV_PCSK_KEX2_1	143	145	PF00082	0.563
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.553
CLV_PCSK_SKI1_1	136	140	PF00082	0.494
CLV_PCSK_SKI1_1	144	148	PF00082	0.538
CLV_PCSK_SKI1_1	153	157	PF00082	0.460
CLV_PCSK_SKI1_1	251	255	PF00082	0.558
CLV_PCSK_SKI1_1	329	333	PF00082	0.498
CLV_PCSK_SKI1_1	387	391	PF00082	0.464
CLV_PCSK_SKI1_1	417	421	PF00082	0.404
CLV_PCSK_SKI1_1	5	9	PF00082	0.451
DEG_APCC_DBOX_1	143	151	PF00400	0.201
DEG_SCF_FBW7_1	525	532	PF00400	0.239
DEG_SPOP_SBC_1	84	88	PF00917	0.260
DOC_CKS1_1	290	295	PF01111	0.205
DOC_CYCLIN_RxL_1	306	316	PF00134	0.187
DOC_CYCLIN_yCln2_LP_2	335	341	PF00134	0.299
DOC_MAPK_gen_1	143	150	PF00069	0.203
DOC_MAPK_MEF2A_6	143	152	PF00069	0.201
DOC_MAPK_MEF2A_6	153	160	PF00069	0.189
DOC_MAPK_NFAT4_5	153	161	PF00069	0.183
DOC_PP1_RVXF_1	358	364	PF00149	0.194
DOC_PP1_RVXF_1	415	421	PF00149	0.187
DOC_PP2B_LxvP_1	335	338	PF13499	0.380
DOC_PP2B_LxvP_1	63	66	PF13499	0.260
DOC_PP4_FxxP_1	185	188	PF00568	0.391
DOC_USP7_MATH_1	465	469	PF00917	0.249
DOC_USP7_MATH_1	488	492	PF00917	0.285
DOC_USP7_MATH_1	529	533	PF00917	0.250
DOC_USP7_MATH_1	536	540	PF00917	0.235
DOC_USP7_MATH_1	66	70	PF00917	0.265
DOC_USP7_MATH_1	72	76	PF00917	0.242
DOC_USP7_UBL2_3	383	387	PF12436	0.207
DOC_WW_Pin1_4	240	245	PF00397	0.207
DOC_WW_Pin1_4	289	294	PF00397	0.255
DOC_WW_Pin1_4	463	468	PF00397	0.256
DOC_WW_Pin1_4	525	530	PF00397	0.399
DOC_WW_Pin1_4	85	90	PF00397	0.278
LIG_14-3-3_CanoR_1	101	107	PF00244	0.373
LIG_14-3-3_CanoR_1	166	174	PF00244	0.188
LIG_14-3-3_CanoR_1	440	444	PF00244	0.207
LIG_14-3-3_CanoR_1	45	51	PF00244	0.364
LIG_14-3-3_CanoR_1	487	497	PF00244	0.284
LIG_14-3-3_CanoR_1	5	14	PF00244	0.597
LIG_14-3-3_CanoR_1	509	515	PF00244	0.365
LIG_APCC_ABBA_1	156	161	PF00400	0.391
LIG_APCC_ABBA_1	265	270	PF00400	0.228
LIG_APCC_ABBA_1	472	477	PF00400	0.399
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_BRCT_BRCA1_1	538	542	PF00533	0.399
LIG_FHA_1	169	175	PF00498	0.299
LIG_FHA_1	252	258	PF00498	0.322
LIG_FHA_1	290	296	PF00498	0.203
LIG_FHA_1	347	353	PF00498	0.391
LIG_FHA_1	406	412	PF00498	0.367
LIG_FHA_1	413	419	PF00498	0.305
LIG_FHA_1	511	517	PF00498	0.382
LIG_FHA_1	6	12	PF00498	0.470
LIG_FHA_1	97	103	PF00498	0.312
LIG_FHA_2	173	179	PF00498	0.232
LIG_FHA_2	264	270	PF00498	0.246
LIG_FHA_2	535	541	PF00498	0.247
LIG_GBD_Chelix_1	257	265	PF00786	0.426
LIG_LIR_Apic_2	184	188	PF02991	0.377
LIG_LIR_Apic_2	284	288	PF02991	0.296
LIG_LIR_Gen_1	105	114	PF02991	0.217
LIG_LIR_Gen_1	193	204	PF02991	0.212
LIG_LIR_Gen_1	218	225	PF02991	0.199
LIG_LIR_Gen_1	243	253	PF02991	0.346
