Putative fatty acid desaturase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fatty acid desaturase, putative

Species:

Leishmania braziliensis

UniProt:

A4H6C4_LEIBR

TriTrypDb:

LbrM.10.1470 , LBRM2903_100005000

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4H6C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6C4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	18
GO:0008152	metabolic process	1	18
GO:0044238	primary metabolic process	2	18
GO:0071704	organic substance metabolic process	2	18

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004768	stearoyl-CoA 9-desaturase activity	6	7
GO:0016215	acyl-CoA desaturase activity	5	7
GO:0016491	oxidoreductase activity	2	8
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	7
GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.549
CLV_NRD_NRD_1	215	217	PF00675	0.335
CLV_NRD_NRD_1	8	10	PF00675	0.357
CLV_PCSK_KEX2_1	215	217	PF00082	0.335
CLV_PCSK_SKI1_1	2	6	PF00082	0.359
CLV_PCSK_SKI1_1	20	24	PF00082	0.424
DEG_MDM2_SWIB_1	196	204	PF02201	0.184
DEG_Nend_UBRbox_1	1	4	PF02207	0.647
DOC_AGCK_PIF_1	193	198	PF00069	0.227
DOC_MAPK_gen_1	172	180	PF00069	0.323
DOC_MAPK_gen_1	229	237	PF00069	0.372
DOC_MAPK_gen_1	6	15	PF00069	0.504
DOC_MAPK_MEF2A_6	9	17	PF00069	0.589
DOC_PP1_SILK_1	2	7	PF00149	0.456
DOC_PP2B_LxvP_1	287	290	PF13499	0.451
DOC_USP7_MATH_1	126	130	PF00917	0.489
DOC_USP7_MATH_1	145	149	PF00917	0.278
DOC_USP7_MATH_1	40	44	PF00917	0.407
DOC_USP7_MATH_2	379	385	PF00917	0.603
DOC_USP7_UBL2_3	2	6	PF12436	0.562
DOC_WW_Pin1_4	122	127	PF00397	0.425
DOC_WW_Pin1_4	181	186	PF00397	0.291
DOC_WW_Pin1_4	221	226	PF00397	0.514
LIG_BRCT_BRCA1_1	223	227	PF00533	0.514
LIG_BRCT_BRCA1_2	223	229	PF00533	0.545
LIG_deltaCOP1_diTrp_1	295	299	PF00928	0.439
LIG_EH1_1	345	353	PF00400	0.568
LIG_FHA_1	158	164	PF00498	0.248
LIG_FHA_1	165	171	PF00498	0.248
LIG_FHA_1	182	188	PF00498	0.332
LIG_FHA_1	80	86	PF00498	0.304
LIG_FHA_2	368	374	PF00498	0.522
LIG_GBD_Chelix_1	327	335	PF00786	0.283
LIG_HP1_1	185	189	PF01393	0.268
LIG_LIR_Apic_2	373	379	PF02991	0.490
LIG_LIR_Gen_1	230	240	PF02991	0.392
LIG_LIR_Gen_1	295	305	PF02991	0.445
LIG_LIR_Gen_1	86	95	PF02991	0.408
LIG_LIR_Nem_3	125	130	PF02991	0.514
LIG_LIR_Nem_3	197	203	PF02991	0.373
LIG_LIR_Nem_3	230	236	PF02991	0.434
LIG_LIR_Nem_3	253	259	PF02991	0.320
LIG_LIR_Nem_3	272	278	PF02991	0.308
LIG_LIR_Nem_3	295	300	PF02991	0.451
LIG_LIR_Nem_3	308	314	PF02991	0.483
LIG_LIR_Nem_3	384	389	PF02991	0.593
LIG_LIR_Nem_3	43	48	PF02991	0.547
LIG_LIR_Nem_3	86	90	PF02991	0.383
LIG_Pex14_2	196	200	PF04695	0.306
LIG_SH2_CRK	127	131	PF00017	0.544
