DUF1861 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania braziliensis

UniProt:

A4H6C1_LEIBR

TriTrypDb:

LbrM.10.1440 , LBRM2903_100024000

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6C1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6C1

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.336
CLV_NRD_NRD_1	102	104	PF00675	0.377
CLV_PCSK_KEX2_1	14	16	PF00082	0.391
CLV_PCSK_KEX2_1	53	55	PF00082	0.375
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.431
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.368
CLV_PCSK_SKI1_1	4	8	PF00082	0.423
DEG_COP1_1	71	79	PF00400	0.418
DOC_CDC14_PxL_1	73	81	PF14671	0.248
DOC_MAPK_gen_1	14	22	PF00069	0.423
DOC_MAPK_gen_1	152	161	PF00069	0.381
DOC_MAPK_HePTP_8	149	161	PF00069	0.192
DOC_MAPK_MEF2A_6	15	24	PF00069	0.441
DOC_MAPK_MEF2A_6	152	161	PF00069	0.350
DOC_PP1_RVXF_1	179	186	PF00149	0.229
DOC_PP4_FxxP_1	185	188	PF00568	0.229
DOC_WW_Pin1_4	117	122	PF00397	0.327
LIG_14-3-3_CanoR_1	138	143	PF00244	0.380
LIG_APCC_ABBA_1	62	67	PF00400	0.336
LIG_BIR_II_1	1	5	PF00653	0.454
LIG_BRCT_BRCA1_1	229	233	PF00533	0.411
LIG_BRCT_BRCA1_1	35	39	PF00533	0.352
LIG_CtBP_PxDLS_1	121	125	PF00389	0.201
LIG_FHA_1	171	177	PF00498	0.344
LIG_FHA_1	235	241	PF00498	0.336
LIG_FHA_2	118	124	PF00498	0.368
LIG_FHA_2	153	159	PF00498	0.375
LIG_FHA_2	166	172	PF00498	0.369
LIG_FHA_2	66	72	PF00498	0.352
LIG_LIR_Gen_1	71	79	PF02991	0.369
LIG_LIR_Nem_3	111	116	PF02991	0.370
LIG_LIR_Nem_3	158	163	PF02991	0.336
LIG_LIR_Nem_3	190	194	PF02991	0.346
LIG_LIR_Nem_3	23	27	PF02991	0.378
LIG_LIR_Nem_3	28	33	PF02991	0.364
LIG_LIR_Nem_3	280	285	PF02991	0.343
LIG_LIR_Nem_3	296	302	PF02991	0.385
LIG_LIR_Nem_3	71	76	PF02991	0.369
LIG_PCNA_yPIPBox_3	238	246	PF02747	0.189
LIG_PDZ_Class_2	306	311	PF00595	0.436
LIG_PTB_Apo_2	225	232	PF02174	0.354
LIG_SH2_CRK	282	286	PF00017	0.352
LIG_SH2_CRK	302	306	PF00017	0.244
LIG_SH2_GRB2like	226	229	PF00017	0.352
LIG_SH2_PTP2	226	229	PF00017	0.229
LIG_SH2_SRC	226	229	PF00017	0.346
LIG_SH2_STAP1	17	21	PF00017	0.361
LIG_SH2_STAT5	115	118	PF00017	0.359
LIG_SH2_STAT5	126	129	PF00017	0.342
LIG_SH2_STAT5	160	163	PF00017	0.415
LIG_SH2_STAT5	198	201	PF00017	0.362
LIG_SH2_STAT5	226	229	PF00017	0.352
LIG_SH2_STAT5	87	90	PF00017	0.328
LIG_SH3_2	253	258	PF14604	0.314
LIG_SH3_3	250	256	PF00018	0.335
LIG_SUMO_SIM_par_1	120	125	PF11976	0.383
LIG_SUMO_SIM_par_1	138	144	PF11976	0.301
LIG_WRC_WIRS_1	21	26	PF05994	0.366
MOD_CK1_1	125	131	PF00069	0.328
MOD_CK2_1	152	158	PF00069	0.372
MOD_GlcNHglycan	178	181	PF01048	0.333
MOD_GlcNHglycan	201	204	PF01048	0.344
MOD_GlcNHglycan	210	213	PF01048	0.331
MOD_GlcNHglycan	218	221	PF01048	0.288
MOD_GlcNHglycan	268	271	PF01048	0.352
MOD_GlcNHglycan	282	285	PF01048	0.352
