Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6C6_LEIBR

TriTrypDb:

LbrM.10.1490

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6C6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.502
CLV_NRD_NRD_1	142	144	PF00675	0.414
CLV_NRD_NRD_1	233	235	PF00675	0.481
CLV_NRD_NRD_1	29	31	PF00675	0.426
CLV_NRD_NRD_1	35	37	PF00675	0.445
CLV_PCSK_FUR_1	179	183	PF00082	0.351
CLV_PCSK_KEX2_1	10	12	PF00082	0.485
CLV_PCSK_KEX2_1	131	133	PF00082	0.469
CLV_PCSK_KEX2_1	142	144	PF00082	0.415
CLV_PCSK_KEX2_1	181	183	PF00082	0.378
CLV_PCSK_KEX2_1	222	224	PF00082	0.458
CLV_PCSK_KEX2_1	232	234	PF00082	0.480
CLV_PCSK_KEX2_1	29	31	PF00082	0.406
CLV_PCSK_KEX2_1	35	37	PF00082	0.399
CLV_PCSK_PC1ET2_1	10	12	PF00082	0.485
CLV_PCSK_PC1ET2_1	181	183	PF00082	0.394
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.458
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.480
CLV_PCSK_PC7_1	228	234	PF00082	0.280
CLV_PCSK_SKI1_1	132	136	PF00082	0.413
CLV_PCSK_SKI1_1	258	262	PF00082	0.373
DEG_Nend_UBRbox_3	1	3	PF02207	0.556
DOC_CYCLIN_RxL_1	255	265	PF00134	0.498
DOC_USP7_MATH_1	104	108	PF00917	0.428
DOC_USP7_MATH_1	149	153	PF00917	0.395
DOC_USP7_MATH_1	286	290	PF00917	0.423
DOC_USP7_MATH_1	311	315	PF00917	0.610
DOC_USP7_MATH_1	348	352	PF00917	0.702
DOC_USP7_MATH_1	385	389	PF00917	0.563
DOC_USP7_MATH_2	123	129	PF00917	0.547
DOC_USP7_UBL2_3	201	205	PF12436	0.459
DOC_USP7_UBL2_3	214	218	PF12436	0.379
DOC_USP7_UBL2_3	232	236	PF12436	0.492
DOC_WW_Pin1_4	305	310	PF00397	0.548
DOC_WW_Pin1_4	87	92	PF00397	0.509
LIG_14-3-3_CanoR_1	179	189	PF00244	0.375
LIG_14-3-3_CanoR_1	258	263	PF00244	0.328
LIG_14-3-3_CanoR_1	35	44	PF00244	0.325
LIG_Actin_WH2_2	158	175	PF00022	0.506
LIG_FHA_1	161	167	PF00498	0.373
LIG_FHA_1	181	187	PF00498	0.409
LIG_FHA_1	295	301	PF00498	0.577
LIG_FHA_1	359	365	PF00498	0.522
LIG_FHA_1	7	13	PF00498	0.439
LIG_FHA_2	92	98	PF00498	0.665
LIG_LIR_Gen_1	235	245	PF02991	0.427
LIG_LIR_Gen_1	289	299	PF02991	0.577
LIG_LIR_Gen_1	60	69	PF02991	0.431
LIG_LIR_Nem_3	187	192	PF02991	0.506
LIG_LIR_Nem_3	20	25	PF02991	0.582
LIG_LIR_Nem_3	224	230	PF02991	0.419
LIG_LIR_Nem_3	235	240	PF02991	0.409
LIG_LIR_Nem_3	289	294	PF02991	0.587
LIG_LIR_Nem_3	318	322	PF02991	0.511
LIG_LIR_Nem_3	60	65	PF02991	0.371
LIG_PDZ_Class_3	384	389	PF00595	0.501
LIG_Pex14_2	237	241	PF04695	0.415
LIG_SH2_CRK	291	295	PF00017	0.573
LIG_SH2_CRK	319	323	PF00017	0.789
LIG_SH2_NCK_1	291	295	PF00017	0.474
LIG_SH2_NCK_1	62	66	PF00017	0.469
LIG_SH2_STAP1	113	117	PF00017	0.534
LIG_SH2_STAT3	100	103	PF00017	0.640