LIG_SH2_CRK	233	237	PF00017	0.501
LIG_SH2_CRK	311	315	PF00017	0.477
LIG_SH2_CRK	338	342	PF00017	0.412
LIG_SH2_CRK	62	66	PF00017	0.353
LIG_SH2_CRK	87	91	PF00017	0.213
LIG_SH2_GRB2like	321	324	PF00017	0.451
LIG_SH2_NCK_1	87	91	PF00017	0.213
LIG_SH2_PTP2	265	268	PF00017	0.427
LIG_SH2_PTP2	376	379	PF00017	0.498
LIG_SH2_SRC	254	257	PF00017	0.464
LIG_SH2_SRC	376	379	PF00017	0.502
LIG_SH2_STAP1	233	237	PF00017	0.379
LIG_SH2_STAT5	203	206	PF00017	0.382
LIG_SH2_STAT5	265	268	PF00017	0.309
LIG_SH2_STAT5	269	272	PF00017	0.301
LIG_SH2_STAT5	278	281	PF00017	0.288
LIG_SH2_STAT5	292	295	PF00017	0.446
LIG_SH2_STAT5	321	324	PF00017	0.459
LIG_SH2_STAT5	35	38	PF00017	0.538
LIG_SH2_STAT5	356	359	PF00017	0.510
LIG_SH2_STAT5	376	379	PF00017	0.498
LIG_SH2_STAT5	46	49	PF00017	0.458
LIG_SH2_STAT5	58	61	PF00017	0.365
LIG_SH3_3	12	18	PF00018	0.495
LIG_SH3_3	219	225	PF00018	0.448
LIG_SUMO_SIM_anti_2	12	17	PF11976	0.572
LIG_SUMO_SIM_par_1	176	184	PF11976	0.323
LIG_SUMO_SIM_par_1	247	253	PF11976	0.245
LIG_TYR_ITIM	60	65	PF00017	0.350
LIG_TYR_ITIM	85	90	PF00017	0.296
LIG_WRC_WIRS_1	195	200	PF05994	0.402
MOD_CDC14_SPxK_1	125	128	PF00782	0.425
MOD_CDK_SPxK_1	122	128	PF00069	0.425
MOD_CK2_1	359	365	PF00069	0.536
MOD_CK2_1	367	373	PF00069	0.504
MOD_Cter_Amidation	213	216	PF01082	0.345
MOD_Cter_Amidation	7	10	PF01082	0.239
MOD_GlcNHglycan	139	142	PF01048	0.254
MOD_GlcNHglycan	37	41	PF01048	0.432
MOD_GSK3_1	122	129	PF00069	0.472
MOD_GSK3_1	145	152	PF00069	0.294
MOD_GSK3_1	157	164	PF00069	0.248
MOD_GSK3_1	36	43	PF00069	0.482
MOD_GSK3_1	377	384	PF00069	0.592
MOD_GSK3_1	79	86	PF00069	0.281
MOD_N-GLC_1	322	327	PF02516	0.240
MOD_N-GLC_1	341	346	PF02516	0.172
MOD_NEK2_1	137	142	PF00069	0.416
MOD_NEK2_1	277	282	PF00069	0.423
MOD_NEK2_1	36	41	PF00069	0.523
MOD_NEK2_1	367	372	PF00069	0.560
MOD_NEK2_2	40	45	PF00069	0.531
MOD_PIKK_1	207	213	PF00454	0.552
MOD_PIKK_1	330	336	PF00454	0.490
MOD_PKA_2	149	155	PF00069	0.248
MOD_PKA_2	214	220	PF00069	0.502
MOD_Plk_1	20	26	PF00069	0.563
MOD_Plk_1	322	328	PF00069	0.440
MOD_Plk_1	359	365	PF00069	0.456
MOD_Plk_1	36	42	PF00069	0.474
MOD_Plk_2-3	359	365	PF00069	0.497
MOD_Plk_4	277	283	PF00069	0.298
MOD_Plk_4	381	387	PF00069	0.571
MOD_Plk_4	40	46	PF00069	0.518
MOD_ProDKin_1	122	128	PF00069	0.425
MOD_ProDKin_1	181	187	PF00069	0.291
MOD_ProDKin_1	221	227	PF00069	0.514
TRG_DiLeu_BaEn_2	294	300	PF01217	0.481
TRG_ENDOCYTIC_2	127	130	PF00928	0.545
TRG_ENDOCYTIC_2	233	236	PF00928	0.458
TRG_ENDOCYTIC_2	259	262	PF00928	0.289
TRG_ENDOCYTIC_2	311	314	PF00928	0.477
TRG_ENDOCYTIC_2	338	341	PF00928	0.450
