Phosphate transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphate-Repressible Phosphate Permease-like protein

Species:

Leishmania braziliensis

UniProt:

A4H6C2_LEIBR

TriTrypDb:

LbrM.10.1450 , LBRM2903_100024100

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	24
GO:0110165	cellular anatomical entity	1	24

Expansion

Sequence features

A4H6C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6C2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	24
GO:0006811	monoatomic ion transport	4	24
GO:0006817	phosphate ion transport	7	24
GO:0006820	monoatomic anion transport	5	24
GO:0015698	inorganic anion transport	6	24
GO:0051179	localization	1	24
GO:0051234	establishment of localization	2	24
GO:0009987	cellular process	1	3
GO:0034220	monoatomic ion transmembrane transport	3	3
GO:0035435	phosphate ion transmembrane transport	6	3
GO:0055085	transmembrane transport	2	3
GO:0098656	monoatomic anion transmembrane transport	4	3
GO:0098660	inorganic ion transmembrane transport	4	3
GO:0098661	inorganic anion transmembrane transport	5	3

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	24
GO:0005315	inorganic phosphate transmembrane transporter activity	4	24
GO:0015291	secondary active transmembrane transporter activity	4	24
GO:0015293	symporter activity	5	24
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	24
GO:0022804	active transmembrane transporter activity	3	24
GO:0022857	transmembrane transporter activity	2	24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.541
CLV_NRD_NRD_1	188	190	PF00675	0.165
CLV_NRD_NRD_1	283	285	PF00675	0.293
CLV_NRD_NRD_1	307	309	PF00675	0.165
CLV_PCSK_KEX2_1	188	190	PF00082	0.244
CLV_PCSK_KEX2_1	216	218	PF00082	0.462
CLV_PCSK_KEX2_1	248	250	PF00082	0.257
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.462
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.319
CLV_PCSK_SKI1_1	216	220	PF00082	0.452
CLV_PCSK_SKI1_1	287	291	PF00082	0.349
CLV_PCSK_SKI1_1	308	312	PF00082	0.244
CLV_PCSK_SKI1_1	41	45	PF00082	0.298
DEG_SPOP_SBC_1	112	116	PF00917	0.271
DEG_SPOP_SBC_1	433	437	PF00917	0.316
DOC_CKS1_1	407	412	PF01111	0.553
DOC_MAPK_gen_1	188	196	PF00069	0.444
DOC_MAPK_MEF2A_6	189	198	PF00069	0.435
DOC_MAPK_MEF2A_6	370	378	PF00069	0.333
DOC_MAPK_MEF2A_6	458	465	PF00069	0.555
DOC_MAPK_NFAT4_5	458	466	PF00069	0.547
DOC_PP1_RVXF_1	214	221	PF00149	0.280
DOC_PP2B_LxvP_1	109	112	PF13499	0.460
DOC_PP4_FxxP_1	159	162	PF00568	0.300
DOC_SPAK_OSR1_1	177	181	PF12202	0.494
DOC_USP7_MATH_1	112	116	PF00917	0.309
DOC_USP7_MATH_1	299	303	PF00917	0.479
DOC_USP7_MATH_1	433	437	PF00917	0.316
DOC_USP7_UBL2_3	212	216	PF12436	0.244
DOC_USP7_UBL2_3	79	83	PF12436	0.279
DOC_WW_Pin1_4	158	163	PF00397	0.300
DOC_WW_Pin1_4	406	411	PF00397	0.468
LIG_14-3-3_CanoR_1	110	119	PF00244	0.444
LIG_14-3-3_CanoR_1	189	195	PF00244	0.459
LIG_14-3-3_CanoR_1	217	223	PF00244	0.290
LIG_14-3-3_CanoR_1	41	46	PF00244	0.507
LIG_Actin_WH2_2	203	221	PF00022	0.263
LIG_BIR_II_1	1	5	PF00653	0.375
LIG_BRCT_BRCA1_1	239	243	PF00533	0.330
LIG_BRCT_BRCA1_1	410	414	PF00533	0.305
LIG_BRCT_BRCA1_1	479	483	PF00533	0.357
LIG_CaM_NSCaTE_8	377	384	PF13499	0.330
LIG_deltaCOP1_diTrp_1	322	329	PF00928	0.444
LIG_FHA_1	114	120	PF00498	0.276
LIG_FHA_1	163	169	PF00498	0.407
LIG_FHA_1	191	197	PF00498	0.503
LIG_FHA_1	288	294	PF00498	0.451
LIG_FHA_1	390	396	PF00498	0.289
LIG_FHA_1	435	441	PF00498	0.328
LIG_FHA_1	44	50	PF00498	0.392
LIG_FHA_1	470	476	PF00498	0.322
LIG_FHA_1	66	72	PF00498	0.254
LIG_FHA_2	266	272	PF00498	0.466
LIG_GBD_Chelix_1	167	175	PF00786	0.214
LIG_GBD_Chelix_1	196	204	PF00786	0.319
LIG_IBAR_NPY_1	5	7	PF08397	0.350
LIG_LIR_Apic_2	157	162	PF02991	0.300