MOD_GSK3_1	148	155	PF00069	0.359
MOD_GSK3_1	16	23	PF00069	0.334
MOD_GSK3_1	247	254	PF00069	0.354
MOD_N-GLC_1	227	232	PF02516	0.365
MOD_N-GLC_1	33	38	PF02516	0.356
MOD_NEK2_1	199	204	PF00069	0.385
MOD_NEK2_1	65	70	PF00069	0.357
MOD_NEK2_1	97	102	PF00069	0.349
MOD_NEK2_2	247	252	PF00069	0.315
MOD_PKA_2	291	297	PF00069	0.362
MOD_Plk_1	122	128	PF00069	0.330
MOD_Plk_1	227	233	PF00069	0.350
MOD_Plk_1	33	39	PF00069	0.326
MOD_Plk_1	71	77	PF00069	0.369
MOD_Plk_4	108	114	PF00069	0.375
MOD_Plk_4	122	128	PF00069	0.360
MOD_Plk_4	16	22	PF00069	0.390
MOD_ProDKin_1	117	123	PF00069	0.327
MOD_SUMO_rev_2	2	9	PF00179	0.428
MOD_SUMO_rev_2	211	219	PF00179	0.226
TRG_ENDOCYTIC_2	113	116	PF00928	0.393
TRG_ENDOCYTIC_2	160	163	PF00928	0.352
TRG_ENDOCYTIC_2	17	20	PF00928	0.394
TRG_ENDOCYTIC_2	226	229	PF00928	0.395
TRG_ENDOCYTIC_2	282	285	PF00928	0.352
TRG_ENDOCYTIC_2	302	305	PF00928	0.241
TRG_ENDOCYTIC_2	48	51	PF00928	0.380
TRG_ER_FFAT_2	123	132	PF00635	0.201
TRG_NES_CRM1_1	132	144	PF08389	0.336
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	60%	98%
A0A0N1HYU8	Leptomonas seymouri	57%	98%
A0A0N1I429	Leptomonas seymouri	52%	95%
A0A0N1I5D6	Leptomonas seymouri	63%	99%
A0A0N1I720	Leptomonas seymouri	56%	99%
A0A0N1IL04	Leptomonas seymouri	75%	100%
A0A0N1PCE9	Leptomonas seymouri	54%	97%
A0A0R6XPC0	Leishmania donovani	55%	98%
A0A3Q8IHB3	Leishmania donovani	52%	97%
A0A3S5H6H4	Leishmania donovani	52%	95%
A0A3S5H6H5	Leishmania donovani	56%	99%
A0A3S7WRC9	Leishmania donovani	63%	98%
A0A3S7WRD5	Leishmania donovani	65%	99%
A0A3S7WRE8	Leishmania donovani	85%	100%
A4H6B5	Leishmania braziliensis	52%	100%
A4H6B6	Leishmania braziliensis	51%	100%
A4H6B7	Leishmania braziliensis	56%	100%
A4H6B8	Leishmania braziliensis	76%	100%
A4H6B9	Leishmania braziliensis	58%	100%
A4H6C0	Leishmania braziliensis	66%	100%
A4HUN8	Leishmania infantum	52%	95%
A4HUN9	Leishmania infantum	52%	97%
A4HUP0	Leishmania infantum	55%	98%
A4HUP1	Leishmania infantum	65%	99%
A4HUP2	Leishmania infantum	56%	99%
A4HUP3	Leishmania infantum	63%	98%
A4HUP4	Leishmania infantum	85%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	95%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	97%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	98%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	99%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	99%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	98%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QH83	Leishmania major	84%	100%
Q4QH84	Leishmania major	64%	100%
Q4QH85	Leishmania major	57%	99%
Q4QH86	Leishmania major	69%	100%
Q4QH87	Leishmania major	56%	100%
Q4QH88	Leishmania major	52%	100%
Q4QH89	Leishmania major	51%	100%