Putative pteridine transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4H6C3_LEIBR

TriTrypDb:

LbrM.10.1460 , LBRM2903_100005100

Length:

656

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4H6C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6C3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	648	652	PF00656	0.633
CLV_NRD_NRD_1	260	262	PF00675	0.321
CLV_PCSK_KEX2_1	134	136	PF00082	0.292
CLV_PCSK_KEX2_1	192	194	PF00082	0.250
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.292
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.207
CLV_PCSK_SKI1_1	117	121	PF00082	0.354
CLV_PCSK_SKI1_1	189	193	PF00082	0.207
CLV_PCSK_SKI1_1	585	589	PF00082	0.483
CLV_PCSK_SKI1_1	81	85	PF00082	0.347
DEG_SPOP_SBC_1	572	576	PF00917	0.246
DOC_ANK_TNKS_1	104	111	PF00023	0.542
DOC_ANK_TNKS_1	192	199	PF00023	0.402
DOC_CKS1_1	593	598	PF01111	0.432
DOC_CYCLIN_RxL_1	77	87	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	395	401	PF00134	0.442
DOC_CYCLIN_yCln2_LP_2	593	599	PF00134	0.378
DOC_MAPK_gen_1	261	268	PF00069	0.553
DOC_MAPK_MEF2A_6	228	235	PF00069	0.328
DOC_MAPK_MEF2A_6	496	503	PF00069	0.356
DOC_MAPK_MEF2A_6	64	71	PF00069	0.547
DOC_MAPK_NFAT4_5	64	72	PF00069	0.609
DOC_PP1_RVXF_1	341	348	PF00149	0.409
DOC_PP2B_LxvP_1	395	398	PF13499	0.442
DOC_USP7_MATH_1	156	160	PF00917	0.267
DOC_USP7_MATH_1	572	576	PF00917	0.270
DOC_USP7_UBL2_3	643	647	PF12436	0.610
DOC_WW_Pin1_4	573	578	PF00397	0.348
DOC_WW_Pin1_4	592	597	PF00397	0.414
LIG_14-3-3_CanoR_1	473	477	PF00244	0.490
LIG_BIR_III_2	43	47	PF00653	0.620
LIG_BRCT_BRCA1_1	110	114	PF00533	0.480
LIG_BRCT_BRCA1_1	123	127	PF00533	0.397
LIG_BRCT_BRCA1_1	541	545	PF00533	0.492
LIG_CaM_NSCaTE_8	630	637	PF13499	0.480
LIG_EVH1_2	577	581	PF00568	0.360
LIG_FHA_1	118	124	PF00498	0.572
LIG_FHA_1	228	234	PF00498	0.349
LIG_FHA_1	358	364	PF00498	0.348
LIG_FHA_1	36	42	PF00498	0.583
LIG_FHA_1	373	379	PF00498	0.254
LIG_FHA_1	390	396	PF00498	0.326
LIG_FHA_1	477	483	PF00498	0.325
LIG_FHA_1	5	11	PF00498	0.739
LIG_FHA_1	54	60	PF00498	0.542
LIG_FHA_1	593	599	PF00498	0.417
LIG_FHA_1	64	70	PF00498	0.610
LIG_FHA_1	97	103	PF00498	0.412
LIG_FHA_2	275	281	PF00498	0.555
LIG_FHA_2	38	44	PF00498	0.558
LIG_GBD_Chelix_1	71	79	PF00786	0.232
LIG_LIR_Apic_2	30	36	PF02991	0.649
LIG_LIR_Gen_1	100	109	PF02991	0.505
LIG_LIR_Gen_1	124	132	PF02991	0.516
LIG_LIR_Gen_1	184	195	PF02991	0.519
LIG_LIR_Gen_1	203	214	PF02991	0.499
LIG_LIR_Gen_1	263	272	PF02991	0.547
LIG_LIR_Gen_1	374	383	PF02991	0.294
LIG_LIR_Gen_1	392	402	PF02991	0.273
LIG_LIR_Gen_1	40	48	PF02991	0.459
LIG_LIR_Gen_1	442	451	PF02991	0.323