LIG_LIR_Apic_2	428	433	PF02991	0.316
LIG_LIR_Gen_1	107	113	PF02991	0.522
LIG_LIR_Gen_1	15	23	PF02991	0.318
LIG_LIR_Gen_1	205	214	PF02991	0.300
LIG_LIR_Gen_1	451	462	PF02991	0.283
LIG_LIR_LC3C_4	419	424	PF02991	0.327
LIG_LIR_Nem_3	107	111	PF02991	0.522
LIG_LIR_Nem_3	143	148	PF02991	0.257
LIG_LIR_Nem_3	15	19	PF02991	0.318
LIG_LIR_Nem_3	205	211	PF02991	0.300
LIG_LIR_Nem_3	240	246	PF02991	0.331
LIG_LIR_Nem_3	326	332	PF02991	0.456
LIG_LIR_Nem_3	451	457	PF02991	0.290
LIG_Pex14_2	203	207	PF04695	0.301
LIG_SH2_CRK	173	177	PF00017	0.245
LIG_SH2_CRK	192	196	PF00017	0.245
LIG_SH2_CRK	430	434	PF00017	0.360
LIG_SH2_CRK	90	94	PF00017	0.336
LIG_SH2_STAT5	192	195	PF00017	0.430
LIG_SH2_STAT5	331	334	PF00017	0.304
LIG_SH2_STAT5	7	10	PF00017	0.292
LIG_SH2_STAT5	86	89	PF00017	0.300
LIG_SH3_3	177	183	PF00018	0.417
LIG_SH3_3	280	286	PF00018	0.525
LIG_SH3_3	404	410	PF00018	0.553
LIG_SH3_3	485	491	PF00018	0.274
LIG_SH3_3	72	78	PF00018	0.384
LIG_Sin3_3	420	427	PF02671	0.415
LIG_SUMO_SIM_anti_2	403	409	PF11976	0.553
LIG_SUMO_SIM_anti_2	46	53	PF11976	0.411
LIG_SUMO_SIM_par_1	276	282	PF11976	0.365
LIG_SUMO_SIM_par_1	41	46	PF11976	0.479
LIG_SUMO_SIM_par_1	443	448	PF11976	0.316
LIG_SUMO_SIM_par_1	47	53	PF11976	0.290
LIG_SUMO_SIM_par_1	471	476	PF11976	0.327
LIG_SUMO_SIM_par_1	9	15	PF11976	0.172
LIG_TRAF2_1	261	264	PF00917	0.479
LIG_TYR_ITIM	171	176	PF00017	0.392
LIG_UBA3_1	460	464	PF00899	0.294
LIG_ULM_U2AF65_1	216	221	PF00076	0.263
LIG_WRC_WIRS_1	13	18	PF05994	0.332
LIG_WRC_WIRS_1	204	209	PF05994	0.257
LIG_WRC_WIRS_1	390	395	PF05994	0.360
LIG_WRC_WIRS_1	423	428	PF05994	0.330
MOD_CDK_SPxK_1	406	412	PF00069	0.316
MOD_CK1_1	115	121	PF00069	0.271
MOD_CK1_1	15	21	PF00069	0.172
MOD_CK1_1	297	303	PF00069	0.339
MOD_CK1_1	347	353	PF00069	0.320
MOD_CK1_1	425	431	PF00069	0.316
MOD_CK1_1	69	75	PF00069	0.298
MOD_CK2_1	264	270	PF00069	0.289
MOD_CK2_1	297	303	PF00069	0.367
MOD_CK2_1	50	56	PF00069	0.311
MOD_GlcNHglycan	148	151	PF01048	0.487
MOD_GlcNHglycan	168	171	PF01048	0.296
MOD_GlcNHglycan	313	316	PF01048	0.452
MOD_GlcNHglycan	364	367	PF01048	0.327
MOD_GlcNHglycan	417	421	PF01048	0.307
MOD_GlcNHglycan	427	430	PF01048	0.279
MOD_GlcNHglycan	479	482	PF01048	0.312
MOD_GlcNHglycan	488	491	PF01048	0.435
MOD_GlcNHglycan	56	60	PF01048	0.374
MOD_GlcNHglycan	72	75	PF01048	0.290
MOD_GSK3_1	111	118	PF00069	0.286
MOD_GSK3_1	154	161	PF00069	0.315
MOD_GSK3_1	162	169	PF00069	0.300
MOD_GSK3_1	265	272	PF00069	0.367
MOD_GSK3_1	364	371	PF00069	0.257
MOD_GSK3_1	434	441	PF00069	0.325
MOD_GSK3_1	469	476	PF00069	0.346
MOD_GSK3_1	55	62	PF00069	0.309
MOD_GSK3_1	65	72	PF00069	0.321
MOD_N-GLC_1	294	299	PF02516	0.229
MOD_NEK2_1	203	208	PF00069	0.276
MOD_NEK2_1	34	39	PF00069	0.317
MOD_NEK2_1	388	393	PF00069	0.331
MOD_NEK2_1	422	427	PF00069	0.317
MOD_NEK2_1	43	48	PF00069	0.326
MOD_NEK2_1	473	478	PF00069	0.363
MOD_PIKK_1	43	49	PF00454	0.415
MOD_PK_1	370	376	PF00069	0.283
MOD_PKA_1	140	146	PF00069	0.250
MOD_PKA_1	308	314	PF00069	0.172
MOD_PKA_2	264	270	PF00069	0.422
MOD_Plk_1	403	409	PF00069	0.283
MOD_Plk_2-3	276	282	PF00069	0.172
MOD_Plk_4	104	110	PF00069	0.320
MOD_Plk_4	12	18	PF00069	0.332
MOD_Plk_4	154	160	PF00069	0.287
MOD_Plk_4	203	209	PF00069	0.275
MOD_Plk_4	403	409	PF00069	0.403
MOD_Plk_4	445	451	PF00069	0.283
MOD_ProDKin_1	158	164	PF00069	0.300
MOD_ProDKin_1	406	412	PF00069	0.316
MOD_SUMO_rev_2	301	311	PF00179	0.172
MOD_SUMO_rev_2	72	81	PF00179	0.283
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.298
TRG_ENDOCYTIC_2	173	176	PF00928	0.250
TRG_ENDOCYTIC_2	331	334	PF00928	0.270
TRG_ENDOCYTIC_2	7	10	PF00928	0.292
TRG_ENDOCYTIC_2	86	89	PF00928	0.307
TRG_ENDOCYTIC_2	90	93	PF00928	0.289
TRG_ER_diArg_1	187	189	PF00400	0.179

