Leishmanolysin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

GP63, leishmanolysin

Species:

Leishmania braziliensis

UniProt:

A4H6D8_LEIBR

TriTrypDb:

LbrM.10.1620 , LBRM2903_100010600

Length:

584

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

LeishMANIAdb interaction annotations

by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 51

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 41, no: 10
NetGPI	no	yes: 0, no: 51

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	52
GO:0110165	cellular anatomical entity	1	52
GO:0005737	cytoplasm	2	4
GO:0018995	host cellular component	2	4
GO:0033643	host cell part	3	4
GO:0033646	host intracellular part	4	4
GO:0033647	host intracellular organelle	5	4
GO:0033648	host intracellular membrane-bounded organelle	6	4
GO:0042025	host cell nucleus	7	4

Expansion

Sequence features

A4H6D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6D8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	52
GO:0006807	nitrogen compound metabolic process	2	52
GO:0007155	cell adhesion	2	52
GO:0008152	metabolic process	1	52
GO:0009987	cellular process	1	52
GO:0019538	protein metabolic process	3	52
GO:0043170	macromolecule metabolic process	3	52
GO:0044238	primary metabolic process	2	52
GO:0071704	organic substance metabolic process	2	52
GO:1901564	organonitrogen compound metabolic process	3	52
GO:0009966	regulation of signal transduction	4	4
GO:0010646	regulation of cell communication	4	4
GO:0010749	regulation of nitric oxide mediated signal transduction	6	4
GO:0023051	regulation of signaling	3	4
GO:0035821	modulation of process of another organism	2	4
GO:0044003	modulation by symbiont of host process	3	4
GO:0044068	modulation by symbiont of host cellular process	4	4
GO:0044081	modulation by symbiont of host nitric oxide-mediated signal transduction	5	4
GO:0044403	biological process involved in symbiotic interaction	2	4
GO:0044419	biological process involved in interspecies interaction between organisms	1	4
GO:0044501	modulation of signal transduction in another organism	3	4
GO:0048583	regulation of response to stimulus	3	4
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0051701	biological process involved in interaction with host	3	4
GO:0052027	modulation by symbiont of host signal transduction pathway	4	4
GO:0065007	biological regulation	1	4
GO:0075130	modulation by symbiont of host protein kinase-mediated signal transduction	5	4
