Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)
by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 2 |
| Forrest at al. (procyclic) | no | yes: 4 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 51 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | yes | yes: 41, no: 10 |
| NetGPI | no | yes: 0, no: 51 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 52 |
| GO:0110165 | cellular anatomical entity | 1 | 52 |
| GO:0005737 | cytoplasm | 2 | 4 |
| GO:0018995 | host cellular component | 2 | 4 |
| GO:0033643 | host cell part | 3 | 4 |
| GO:0033646 | host intracellular part | 4 | 4 |
| GO:0033647 | host intracellular organelle | 5 | 4 |
| GO:0033648 | host intracellular membrane-bounded organelle | 6 | 4 |
| GO:0042025 | host cell nucleus | 7 | 4 |
Related structures:
AlphaFold database: A4H6D9
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006508 | proteolysis | 4 | 52 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 52 |
| GO:0007155 | cell adhesion | 2 | 52 |
| GO:0008152 | metabolic process | 1 | 52 |
| GO:0009987 | cellular process | 1 | 52 |
| GO:0019538 | protein metabolic process | 3 | 52 |
| GO:0043170 | macromolecule metabolic process | 3 | 52 |
| GO:0044238 | primary metabolic process | 2 | 52 |
| GO:0071704 | organic substance metabolic process | 2 | 52 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 52 |
| GO:0009966 | regulation of signal transduction | 4 | 4 |
| GO:0010646 | regulation of cell communication | 4 | 4 |
| GO:0010749 | regulation of nitric oxide mediated signal transduction | 6 | 4 |
| GO:0023051 | regulation of signaling | 3 | 4 |
| GO:0035821 | modulation of process of another organism | 2 | 4 |
| GO:0044003 | modulation by symbiont of host process | 3 | 4 |
| GO:0044068 | modulation by symbiont of host cellular process | 4 | 4 |
| GO:0044081 | modulation by symbiont of host nitric oxide-mediated signal transduction | 5 | 4 |
| GO:0044403 | biological process involved in symbiotic interaction | 2 | 4 |
| GO:0044419 | biological process involved in interspecies interaction between organisms | 1 | 4 |
| GO:0044501 | modulation of signal transduction in another organism | 3 | 4 |
| GO:0048583 | regulation of response to stimulus | 3 | 4 |
| GO:0050789 | regulation of biological process | 2 | 4 |
| GO:0050794 | regulation of cellular process | 3 | 4 |
| GO:0051701 | biological process involved in interaction with host | 3 | 4 |
| GO:0052027 | modulation by symbiont of host signal transduction pathway | 4 | 4 |
| GO:0065007 | biological regulation | 1 | 4 |
| GO:0075130 | modulation by symbiont of host protein kinase-mediated signal transduction | 5 | 4 |
| GO:1902531 | regulation of intracellular signal transduction | 5 | 4 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 52 |