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S5	Leptomonas seymouri	69%	94%
A0A1X0NXY5	Trypanosomatidae	59%	93%
A0A3Q8I8Y3	Leishmania donovani	92%	100%
A0A3Q8IBK1	Leishmania donovani	62%	91%
A0A3R7K4N2	Trypanosoma rangeli	55%	100%
A0A3S5H545	Leishmania donovani	47%	86%
A4H5Y5	Leishmania braziliensis	100%	100%
A4HBH2	Leishmania braziliensis	61%	91%
A4HH06	Leishmania braziliensis	47%	88%
A4HUP5	Leishmania infantum	92%	100%
A4HYJ6	Leishmania infantum	62%	91%
C9ZHT9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	96%
C9ZHU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	96%
E9ACJ5	Leishmania major	47%	100%
E9AG39	Leishmania infantum	47%	86%
E9AJT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	93%
E9AN09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9ANE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AUE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	86%
O26024	Helicobacter pylori (strain ATCC 700392 / 26695)	27%	92%
P38361	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	86%
Q38954	Arabidopsis thaliana	33%	84%
Q4QH82	Leishmania major	91%	100%
Q4QHL7	Leishmania major	91%	100%
Q5BL44	Xenopus tropicalis	33%	72%
Q5R9L5	Pongo abelii	30%	73%
Q9JJP0	Rattus norvegicus	31%	72%
Q9PLN5	Chlamydia muridarum (strain MoPn / Nigg)	31%	100%
Q9Z7M4	Chlamydia pneumoniae	32%	100%
V5DS90	Trypanosoma cruzi	59%	100%