DUF1861 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania braziliensis

UniProt:

A4H6C0_LEIBR

TriTrypDb:

LbrM.10.1430 , LBRM2903_100023900

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6C0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6C0

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.336
CLV_NRD_NRD_1	107	109	PF00675	0.377
CLV_NRD_NRD_1	18	20	PF00675	0.262
CLV_PCSK_KEX2_1	18	20	PF00082	0.391
CLV_PCSK_KEX2_1	57	59	PF00082	0.375
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.368
CLV_PCSK_SKI1_1	113	117	PF00082	0.349
CLV_PCSK_SKI1_1	8	12	PF00082	0.456
DOC_CKS1_1	1	6	PF01111	0.369
DOC_MAPK_gen_1	18	26	PF00069	0.423
DOC_MAPK_MEF2A_6	19	28	PF00069	0.441
DOC_PP4_FxxP_1	155	158	PF00568	0.352
DOC_USP7_MATH_1	271	275	PF00917	0.347
DOC_USP7_MATH_1	91	95	PF00917	0.385
LIG_14-3-3_CanoR_1	108	117	PF00244	0.353
LIG_14-3-3_CanoR_1	157	166	PF00244	0.348
LIG_AP2alpha_2	90	92	PF02296	0.371
LIG_APCC_ABBA_1	66	71	PF00400	0.336
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BRCT_BRCA1_1	39	43	PF00533	0.352
LIG_FHA_1	1	7	PF00498	0.432
LIG_FHA_1	83	89	PF00498	0.350
LIG_FHA_2	132	138	PF00498	0.364
LIG_FHA_2	167	173	PF00498	0.391
LIG_FHA_2	70	76	PF00498	0.352
LIG_LIR_Gen_1	116	126	PF02991	0.354
LIG_LIR_Gen_1	160	171	PF02991	0.334
LIG_LIR_Gen_1	75	84	PF02991	0.369
LIG_LIR_Nem_3	116	121	PF02991	0.370
LIG_LIR_Nem_3	160	166	PF02991	0.338
LIG_LIR_Nem_3	193	199	PF02991	0.348
LIG_LIR_Nem_3	228	234	PF02991	0.368
LIG_LIR_Nem_3	27	31	PF02991	0.378
LIG_LIR_Nem_3	285	290	PF02991	0.343
LIG_LIR_Nem_3	301	307	PF02991	0.385
LIG_LIR_Nem_3	32	37	PF02991	0.364
LIG_LIR_Nem_3	75	80	PF02991	0.369
LIG_PDZ_Class_2	311	316	PF00595	0.430
LIG_PTB_Apo_2	230	237	PF02174	0.354
LIG_Rb_LxCxE_1	137	156	PF01857	0.229
LIG_SH2_CRK	163	167	PF00017	0.352
LIG_SH2_CRK	234	238	PF00017	0.363
LIG_SH2_CRK	287	291	PF00017	0.352
LIG_SH2_CRK	307	311	PF00017	0.237
LIG_SH2_GRB2like	231	234	PF00017	0.352
LIG_SH2_NCK_1	163	167	PF00017	0.352
LIG_SH2_STAP1	21	25	PF00017	0.361
LIG_SH2_STAP1	234	238	PF00017	0.340
LIG_SH2_STAT5	118	121	PF00017	0.358
LIG_SH2_STAT5	131	134	PF00017	0.342
LIG_SH2_STAT5	163	166	PF00017	0.423
LIG_SH2_STAT5	203	206	PF00017	0.362
LIG_SH2_STAT5	231	234	PF00017	0.352
LIG_SH2_STAT5	87	90	PF00017	0.330
LIG_SH3_2	258	263	PF14604	0.314
LIG_SH3_3	234	240	PF00018	0.352
LIG_SH3_3	255	261	PF00018	0.335
LIG_TRFH_1	236	240	PF08558	0.352
LIG_TYR_ITIM	232	237	PF00017	0.352
LIG_WRC_WIRS_1	25	30	PF05994	0.366
MOD_CK1_1	175	181	PF00069	0.392
MOD_CK1_1	217	223	PF00069	0.418
MOD_CK2_1	180	186	PF00069	0.388
MOD_GlcNHglycan	192	195	PF01048	0.333
MOD_GlcNHglycan	206	209	PF01048	0.344
MOD_GlcNHglycan	273	276	PF01048	0.352
MOD_GlcNHglycan	287	290	PF01048	0.352