| GO:0004175 | endopeptidase activity | 4 | 52 |
| GO:0004222 | metalloendopeptidase activity | 5 | 52 |
| GO:0005488 | binding | 1 | 52 |
| GO:0008233 | peptidase activity | 3 | 52 |
| GO:0008237 | metallopeptidase activity | 4 | 52 |
| GO:0016787 | hydrolase activity | 2 | 52 |
| GO:0043167 | ion binding | 2 | 52 |
| GO:0043169 | cation binding | 3 | 52 |
| GO:0046872 | metal ion binding | 4 | 52 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 52 |
| GO:0008047 | enzyme activator activity | 3 | 4 |
| GO:0008160 | protein tyrosine phosphatase activator activity | 6 | 4 |
| GO:0019208 | phosphatase regulator activity | 3 | 4 |
| GO:0019211 | phosphatase activator activity | 4 | 4 |
| GO:0019888 | protein phosphatase regulator activity | 4 | 4 |
| GO:0030234 | enzyme regulator activity | 2 | 4 |
| GO:0072542 | protein phosphatase activator activity | 5 | 4 |
| GO:0098772 | molecular function regulator activity | 1 | 4 |
| GO:0140677 | molecular function activator activity | 2 | 4 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 11 | 13 | PF00675 | 0.608 |
| CLV_NRD_NRD_1 | 409 | 411 | PF00675 | 0.420 |
| CLV_PCSK_KEX2_1 | 10 | 12 | PF00082 | 0.615 |
| CLV_PCSK_KEX2_1 | 150 | 152 | PF00082 | 0.570 |
| CLV_PCSK_KEX2_1 | 409 | 411 | PF00082 | 0.419 |
| CLV_PCSK_PC1ET2_1 | 150 | 152 | PF00082 | 0.559 |
| CLV_PCSK_SKI1_1 | 336 | 340 | PF00082 | 0.493 |
| CLV_PCSK_SKI1_1 | 437 | 441 | PF00082 | 0.410 |
| DEG_SPOP_SBC_1 | 543 | 547 | PF00917 | 0.195 |
| DEG_SPOP_SBC_1 | 91 | 95 | PF00917 | 0.263 |
| DOC_MAPK_gen_1 | 288 | 296 | PF00069 | 0.332 |
| DOC_PP2B_LxvP_1 | 342 | 345 | PF13499 | 0.378 |
| DOC_PP2B_LxvP_1 | 70 | 73 | PF13499 | 0.263 |
| DOC_PP4_FxxP_1 | 192 | 195 | PF00568 | 0.398 |
| DOC_USP7_MATH_1 | 472 | 476 | PF00917 | 0.250 |
| DOC_USP7_MATH_1 | 495 | 499 | PF00917 | 0.287 |
| DOC_USP7_MATH_1 | 543 | 547 | PF00917 | 0.233 |
| DOC_USP7_MATH_1 | 73 | 77 | PF00917 | 0.267 |
| DOC_USP7_MATH_1 | 79 | 83 | PF00917 | 0.245 |
| DOC_WW_Pin1_4 | 296 | 301 | PF00397 | 0.258 |
| DOC_WW_Pin1_4 | 470 | 475 | PF00397 | 0.254 |
| DOC_WW_Pin1_4 | 491 | 496 | PF00397 | 0.232 |
| DOC_WW_Pin1_4 | 532 | 537 | PF00397 | 0.398 |
| DOC_WW_Pin1_4 | 92 | 97 | PF00397 | 0.281 |
| LIG_14-3-3_CanoR_1 | 108 | 114 | PF00244 | 0.380 |
| LIG_14-3-3_CanoR_1 | 151 | 155 | PF00244 | 0.221 |
| LIG_14-3-3_CanoR_1 | 5 | 14 | PF00244 | 0.628 |
| LIG_14-3-3_CanoR_1 | 516 | 522 | PF00244 | 0.364 |
| LIG_14-3-3_CanoR_1 | 52 | 58 | PF00244 | 0.371 |
| LIG_APCC_ABBA_1 | 163 | 168 | PF00400 | 0.398 |
| LIG_APCC_ABBA_1 | 357 | 362 | PF00400 | 0.373 |
| LIG_APCC_ABBA_1 | 479 | 484 | PF00400 | 0.398 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.700 |
| LIG_BRCT_BRCA1_1 | 382 | 386 | PF00533 | 0.265 |
| LIG_BRCT_BRCA1_1 | 446 | 450 | PF00533 | 0.203 |
| LIG_BRCT_BRCA1_1 | 545 | 549 | PF00533 | 0.398 |