GO:1902531	regulation of intracellular signal transduction	5	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	52
GO:0004175	endopeptidase activity	4	52
GO:0004222	metalloendopeptidase activity	5	52
GO:0005488	binding	1	52
GO:0008233	peptidase activity	3	52
GO:0008237	metallopeptidase activity	4	52
GO:0016787	hydrolase activity	2	52
GO:0043167	ion binding	2	52
GO:0043169	cation binding	3	52
GO:0046872	metal ion binding	4	52
GO:0140096	catalytic activity, acting on a protein	2	52
GO:0008047	enzyme activator activity	3	4
GO:0008160	protein tyrosine phosphatase activator activity	6	4
GO:0019208	phosphatase regulator activity	3	4
GO:0019211	phosphatase activator activity	4	4
GO:0019888	protein phosphatase regulator activity	4	4
GO:0030234	enzyme regulator activity	2	4
GO:0072542	protein phosphatase activator activity	5	4
GO:0098772	molecular function regulator activity	1	4
GO:0140677	molecular function activator activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.611
CLV_NRD_NRD_1	409	411	PF00675	0.421
CLV_PCSK_KEX2_1	10	12	PF00082	0.624
CLV_PCSK_KEX2_1	150	152	PF00082	0.571
CLV_PCSK_KEX2_1	409	411	PF00082	0.420
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.560
CLV_PCSK_SKI1_1	336	340	PF00082	0.494
CLV_PCSK_SKI1_1	437	441	PF00082	0.411
DEG_SPOP_SBC_1	91	95	PF00917	0.264
DOC_MAPK_gen_1	288	296	PF00069	0.332
DOC_PP2B_LxvP_1	342	345	PF13499	0.379
DOC_PP2B_LxvP_1	70	73	PF13499	0.264
DOC_PP4_FxxP_1	192	195	PF00568	0.399
DOC_USP7_MATH_1	495	499	PF00917	0.288
DOC_USP7_MATH_1	543	547	PF00917	0.234
DOC_USP7_MATH_1	73	77	PF00917	0.268
DOC_USP7_MATH_1	79	83	PF00917	0.246
DOC_WW_Pin1_4	296	301	PF00397	0.258
DOC_WW_Pin1_4	491	496	PF00397	0.233
DOC_WW_Pin1_4	532	537	PF00397	0.399
DOC_WW_Pin1_4	92	97	PF00397	0.282
LIG_14-3-3_CanoR_1	108	114	PF00244	0.381
LIG_14-3-3_CanoR_1	151	155	PF00244	0.221
LIG_14-3-3_CanoR_1	5	14	PF00244	0.630
LIG_14-3-3_CanoR_1	516	522	PF00244	0.364
LIG_14-3-3_CanoR_1	52	58	PF00244	0.371
LIG_APCC_ABBA_1	163	168	PF00400	0.399
LIG_APCC_ABBA_1	357	362	PF00400	0.373
LIG_APCC_ABBA_1	479	484	PF00400	0.399
LIG_BIR_II_1	1	5	PF00653	0.699
LIG_BRCT_BRCA1_1	382	386	PF00533	0.266
LIG_BRCT_BRCA1_1	446	450	PF00533	0.204
LIG_BRCT_BRCA1_1	545	549	PF00533	0.399
LIG_FHA_1	104	110	PF00498	0.318
LIG_FHA_1	154	160	PF00498	0.260
LIG_FHA_1	165	171	PF00498	0.319
LIG_FHA_1	176	182	PF00498	0.304
LIG_FHA_1	189	195	PF00498	0.301