LIG_LIR_Gen_1	266	274	PF02991	0.254
LIG_LIR_Gen_1	307	315	PF02991	0.398
LIG_LIR_Gen_1	427	437	PF02991	0.286
LIG_LIR_Gen_1	471	479	PF02991	0.279
LIG_LIR_Nem_3	105	109	PF02991	0.256
LIG_LIR_Nem_3	113	118	PF02991	0.207
LIG_LIR_Nem_3	193	199	PF02991	0.338
LIG_LIR_Nem_3	200	204	PF02991	0.366
LIG_LIR_Nem_3	218	223	PF02991	0.191
LIG_LIR_Nem_3	243	248	PF02991	0.346
LIG_LIR_Nem_3	284	289	PF02991	0.196
LIG_LIR_Nem_3	307	313	PF02991	0.363
LIG_LIR_Nem_3	355	361	PF02991	0.215
LIG_LIR_Nem_3	427	432	PF02991	0.324
LIG_LIR_Nem_3	441	446	PF02991	0.284
LIG_LIR_Nem_3	471	475	PF02991	0.286
LIG_Pex14_2	220	224	PF04695	0.199
LIG_PTB_Apo_2	195	202	PF02174	0.383
LIG_SH2_CRK	245	249	PF00017	0.342
LIG_SH2_CRK	345	349	PF00017	0.403
LIG_SH2_CRK	421	425	PF00017	0.235
LIG_SH2_CRK	446	450	PF00017	0.271
LIG_SH2_CRK	498	502	PF00017	0.356
LIG_SH2_GRB2like	421	424	PF00017	0.199
LIG_SH2_PTP2	286	289	PF00017	0.194
LIG_SH2_PTP2	553	556	PF00017	0.396
LIG_SH2_SRC	286	289	PF00017	0.207
LIG_SH2_SRC	421	424	PF00017	0.217
LIG_SH2_SRC	553	556	PF00017	0.396
LIG_SH2_STAP1	106	110	PF00017	0.199
LIG_SH2_STAP1	245	249	PF00017	0.349
LIG_SH2_STAP1	514	518	PF00017	0.399
LIG_SH2_STAT3	118	121	PF00017	0.253
LIG_SH2_STAT3	514	517	PF00017	0.385
LIG_SH2_STAT5	103	106	PF00017	0.231
LIG_SH2_STAT5	115	118	PF00017	0.237
LIG_SH2_STAT5	204	207	PF00017	0.376
LIG_SH2_STAT5	286	289	PF00017	0.197
LIG_SH2_STAT5	310	313	PF00017	0.358
LIG_SH2_STAT5	428	431	PF00017	0.384
LIG_SH2_STAT5	446	449	PF00017	0.214
LIG_SH2_STAT5	524	527	PF00017	0.335
LIG_SH2_STAT5	547	550	PF00017	0.396
LIG_SH2_STAT5	553	556	PF00017	0.330
LIG_SH2_STAT5	67	70	PF00017	0.362
LIG_SH3_3	287	293	PF00018	0.192
LIG_SH3_3	401	407	PF00018	0.195
LIG_SH3_3	482	488	PF00018	0.248
LIG_SH3_3	491	497	PF00018	0.234
LIG_SUMO_SIM_par_1	447	455	PF11976	0.194
LIG_TYR_ITIM	104	109	PF00017	0.226
LIG_TYR_ITIM	308	313	PF00017	0.384
LIG_UBA3_1	352	360	PF00899	0.191
MOD_CDK_SPxxK_3	463	470	PF00069	0.221
MOD_CK1_1	207	213	PF00069	0.474
MOD_CK1_1	346	352	PF00069	0.279
MOD_CK1_1	463	469	PF00069	0.356
MOD_CK1_1	75	81	PF00069	0.307
MOD_CK2_1	172	178	PF00069	0.249
MOD_CK2_1	263	269	PF00069	0.239
MOD_CK2_1	361	367	PF00069	0.494
MOD_CK2_1	465	471	PF00069	0.265
MOD_GlcNHglycan	217	220	PF01048	0.212
MOD_GlcNHglycan	339	342	PF01048	0.275
MOD_GlcNHglycan	345	348	PF01048	0.360
MOD_GlcNHglycan	434	437	PF01048	0.301
MOD_GlcNHglycan	521	524	PF01048	0.420
MOD_GlcNHglycan	60	63	PF01048	0.441
MOD_GlcNHglycan	68	71	PF01048	0.332
MOD_GlcNHglycan	74	77	PF01048	0.253
MOD_GlcNHglycan	93	96	PF01048	0.290