| LIG_CaM_IQ_9 | 172 | 187 | PF13499 | 0.184 |
| LIG_FHA_1 | 104 | 110 | PF00498 | 0.317 |
| LIG_FHA_1 | 165 | 171 | PF00498 | 0.319 |
| LIG_FHA_1 | 176 | 182 | PF00498 | 0.304 |
| LIG_FHA_1 | 189 | 195 | PF00498 | 0.300 |
| LIG_FHA_1 | 198 | 204 | PF00498 | 0.284 |
| LIG_FHA_1 | 243 | 249 | PF00498 | 0.218 |
| LIG_FHA_1 | 354 | 360 | PF00498 | 0.389 |
| LIG_FHA_1 | 420 | 426 | PF00498 | 0.306 |
| LIG_FHA_1 | 518 | 524 | PF00498 | 0.380 |
| LIG_FHA_1 | 545 | 551 | PF00498 | 0.276 |
| LIG_FHA_2 | 115 | 121 | PF00498 | 0.231 |
| LIG_FHA_2 | 271 | 277 | PF00498 | 0.248 |
| LIG_FHA_2 | 314 | 320 | PF00498 | 0.216 |
| LIG_FHA_2 | 369 | 375 | PF00498 | 0.233 |
| LIG_GBD_Chelix_1 | 264 | 272 | PF00786 | 0.428 |
| LIG_LIR_Apic_2 | 191 | 195 | PF02991 | 0.384 |
| LIG_LIR_Apic_2 | 289 | 295 | PF02991 | 0.287 |
| LIG_LIR_Apic_2 | 408 | 414 | PF02991 | 0.228 |
| LIG_LIR_Gen_1 | 112 | 119 | PF02991 | 0.219 |
| LIG_LIR_Gen_1 | 250 | 260 | PF02991 | 0.352 |
| LIG_LIR_Gen_1 | 273 | 281 | PF02991 | 0.257 |
| LIG_LIR_Gen_1 | 314 | 322 | PF02991 | 0.397 |
| LIG_LIR_Gen_1 | 478 | 485 | PF02991 | 0.275 |
| LIG_LIR_Nem_3 | 101 | 107 | PF02991 | 0.288 |
| LIG_LIR_Nem_3 | 112 | 116 | PF02991 | 0.259 |
| LIG_LIR_Nem_3 | 120 | 125 | PF02991 | 0.208 |
| LIG_LIR_Nem_3 | 206 | 211 | PF02991 | 0.376 |
| LIG_LIR_Nem_3 | 250 | 255 | PF02991 | 0.352 |
| LIG_LIR_Nem_3 | 273 | 278 | PF02991 | 0.258 |
| LIG_LIR_Nem_3 | 314 | 320 | PF02991 | 0.361 |
| LIG_LIR_Nem_3 | 362 | 366 | PF02991 | 0.217 |
| LIG_LIR_Nem_3 | 434 | 439 | PF02991 | 0.320 |
| LIG_LIR_Nem_3 | 447 | 453 | PF02991 | 0.277 |
| LIG_LIR_Nem_3 | 478 | 482 | PF02991 | 0.283 |
| LIG_Pex14_1 | 399 | 403 | PF04695 | 0.387 |
| LIG_PTB_Apo_2 | 202 | 209 | PF02174 | 0.387 |
| LIG_SH2_CRK | 252 | 256 | PF00017 | 0.348 |
| LIG_SH2_CRK | 352 | 356 | PF00017 | 0.402 |
| LIG_SH2_CRK | 411 | 415 | PF00017 | 0.233 |
| LIG_SH2_CRK | 453 | 457 | PF00017 | 0.275 |
| LIG_SH2_CRK | 505 | 509 | PF00017 | 0.361 |
| LIG_SH2_GRB2like | 352 | 355 | PF00017 | 0.208 |
| LIG_SH2_PTP2 | 560 | 563 | PF00017 | 0.395 |
| LIG_SH2_SRC | 560 | 563 | PF00017 | 0.395 |
| LIG_SH2_STAP1 | 252 | 256 | PF00017 | 0.356 |
| LIG_SH2_STAP1 | 521 | 525 | PF00017 | 0.398 |
| LIG_SH2_STAT3 | 125 | 128 | PF00017 | 0.256 |
| LIG_SH2_STAT3 | 521 | 524 | PF00017 | 0.384 |
| LIG_SH2_STAT5 | 110 | 113 | PF00017 | 0.233 |
| LIG_SH2_STAT5 | 122 | 125 | PF00017 | 0.239 |
| LIG_SH2_STAT5 | 211 | 214 | PF00017 | 0.380 |
| LIG_SH2_STAT5 | 247 | 250 | PF00017 | 0.211 |
| LIG_SH2_STAT5 | 352 | 355 | PF00017 | 0.326 |
| LIG_SH2_STAT5 | 435 | 438 | PF00017 | 0.383 |
| LIG_SH2_STAT5 | 453 | 456 | PF00017 | 0.214 |
| LIG_SH2_STAT5 | 531 | 534 | PF00017 | 0.332 |
| LIG_SH2_STAT5 | 554 | 557 | PF00017 | 0.395 |
| LIG_SH2_STAT5 | 560 | 563 | PF00017 | 0.329 |
| LIG_SH2_STAT5 | 74 | 77 | PF00017 | 0.369 |
