DUF3421 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania braziliensis

UniProt:

A4H6B6_LEIBR

TriTrypDb:

LbrM.10.1390 , LBRM2903_100023500

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6B6

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	82	84	PF00675	0.297
CLV_PCSK_KEX2_1	82	84	PF00082	0.549
CLV_PCSK_SKI1_1	15	19	PF00082	0.404
CLV_PCSK_SKI1_1	27	31	PF00082	0.449
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.396
DOC_MAPK_gen_1	142	151	PF00069	0.344
DOC_USP7_MATH_1	185	189	PF00917	0.242
DOC_USP7_MATH_1	236	240	PF00917	0.402
DOC_USP7_MATH_1	275	279	PF00917	0.397
DOC_USP7_UBL2_3	113	117	PF12436	0.370

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	49%	100%
A0A0N1HYU8	Leptomonas seymouri	50%	100%
A0A0N1I429	Leptomonas seymouri	54%	98%
A0A0N1I5D6	Leptomonas seymouri	48%	100%
A0A0N1I720	Leptomonas seymouri	51%	100%
A0A0N1IL04	Leptomonas seymouri	50%	100%
A0A0N1PCE9	Leptomonas seymouri	83%	100%
A0A0R6XPC0	Leishmania donovani	48%	100%
A0A3Q8IHB3	Leishmania donovani	90%	100%
A0A3S5H6H4	Leishmania donovani	53%	98%

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