LIG_FHA_1	198	204	PF00498	0.285
LIG_FHA_1	243	249	PF00498	0.218
LIG_FHA_1	354	360	PF00498	0.390
LIG_FHA_1	420	426	PF00498	0.306
LIG_FHA_1	518	524	PF00498	0.381
LIG_FHA_2	115	121	PF00498	0.231
LIG_FHA_2	180	186	PF00498	0.234
LIG_FHA_2	271	277	PF00498	0.249
LIG_FHA_2	314	320	PF00498	0.216
LIG_FHA_2	369	375	PF00498	0.234
LIG_FHA_2	473	479	PF00498	0.210
LIG_GBD_Chelix_1	264	272	PF00786	0.429
LIG_LIR_Apic_2	156	160	PF02991	0.225
LIG_LIR_Apic_2	191	195	PF02991	0.385
LIG_LIR_Apic_2	289	295	PF02991	0.288
LIG_LIR_Apic_2	408	414	PF02991	0.229
LIG_LIR_Gen_1	112	119	PF02991	0.219
LIG_LIR_Gen_1	250	260	PF02991	0.353
LIG_LIR_Gen_1	273	281	PF02991	0.258
LIG_LIR_Gen_1	314	322	PF02991	0.398
LIG_LIR_Gen_1	478	485	PF02991	0.276
LIG_LIR_Nem_3	101	107	PF02991	0.289
LIG_LIR_Nem_3	112	116	PF02991	0.259
LIG_LIR_Nem_3	120	125	PF02991	0.209
LIG_LIR_Nem_3	206	211	PF02991	0.377
LIG_LIR_Nem_3	250	255	PF02991	0.353
LIG_LIR_Nem_3	273	278	PF02991	0.259
LIG_LIR_Nem_3	314	320	PF02991	0.362
LIG_LIR_Nem_3	362	366	PF02991	0.218
LIG_LIR_Nem_3	434	439	PF02991	0.320
LIG_LIR_Nem_3	447	453	PF02991	0.278
LIG_LIR_Nem_3	478	482	PF02991	0.283
LIG_Pex14_1	399	403	PF04695	0.388
LIG_PTB_Apo_2	202	209	PF02174	0.388
LIG_SH2_CRK	152	156	PF00017	0.183
LIG_SH2_CRK	252	256	PF00017	0.349
LIG_SH2_CRK	352	356	PF00017	0.403
LIG_SH2_CRK	411	415	PF00017	0.233
LIG_SH2_CRK	453	457	PF00017	0.276
LIG_SH2_GRB2like	352	355	PF00017	0.208
LIG_SH2_NCK_1	152	156	PF00017	0.183
LIG_SH2_PTP2	560	563	PF00017	0.396
LIG_SH2_SRC	560	563	PF00017	0.396
LIG_SH2_STAP1	252	256	PF00017	0.357
LIG_SH2_STAP1	521	525	PF00017	0.399
LIG_SH2_STAT3	125	128	PF00017	0.257
LIG_SH2_STAT3	521	524	PF00017	0.384
LIG_SH2_STAT5	110	113	PF00017	0.233
LIG_SH2_STAT5	122	125	PF00017	0.240
LIG_SH2_STAT5	152	155	PF00017	0.246
LIG_SH2_STAT5	157	160	PF00017	0.266
LIG_SH2_STAT5	211	214	PF00017	0.381
LIG_SH2_STAT5	247	250	PF00017	0.212
LIG_SH2_STAT5	352	355	PF00017	0.327
LIG_SH2_STAT5	435	438	PF00017	0.383
LIG_SH2_STAT5	453	456	PF00017	0.215
LIG_SH2_STAT5	531	534	PF00017	0.332
LIG_SH2_STAT5	554	557	PF00017	0.396
LIG_SH2_STAT5	560	563	PF00017	0.330
LIG_SH2_STAT5	74	77	PF00017	0.370
LIG_SH3_3	213	219	PF00018	0.255
LIG_SH3_3	238	244	PF00018	0.203
LIG_SH3_3	498	504	PF00018	0.235
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.228
LIG_TYR_ITIM	111	116	PF00017	0.229
MOD_CDK_SPK_2	491	496	PF00069	0.254
MOD_CDK_SPxxK_3	532	539	PF00069	0.405
MOD_CK1_1	214	220	PF00069	0.480