MOD_GSK3_1	168	175	PF00069	0.329
MOD_GSK3_1	190	197	PF00069	0.472
MOD_GSK3_1	313	320	PF00069	0.236
MOD_GSK3_1	461	468	PF00069	0.273
MOD_GSK3_1	525	532	PF00069	0.255
MOD_GSK3_1	71	78	PF00069	0.264
MOD_GSK3_1	83	90	PF00069	0.250
MOD_N-GLC_1	387	392	PF02516	0.440
MOD_N-GLC_1	397	402	PF02516	0.329
MOD_N-GLC_2	180	182	PF02516	0.186
MOD_N-GLC_2	279	281	PF02516	0.186
MOD_NEK2_1	215	220	PF00069	0.218
MOD_NEK2_1	249	254	PF00069	0.367
MOD_NEK2_1	263	268	PF00069	0.395
MOD_NEK2_1	313	318	PF00069	0.254
MOD_NEK2_1	432	437	PF00069	0.304
MOD_NEK2_2	304	309	PF00069	0.191
MOD_PIKK_1	387	393	PF00454	0.379
MOD_PK_1	3	9	PF00069	0.602
MOD_PKA_2	439	445	PF00069	0.224
MOD_PKB_1	3	11	PF00069	0.485
MOD_PKB_1	410	418	PF00069	0.244
MOD_Plk_1	263	269	PF00069	0.247
MOD_Plk_1	3	9	PF00069	0.454
MOD_Plk_1	361	367	PF00069	0.244
MOD_Plk_1	387	393	PF00069	0.396
MOD_Plk_2-3	137	143	PF00069	0.379
MOD_Plk_4	114	120	PF00069	0.266
MOD_Plk_4	263	269	PF00069	0.334
MOD_Plk_4	291	297	PF00069	0.322
MOD_Plk_4	424	430	PF00069	0.333
MOD_Plk_4	439	445	PF00069	0.220
MOD_Plk_4	543	549	PF00069	0.334
MOD_ProDKin_1	240	246	PF00069	0.219
MOD_ProDKin_1	289	295	PF00069	0.286
MOD_ProDKin_1	463	469	PF00069	0.288
MOD_ProDKin_1	525	531	PF00069	0.489
MOD_ProDKin_1	85	91	PF00069	0.318
MOD_SUMO_for_1	331	334	PF00179	0.346
MOD_SUMO_rev_2	131	138	PF00179	0.219
MOD_SUMO_rev_2	178	188	PF00179	0.333
TRG_DiLeu_BaEn_3	141	147	PF01217	0.261
TRG_ENDOCYTIC_2	106	109	PF00928	0.226
TRG_ENDOCYTIC_2	245	248	PF00928	0.424
TRG_ENDOCYTIC_2	286	289	PF00928	0.224
TRG_ENDOCYTIC_2	310	313	PF00928	0.431
TRG_ENDOCYTIC_2	345	348	PF00928	0.494
TRG_ENDOCYTIC_2	446	449	PF00928	0.376
TRG_ENDOCYTIC_2	498	501	PF00928	0.463
TRG_ENDOCYTIC_2	553	556	PF00928	0.484
TRG_ER_diArg_1	410	413	PF00400	0.257
TRG_NES_CRM1_1	256	270	PF08389	0.250

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL11	Leptomonas seymouri	34%	88%
A0A0S4IP65	Bodo saltans	23%	71%
A0A0S4IUT6	Bodo saltans	27%	70%
A0A0S4IUU1	Bodo saltans	30%	88%
A0A0S4IYM3	Bodo saltans	30%	79%
A0A1L8HYT7	Xenopus laevis	24%	80%
A0A1X0NDG7	Trypanosomatidae	29%	88%
A0A1X0NDJ3	Trypanosomatidae	28%	80%
A0A1X0NDK2	Trypanosomatidae	32%	100%
A0A1X0NDK7	Trypanosomatidae	30%	81%
A0A1X0NDM7	Trypanosomatidae	29%	90%
A0A1X0NDU8	Trypanosomatidae	31%	87%
A0A1X0NE71	Trypanosomatidae	30%	100%
A0A1X0NER9	Trypanosomatidae	30%	90%
A0A1X0NET7	Trypanosomatidae	32%	100%
A0A1X0NEX7	Trypanosomatidae	32%	88%
A0A1X0NEZ6	Trypanosomatidae	29%	88%
A0A1X0NF32	Trypanosomatidae	31%	100%
A0A1X0NF41	Trypanosomatidae	31%	94%
A0A1X0NFJ0	Trypanosomatidae	29%	100%