| LIG_SH3_3 | 238 | 244 | PF00018 | 0.202 |
| LIG_SH3_3 | 498 | 504 | PF00018 | 0.235 |
| LIG_SUMO_SIM_anti_2 | 276 | 283 | PF11976 | 0.227 |
| LIG_TYR_ITIM | 111 | 116 | PF00017 | 0.228 |
| MOD_CDK_SPK_2 | 491 | 496 | PF00069 | 0.253 |
| MOD_CDK_SPxxK_3 | 470 | 477 | PF00069 | 0.220 |
| MOD_CDK_SPxxK_3 | 532 | 539 | PF00069 | 0.404 |
| MOD_CK1_1 | 214 | 220 | PF00069 | 0.480 |
| MOD_CK1_1 | 298 | 304 | PF00069 | 0.229 |
| MOD_CK1_1 | 470 | 476 | PF00069 | 0.353 |
| MOD_CK1_1 | 480 | 486 | PF00069 | 0.276 |
| MOD_CK1_1 | 82 | 88 | PF00069 | 0.312 |
| MOD_CK2_1 | 313 | 319 | PF00069 | 0.250 |
| MOD_CK2_1 | 368 | 374 | PF00069 | 0.493 |
| MOD_CK2_1 | 472 | 478 | PF00069 | 0.266 |
| MOD_GlcNHglycan | 100 | 103 | PF01048 | 0.294 |
| MOD_GlcNHglycan | 216 | 219 | PF01048 | 0.202 |
| MOD_GlcNHglycan | 249 | 252 | PF01048 | 0.246 |
| MOD_GlcNHglycan | 325 | 328 | PF01048 | 0.406 |
| MOD_GlcNHglycan | 528 | 531 | PF01048 | 0.421 |
| MOD_GlcNHglycan | 67 | 70 | PF01048 | 0.451 |
| MOD_GlcNHglycan | 75 | 78 | PF01048 | 0.337 |
| MOD_GlcNHglycan | 81 | 84 | PF01048 | 0.256 |
| MOD_GSK3_1 | 175 | 182 | PF00069 | 0.334 |
| MOD_GSK3_1 | 197 | 204 | PF00069 | 0.483 |
| MOD_GSK3_1 | 440 | 447 | PF00069 | 0.222 |
| MOD_GSK3_1 | 468 | 475 | PF00069 | 0.276 |
| MOD_GSK3_1 | 491 | 498 | PF00069 | 0.253 |
| MOD_GSK3_1 | 78 | 85 | PF00069 | 0.267 |
| MOD_GSK3_1 | 90 | 97 | PF00069 | 0.253 |
| MOD_N-GLC_1 | 353 | 358 | PF02516 | 0.220 |
| MOD_N-GLC_1 | 394 | 399 | PF02516 | 0.394 |
| MOD_N-GLC_1 | 404 | 409 | PF02516 | 0.242 |
| MOD_NEK2_1 | 256 | 261 | PF00069 | 0.369 |
| MOD_NEK2_1 | 270 | 275 | PF00069 | 0.391 |
| MOD_NEK2_1 | 320 | 325 | PF00069 | 0.257 |
| MOD_NEK2_1 | 328 | 333 | PF00069 | 0.227 |
| MOD_NEK2_1 | 439 | 444 | PF00069 | 0.305 |
| MOD_NEK2_1 | 542 | 547 | PF00069 | 0.226 |
| MOD_PIKK_1 | 394 | 400 | PF00454 | 0.373 |
| MOD_PK_1 | 10 | 16 | PF00069 | 0.631 |
| MOD_PK_1 | 477 | 483 | PF00069 | 0.218 |
| MOD_PKA_1 | 10 | 16 | PF00069 | 0.565 |
| MOD_PKA_1 | 150 | 156 | PF00069 | 0.249 |
| MOD_PKA_2 | 150 | 156 | PF00069 | 0.249 |
| MOD_PKA_2 | 4 | 10 | PF00069 | 0.565 |
| MOD_PKB_1 | 3 | 11 | PF00069 | 0.548 |
| MOD_PKB_1 | 410 | 418 | PF00069 | 0.253 |
| MOD_Plk_1 | 270 | 276 | PF00069 | 0.249 |
| MOD_Plk_1 | 353 | 359 | PF00069 | 0.235 |
| MOD_Plk_1 | 394 | 400 | PF00069 | 0.372 |
| MOD_Plk_1 | 477 | 483 | PF00069 | 0.238 |
| MOD_Plk_2-3 | 114 | 120 | PF00069 | 0.189 |
| MOD_Plk_4 | 150 | 156 | PF00069 | 0.297 |
| MOD_Plk_4 | 298 | 304 | PF00069 | 0.317 |
| MOD_Plk_4 | 313 | 319 | PF00069 | 0.220 |
| MOD_Plk_4 | 421 | 427 | PF00069 | 0.262 |
| MOD_Plk_4 | 431 | 437 | PF00069 | 0.325 |
| MOD_Plk_4 | 550 | 556 | PF00069 | 0.327 |
| MOD_ProDKin_1 | 296 | 302 | PF00069 | 0.290 |
| MOD_ProDKin_1 | 470 | 476 | PF00069 | 0.285 |
| MOD_ProDKin_1 | 491 | 497 | PF00069 | 0.255 |
