SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H6C5_LEIBR

TriTrypDb:

LbrM.10.1480 , LBRM2903_080014400

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6C5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6C5

Function

Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	3
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032259	methylation	2	3
GO:0034968	histone lysine methylation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3
GO:0018024	obsolete histone lysine N-methyltransferase activity	5	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.591
CLV_NRD_NRD_1	168	170	PF00675	0.779
CLV_NRD_NRD_1	28	30	PF00675	0.677
CLV_NRD_NRD_1	32	34	PF00675	0.539
CLV_NRD_NRD_1	416	418	PF00675	0.402
CLV_PCSK_KEX2_1	168	170	PF00082	0.767
CLV_PCSK_KEX2_1	173	175	PF00082	0.663
CLV_PCSK_KEX2_1	28	30	PF00082	0.675
CLV_PCSK_KEX2_1	32	34	PF00082	0.541
CLV_PCSK_KEX2_1	416	418	PF00082	0.391
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.746
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.716
CLV_PCSK_PC7_1	169	175	PF00082	0.752
CLV_PCSK_SKI1_1	337	341	PF00082	0.223
CLV_PCSK_SKI1_1	482	486	PF00082	0.486
DEG_APCC_DBOX_1	181	189	PF00400	0.561
DEG_SCF_FBW7_1	273	280	PF00400	0.515
DEG_SPOP_SBC_1	429	433	PF00917	0.575
DEG_SPOP_SBC_1	436	440	PF00917	0.544
DOC_CYCLIN_RxL_1	479	486	PF00134	0.484
DOC_MAPK_gen_1	28	40	PF00069	0.649
DOC_MAPK_gen_1	342	350	PF00069	0.531
DOC_PP2B_LxvP_1	134	137	PF13499	0.543
DOC_PP2B_PxIxI_1	50	56	PF00149	0.494
DOC_PP4_FxxP_1	47	50	PF00568	0.489
DOC_USP7_MATH_1	120	124	PF00917	0.546
DOC_USP7_MATH_1	298	302	PF00917	0.690
DOC_USP7_MATH_1	430	434	PF00917	0.592
DOC_USP7_MATH_1	59	63	PF00917	0.434
DOC_WW_Pin1_4	116	121	PF00397	0.664
DOC_WW_Pin1_4	271	276	PF00397	0.478
DOC_WW_Pin1_4	432	437	PF00397	0.565
DOC_WW_Pin1_4	439	444	PF00397	0.567
DOC_WW_Pin1_4	55	60	PF00397	0.415
DOC_WW_Pin1_4	95	100	PF00397	0.758
LIG_14-3-3_CanoR_1	174	179	PF00244	0.576
LIG_14-3-3_CanoR_1	182	186	PF00244	0.561
LIG_14-3-3_CanoR_1	235	241	PF00244	0.594
LIG_14-3-3_CanoR_1	262	268	PF00244	0.508
LIG_14-3-3_CanoR_1	317	326	PF00244	0.630
LIG_14-3-3_CanoR_1	33	39	PF00244	0.565
LIG_14-3-3_CanoR_1	416	426	PF00244	0.592
LIG_14-3-3_CanoR_1	427	436	PF00244	0.461
LIG_14-3-3_CanoR_1	489	498	PF00244	0.562
LIG_14-3-3_CanoR_1	92	96	PF00244	0.796
LIG_AP2alpha_2	323	325	PF02296	0.400
LIG_BIR_II_1	1	5	PF00653	0.755
LIG_BRCT_BRCA1_1	346	350	PF00533	0.521
LIG_FHA_1	154	160	PF00498	0.712
LIG_FHA_1	211	217	PF00498	0.401
LIG_FHA_1	35	41	PF00498	0.548
LIG_FHA_1	452	458	PF00498	0.585
LIG_FHA_1	491	497	PF00498	0.514
LIG_FHA_2	429	435	PF00498	0.591
LIG_LIR_Apic_2	123	127	PF02991	0.338
LIG_LIR_Gen_1	212	222	PF02991	0.400
LIG_LIR_Gen_1	464	473	PF02991	0.563
LIG_LIR_Nem_3	212	218	PF02991	0.416
LIG_LIR_Nem_3	464	470	PF02991	0.490
LIG_LIR_Nem_3	486	491	PF02991	0.446
LIG_Rb_pABgroove_1	377	385	PF01858	0.557
LIG_SH2_CRK	124	128	PF00017	0.556
LIG_SH2_CRK	199	203	PF00017	0.510
LIG_SH2_CRK	488	492	PF00017	0.451
LIG_SH2_NCK_1	383	387	PF00017	0.563
LIG_SH2_PTP2	467	470	PF00017	0.441
LIG_SH2_STAT5	124	127	PF00017	0.549
LIG_SH2_STAT5	199	202	PF00017	0.449
LIG_SH2_STAT5	467	470	PF00017	0.427
LIG_SH3_3	321	327	PF00018	0.625
