LeishMANIAdb
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Amastin

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Amastin
Gene product:
amastin
Species:
Leishmania braziliensis
UniProt:
A4H6C8_LEIBR
TriTrypDb:
LbrM.10.1520 , LBRM2903_080014000 *
Length:
199

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 2
Forrest at al. (procyclic) no yes: 8
Silverman et al. no yes: 0
Pissara et al. no yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 12, no: 207
NetGPI no yes: 0, no: 219
Cellular components
Term Name Level Count
GO:0016020 membrane 2 196
GO:0110165 cellular anatomical entity 1 196

Expansion

Sequence features

A4H6C8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6C8

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016485 protein processing 5 1
GO:0016540 protein autoprocessing 6 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0051604 protein maturation 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0004175 endopeptidase activity 4 1
GO:0004197 cysteine-type endopeptidase activity 5 1
GO:0008233 peptidase activity 3 1
GO:0008234 cysteine-type peptidase activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0140096 catalytic activity, acting on a protein 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 194 196 PF00675 0.418
CLV_PCSK_KEX2_1 194 196 PF00082 0.537
CLV_PCSK_SKI1_1 195 199 PF00082 0.649
DEG_APCC_KENBOX_2 49 53 PF00400 0.196
DEG_MDM2_SWIB_1 156 164 PF02201 0.485
DOC_CKS1_1 23 28 PF01111 0.355
DOC_MAPK_MEF2A_6 37 46 PF00069 0.344
DOC_USP7_MATH_1 179 183 PF00917 0.773
DOC_USP7_MATH_1 185 189 PF00917 0.849
DOC_WW_Pin1_4 22 27 PF00397 0.350
DOC_WW_Pin1_4 38 43 PF00397 0.270
LIG_BIR_II_1 1 5 PF00653 0.707
LIG_Clathr_ClatBox_1 128 132 PF01394 0.196
LIG_deltaCOP1_diTrp_1 64 68 PF00928 0.209
LIG_eIF4E_1 90 96 PF01652 0.269
LIG_FHA_1 115 121 PF00498 0.381
LIG_FHA_1 165 171 PF00498 0.296
LIG_FHA_1 39 45 PF00498 0.313
LIG_FHA_2 143 149 PF00498 0.194
LIG_FHA_2 23 29 PF00498 0.403
LIG_LIR_Gen_1 105 114 PF02991 0.501
LIG_LIR_Gen_1 59 70 PF02991 0.334
LIG_LIR_Gen_1 80 90 PF02991 0.246
LIG_LIR_Nem_3 105 110 PF02991 0.573
LIG_LIR_Nem_3 59 65 PF02991 0.317
LIG_LIR_Nem_3 80 85 PF02991 0.265
LIG_Pex14_2 149 153 PF04695 0.354
LIG_Pex14_2 156 160 PF04695 0.389
LIG_Pex14_2 98 102 PF04695 0.396
LIG_SH2_GRB2like 133 136 PF00017 0.227
LIG_SH3_3 20 26 PF00018 0.362
LIG_SUMO_SIM_anti_2 167 173 PF11976 0.398
LIG_SUMO_SIM_par_1 126 132 PF11976 0.296
LIG_WRC_WIRS_1 65 70 PF05994 0.329
MOD_CK1_1 58 64 PF00069 0.333
MOD_CK2_1 58 64 PF00069 0.377
MOD_GlcNHglycan 181 184 PF01048 0.629
MOD_GlcNHglycan 187 190 PF01048 0.635
MOD_GSK3_1 114 121 PF00069 0.291
MOD_GSK3_1 179 186 PF00069 0.819
MOD_GSK3_1 38 45 PF00069 0.282
MOD_N-GLC_1 114 119 PF02516 0.197
MOD_NEK2_1 102 107 PF00069 0.323
MOD_NEK2_1 114 119 PF00069 0.306
MOD_NEK2_1 164 169 PF00069 0.281
MOD_NEK2_2 83 88 PF00069 0.472
MOD_PKB_1 175 183 PF00069 0.540
MOD_Plk_1 58 64 PF00069 0.393
MOD_Plk_4 102 108 PF00069 0.364
MOD_Plk_4 164 170 PF00069 0.292
MOD_Plk_4 42 48 PF00069 0.309
MOD_ProDKin_1 22 28 PF00069 0.350
MOD_ProDKin_1 38 44 PF00069 0.270
MOD_SUMO_rev_2 51 58 PF00179 0.251
TRG_ENDOCYTIC_2 10 13 PF00928 0.433
TRG_ENDOCYTIC_2 62 65 PF00928 0.298