| MOD_ProDKin_1 | 532 | 538 | PF00069 | 0.487 |
| MOD_ProDKin_1 | 92 | 98 | PF00069 | 0.323 |
| MOD_SUMO_for_1 | 338 | 341 | PF00179 | 0.340 |
| MOD_SUMO_rev_2 | 279 | 287 | PF00179 | 0.204 |
| TRG_ENDOCYTIC_2 | 113 | 116 | PF00928 | 0.228 |
| TRG_ENDOCYTIC_2 | 252 | 255 | PF00928 | 0.433 |
| TRG_ENDOCYTIC_2 | 352 | 355 | PF00928 | 0.493 |
| TRG_ENDOCYTIC_2 | 453 | 456 | PF00928 | 0.373 |
| TRG_ENDOCYTIC_2 | 505 | 508 | PF00928 | 0.463 |
| TRG_ENDOCYTIC_2 | 560 | 563 | PF00928 | 0.482 |
| TRG_ER_diArg_1 | 10 | 12 | PF00400 | 0.614 |
| TRG_ER_diArg_1 | 409 | 411 | PF00400 | 0.256 |
| TRG_NES_CRM1_1 | 271 | 283 | PF08389 | 0.264 |
| TRG_Pf-PMV_PEXEL_1 | 285 | 289 | PF00026 | 0.187 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IL11 | Leptomonas seymouri | 34% | 89% |
| A0A0S4IP65 | Bodo saltans | 23% | 72% |
| A0A0S4IUT6 | Bodo saltans | 29% | 71% |
| A0A0S4IUU1 | Bodo saltans | 30% | 89% |
| A0A0S4IYM3 | Bodo saltans | 29% | 80% |
| A0A1X0NDG7 | Trypanosomatidae | 30% | 89% |
| A0A1X0NDJ3 | Trypanosomatidae | 28% | 81% |
| A0A1X0NDK2 | Trypanosomatidae | 33% | 100% |
| A0A1X0NDK7 | Trypanosomatidae | 32% | 82% |
| A0A1X0NDK9 | Trypanosomatidae | 31% | 100% |
| A0A1X0NDM7 | Trypanosomatidae | 30% | 91% |
| A0A1X0NDU8 | Trypanosomatidae | 32% | 88% |
| A0A1X0NE71 | Trypanosomatidae | 31% | 100% |
| A0A1X0NER9 | Trypanosomatidae | 34% | 91% |
| A0A1X0NET7 | Trypanosomatidae | 33% | 100% |
| A0A1X0NEX7 | Trypanosomatidae | 32% | 89% |
| A0A1X0NEZ6 | Trypanosomatidae | 31% | 89% |
| A0A1X0NF32 | Trypanosomatidae | 33% | 100% |
| A0A1X0NF41 | Trypanosomatidae | 31% | 95% |
| A0A1X0NFJ0 | Trypanosomatidae | 29% | 100% |
| A0A1X0NFK3 | Trypanosomatidae | 31% | 87% |
| A0A1X0NFS0 | Trypanosomatidae | 33% | 67% |
| A0A1X0NFU4 | Trypanosomatidae | 31% | 71% |
| A0A1X0NFZ9 | Trypanosomatidae | 32% | 100% |
| A0A1X0NG20 | Trypanosomatidae | 32% | 94% |
| A0A1X0NGP3 | Trypanosomatidae | 31% | 68% |
| A0A1X0NGY3 | Trypanosomatidae | 30% | 76% |
| A0A1X0NGZ3 | Trypanosomatidae | 34% | 97% |
| A0A1X0NH86 | Trypanosomatidae | 33% | 66% |
| A0A1X0NHP6 | Trypanosomatidae | 33% | 100% |
| A0A1X0NHQ6 | Trypanosomatidae | 32% | 100% |
| A0A1X0NI38 | Trypanosomatidae | 29% | 66% |
| A0A1X0NI74 | Trypanosomatidae | 33% | 78% |
| A0A1X0NII4 | Trypanosomatidae | 30% | 69% |
| A0A1X0NIZ3 | Trypanosomatidae | 32% | 100% |
| A0A1X0NJS3 | Trypanosomatidae | 30% | 89% |
| A0A1X0NJU4 | Trypanosomatidae | 30% | 68% |
| A0A1X0NK66 | Trypanosomatidae | 34% | 88% |
| A0A1X0NKJ8 | Trypanosomatidae | 29% | 78% |
| A0A1X0NKW9 | Trypanosomatidae | 29% | 100% |
| A0A1X0NME2 | Trypanosomatidae | 32% | 93% |
| A0A1X0NMK3 | Trypanosomatidae | 29% | 100% |
| A0A1X0NMK7 | Trypanosomatidae | 39% | 100% |
| A0A1X0NMV0 | Trypanosomatidae | 32% | 79% |
| A0A1X0NN43 | Trypanosomatidae | 30% | 81% |