A0A1X0NFK3	Trypanosomatidae	29%	86%
A0A1X0NFS0	Trypanosomatidae	32%	66%
A0A1X0NFU4	Trypanosomatidae	30%	70%
A0A1X0NG20	Trypanosomatidae	31%	93%
A0A1X0NGP3	Trypanosomatidae	31%	67%
A0A1X0NGY3	Trypanosomatidae	28%	75%
A0A1X0NGZ3	Trypanosomatidae	34%	96%
A0A1X0NHP6	Trypanosomatidae	30%	100%
A0A1X0NHQ6	Trypanosomatidae	30%	100%
A0A1X0NI74	Trypanosomatidae	30%	77%
A0A1X0NII4	Trypanosomatidae	29%	69%
A0A1X0NIZ3	Trypanosomatidae	31%	100%
A0A1X0NJU4	Trypanosomatidae	29%	67%
A0A1X0NK66	Trypanosomatidae	31%	87%
A0A1X0NKJ8	Trypanosomatidae	29%	77%
A0A1X0NKW9	Trypanosomatidae	30%	100%
A0A1X0NME2	Trypanosomatidae	30%	92%
A0A1X0NMK3	Trypanosomatidae	27%	100%
A0A1X0NMK7	Trypanosomatidae	36%	100%
A0A1X0NMV0	Trypanosomatidae	30%	78%
A0A1X0NN43	Trypanosomatidae	28%	80%
A0A1X0NNK8	Trypanosomatidae	31%	88%
A0A1X0NPW0	Trypanosomatidae	30%	90%
A0A1X0NQJ5	Trypanosomatidae	33%	100%
A0A1X0NQM4	Trypanosomatidae	33%	100%
A0A1X0NQN3	Trypanosomatidae	33%	100%
A0A1X0NQU4	Trypanosomatidae	32%	89%
A0A1X0NQW6	Trypanosomatidae	33%	100%
A0A1X0NRF3	Trypanosomatidae	30%	86%
A0A1X0NRY8	Trypanosomatidae	35%	100%
A0A1X0NU16	Trypanosomatidae	34%	96%
A0A1X0NUR2	Trypanosomatidae	33%	78%
A0A1X0NV28	Trypanosomatidae	35%	98%
A0A1X0NVC3	Trypanosomatidae	32%	85%
A0A1X0NVE0	Trypanosomatidae	30%	74%
A0A1X0NW07	Trypanosomatidae	27%	92%
A0A1X0NX94	Trypanosomatidae	30%	89%
A0A1X0NX98	Trypanosomatidae	30%	72%
A0A1X0NXB6	Trypanosomatidae	30%	82%
A0A1X0NXH6	Trypanosomatidae	31%	79%
A0A1X0NXQ4	Trypanosomatidae	29%	85%
A0A1X0NXR7	Trypanosomatidae	34%	77%
A0A1X0NYE3	Trypanosomatidae	29%	92%
A0A1X0NYE7	Trypanosomatidae	31%	100%
A0A1X0NYN2	Trypanosomatidae	31%	100%
A0A1X0NYN4	Trypanosomatidae	28%	81%
A0A1X0NYS5	Trypanosomatidae	31%	96%
A0A1X0NYZ2	Trypanosomatidae	36%	100%
A0A1X0NZ46	Trypanosomatidae	29%	99%
A0A1X0NZ63	Trypanosomatidae	31%	90%
A0A1X0NZN6	Trypanosomatidae	29%	89%
A0A1X0P055	Trypanosomatidae	32%	97%
A0A1X0P0C4	Trypanosomatidae	30%	100%
A0A1X0P154	Trypanosomatidae	29%	96%
A0A1X0P331	Trypanosomatidae	31%	100%
A0A1X0P3K0	Trypanosomatidae	29%	79%
A0A1X0P3S2	Trypanosomatidae	28%	100%
A0A1X0P4L8	Trypanosomatidae	32%	100%
A0A1X0P4Y5	Trypanosomatidae	29%	90%
A0A1X0P544	Trypanosomatidae	31%	90%
A0A1X0P5J0	Trypanosomatidae	31%	84%
A0A1X0P7R3	Trypanosomatidae	34%	100%
A0A1X0P8B4	Trypanosomatidae	34%	100%
A0A1X0P9Z4	Trypanosomatidae	33%	100%
A0A1X0PB04	Trypanosomatidae	31%	100%
A0A3Q8I8N3	Leishmania donovani	59%	96%
A0A3Q8I8P8	Leishmania donovani	60%	96%
A0A3Q8I8S6	Leishmania donovani	62%	90%
