Leishmanolysin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Leishmanolysin

Gene product:

GP63, leishmanolysin

Species:

Leishmania braziliensis

UniProt:

A4H6D1_LEIBR

TriTrypDb:

LbrM.10.1550 , LBRM2903_310032100

Length:

559

Annotations

LeishMANIAdb annotations

Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 12, no: 4
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

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Expansion

Sequence features

A4H6D1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6D1

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0007155	cell adhesion	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0019538	protein metabolic process	3	17
GO:0043170	macromolecule metabolic process	3	17
GO:0044238	primary metabolic process	2	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004175	endopeptidase activity	4	17
GO:0004222	metalloendopeptidase activity	5	17
GO:0005488	binding	1	17
GO:0008233	peptidase activity	3	17
GO:0008237	metallopeptidase activity	4	17
GO:0016787	hydrolase activity	2	17
GO:0043167	ion binding	2	17
GO:0043169	cation binding	3	17
GO:0046872	metal ion binding	4	17

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	463	467	PF00656	0.158
CLV_NRD_NRD_1	161	163	PF00675	0.518
CLV_NRD_NRD_1	476	478	PF00675	0.358
CLV_NRD_NRD_1	9	11	PF00675	0.382
CLV_PCSK_KEX2_1	160	162	PF00082	0.537
CLV_PCSK_KEX2_1	291	293	PF00082	0.598
CLV_PCSK_KEX2_1	475	477	PF00082	0.358
CLV_PCSK_KEX2_1	9	11	PF00082	0.382
CLV_PCSK_PC1ET2_1	291	293	PF00082	0.582
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.358

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IYM3	Bodo saltans	29%	77%
A0A3R7M5K4	Trypanosoma rangeli	33%	100%
A0A3R7MW36	Trypanosoma rangeli	32%	100%
A0A422MRQ6	Trypanosoma rangeli	33%	75%
A4H626	Leishmania braziliensis	79%	97%
A4H627	Leishmania braziliensis	72%	96%
A4H630	Leishmania braziliensis	72%	90%
A4H634	Leishmania braziliensis	74%	91%
A4H635	Leishmania braziliensis	73%	90%
A4H637	Leishmania braziliensis	74%	90%

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