| A0A1X0NNK8 | Trypanosomatidae | 30% | 89% |
| A0A1X0NPW0 | Trypanosomatidae | 32% | 91% |
| A0A1X0NQM4 | Trypanosomatidae | 36% | 100% |
| A0A1X0NQN3 | Trypanosomatidae | 36% | 100% |
| A0A1X0NQU4 | Trypanosomatidae | 35% | 91% |
| A0A1X0NQW6 | Trypanosomatidae | 35% | 100% |
| A0A1X0NRF3 | Trypanosomatidae | 32% | 87% |
| A0A1X0NRY8 | Trypanosomatidae | 38% | 100% |
| A0A1X0NU16 | Trypanosomatidae | 37% | 97% |
| A0A1X0NUR2 | Trypanosomatidae | 33% | 79% |
| A0A1X0NV28 | Trypanosomatidae | 37% | 99% |
| A0A1X0NVC3 | Trypanosomatidae | 31% | 86% |
| A0A1X0NVE0 | Trypanosomatidae | 30% | 75% |
| A0A1X0NW07 | Trypanosomatidae | 30% | 93% |
| A0A1X0NX94 | Trypanosomatidae | 31% | 90% |
| A0A1X0NX98 | Trypanosomatidae | 32% | 73% |
| A0A1X0NXB6 | Trypanosomatidae | 32% | 83% |
| A0A1X0NXH6 | Trypanosomatidae | 32% | 80% |
| A0A1X0NXQ4 | Trypanosomatidae | 32% | 86% |
| A0A1X0NXR7 | Trypanosomatidae | 33% | 78% |
| A0A1X0NYE3 | Trypanosomatidae | 31% | 93% |
| A0A1X0NYE7 | Trypanosomatidae | 32% | 100% |
| A0A1X0NYN2 | Trypanosomatidae | 34% | 100% |
| A0A1X0NYN4 | Trypanosomatidae | 30% | 82% |
| A0A1X0NYS5 | Trypanosomatidae | 32% | 97% |
| A0A1X0NYZ2 | Trypanosomatidae | 38% | 100% |
| A0A1X0NZ46 | Trypanosomatidae | 31% | 100% |
| A0A1X0NZ63 | Trypanosomatidae | 33% | 92% |
| A0A1X0NZN6 | Trypanosomatidae | 29% | 90% |
| A0A1X0P055 | Trypanosomatidae | 34% | 99% |
| A0A1X0P0C4 | Trypanosomatidae | 32% | 100% |
| A0A1X0P154 | Trypanosomatidae | 32% | 97% |
| A0A1X0P331 | Trypanosomatidae | 33% | 100% |
| A0A1X0P3K0 | Trypanosomatidae | 30% | 80% |
| A0A1X0P3S2 | Trypanosomatidae | 29% | 100% |
| A0A1X0P4L8 | Trypanosomatidae | 32% | 100% |
| A0A1X0P4Y5 | Trypanosomatidae | 31% | 91% |
| A0A1X0P544 | Trypanosomatidae | 31% | 91% |
| A0A1X0P5J0 | Trypanosomatidae | 31% | 85% |
| A0A1X0P7R3 | Trypanosomatidae | 35% | 100% |
| A0A1X0P8B4 | Trypanosomatidae | 34% | 100% |
| A0A1X0P9Z4 | Trypanosomatidae | 31% | 100% |
| A0A1X0PB04 | Trypanosomatidae | 32% | 100% |
| A0A3Q8I8N3 | Leishmania donovani | 56% | 98% |
| A0A3Q8I8P8 | Leishmania donovani | 57% | 97% |
| A0A3Q8I8S6 | Leishmania donovani | 58% | 91% |
| A0A3Q8I8S9 | Leishmania donovani | 57% | 97% |
| A0A3Q8IAZ8 | Leishmania donovani | 57% | 98% |
| A0A3Q8IC35 | Leishmania donovani | 57% | 98% |
| A0A3Q8IC44 | Leishmania donovani | 57% | 99% |
| A0A3Q8IH61 | Leishmania donovani | 56% | 99% |
| A0A3Q8IIN4 | Leishmania donovani | 35% | 92% |
| A0A3R7JT49 | Trypanosoma rangeli | 35% | 69% |
| A0A3R7JTB6 | Trypanosoma rangeli | 32% | 83% |
| A0A3R7JV87 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7K7T9 | Trypanosoma rangeli | 35% | 97% |
| A0A3R7K9S1 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7KB14 | Trypanosoma rangeli | 34% | 67% |
| A0A3R7KLR6 | Trypanosoma rangeli | 32% | 91% |