A0A3Q8I8S9	Leishmania donovani	60%	96%
A0A3Q8IAZ8	Leishmania donovani	59%	96%
A0A3Q8IC35	Leishmania donovani	59%	96%
A0A3Q8IC44	Leishmania donovani	60%	98%
A0A3Q8IH61	Leishmania donovani	59%	98%
A0A3Q8IIN4	Leishmania donovani	35%	91%
A0A3R7JT49	Trypanosoma rangeli	33%	68%
A0A3R7JTB6	Trypanosoma rangeli	32%	82%
A0A3R7JUS0	Trypanosoma rangeli	33%	100%
A0A3R7JV87	Trypanosoma rangeli	32%	100%
A0A3R7K7T9	Trypanosoma rangeli	34%	96%
A0A3R7K9S1	Trypanosoma rangeli	33%	100%
A0A3R7KLR6	Trypanosoma rangeli	30%	90%
A0A3R7KMY2	Trypanosoma rangeli	33%	86%
A0A3R7LFC4	Trypanosoma rangeli	32%	86%
A0A3R7LFZ4	Trypanosoma rangeli	35%	100%
A0A3R7LWG1	Trypanosoma rangeli	31%	100%
A0A3R7LX11	Trypanosoma rangeli	33%	100%
A0A3R7M1R8	Trypanosoma rangeli	34%	100%
A0A3R7M574	Trypanosoma rangeli	32%	90%
A0A3R7M7N6	Trypanosoma rangeli	33%	84%
A0A3R7MTS2	Trypanosoma rangeli	38%	100%
A0A3R7MW36	Trypanosoma rangeli	30%	100%
A0A3R7MXF4	Trypanosoma rangeli	35%	94%
A0A3R7N1W7	Trypanosoma rangeli	33%	99%
A0A3R7N289	Trypanosoma rangeli	32%	80%
A0A3R7N7I3	Trypanosoma rangeli	38%	100%
A0A3R7NTI8	Trypanosoma rangeli	33%	100%
A0A3R7R2J4	Trypanosoma rangeli	32%	89%
A0A3R7R5R1	Trypanosoma rangeli	34%	96%
A0A3R7R818	Trypanosoma rangeli	32%	100%
A0A3S5H6G0	Leishmania donovani	60%	96%
A0A3S5IQY2	Trypanosoma rangeli	36%	100%
A0A3S7WR43	Leishmania donovani	59%	96%
A0A3S7WR46	Leishmania donovani	60%	96%
A0A3S7WR60	Leishmania donovani	60%	96%
A0A3S7X192	Leishmania donovani	34%	100%
A0A422MP17	Trypanosoma rangeli	35%	100%
A0A422MRQ6	Trypanosoma rangeli	34%	77%
A0A422MTE4	Trypanosoma rangeli	32%	100%
A0A422MU95	Trypanosoma rangeli	33%	100%
A0A422MVF5	Trypanosoma rangeli	32%	100%
A0A422MVS3	Trypanosoma rangeli	33%	100%
A0A422MW99	Trypanosoma rangeli	30%	78%
A0A422MZ47	Trypanosoma rangeli	37%	100%
A0A422MZG4	Trypanosoma rangeli	33%	98%
A0A422N361	Trypanosoma rangeli	31%	100%
A0A422N7Q6	Trypanosoma rangeli	32%	89%
A0A422NDS2	Trypanosoma rangeli	31%	99%
A0A422NDT3	Trypanosoma rangeli	30%	100%
A0A422NP82	Trypanosoma rangeli	37%	100%
A4H626	Leishmania braziliensis	79%	100%
A4H627	Leishmania braziliensis	81%	100%
A4H629	Leishmania braziliensis	71%	100%
A4H630	Leishmania braziliensis	72%	100%
A4H631	Leishmania braziliensis	74%	98%
A4H632	Leishmania braziliensis	70%	100%
A4H633	Leishmania braziliensis	74%	98%
A4H634	Leishmania braziliensis	73%	100%
A4H635	Leishmania braziliensis	73%	100%
A4H636	Leishmania braziliensis	78%	100%
A4H637	Leishmania braziliensis	73%	100%
A4H638	Leishmania braziliensis	62%	100%
A4H639	Leishmania braziliensis	66%	100%