MOD_CK1_1	298	304	PF00069	0.230
MOD_CK1_1	470	476	PF00069	0.353
MOD_CK1_1	480	486	PF00069	0.277
MOD_CK1_1	82	88	PF00069	0.312
MOD_CK2_1	179	185	PF00069	0.252
MOD_CK2_1	313	319	PF00069	0.250
MOD_CK2_1	368	374	PF00069	0.493
MOD_CK2_1	472	478	PF00069	0.267
MOD_GlcNHglycan	100	103	PF01048	0.294
MOD_GlcNHglycan	249	252	PF01048	0.247
MOD_GlcNHglycan	325	328	PF01048	0.407
MOD_GlcNHglycan	528	531	PF01048	0.422
MOD_GlcNHglycan	545	548	PF01048	0.223
MOD_GlcNHglycan	67	70	PF01048	0.452
MOD_GlcNHglycan	75	78	PF01048	0.338
MOD_GlcNHglycan	81	84	PF01048	0.257
MOD_GSK3_1	175	182	PF00069	0.335
MOD_GSK3_1	197	204	PF00069	0.483
MOD_GSK3_1	440	447	PF00069	0.223
MOD_GSK3_1	467	474	PF00069	0.278
MOD_GSK3_1	491	498	PF00069	0.254
MOD_GSK3_1	78	85	PF00069	0.268
MOD_GSK3_1	90	97	PF00069	0.254
MOD_N-GLC_1	353	358	PF02516	0.221
MOD_N-GLC_1	394	399	PF02516	0.395
MOD_N-GLC_1	404	409	PF02516	0.242
MOD_NEK2_1	256	261	PF00069	0.370
MOD_NEK2_1	270	275	PF00069	0.392
MOD_NEK2_1	320	325	PF00069	0.257
MOD_NEK2_1	328	333	PF00069	0.228
MOD_NEK2_1	439	444	PF00069	0.306
MOD_NEK2_1	542	547	PF00069	0.226
MOD_NEK2_2	472	477	PF00069	0.203
MOD_PIKK_1	394	400	PF00454	0.374
MOD_PK_1	10	16	PF00069	0.634
MOD_PK_1	477	483	PF00069	0.218
MOD_PKA_1	10	16	PF00069	0.568
MOD_PKA_1	150	156	PF00069	0.249
MOD_PKA_2	150	156	PF00069	0.250
MOD_PKA_2	4	10	PF00069	0.566
MOD_PKA_2	525	531	PF00069	0.304
MOD_PKB_1	3	11	PF00069	0.550
MOD_PKB_1	410	418	PF00069	0.253
MOD_Plk_1	270	276	PF00069	0.250
MOD_Plk_1	353	359	PF00069	0.235
MOD_Plk_1	394	400	PF00069	0.373
MOD_Plk_1	477	483	PF00069	0.238
MOD_Plk_4	150	156	PF00069	0.298
MOD_Plk_4	298	304	PF00069	0.317
MOD_Plk_4	313	319	PF00069	0.221
MOD_Plk_4	421	427	PF00069	0.262
MOD_Plk_4	431	437	PF00069	0.326
MOD_Plk_4	550	556	PF00069	0.328
MOD_ProDKin_1	296	302	PF00069	0.291
MOD_ProDKin_1	491	497	PF00069	0.255
MOD_ProDKin_1	532	538	PF00069	0.488
MOD_ProDKin_1	92	98	PF00069	0.324
MOD_SUMO_for_1	338	341	PF00179	0.340
MOD_SUMO_rev_2	279	287	PF00179	0.205
TRG_ENDOCYTIC_2	113	116	PF00928	0.229
TRG_ENDOCYTIC_2	152	155	PF00928	0.185
TRG_ENDOCYTIC_2	252	255	PF00928	0.434
TRG_ENDOCYTIC_2	352	355	PF00928	0.493
TRG_ENDOCYTIC_2	453	456	PF00928	0.373
TRG_ENDOCYTIC_2	505	508	PF00928	0.464
TRG_ENDOCYTIC_2	560	563	PF00928	0.483
TRG_ER_diArg_1	10	12	PF00400	0.623
TRG_ER_diArg_1	409	411	PF00400	0.256
TRG_NES_CRM1_1	271	283	PF08389	0.265
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.187