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P2C4 Leptomonas seymouri 30% 100%
A0A0N0P547 Leptomonas seymouri 43% 100%
A0A0N0P6P9 Leptomonas seymouri 24% 87%
A0A0N0P993 Leptomonas seymouri 25% 89%
A0A0N1HWY5 Leptomonas seymouri 26% 100%
A0A0N1PAD5 Leptomonas seymouri 27% 79%
A0A0N1PDH0 Leptomonas seymouri 39% 99%
A0A0N1PFN2 Leptomonas seymouri 24% 100%
A0A0S4J784 Bodo saltans 27% 89%
A0A1X0NQ58 Trypanosomatidae 30% 100%
A0A1X0NUH1 Trypanosomatidae 29% 88%
A0A1X0NVT7 Trypanosomatidae 30% 100%
A0A1X0P2R3 Trypanosomatidae 31% 94%
A0A1X0P988 Trypanosomatidae 42% 100%
A0A381MTA7 Leishmania infantum 43% 100%
A0A381MTB8 Leishmania infantum 44% 100%
A0A381MTC7 Leishmania infantum 43% 97%
A0A381MTN2 Leishmania infantum 42% 100%
A0A381MVY0 Leishmania infantum 43% 100%
A0A3Q8ID16 Leishmania donovani 29% 100%
A0A3Q8IE85 Leishmania donovani 52% 100%
A0A3Q8IEC2 Leishmania donovani 40% 100%
A0A3Q8IEI1 Leishmania donovani 44% 100%
A0A3Q8IF65 Leishmania donovani 43% 100%
A0A3Q8IFB9 Leishmania donovani 34% 98%
A0A3Q8IFH7 Leishmania donovani 43% 97%
A0A3Q8IFI8 Leishmania donovani 23% 100%
A0A3Q8IH65 Leishmania donovani 40% 100%
A0A3Q8IHN2 Leishmania donovani 46% 100%
A0A3Q8IHW7 Leishmania donovani 48% 100%
A0A3Q8IHZ6 Leishmania donovani 50% 94%
A0A3Q8IIH1 Leishmania donovani 44% 100%
A0A3Q8IL03 Leishmania donovani 42% 100%
A0A3Q8IMR4 Leishmania donovani 27% 100%
A0A3Q8IUK8 Leishmania donovani 42% 100%
A0A3Q8IUR5 Leishmania donovani 42% 100%
A0A3S5H662 Leishmania donovani 47% 99%
A0A3S5H663 Leishmania donovani 47% 99%
A0A3S5H665 Leishmania donovani 47% 99%
A0A3S5H666 Leishmania donovani 51% 100%
A0A3S5H667 Leishmania donovani 46% 98%
A0A3S5H7D2 Leishmania donovani 28% 100%
A0A3S5H7L2 Leishmania donovani 47% 97%
A0A3S5H7V9 Leishmania donovani 47% 100%
A0A3S5H7W2 Leishmania donovani 26% 100%
A0A3S5H7W6 Leishmania donovani 46% 100%
A0A3S7WQA0 Leishmania donovani 45% 98%
A0A3S7WQA8 Leishmania donovani 50% 100%
A0A3S7WQC1 Leishmania donovani 56% 100%
A0A3S7X2E6 Leishmania donovani 45% 100%
A0A3S7X357 Leishmania donovani 29% 90%
A0A3S7X381 Leishmania donovani 23% 100%
A0A3S7X453 Leishmania donovani 42% 100%
A0A3S7X472 Leishmania donovani 42% 100%
A0A3S7X7E5 Leishmania donovani 45% 80%
A0A3S7X7M4 Leishmania donovani 50% 94%
A0A3S7X7U1 Leishmania donovani 45% 95%
A0A3S7X7U4 Leishmania donovani 46% 77%
A0A3S7X7W2 Leishmania donovani 37% 95%
A0A3S7X7Y0 Leishmania donovani 42% 100%
A4H595 Leishmania braziliensis 46% 100%
A4H596 Leishmania braziliensis 45% 100%
A4H597 Leishmania braziliensis 46% 100%
A4H5D1 Leishmania braziliensis 42% 97%
A4H5D2 Leishmania braziliensis 40% 100%
A4H5G0 Leishmania braziliensis 52% 100%
A4H5G4 Leishmania braziliensis 49% 100%
A4H5G6 Leishmania braziliensis 41% 100%
A4H5G7 Leishmania braziliensis 45% 100%
A4H5G9 Leishmania braziliensis 54% 99%
A4H5H0 Leishmania braziliensis 54% 100%
A4H5H1 Leishmania braziliensis 52% 100%
A4H5H2 Leishmania braziliensis 76% 100%
A4H5H3 Leishmania braziliensis 43% 100%
A4H7D7 Leishmania braziliensis 42% 100%
A4H9E8 Leishmania braziliensis 48% 95%
A4H9E9 Leishmania braziliensis 47% 100%
A4HAJ4 Leishmania braziliensis 48% 94%
A4HAJ5 Leishmania braziliensis 39% 90%