LIG_SH2_STAT3	266	269	PF00017	0.474
LIG_SH2_STAT5	230	233	PF00017	0.413
LIG_SH2_STAT5	259	262	PF00017	0.430
LIG_SH2_STAT5	266	269	PF00017	0.444
LIG_SH3_3	77	83	PF00018	0.674
LIG_SUMO_SIM_par_1	296	301	PF11976	0.577
MOD_CK1_1	116	122	PF00069	0.564
MOD_CK1_1	152	158	PF00069	0.290
MOD_CK1_1	351	357	PF00069	0.668
MOD_CK2_1	171	177	PF00069	0.563
MOD_CK2_1	57	63	PF00069	0.448
MOD_GlcNHglycan	38	41	PF01048	0.394
MOD_GlcNHglycan	59	62	PF01048	0.476
MOD_GSK3_1	11	18	PF00069	0.486
MOD_GSK3_1	113	120	PF00069	0.637
MOD_GSK3_1	286	293	PF00069	0.460
MOD_GSK3_1	311	318	PF00069	0.661
MOD_GSK3_1	348	355	PF00069	0.689
MOD_GSK3_1	87	94	PF00069	0.759
MOD_LATS_1	313	319	PF00433	0.562
MOD_N-GLC_1	104	109	PF02516	0.425
MOD_N-GLC_1	15	20	PF02516	0.611
MOD_N-GLC_1	212	217	PF02516	0.352
MOD_NEK2_1	72	77	PF00069	0.543
MOD_PIKK_1	125	131	PF00454	0.511
MOD_PIKK_1	46	52	PF00454	0.349
MOD_PIKK_1	99	105	PF00454	0.547
MOD_PK_1	236	242	PF00069	0.264
MOD_Plk_1	104	110	PF00069	0.537
MOD_Plk_1	15	21	PF00069	0.612
MOD_Plk_1	349	355	PF00069	0.563
MOD_Plk_1	70	76	PF00069	0.524
MOD_Plk_4	104	110	PF00069	0.428
MOD_Plk_4	236	242	PF00069	0.411
MOD_Plk_4	294	300	PF00069	0.567
MOD_ProDKin_1	305	311	PF00069	0.550
MOD_ProDKin_1	87	93	PF00069	0.505
MOD_SUMO_rev_2	375	383	PF00179	0.495
TRG_DiLeu_BaEn_4	339	345	PF01217	0.529
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.379
TRG_ENDOCYTIC_2	259	262	PF00928	0.430
TRG_ENDOCYTIC_2	291	294	PF00928	0.542
TRG_ENDOCYTIC_2	319	322	PF00928	0.508
TRG_ENDOCYTIC_2	62	65	PF00928	0.432
TRG_ER_diArg_1	130	132	PF00400	0.490
TRG_ER_diArg_1	142	144	PF00400	0.393
TRG_ER_diArg_1	29	31	PF00400	0.507
TRG_ER_diArg_1	34	36	PF00400	0.481
TRG_NLS_MonoExtC_3	204	209	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P348	Leptomonas seymouri	67%	89%
A0A0N0P3S1	Leptomonas seymouri	24%	85%
A0A1X0NK28	Trypanosomatidae	26%	95%
A0A1X0NY72	Trypanosomatidae	22%	100%
A0A3Q8IG21	Leishmania donovani	25%	92%
A0A3Q8IIE7	Leishmania donovani	23%	100%
A0A3S7WQB3	Leishmania donovani	77%	93%
A0A422NQZ1	Trypanosoma rangeli	23%	94%
A4HJ56	Leishmania braziliensis	21%	89%
A4HTM7	Leishmania infantum	77%	93%
A4I6H9	Leishmania infantum	24%	92%
E9AHL0	Leishmania infantum	23%	100%
E9AMG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	93%
E9B1M8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9B1N5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B1N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	92%
Q4Q6H8	Leishmania major	23%	89%
Q4Q6I6	Leishmania major	24%	100%
Q4QI82	Leishmania major	76%	100%