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL11	Leptomonas seymouri	34%	89%
A0A0S4IP65	Bodo saltans	24%	72%
A0A0S4IUT6	Bodo saltans	27%	71%
A0A0S4IUU1	Bodo saltans	30%	89%
A0A0S4IYM3	Bodo saltans	29%	80%
A0A1X0NDG7	Trypanosomatidae	30%	89%
A0A1X0NDJ3	Trypanosomatidae	29%	81%
A0A1X0NDK2	Trypanosomatidae	32%	100%
A0A1X0NDK7	Trypanosomatidae	31%	82%
A0A1X0NDK9	Trypanosomatidae	31%	100%
A0A1X0NDM7	Trypanosomatidae	30%	91%
A0A1X0NDU8	Trypanosomatidae	31%	88%
A0A1X0NE71	Trypanosomatidae	30%	100%
A0A1X0NER9	Trypanosomatidae	35%	91%
A0A1X0NET7	Trypanosomatidae	34%	100%
A0A1X0NEX7	Trypanosomatidae	33%	89%
A0A1X0NEZ6	Trypanosomatidae	30%	89%
A0A1X0NF32	Trypanosomatidae	32%	100%
A0A1X0NF41	Trypanosomatidae	31%	95%
A0A1X0NFJ0	Trypanosomatidae	29%	100%
A0A1X0NFK3	Trypanosomatidae	31%	87%
A0A1X0NFS0	Trypanosomatidae	32%	67%
A0A1X0NFU4	Trypanosomatidae	31%	71%
A0A1X0NG20	Trypanosomatidae	33%	94%
A0A1X0NGP3	Trypanosomatidae	31%	68%
A0A1X0NGY3	Trypanosomatidae	30%	76%
A0A1X0NGZ3	Trypanosomatidae	33%	97%
A0A1X0NH86	Trypanosomatidae	32%	66%
A0A1X0NHP6	Trypanosomatidae	33%	100%
A0A1X0NHQ6	Trypanosomatidae	31%	100%
A0A1X0NI38	Trypanosomatidae	29%	66%
A0A1X0NI74	Trypanosomatidae	32%	78%
A0A1X0NII4	Trypanosomatidae	30%	69%
A0A1X0NIZ3	Trypanosomatidae	33%	100%
A0A1X0NJS3	Trypanosomatidae	31%	89%
A0A1X0NJU4	Trypanosomatidae	30%	68%
A0A1X0NK66	Trypanosomatidae	33%	88%
A0A1X0NKJ8	Trypanosomatidae	29%	78%
A0A1X0NKW9	Trypanosomatidae	29%	100%
A0A1X0NME2	Trypanosomatidae	32%	93%
A0A1X0NMK3	Trypanosomatidae	28%	100%
A0A1X0NMK7	Trypanosomatidae	38%	100%
A0A1X0NMV0	Trypanosomatidae	32%	79%
A0A1X0NN43	Trypanosomatidae	31%	81%
A0A1X0NNK8	Trypanosomatidae	30%	89%
A0A1X0NPW0	Trypanosomatidae	31%	91%
A0A1X0NQJ5	Trypanosomatidae	36%	100%
A0A1X0NQM4	Trypanosomatidae	35%	100%
A0A1X0NQN3	Trypanosomatidae	35%	100%
A0A1X0NQU4	Trypanosomatidae	35%	91%
A0A1X0NQW6	Trypanosomatidae	34%	100%
A0A1X0NRF3	Trypanosomatidae	32%	87%
A0A1X0NRY8	Trypanosomatidae	37%	100%
A0A1X0NU16	Trypanosomatidae	37%	97%
A0A1X0NUR2	Trypanosomatidae	33%	79%
A0A1X0NV28	Trypanosomatidae	37%	99%
A0A1X0NVC3	Trypanosomatidae	31%	86%
A0A1X0NVE0	Trypanosomatidae	30%	75%
A0A1X0NW07	Trypanosomatidae	31%	93%
A0A1X0NX94	Trypanosomatidae	31%	90%
A0A1X0NX98	Trypanosomatidae	31%	73%
A0A1X0NXB6	Trypanosomatidae	32%	83%
A0A1X0NXH6	Trypanosomatidae	32%	80%
A0A1X0NXQ4	Trypanosomatidae	31%	86%
A0A1X0NXR7	Trypanosomatidae	34%	78%
A0A1X0NYE3	Trypanosomatidae	32%	93%
A0A1X0NYE7	Trypanosomatidae	32%	100%
A0A1X0NYN2	Trypanosomatidae	34%	100%
A0A1X0NYN4	Trypanosomatidae	29%	82%
A0A1X0NYS5	Trypanosomatidae	32%	97%
A0A1X0NYZ2	Trypanosomatidae	37%	100%
A0A1X0NZ46	Trypanosomatidae	30%	100%
A0A1X0NZ63	Trypanosomatidae	33%	92%
A0A1X0NZN6	Trypanosomatidae	28%	90%
A0A1X0P055	Trypanosomatidae	34%	99%
A0A1X0P0C4	Trypanosomatidae	32%	100%