TRG_ENDOCYTIC_2	45	48	PF00928	0.544
TRG_ENDOCYTIC_2	58	61	PF00928	0.271
TRG_ENDOCYTIC_2	62	65	PF00928	0.264
TRG_ENDOCYTIC_2	87	90	PF00928	0.291
TRG_NES_CRM1_1	105	118	PF08389	0.295
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5L0	Leptomonas seymouri	70%	100%
A0A0S4IVK0	Bodo saltans	51%	94%
A0A1X0NKF1	Trypanosomatidae	44%	85%
A0A3Q8I8P6	Leishmania donovani	90%	100%
A0A3S7X797	Leishmania donovani	74%	100%
A0A422MYL0	Trypanosoma rangeli	54%	94%
A3F5L2	Sorghum bicolor	33%	100%
A3F5L3	Sorghum bicolor	38%	100%
A4H5Y3	Leishmania braziliensis	99%	100%
A4HM35	Leishmania braziliensis	73%	100%
A4HUP7	Leishmania infantum	90%	100%
A4I9G8	Leishmania infantum	74%	100%
B4YQU1	Claviceps purpurea	34%	83%
C9ZJ57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	97%
E9ANE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B4G6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
G5EGA5	Caenorhabditis elegans	29%	100%
O34653	Bacillus subtilis (strain 168)	23%	100%
O81931	Crepis alpina	36%	100%
P20388	Synechocystis sp. (strain PCC 6803 / Kazusa)	23%	100%
P32291	Vigna radiata var. radiata	33%	100%
P46310	Arabidopsis thaliana	33%	88%
P46312	Arabidopsis thaliana	25%	88%
P46313	Arabidopsis thaliana	36%	100%
P48618	Brassica napus	33%	98%
P48619	Ricinus communis	33%	86%
P48620	Sesamum indicum	33%	88%
P48621	Glycine max	33%	87%
P48622	Arabidopsis thaliana	31%	91%
P48623	Arabidopsis thaliana	37%	100%
P48624	Brassica napus	38%	100%
P48625	Glycine max	32%	100%
P48626	Nicotiana tabacum	33%	100%
P48627	Brassica napus	24%	89%
P48628	Glycine max	29%	93%
P48629	Spinacia oleracea	26%	88%
P48630	Glycine max	36%	100%
P48631	Glycine max	36%	100%
P59668	Mortierella isabellina	42%	98%
Q39287	Brassica juncea	37%	100%
Q41131	Ricinus communis	35%	100%
Q4Q3K9	Leishmania major	74%	100%
Q4QH80	Leishmania major	90%	100%
Q54794	Arthrospira platensis	28%	100%
Q56VS4	Helianthus annuus	32%	89%
Q594P3	Sorghum bicolor	38%	100%
Q59J82	Mortierella alpina	35%	98%
Q6RS95	Dimorphotheca sinuata	34%	100%
Q6RS96	Dimorphotheca sinuata	32%	100%
Q84UB8	Punica granatum	36%	100%
Q84UB9	Trichosanthes kirilowii	35%	100%
Q84UC0	Trichosanthes kirilowii	35%	100%
Q84VT2	Punica granatum	38%	100%
Q8GZC2	Vernicia fordii	35%	100%
Q8GZC3	Vernicia fordii	37%	100%
Q9AT72	Calendula officinalis	35%	100%
Q9FPP7	Calendula officinalis	32%	100%
Q9FPP8	Calendula officinalis	33%	100%
Q9NEQ0	Caenorhabditis elegans	31%	98%
Q9SCG2	Calendula officinalis	34%	100%
Q9SP61	Momordica charantia	33%	99%
Q9SP62	Impatiens balsamina	33%	100%
Q9Y8H5	Mortierella alpina	43%	98%
V5BA48	Trypanosoma cruzi	55%	96%