Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6C7_LEIBR

TriTrypDb:

LbrM.10.1500 , LBRM2903_080014300

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6C7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	246	248	PF00675	0.691
CLV_NRD_NRD_1	33	35	PF00675	0.646
CLV_PCSK_KEX2_1	246	248	PF00082	0.691
CLV_PCSK_KEX2_1	256	258	PF00082	0.544
CLV_PCSK_KEX2_1	33	35	PF00082	0.646
CLV_PCSK_KEX2_1	71	73	PF00082	0.451
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.558
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.451
CLV_PCSK_SKI1_1	33	37	PF00082	0.503
DEG_SCF_TRCP1_1	175	180	PF00400	0.570
DEG_SIAH_1	309	317	PF03145	0.460
DOC_CYCLIN_yCln2_LP_2	209	215	PF00134	0.529
DOC_MAPK_MEF2A_6	221	229	PF00069	0.558
DOC_PP4_FxxP_1	229	232	PF00568	0.571
DOC_PP4_MxPP_1	223	226	PF00568	0.718
DOC_USP7_MATH_1	23	27	PF00917	0.749
DOC_USP7_MATH_1	249	253	PF00917	0.640
DOC_USP7_MATH_1	51	55	PF00917	0.587
DOC_USP7_UBL2_3	147	151	PF12436	0.673
DOC_WW_Pin1_4	279	284	PF00397	0.618
LIG_AP2alpha_1	229	233	PF02296	0.738
LIG_AP2alpha_1	273	277	PF02296	0.477
LIG_AP2alpha_2	211	213	PF02296	0.724
LIG_AP2alpha_2	231	233	PF02296	0.562
LIG_AP2alpha_2	309	311	PF02296	0.512
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BIR_III_2	199	203	PF00653	0.558
LIG_BRCT_BRCA1_1	84	88	PF00533	0.534
LIG_EH_1	284	288	PF12763	0.476
LIG_EVH1_2	225	229	PF00568	0.726
LIG_FHA_2	136	142	PF00498	0.557
LIG_FHA_2	155	161	PF00498	0.570
LIG_FHA_2	194	200	PF00498	0.577
LIG_LIR_Gen_1	284	293	PF02991	0.471
LIG_LIR_Gen_1	308	316	PF02991	0.515
LIG_LIR_Gen_1	85	96	PF02991	0.465
LIG_LIR_Nem_3	100	105	PF02991	0.704
LIG_LIR_Nem_3	274	280	PF02991	0.560
LIG_LIR_Nem_3	308	314	PF02991	0.532
LIG_LIR_Nem_3	54	60	PF02991	0.487
LIG_Pex14_2	229	233	PF04695	0.738
LIG_Pex14_2	273	277	PF04695	0.548
LIG_Pex14_2	311	315	PF04695	0.446
LIG_Pex14_2	69	73	PF04695	0.662
LIG_SH2_GRB2like	60	63	PF00017	0.457
LIG_SH2_STAP1	57	61	PF00017	0.485
LIG_SH2_STAT3	235	238	PF00017	0.549
LIG_SH2_STAT5	263	266	PF00017	0.581
LIG_SH3_3	114	120	PF00018	0.691
LIG_SH3_3	160	166	PF00018	0.635
LIG_SH3_3	17	23	PF00018	0.554
LIG_SH3_3	24	30	PF00018	0.591
LIG_SH3_3	280	286	PF00018	0.588
LIG_SUMO_SIM_par_1	119	126	PF11976	0.775
LIG_TRAF2_1	112	115	PF00917	0.578
MOD_CK1_1	154	160	PF00069	0.578
MOD_CK1_1	252	258	PF00069	0.780
MOD_CK2_1	123	129	PF00069	0.564
MOD_CK2_1	214	220	PF00069	0.523
MOD_Cter_Amidation	184	187	PF01082	0.783
MOD_Cter_Amidation	244	247	PF01082	0.577
MOD_GlcNHglycan	175	178	PF01048	0.649
MOD_GlcNHglycan	243	246	PF01048	0.670
MOD_GlcNHglycan	249	252	PF01048	0.684
MOD_GlcNHglycan	84	87	PF01048	0.637
MOD_GSK3_1	135	142	PF00069	0.582
MOD_GSK3_1	173	180	PF00069	0.697
MOD_GSK3_1	189	196	PF00069	0.583
MOD_GSK3_1	200	207	PF00069	0.583
MOD_GSK3_1	38	45	PF00069	0.508
MOD_GSK3_1	56	63	PF00069	0.584
MOD_GSK3_1	82	89	PF00069	0.519
MOD_LATS_1	3	9	PF00433	0.560
MOD_N-GLC_1	203	208	PF02516	0.559
MOD_NEK2_1	56	61	PF00069	0.615
MOD_NEK2_1	82	87	PF00069	0.518
MOD_PIKK_1	151	157	PF00454	0.572
MOD_PIKK_1	97	103	PF00454	0.548
MOD_PKA_2	189	195	PF00069	0.652
MOD_Plk_1	123	129	PF00069	0.567
MOD_Plk_1	203	209	PF00069	0.539
MOD_Plk_4	204	210	PF00069	0.637
MOD_Plk_4	214	220	PF00069	0.690
MOD_Plk_4	56	62	PF00069	0.560
MOD_ProDKin_1	279	285	PF00069	0.614
TRG_ER_diArg_1	105	108	PF00400	0.656
TRG_ER_diArg_1	246	248	PF00400	0.631
TRG_ER_diArg_1	33	35	PF00400	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEG2	Leptomonas seymouri	37%	100%
A0A3S5H670	Leishmania donovani	58%	100%
A4HTM6	Leishmania infantum	58%	100%
E9AMG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4QI83	Leishmania major	58%	93%