LIG_LIR_Gen_1	487	494	PF02991	0.333
LIG_LIR_Gen_1	542	551	PF02991	0.510
LIG_LIR_Gen_1	580	589	PF02991	0.264
LIG_LIR_Gen_1	87	96	PF02991	0.539
LIG_LIR_Nem_3	100	106	PF02991	0.469
LIG_LIR_Nem_3	124	130	PF02991	0.490
LIG_LIR_Nem_3	184	190	PF02991	0.525
LIG_LIR_Nem_3	203	209	PF02991	0.295
LIG_LIR_Nem_3	263	268	PF02991	0.532
LIG_LIR_Nem_3	344	350	PF02991	0.499
LIG_LIR_Nem_3	374	379	PF02991	0.289
LIG_LIR_Nem_3	392	397	PF02991	0.366
LIG_LIR_Nem_3	40	45	PF02991	0.609
LIG_LIR_Nem_3	414	418	PF02991	0.375
LIG_LIR_Nem_3	442	447	PF02991	0.299
LIG_LIR_Nem_3	487	492	PF02991	0.334
LIG_LIR_Nem_3	495	500	PF02991	0.286
LIG_LIR_Nem_3	542	548	PF02991	0.472
LIG_LIR_Nem_3	580	584	PF02991	0.259
LIG_LIR_Nem_3	87	92	PF02991	0.447
LIG_NRBOX	583	589	PF00104	0.223
LIG_Pex14_2	170	174	PF04695	0.365
LIG_Pex14_2	242	246	PF04695	0.299
LIG_Pex14_2	247	251	PF04695	0.285
LIG_Pex14_2	406	410	PF04695	0.360
LIG_Pex14_2	439	443	PF04695	0.305
LIG_Pex14_2	463	467	PF04695	0.364
LIG_Pex14_2	47	51	PF04695	0.535
LIG_SH2_CRK	103	107	PF00017	0.512
LIG_SH2_CRK	152	156	PF00017	0.312
LIG_SH2_CRK	187	191	PF00017	0.515
LIG_SH2_CRK	355	359	PF00017	0.345
LIG_SH2_CRK	380	384	PF00017	0.355
LIG_SH2_CRK	444	448	PF00017	0.297
LIG_SH2_CRK	525	529	PF00017	0.264
LIG_SH2_NCK_1	444	448	PF00017	0.300
LIG_SH2_PTP2	33	36	PF00017	0.639
LIG_SH2_PTP2	415	418	PF00017	0.349
LIG_SH2_PTP2	500	503	PF00017	0.399
LIG_SH2_SRC	33	36	PF00017	0.645
LIG_SH2_STAP1	132	136	PF00017	0.500
LIG_SH2_STAP1	187	191	PF00017	0.486
LIG_SH2_STAP1	376	380	PF00017	0.257
LIG_SH2_STAP1	517	521	PF00017	0.405
LIG_SH2_STAP1	89	93	PF00017	0.536
LIG_SH2_STAT5	132	135	PF00017	0.501
LIG_SH2_STAT5	265	268	PF00017	0.468
LIG_SH2_STAT5	33	36	PF00017	0.637
LIG_SH2_STAT5	415	418	PF00017	0.339
LIG_SH2_STAT5	500	503	PF00017	0.302
LIG_SH2_STAT5	509	512	PF00017	0.293
LIG_SH2_STAT5	73	76	PF00017	0.519
LIG_SH3_3	431	437	PF00018	0.279
LIG_SH3_3	57	63	PF00018	0.526
LIG_SH3_3	602	608	PF00018	0.390
LIG_SH3_3	612	618	PF00018	0.493
LIG_SH3_4	643	650	PF00018	0.628
LIG_SUMO_SIM_par_1	362	367	PF11976	0.297
LIG_SUMO_SIM_par_1	490	495	PF11976	0.347
LIG_TRFH_1	152	156	PF08558	0.361
LIG_TRFH_1	604	608	PF08558	0.291
LIG_TYR_ITIM	150	155	PF00017	0.378
LIG_TYR_ITIM	378	383	PF00017	0.374
LIG_TYR_ITIM	413	418	PF00017	0.333
LIG_TYR_ITIM	523	528	PF00017	0.236
LIG_TYR_ITSM	440	447	PF00017	0.404
LIG_UBA3_1	266	270	PF00899	0.522
LIG_UBA3_1	531	538	PF00899	0.222
LIG_Vh1_VBS_1	364	382	PF01044	0.447
LIG_WRC_WIRS_1	548	553	PF05994	0.225
MOD_CK1_1	419	425	PF00069	0.379
MOD_CK1_1	468	474	PF00069	0.351