A4HAJ6 Leishmania braziliensis 41% 86%
A4HAL1 Leishmania braziliensis 47% 100%
A4HAL2 Leishmania braziliensis 29% 100%
A4HAM2 Leishmania braziliensis 44% 100%
A4HAM4 Leishmania braziliensis 46% 100%
A4HAR1 Leishmania braziliensis 46% 100%
A4HAZ8 Leishmania braziliensis 49% 100%
A4HB00 Leishmania braziliensis 43% 100%
A4HB02 Leishmania braziliensis 42% 100%
A4HB47 Leishmania braziliensis 35% 98%
A4HBJ0 Leishmania braziliensis 43% 100%
A4HBJ1 Leishmania braziliensis 44% 100%
A4HBJ2 Leishmania braziliensis 44% 96%
A4HDI2 Leishmania braziliensis 27% 100%
A4HDI3 Leishmania braziliensis 29% 82%
A4HDI4 Leishmania braziliensis 27% 100%
A4HDL3 Leishmania braziliensis 31% 100%
A4HDL4 Leishmania braziliensis 28% 100%
A4HI41 Leishmania braziliensis 25% 100%
A4HI43 Leishmania braziliensis 26% 94%
A4HTM3 Leishmania infantum 57% 100%
A4HTM4 Leishmania infantum 53% 100%
A4HTM5 Leishmania infantum 48% 100%
A4I0W4 Leishmania infantum 31% 100%
A4I0W5 Leishmania infantum 29% 100%
A4I0W6 Leishmania infantum 28% 67%
A4I4J2 Leishmania infantum 42% 97%
A4I4J3 Leishmania infantum 49% 77%
A4I5B8 Leishmania infantum 23% 100%
A4I5B9 Leishmania infantum 29% 90%
A4I6E5 Leishmania infantum 41% 100%
A4I9Q4 Leishmania infantum 44% 100%
A4I9R4 Leishmania infantum 26% 100%
A4I9R5 Leishmania infantum 34% 98%
A4I9R7 Leishmania infantum 44% 100%
A4I9W8 Leishmania infantum 47% 77%
A4I9X0 Leishmania infantum 37% 95%
A4IA59 Leishmania infantum 42% 77%
A4IAL7 Leishmania infantum 48% 100%
A4IAM1 Leishmania infantum 45% 100%
A4IAM2 Leishmania infantum 45% 100%
C6K3X9 Leptomonas seymouri 25% 100%
E8NHC3 Leishmania infantum 45% 99%
E8NHD3 Leishmania infantum 46% 97%
E8NHD9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E8NHE0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 95%
E8NHF4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 96%
E8NHF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E8NHF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHG2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 94%
E8NHH5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 94%
E8NHH9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E8NHI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E8NHI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E8NHK7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 94%
E8NHK9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E8NHL7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E8NHL9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E8NHM0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E8NHM1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E8NHM3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 94%
E8NHM5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 94%
E8NHM6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHM7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 100%
E8NHP0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 97%
E8NHQ0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 95%
E8NHQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E8NHR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E8NHR8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E8NHS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 94%