A0A1X0P154	Trypanosomatidae	30%	97%
A0A1X0P331	Trypanosomatidae	33%	100%
A0A1X0P3K0	Trypanosomatidae	30%	80%
A0A1X0P3S2	Trypanosomatidae	29%	100%
A0A1X0P4L8	Trypanosomatidae	32%	100%
A0A1X0P4Y5	Trypanosomatidae	30%	91%
A0A1X0P544	Trypanosomatidae	31%	91%
A0A1X0P5J0	Trypanosomatidae	31%	85%
A0A1X0P7R3	Trypanosomatidae	35%	100%
A0A1X0P8B4	Trypanosomatidae	34%	100%
A0A1X0P9Z4	Trypanosomatidae	31%	100%
A0A1X0PB04	Trypanosomatidae	33%	100%
A0A286YEC0	Mus musculus	24%	84%
A0A3Q8I8N3	Leishmania donovani	57%	98%
A0A3Q8I8P8	Leishmania donovani	57%	97%
A0A3Q8I8S6	Leishmania donovani	58%	91%
A0A3Q8I8S9	Leishmania donovani	57%	97%
A0A3Q8IAZ8	Leishmania donovani	57%	98%
A0A3Q8IC35	Leishmania donovani	57%	98%
A0A3Q8IC44	Leishmania donovani	57%	99%
A0A3Q8IH61	Leishmania donovani	56%	99%
A0A3Q8IIN4	Leishmania donovani	35%	92%
A0A3R7JT49	Trypanosoma rangeli	35%	69%
A0A3R7JTB6	Trypanosoma rangeli	31%	83%
A0A3R7JV87	Trypanosoma rangeli	34%	100%
A0A3R7K7T9	Trypanosoma rangeli	36%	97%
A0A3R7K9S1	Trypanosoma rangeli	34%	100%
A0A3R7KB14	Trypanosoma rangeli	34%	67%
A0A3R7KLR6	Trypanosoma rangeli	32%	91%
A0A3R7KMY2	Trypanosoma rangeli	35%	87%
A0A3R7LFC4	Trypanosoma rangeli	35%	87%
A0A3R7LFZ4	Trypanosoma rangeli	37%	100%
A0A3R7LWG1	Trypanosoma rangeli	33%	100%
A0A3R7LX11	Trypanosoma rangeli	34%	100%
A0A3R7M1R8	Trypanosoma rangeli	34%	100%
A0A3R7M574	Trypanosoma rangeli	35%	91%
A0A3R7M7N6	Trypanosoma rangeli	34%	85%
A0A3R7MTS2	Trypanosoma rangeli	39%	100%
A0A3R7MW36	Trypanosoma rangeli	32%	100%
A0A3R7MXF4	Trypanosoma rangeli	35%	95%
A0A3R7N1W7	Trypanosoma rangeli	34%	100%
A0A3R7N289	Trypanosoma rangeli	33%	81%
A0A3R7N7I3	Trypanosoma rangeli	38%	100%
A0A3R7NTI8	Trypanosoma rangeli	33%	100%
A0A3R7R2J4	Trypanosoma rangeli	34%	90%
A0A3R7R5R1	Trypanosoma rangeli	36%	97%
A0A3R7R818	Trypanosoma rangeli	33%	100%
A0A3S5H6G0	Leishmania donovani	57%	97%
A0A3S5IQY2	Trypanosoma rangeli	36%	100%
A0A3S7WR43	Leishmania donovani	57%	98%
A0A3S7WR46	Leishmania donovani	57%	97%
A0A3S7WR60	Leishmania donovani	57%	97%
A0A3S7X192	Leishmania donovani	37%	100%
A0A422MRQ6	Trypanosoma rangeli	35%	78%
A0A422MTE4	Trypanosoma rangeli	32%	100%
A0A422MU95	Trypanosoma rangeli	33%	100%
A0A422MVF5	Trypanosoma rangeli	33%	100%
A0A422MVS3	Trypanosoma rangeli	36%	100%
A0A422MW99	Trypanosoma rangeli	32%	78%
A0A422MZ47	Trypanosoma rangeli	39%	100%
A0A422MZG4	Trypanosoma rangeli	35%	99%
A0A422N361	Trypanosoma rangeli	34%	100%
A0A422N7Q6	Trypanosoma rangeli	33%	90%
A0A422NDS2	Trypanosoma rangeli	33%	100%
A0A422NDT3	Trypanosoma rangeli	30%	100%
A0A422NP82	Trypanosoma rangeli	39%	100%
A4H626	Leishmania braziliensis	81%	99%
A4H627	Leishmania braziliensis	77%	100%
A4H630	Leishmania braziliensis	72%	100%
A4H631	Leishmania braziliensis	81%	98%
A4H632	Leishmania braziliensis	68%	100%
A4H633	Leishmania braziliensis	78%	99%
A4H634	Leishmania braziliensis	73%	100%