A4H640	Leishmania braziliensis	72%	100%
A4H6D1	Leishmania braziliensis	76%	100%
A4H6D3	Leishmania braziliensis	96%	100%
A4H6D5	Leishmania braziliensis	85%	100%
A4H6D7	Leishmania braziliensis	80%	100%
A4H6D8	Leishmania braziliensis	77%	100%
A4H6D9	Leishmania braziliensis	79%	100%
A4H6E0	Leishmania braziliensis	82%	100%
A4H6E1	Leishmania braziliensis	96%	100%
A4H6E3	Leishmania braziliensis	77%	100%
A4H6E4	Leishmania braziliensis	75%	100%
A4H6E5	Leishmania braziliensis	67%	100%
A4HJI2	Leishmania braziliensis	35%	89%
A4HUF6	Leishmania infantum	59%	96%
A4HUF8	Leishmania infantum	60%	96%
A4HUF9	Leishmania infantum	62%	90%
A4HUG0	Leishmania infantum	59%	76%
A4I6X5	Leishmania infantum	36%	91%
C9ZUT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	99%
D0A1R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	98%
D0A7S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	85%
D0A855	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	94%
E9AHH5	Leishmania infantum	35%	100%
E9AN53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	88%
E9AN54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	96%
E9AN55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	90%
E9AN56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	89%
E9AN57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	96%
E9AZL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9B1Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	91%
P08148	Leishmania major	60%	96%
P15706	Leishmania chagasi	60%	96%
P23223	Leishmania donovani	59%	98%
P43150	Leishmania mexicana	61%	89%
Q00689	Leishmania guyanensis	70%	93%
Q06031	Crithidia fasciculata	51%	88%
Q27673	Leishmania amazonensis	57%	97%
Q29AK2	Drosophila pseudoobscura pseudoobscura	23%	84%
Q4Q662	Leishmania major	34%	100%
Q4Q8L3	Leishmania major	35%	100%
Q4QHG9	Leishmania major	59%	100%
Q4QHH0	Leishmania major	60%	100%
Q4QHH1	Leishmania major	59%	100%
Q4QHH2	Leishmania major	59%	100%
Q61YG1	Caenorhabditis briggsae	24%	87%
Q6LA77	Leishmania infantum	60%	96%
Q8MNZ1	Leishmania tropica	61%	88%
Q9VH19	Drosophila melanogaster	23%	84%
V5A303	Trypanosoma cruzi	37%	100%
V5A359	Trypanosoma cruzi	36%	100%
V5A488	Trypanosoma cruzi	32%	71%
V5AII7	Trypanosoma cruzi	36%	100%
V5AN34	Trypanosoma cruzi	37%	100%
V5APQ4	Trypanosoma cruzi	32%	73%
V5AX72	Trypanosoma cruzi	34%	78%
V5B5M0	Trypanosoma cruzi	34%	78%
V5BAN1	Trypanosoma cruzi	33%	73%
V5BD39	Trypanosoma cruzi	38%	100%
V5BLT3	Trypanosoma cruzi	32%	92%
V5CI97	Trypanosoma cruzi	30%	90%
V5D358	Trypanosoma cruzi	33%	68%