MOD_CK1_1	556	562	PF00069	0.353
MOD_CK2_1	274	280	PF00069	0.387
MOD_CK2_1	313	319	PF00069	0.258
MOD_CK2_1	371	377	PF00069	0.200
MOD_GlcNHglycan	106	109	PF01048	0.409
MOD_GlcNHglycan	160	163	PF01048	0.361
MOD_GlcNHglycan	18	21	PF01048	0.606
MOD_GlcNHglycan	216	219	PF01048	0.388
MOD_GlcNHglycan	235	238	PF01048	0.372
MOD_GlcNHglycan	297	300	PF01048	0.271
MOD_GlcNHglycan	418	421	PF01048	0.434
MOD_GSK3_1	104	111	PF00069	0.406
MOD_GSK3_1	117	124	PF00069	0.346
MOD_GSK3_1	289	296	PF00069	0.437
MOD_GSK3_1	439	446	PF00069	0.369
MOD_GSK3_1	468	475	PF00069	0.363
MOD_GSK3_1	549	556	PF00069	0.373
MOD_GSK3_1	622	629	PF00069	0.442
MOD_GSK3_1	645	652	PF00069	0.710
MOD_N-GLC_1	293	298	PF02516	0.191
MOD_N-GLC_1	348	353	PF02516	0.519
MOD_N-GLC_1	369	374	PF02516	0.361
MOD_N-GLC_1	84	89	PF02516	0.400
MOD_NEK2_1	112	117	PF00069	0.366
MOD_NEK2_1	123	128	PF00069	0.350
MOD_NEK2_1	130	135	PF00069	0.303
MOD_NEK2_1	138	143	PF00069	0.357
MOD_NEK2_1	157	162	PF00069	0.217
MOD_NEK2_1	329	334	PF00069	0.511
MOD_NEK2_1	369	374	PF00069	0.319
MOD_NEK2_1	389	394	PF00069	0.289
MOD_NEK2_1	439	444	PF00069	0.355
MOD_NEK2_1	476	481	PF00069	0.362
MOD_NEK2_1	530	535	PF00069	0.302
MOD_NEK2_1	554	559	PF00069	0.353
MOD_NEK2_1	566	571	PF00069	0.351
MOD_NEK2_1	79	84	PF00069	0.358
MOD_NEK2_2	540	545	PF00069	0.222
MOD_OFUCOSY	327	334	PF10250	0.186
MOD_PIKK_1	437	443	PF00454	0.222
MOD_PK_1	348	354	PF00069	0.222
MOD_PKA_2	104	110	PF00069	0.324
MOD_PKA_2	227	233	PF00069	0.229
MOD_PKA_2	274	280	PF00069	0.186
MOD_PKA_2	472	478	PF00069	0.349
MOD_Plk_1	348	354	PF00069	0.443
MOD_Plk_1	540	546	PF00069	0.296
MOD_Plk_1	84	90	PF00069	0.430
MOD_Plk_2-3	37	43	PF00069	0.471
MOD_Plk_4	302	308	PF00069	0.389
MOD_Plk_4	364	370	PF00069	0.314
MOD_Plk_4	37	43	PF00069	0.515
MOD_Plk_4	397	403	PF00069	0.415
MOD_Plk_4	411	417	PF00069	0.368
MOD_Plk_4	439	445	PF00069	0.437
MOD_Plk_4	446	452	PF00069	0.346
MOD_Plk_4	476	482	PF00069	0.313
MOD_Plk_4	484	490	PF00069	0.320
MOD_Plk_4	540	546	PF00069	0.372
MOD_Plk_4	566	572	PF00069	0.347
MOD_Plk_4	622	628	PF00069	0.585
MOD_ProDKin_1	573	579	PF00069	0.417
MOD_ProDKin_1	592	598	PF00069	0.414
TRG_DiLeu_BaEn_1	254	259	PF01217	0.453
TRG_DiLeu_BaEn_2	262	268	PF01217	0.306
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.276
TRG_DiLeu_BaLyEn_6	593	598	PF01217	0.320
TRG_ENDOCYTIC_2	103	106	PF00928	0.327
TRG_ENDOCYTIC_2	137	140	PF00928	0.351
TRG_ENDOCYTIC_2	152	155	PF00928	0.341
TRG_ENDOCYTIC_2	187	190	PF00928	0.339
TRG_ENDOCYTIC_2	265	268	PF00928	0.444
TRG_ENDOCYTIC_2	355	358	PF00928	0.346
TRG_ENDOCYTIC_2	376	379	PF00928	0.359