A4H635	Leishmania braziliensis	71%	100%
A4H636	Leishmania braziliensis	71%	100%
A4H637	Leishmania braziliensis	72%	100%
A4H638	Leishmania braziliensis	63%	100%
A4H639	Leishmania braziliensis	68%	100%
A4H640	Leishmania braziliensis	72%	100%
A4H6D1	Leishmania braziliensis	80%	100%
A4H6D3	Leishmania braziliensis	80%	100%
A4H6D5	Leishmania braziliensis	85%	100%
A4H6D7	Leishmania braziliensis	75%	100%
A4H6D9	Leishmania braziliensis	97%	100%
A4H6E0	Leishmania braziliensis	93%	82%
A4H6E1	Leishmania braziliensis	77%	100%
A4H6E2	Leishmania braziliensis	77%	100%
A4H6E3	Leishmania braziliensis	85%	100%
A4H6E4	Leishmania braziliensis	81%	100%
A4H6E5	Leishmania braziliensis	65%	100%
A4HJI2	Leishmania braziliensis	36%	90%
A4HUF6	Leishmania infantum	57%	98%
A4HUF8	Leishmania infantum	57%	97%
A4HUF9	Leishmania infantum	59%	91%
A4HUG0	Leishmania infantum	57%	77%
A4I6X5	Leishmania infantum	36%	92%
C9ZUT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A1R8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	99%
D0A7S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	87%
D0A855	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	95%
E9AHH5	Leishmania infantum	37%	100%
E9AN53	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	89%
E9AN54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	97%
E9AN55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	91%
E9AN56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	90%
E9AN57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	97%
E9AZL8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B1Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	92%
O62446	Caenorhabditis elegans	25%	88%
P08148	Leishmania major	57%	97%
P15706	Leishmania chagasi	57%	97%
P23223	Leishmania donovani	56%	99%
P43150	Leishmania mexicana	59%	90%
Q00689	Leishmania guyanensis	72%	94%
Q06031	Crithidia fasciculata	50%	89%
Q27673	Leishmania amazonensis	56%	98%
Q29AK2	Drosophila pseudoobscura pseudoobscura	24%	85%
Q4Q662	Leishmania major	35%	100%
Q4Q8L3	Leishmania major	40%	100%
Q4QHG9	Leishmania major	58%	100%
Q4QHH0	Leishmania major	59%	100%
Q4QHH1	Leishmania major	58%	100%
Q4QHH2	Leishmania major	58%	100%
Q61YG1	Caenorhabditis briggsae	25%	88%
Q6LA77	Leishmania infantum	57%	97%
Q8BMN4	Mus musculus	25%	86%
Q8MNZ1	Leishmania tropica	60%	89%
Q9VH19	Drosophila melanogaster	22%	86%
V5A303	Trypanosoma cruzi	40%	100%
V5A359	Trypanosoma cruzi	38%	100%
V5A488	Trypanosoma cruzi	33%	72%
V5AII7	Trypanosoma cruzi	37%	100%
V5AN34	Trypanosoma cruzi	39%	100%
V5APQ4	Trypanosoma cruzi	34%	74%
V5AX72	Trypanosoma cruzi	35%	79%
V5B5M0	Trypanosoma cruzi	35%	79%
V5B9W5	Trypanosoma cruzi	29%	86%
V5BAN1	Trypanosoma cruzi	33%	74%
V5BD39	Trypanosoma cruzi	40%	100%
V5BLT3	Trypanosoma cruzi	33%	93%
V5CI97	Trypanosoma cruzi	33%	92%
V5D358	Trypanosoma cruzi	33%	69%