| A0A3R7KMY2 | Trypanosoma rangeli | 35% | 87% |
| A0A3R7LFC4 | Trypanosoma rangeli | 35% | 87% |
| A0A3R7LFZ4 | Trypanosoma rangeli | 37% | 100% |
| A0A3R7LWG1 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7LX11 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7M1R8 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7M574 | Trypanosoma rangeli | 33% | 91% |
| A0A3R7M7N6 | Trypanosoma rangeli | 34% | 85% |
| A0A3R7MTS2 | Trypanosoma rangeli | 40% | 100% |
| A0A3R7MW36 | Trypanosoma rangeli | 32% | 100% |
| A0A3R7MXF4 | Trypanosoma rangeli | 35% | 95% |
| A0A3R7N1W7 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7N289 | Trypanosoma rangeli | 33% | 81% |
| A0A3R7N7I3 | Trypanosoma rangeli | 39% | 100% |
| A0A3R7NTI8 | Trypanosoma rangeli | 33% | 100% |
| A0A3R7R2J4 | Trypanosoma rangeli | 34% | 90% |
| A0A3R7R5R1 | Trypanosoma rangeli | 36% | 97% |
| A0A3R7R818 | Trypanosoma rangeli | 33% | 100% |
| A0A3S5H6G0 | Leishmania donovani | 57% | 97% |
| A0A3S5IQY2 | Trypanosoma rangeli | 36% | 100% |
| A0A3S7WR43 | Leishmania donovani | 57% | 98% |
| A0A3S7WR46 | Leishmania donovani | 57% | 97% |
| A0A3S7WR60 | Leishmania donovani | 57% | 97% |
| A0A3S7X192 | Leishmania donovani | 37% | 100% |
| A0A422MRQ6 | Trypanosoma rangeli | 36% | 78% |
| A0A422MTE4 | Trypanosoma rangeli | 32% | 100% |
| A0A422MU95 | Trypanosoma rangeli | 34% | 100% |
| A0A422MVF5 | Trypanosoma rangeli | 33% | 100% |
| A0A422MVS3 | Trypanosoma rangeli | 36% | 100% |
| A0A422MW99 | Trypanosoma rangeli | 32% | 78% |
| A0A422MZ47 | Trypanosoma rangeli | 39% | 100% |
| A0A422MZG4 | Trypanosoma rangeli | 35% | 99% |
| A0A422N361 | Trypanosoma rangeli | 34% | 100% |
| A0A422N7Q6 | Trypanosoma rangeli | 34% | 90% |
| A0A422NDS2 | Trypanosoma rangeli | 33% | 100% |
| A0A422NDT3 | Trypanosoma rangeli | 31% | 100% |
| A0A422NP82 | Trypanosoma rangeli | 40% | 100% |
| A4H626 | Leishmania braziliensis | 80% | 99% |
| A4H627 | Leishmania braziliensis | 77% | 100% |
| A4H630 | Leishmania braziliensis | 71% | 100% |
| A4H631 | Leishmania braziliensis | 80% | 98% |
| A4H632 | Leishmania braziliensis | 67% | 100% |
| A4H633 | Leishmania braziliensis | 78% | 99% |
| A4H634 | Leishmania braziliensis | 72% | 100% |
| A4H635 | Leishmania braziliensis | 71% | 100% |
| A4H636 | Leishmania braziliensis | 73% | 100% |
| A4H637 | Leishmania braziliensis | 72% | 100% |
| A4H638 | Leishmania braziliensis | 62% | 100% |
| A4H639 | Leishmania braziliensis | 68% | 100% |
| A4H640 | Leishmania braziliensis | 72% | 100% |
| A4H6D1 | Leishmania braziliensis | 80% | 100% |
| A4H6D3 | Leishmania braziliensis | 81% | 100% |
| A4H6D5 | Leishmania braziliensis | 86% | 100% |
| A4H6D7 | Leishmania braziliensis | 76% | 100% |
| A4H6D8 | Leishmania braziliensis | 97% | 100% |
| A4H6E0 | Leishmania braziliensis | 92% | 82% |