E9AG81 Leishmania infantum 48% 98%
E9AG82 Leishmania infantum 48% 98%
E9AG83 Leishmania infantum 43% 100%
E9AG85 Leishmania infantum 48% 98%
E9AHI9 Leishmania infantum 45% 100%
E9AHT2 Leishmania infantum 51% 94%
E9AME9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
E9AMF0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 100%
E9AMF1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 96%
E9AMF2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 100%
E9AMF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
E9AMF4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 77%
E9AMF5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 96%
E9AMF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AMF8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 100%
E9AMF9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E9ASP7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 95%
E9AWW7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AWW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9AWW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AWX0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B0L5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 100%
E9B0L6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 90%
E9B1J3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9B1J4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 96%
E9B1J5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 94%
E9B4L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B4R7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 46% 100%
E9B4R8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9B4R9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 98%
E9B4S0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B4Y3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 97%
Q4Q1U9 Leishmania major 41% 98%
Q4Q305 Leishmania major 45% 100%
Q4Q309 Leishmania major 41% 100%
Q4Q313 Leishmania major 43% 98%
Q4Q317 Leishmania major 45% 100%
Q4Q325 Leishmania major 43% 100%
Q4Q327 Leishmania major 40% 99%
Q4Q329 Leishmania major 45% 99%
Q4Q333 Leishmania major 42% 98%
Q4Q335 Leishmania major 44% 98%
Q4Q337 Leishmania major 42% 100%
Q4Q339 Leishmania major 43% 98%
Q4Q341 Leishmania major 45% 98%
Q4Q397 Leishmania major 45% 100%
Q4Q3A7 Leishmania major 28% 100%
Q4Q3A8 Leishmania major 34% 100%
Q4Q3A9 Leishmania major 46% 99%
Q4Q3F7 Leishmania major 49% 100%
Q4Q6L8 Leishmania major 42% 100%
Q4Q7L6 Leishmania major 30% 100%
Q4Q7L7 Leishmania major 22% 100%
Q4Q7L8 Leishmania major 23% 100%
Q4QAK4 Leishmania major 24% 100%
Q4QAK5 Leishmania major 28% 100%
Q4QAK6 Leishmania major 32% 100%
Q4QAK7 Leishmania major 24% 100%
Q4QI84 Leishmania major 53% 100%
Q4QI85 Leishmania major 51% 100%
Q4QI86 Leishmania major 56% 100%
Q4QI87 Leishmania major 59% 98%
Q4QI88 Leishmania major 48% 100%
Q4QI92 Leishmania major 45% 100%
Q4QI93 Leishmania major 45% 100%
Q4QI95 Leishmania major 44% 100%
Q4QI97 Leishmania major 45% 100%
Q4QIA0 Leishmania major 44% 100%
Q4QIA1 Leishmania major 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS