DUF1861 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania braziliensis

UniProt:

A4H6B8_LEIBR

TriTrypDb:

LbrM.10.1410 , LBRM2903_100023700

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6B8

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.336
CLV_NRD_NRD_1	100	102	PF00675	0.377
CLV_NRD_NRD_1	154	156	PF00675	0.208
CLV_PCSK_KEX2_1	12	14	PF00082	0.391
CLV_PCSK_KEX2_1	51	53	PF00082	0.375
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.431
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.368
CLV_PCSK_SKI1_1	2	6	PF00082	0.441
DEG_COP1_1	69	77	PF00400	0.418
DEG_Nend_UBRbox_1	1	4	PF02207	0.450
DOC_ANK_TNKS_1	235	242	PF00023	0.192
DOC_CDC14_PxL_1	175	183	PF14671	0.408
DOC_CDC14_PxL_1	71	79	PF14671	0.248
DOC_MAPK_gen_1	12	20	PF00069	0.423
DOC_MAPK_gen_1	152	161	PF00069	0.392
DOC_MAPK_MEF2A_6	13	22	PF00069	0.441
DOC_PP4_FxxP_1	148	151	PF00568	0.352
DOC_WW_Pin1_4	115	120	PF00397	0.327
LIG_14-3-3_CanoR_1	136	141	PF00244	0.380
LIG_APCC_ABBA_1	60	65	PF00400	0.336
LIG_BRCT_BRCA1_1	157	161	PF00533	0.294
LIG_BRCT_BRCA1_1	33	37	PF00533	0.352
LIG_CtBP_PxDLS_1	119	123	PF00389	0.201
LIG_FHA_1	264	270	PF00498	0.251
LIG_FHA_2	116	122	PF00498	0.368
LIG_FHA_2	64	70	PF00498	0.352
LIG_Integrin_RGD_1	272	274	PF01839	0.192
LIG_LIR_Gen_1	158	167	PF02991	0.331
LIG_LIR_Gen_1	69	77	PF02991	0.369
LIG_LIR_Nem_3	109	114	PF02991	0.370
LIG_LIR_Nem_3	158	164	PF02991	0.335
LIG_LIR_Nem_3	186	192	PF02991	0.348
LIG_LIR_Nem_3	21	25	PF02991	0.378
LIG_LIR_Nem_3	26	31	PF02991	0.364
LIG_LIR_Nem_3	278	283	PF02991	0.343
LIG_LIR_Nem_3	69	74	PF02991	0.369
LIG_PDZ_Class_1	310	315	PF00595	0.538
LIG_PTB_Apo_2	223	230	PF02174	0.354
LIG_SH2_CRK	227	231	PF00017	0.363
LIG_SH2_CRK	280	284	PF00017	0.352
LIG_SH2_GRB2like	224	227	PF00017	0.352
LIG_SH2_STAP1	15	19	PF00017	0.361
LIG_SH2_STAP1	227	231	PF00017	0.340
LIG_SH2_STAT5	113	116	PF00017	0.359
LIG_SH2_STAT5	124	127	PF00017	0.342
LIG_SH2_STAT5	196	199	PF00017	0.362
LIG_SH2_STAT5	224	227	PF00017	0.352
LIG_SH2_STAT5	85	88	PF00017	0.328
LIG_SH3_3	227	233	PF00018	0.352
LIG_SH3_3	249	255	PF00018	0.336
LIG_SUMO_SIM_par_1	118	123	PF11976	0.383
LIG_SUMO_SIM_par_1	136	142	PF11976	0.301
LIG_TRFH_1	229	233	PF08558	0.352
LIG_TYR_ITIM	225	230	PF00017	0.352
LIG_WRC_WIRS_1	19	24	PF05994	0.366
MOD_CK1_1	123	129	PF00069	0.328
MOD_CK2_1	163	169	PF00069	0.390
MOD_Cter_Amidation	153	156	PF01082	0.208
MOD_GlcNHglycan	199	202	PF01048	0.344
MOD_GlcNHglycan	266	269	PF01048	0.352
MOD_GlcNHglycan	280	283	PF01048	0.352
MOD_GSK3_1	14	21	PF00069	0.334
MOD_GSK3_1	307	314	PF00069	0.349