| A4H6E1 | Leishmania braziliensis | 78% | 100% |
| A4H6E2 | Leishmania braziliensis | 79% | 100% |
| A4H6E3 | Leishmania braziliensis | 84% | 100% |
| A4H6E4 | Leishmania braziliensis | 81% | 100% |
| A4H6E5 | Leishmania braziliensis | 63% | 100% |
| A4HJI2 | Leishmania braziliensis | 36% | 90% |
| A4HUF6 | Leishmania infantum | 56% | 98% |
| A4HUF8 | Leishmania infantum | 57% | 97% |
| A4HUF9 | Leishmania infantum | 58% | 91% |
| A4HUG0 | Leishmania infantum | 57% | 77% |
| A4I6X5 | Leishmania infantum | 36% | 92% |
| C9ZUT5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 35% | 100% |
| D0A1R8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 31% | 99% |
| D0A7S8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 27% | 87% |
| D0A855 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 36% | 95% |
| E9AHH5 | Leishmania infantum | 37% | 100% |
| E9AN53 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 61% | 89% |
| E9AN54 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 56% | 97% |
| E9AN55 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 57% | 91% |
| E9AN56 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 60% | 90% |
| E9AN57 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 57% | 97% |
| E9AZL8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 100% |
| E9B1Z9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 37% | 92% |
| P08148 | Leishmania major | 57% | 97% |
| P15706 | Leishmania chagasi | 57% | 97% |
| P23223 | Leishmania donovani | 56% | 99% |
| P43150 | Leishmania mexicana | 59% | 90% |
| Q00689 | Leishmania guyanensis | 71% | 94% |
| Q06031 | Crithidia fasciculata | 50% | 89% |
| Q27673 | Leishmania amazonensis | 56% | 98% |
| Q29AK2 | Drosophila pseudoobscura pseudoobscura | 24% | 85% |
| Q4Q662 | Leishmania major | 36% | 100% |
| Q4Q8L3 | Leishmania major | 40% | 100% |
| Q4QHG9 | Leishmania major | 58% | 100% |
| Q4QHH0 | Leishmania major | 58% | 100% |
| Q4QHH1 | Leishmania major | 59% | 100% |
| Q4QHH2 | Leishmania major | 59% | 100% |
| Q61YG1 | Caenorhabditis briggsae | 25% | 88% |
| Q6LA77 | Leishmania infantum | 57% | 97% |
| Q8MNZ1 | Leishmania tropica | 60% | 89% |
| Q9VH19 | Drosophila melanogaster | 23% | 86% |
| V5A303 | Trypanosoma cruzi | 41% | 100% |
| V5A359 | Trypanosoma cruzi | 38% | 100% |
| V5A488 | Trypanosoma cruzi | 33% | 72% |
| V5AII7 | Trypanosoma cruzi | 38% | 100% |
| V5AN34 | Trypanosoma cruzi | 39% | 100% |
| V5APQ4 | Trypanosoma cruzi | 34% | 74% |
| V5AX72 | Trypanosoma cruzi | 36% | 79% |
| V5B5M0 | Trypanosoma cruzi | 35% | 79% |
| V5B9W5 | Trypanosoma cruzi | 30% | 86% |
| V5BAN1 | Trypanosoma cruzi | 33% | 74% |
| V5BD39 | Trypanosoma cruzi | 41% | 100% |
| V5BLT3 | Trypanosoma cruzi | 31% | 93% |
| V5CI97 | Trypanosoma cruzi | 32% | 92% |
| V5D358 | Trypanosoma cruzi | 33% | 69% |