MOD_GSK3_1	153	160	PF00069	0.359
MOD_GSK3_1	20	27	PF00069	0.334
MOD_N-GLC_1	232	237	PF02516	0.365
MOD_N-GLC_1	37	42	PF02516	0.356
MOD_NEK2_1	102	107	PF00069	0.349
MOD_NEK2_1	130	135	PF00069	0.259
MOD_NEK2_1	204	209	PF00069	0.385
MOD_NEK2_1	232	237	PF00069	0.362
MOD_NEK2_1	69	74	PF00069	0.357
MOD_PIKK_1	175	181	PF00454	0.409
MOD_PKA_1	108	114	PF00069	0.352
MOD_PKA_2	296	302	PF00069	0.362
MOD_PKB_1	106	114	PF00069	0.352
MOD_Plk_1	232	238	PF00069	0.350
MOD_Plk_1	37	43	PF00069	0.326
MOD_Plk_1	75	81	PF00069	0.369
MOD_Plk_4	113	119	PF00069	0.375
MOD_Plk_4	20	26	PF00069	0.390
MOD_Plk_4	226	232	PF00069	0.361
MOD_Plk_4	82	88	PF00069	0.333
MOD_SUMO_for_1	10	13	PF00179	0.404
MOD_SUMO_for_1	262	265	PF00179	0.352
MOD_SUMO_for_1	96	99	PF00179	0.325
MOD_SUMO_rev_2	235	245	PF00179	0.331
TRG_DiLeu_BaLyEn_6	110	115	PF01217	0.229
TRG_ENDOCYTIC_2	118	121	PF00928	0.393
TRG_ENDOCYTIC_2	163	166	PF00928	0.352
TRG_ENDOCYTIC_2	21	24	PF00928	0.394
TRG_ENDOCYTIC_2	234	237	PF00928	0.392
TRG_ENDOCYTIC_2	287	290	PF00928	0.352
TRG_ENDOCYTIC_2	307	310	PF00928	0.230
TRG_ENDOCYTIC_2	52	55	PF00928	0.380
TRG_ER_diArg_1	18	20	PF00400	0.238
TRG_NES_CRM1_1	137	149	PF08389	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	80%	100%
A0A0N1HYU8	Leptomonas seymouri	63%	99%
A0A0N1I429	Leptomonas seymouri	56%	97%
A0A0N1I5D6	Leptomonas seymouri	60%	100%
A0A0N1I720	Leptomonas seymouri	56%	100%
A0A0N1IL04	Leptomonas seymouri	62%	100%
A0A0N1PCE9	Leptomonas seymouri	51%	98%
A0A0R6XPC0	Leishmania donovani	63%	99%
A0A3Q8IHB3	Leishmania donovani	47%	98%
A0A3S5H6H4	Leishmania donovani	53%	96%
A0A3S5H6H5	Leishmania donovani	56%	100%
A0A3S7WRC9	Leishmania donovani	89%	100%
A0A3S7WRD5	Leishmania donovani	61%	100%
A0A3S7WRE8	Leishmania donovani	63%	100%
A4H6B5	Leishmania braziliensis	54%	100%
A4H6B6	Leishmania braziliensis	47%	100%
A4H6B7	Leishmania braziliensis	63%	100%
A4H6B8	Leishmania braziliensis	65%	100%
A4H6B9	Leishmania braziliensis	57%	100%
A4H6C1	Leishmania braziliensis	66%	100%
A4HUN8	Leishmania infantum	53%	96%
A4HUN9	Leishmania infantum	47%	98%
A4HUP0	Leishmania infantum	64%	99%
A4HUP1	Leishmania infantum	61%	100%
A4HUP2	Leishmania infantum	56%	100%
A4HUP3	Leishmania infantum	89%	100%
A4HUP4	Leishmania infantum	63%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	96%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	98%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	99%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
Q4QH83	Leishmania major	62%	100%
Q4QH84	Leishmania major	89%	100%
Q4QH85	Leishmania major	56%	100%
Q4QH86	Leishmania major	61%	100%
Q4QH87	Leishmania major	63%	100%
Q4QH88	Leishmania major	47%	100%
Q4QH89	Leishmania major	53%	100%