MOD_N-GLC_1	225	230	PF02516	0.365
MOD_N-GLC_1	307	312	PF02516	0.292
MOD_N-GLC_1	31	36	PF02516	0.356
MOD_NEK2_1	197	202	PF00069	0.385
MOD_NEK2_1	307	312	PF00069	0.338
MOD_NEK2_1	63	68	PF00069	0.357
MOD_NEK2_1	95	100	PF00069	0.349
MOD_PK_1	155	161	PF00069	0.208
MOD_PKA_1	155	161	PF00069	0.208
MOD_Plk_1	120	126	PF00069	0.330
MOD_Plk_1	225	231	PF00069	0.350
MOD_Plk_1	307	313	PF00069	0.307
MOD_Plk_1	31	37	PF00069	0.326
MOD_Plk_1	69	75	PF00069	0.369
MOD_Plk_4	106	112	PF00069	0.375
MOD_Plk_4	120	126	PF00069	0.360
MOD_Plk_4	14	20	PF00069	0.390
MOD_Plk_4	225	231	PF00069	0.347
MOD_Plk_4	299	305	PF00069	0.438
MOD_ProDKin_1	115	121	PF00069	0.327
MOD_SUMO_rev_2	235	244	PF00179	0.313
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.238
TRG_ENDOCYTIC_2	111	114	PF00928	0.393
TRG_ENDOCYTIC_2	15	18	PF00928	0.394
TRG_ENDOCYTIC_2	227	230	PF00928	0.392
TRG_ENDOCYTIC_2	280	283	PF00928	0.352
TRG_ENDOCYTIC_2	46	49	PF00928	0.380
TRG_ER_diArg_1	150	153	PF00400	0.244
TRG_ER_FFAT_2	121	130	PF00635	0.201
TRG_NES_CRM1_1	130	142	PF08389	0.336
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	60%	100%
A0A0N1HYU8	Leptomonas seymouri	60%	99%
A0A0N1I429	Leptomonas seymouri	52%	96%
A0A0N1I5D6	Leptomonas seymouri	73%	100%
A0A0N1I720	Leptomonas seymouri	56%	100%
A0A0N1IL04	Leptomonas seymouri	64%	100%
A0A0N1PCE9	Leptomonas seymouri	51%	98%
A0A0R6XPC0	Leishmania donovani	58%	99%
A0A3Q8IHB3	Leishmania donovani	51%	98%
A0A3S5H6H4	Leishmania donovani	50%	96%
A0A3S5H6H5	Leishmania donovani	54%	100%
A0A3S7WRC9	Leishmania donovani	63%	100%
A0A3S7WRD5	Leishmania donovani	82%	100%
A0A3S7WRE8	Leishmania donovani	70%	100%
A4H6B5	Leishmania braziliensis	50%	100%
A4H6B6	Leishmania braziliensis	49%	100%
A4H6B7	Leishmania braziliensis	60%	100%
A4H6B9	Leishmania braziliensis	55%	100%
A4H6C0	Leishmania braziliensis	65%	100%
A4H6C1	Leishmania braziliensis	76%	100%
A4HUN8	Leishmania infantum	50%	96%
A4HUN9	Leishmania infantum	51%	98%
A4HUP0	Leishmania infantum	58%	99%
A4HUP1	Leishmania infantum	82%	100%
A4HUP2	Leishmania infantum	54%	100%
A4HUP3	Leishmania infantum	63%	100%
A4HUP4	Leishmania infantum	70%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	96%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	98%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	99%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4QH83	Leishmania major	69%	100%
Q4QH84	Leishmania major	63%	100%
Q4QH85	Leishmania major	54%	100%
Q4QH86	Leishmania major	85%	100%
Q4QH87	Leishmania major	59%	100%
Q4QH88	Leishmania major	51%	100%
Q4QH89	Leishmania major	50%	100%