LIG_SUMO_SIM_anti_2	52	58	PF11976	0.382
LIG_SUMO_SIM_par_1	378	385	PF11976	0.561
LIG_TRAF2_1	19	22	PF00917	0.616
LIG_TRAF2_1	459	462	PF00917	0.490
LIG_TYR_ITIM	465	470	PF00017	0.568
LIG_WRC_WIRS_1	264	269	PF05994	0.484
LIG_WRC_WIRS_1	470	475	PF05994	0.375
LIG_WW_1	326	329	PF00397	0.536
LIG_WW_3	325	329	PF00397	0.590
MOD_CDC14_SPxK_1	119	122	PF00782	0.395
MOD_CDK_SPxK_1	116	122	PF00069	0.429
MOD_CK1_1	104	110	PF00069	0.737
MOD_CK1_1	153	159	PF00069	0.733
MOD_CK1_1	245	251	PF00069	0.604
MOD_CK1_1	301	307	PF00069	0.539
MOD_CK1_1	432	438	PF00069	0.540
MOD_CK2_1	358	364	PF00069	0.457
MOD_CK2_1	428	434	PF00069	0.579
MOD_Cter_Amidation	171	174	PF01082	0.632
MOD_Cter_Amidation	30	33	PF01082	0.608
MOD_GlcNHglycan	152	155	PF01048	0.618
MOD_GlcNHglycan	282	285	PF01048	0.753
MOD_GlcNHglycan	384	387	PF01048	0.365
MOD_GlcNHglycan	403	406	PF01048	0.367
MOD_GSK3_1	101	108	PF00069	0.651
MOD_GSK3_1	109	116	PF00069	0.744
MOD_GSK3_1	149	156	PF00069	0.586
MOD_GSK3_1	198	205	PF00069	0.422
MOD_GSK3_1	273	280	PF00069	0.717
MOD_GSK3_1	340	347	PF00069	0.480
MOD_GSK3_1	351	358	PF00069	0.464
MOD_GSK3_1	428	435	PF00069	0.581
MOD_GSK3_1	437	444	PF00069	0.512
MOD_GSK3_1	55	62	PF00069	0.288
MOD_GSK3_1	91	98	PF00069	0.793
MOD_N-GLC_1	159	164	PF02516	0.492
MOD_N-GLC_1	210	215	PF02516	0.539
MOD_N-GLC_1	242	247	PF02516	0.569
MOD_N-GLC_1	369	374	PF02516	0.305
MOD_NEK2_1	106	111	PF00069	0.719
MOD_NEK2_1	228	233	PF00069	0.415
MOD_NEK2_1	340	345	PF00069	0.466
MOD_NEK2_1	362	367	PF00069	0.536
MOD_NEK2_1	369	374	PF00069	0.539
MOD_OFUCOSY	190	196	PF10250	0.259
MOD_OFUCOSY	367	373	PF10250	0.290
MOD_PIKK_1	499	505	PF00454	0.525
MOD_PIKK_1	5	11	PF00454	0.774
MOD_PK_1	174	180	PF00069	0.684
MOD_PK_1	344	350	PF00069	0.508
MOD_PKA_1	417	423	PF00069	0.591
MOD_PKA_2	181	187	PF00069	0.345
MOD_PKA_2	248	254	PF00069	0.350
MOD_PKA_2	316	322	PF00069	0.755
MOD_PKA_2	91	97	PF00069	0.740
MOD_PKB_1	315	323	PF00069	0.501
MOD_PKB_1	342	350	PF00069	0.561
MOD_Plk_1	242	248	PF00069	0.610
MOD_Plk_1	369	375	PF00069	0.526
MOD_Plk_1	461	467	PF00069	0.490
MOD_Plk_2-3	408	414	PF00069	0.411
MOD_Plk_2-3	469	475	PF00069	0.626
MOD_Plk_4	161	167	PF00069	0.735
MOD_ProDKin_1	116	122	PF00069	0.655
MOD_ProDKin_1	271	277	PF00069	0.485
MOD_ProDKin_1	432	438	PF00069	0.565
MOD_ProDKin_1	439	445	PF00069	0.567
MOD_ProDKin_1	55	61	PF00069	0.412
MOD_ProDKin_1	95	101	PF00069	0.757
TRG_DiLeu_BaEn_2	485	491	PF01217	0.447
TRG_DiLeu_BaLyEn_6	184	189	PF01217	0.427
TRG_ENDOCYTIC_2	199	202	PF00928	0.473
TRG_ENDOCYTIC_2	467	470	PF00928	0.433
TRG_ENDOCYTIC_2	488	491	PF00928	0.439
TRG_ENDOCYTIC_2	57	60	PF00928	0.410
TRG_ER_diArg_1	32	34	PF00400	0.555
TRG_ER_diArg_1	341	344	PF00400	0.561
TRG_ER_diArg_1	498	501	PF00400	0.571
TRG_NLS_MonoExtC_3	27	32	PF00514	0.695
TRG_NLS_MonoExtN_4	25	32	PF00514	0.736
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I8	Leptomonas seymouri	49%	91%
A0A1X0NPE5	Trypanosomatidae	25%	100%
A0A3S5H671	Leishmania donovani	84%	78%
A0A3S5IRB9	Trypanosoma rangeli	29%	100%
A4HTM8	Leishmania infantum	84%	99%
C9ZPC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AMG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QI81	Leishmania major	86%	100%