TRG_ENDOCYTIC_2	380	383	PF00928	0.358
TRG_ENDOCYTIC_2	415	418	PF00928	0.351
TRG_ENDOCYTIC_2	444	447	PF00928	0.350
TRG_ENDOCYTIC_2	500	503	PF00928	0.481
TRG_ENDOCYTIC_2	525	528	PF00928	0.304
TRG_ENDOCYTIC_2	89	92	PF00928	0.356
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	46%	93%
A0A0N1HY49	Leptomonas seymouri	47%	97%
A0A0N1HZ06	Leptomonas seymouri	38%	100%
A0A0N1IHL1	Leptomonas seymouri	38%	92%
A0A0N1PAY4	Leptomonas seymouri	39%	75%
A0A0N1PB77	Leptomonas seymouri	39%	100%
A0A0N1PBZ2	Leptomonas seymouri	46%	97%
A0A0N1PCC1	Leptomonas seymouri	44%	98%
A0A0S4INN8	Bodo saltans	30%	100%
A0A381MBI0	Leishmania infantum	84%	100%
A0A3Q8I8X7	Leishmania donovani	84%	100%
A0A3Q8IAZ0	Leishmania donovani	44%	94%
A0A3Q8IH50	Leishmania donovani	47%	91%
A0A3Q8IVN0	Leishmania donovani	40%	100%
A0A3R7M4J1	Trypanosoma rangeli	40%	100%
A0A3S5H5P4	Leishmania donovani	45%	97%
A0A3S5H5V2	Leishmania donovani	44%	100%
A0A3S5H6F6	Leishmania donovani	44%	94%
A0A3S5H763	Leishmania donovani	48%	97%
A0A3S7WR10	Leishmania donovani	41%	88%
A0A3S7WR14	Leishmania donovani	46%	96%
A0A3S7WR15	Leishmania donovani	42%	77%
A0A3S7WR24	Leishmania donovani	43%	93%
A4H4T8	Leishmania braziliensis	42%	100%
A4H5Y4	Leishmania braziliensis	99%	100%
A4H617	Leishmania braziliensis	44%	100%
A4H618	Leishmania braziliensis	44%	100%
A4H619	Leishmania braziliensis	44%	100%
A4H620	Leishmania braziliensis	50%	100%
A4HNH7	Leishmania braziliensis	39%	100%
A4HSS2	Leishmania infantum	45%	97%
A4HUE4	Leishmania infantum	41%	88%
A4HUE5	Leishmania infantum	42%	95%
A4HUE6	Leishmania infantum	46%	96%
A4HUE7	Leishmania infantum	44%	94%
A4HUE8	Leishmania infantum	43%	93%
A4HUF4	Leishmania infantum	44%	94%
A4HUF5	Leishmania infantum	49%	100%
A4HYA9	Leishmania infantum	48%	97%
A4IC33	Leishmania infantum	39%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	94%
E9AG72	Leishmania infantum	44%	100%
E9AI40	Leishmania braziliensis	47%	96%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	97%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	88%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	92%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	98%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4QDC4	Leishmania major	48%	100%
Q4QH81	Leishmania major	84%	100%
Q4QHH7	Leishmania major	47%	100%
Q4QHH8	Leishmania major	43%	100%
Q4QHH9	Leishmania major	42%	100%
Q4QHI0	Leishmania major	42%	100%
Q4QHI1	Leishmania major	45%	100%
Q4QHI2	Leishmania major	44%	100%
Q4QIU9	Leishmania major	45%	100%
Q4QJ48	Leishmania major	46%	100%
Q7KIP2	Leishmania major	39%	100%