DUF3421 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania braziliensis

UniProt:

A4H6B6_LEIBR

TriTrypDb:

LbrM.10.1390 , LBRM2903_100023500

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6B6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6B6

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	82	84	PF00675	0.297
CLV_PCSK_KEX2_1	82	84	PF00082	0.549
CLV_PCSK_SKI1_1	15	19	PF00082	0.404
CLV_PCSK_SKI1_1	27	31	PF00082	0.449
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.396
DOC_MAPK_gen_1	142	151	PF00069	0.344
DOC_USP7_MATH_1	185	189	PF00917	0.242
DOC_USP7_MATH_1	236	240	PF00917	0.402
DOC_USP7_MATH_1	275	279	PF00917	0.397
DOC_USP7_UBL2_3	113	117	PF12436	0.370
DOC_USP7_UBL2_3	23	27	PF12436	0.360
DOC_WW_Pin1_4	126	131	PF00397	0.377
LIG_14-3-3_CanoR_1	83	89	PF00244	0.273
LIG_AP2alpha_2	94	96	PF02296	0.421
LIG_APCC_ABBA_1	98	103	PF00400	0.402
LIG_BIR_III_4	199	203	PF00653	0.394
LIG_BRCT_BRCA1_1	238	242	PF00533	0.461
LIG_BRCT_BRCA1_1	43	47	PF00533	0.402
LIG_FHA_1	236	242	PF00498	0.406
LIG_FHA_1	244	250	PF00498	0.386
LIG_FHA_1	87	93	PF00498	0.400
LIG_FHA_2	243	249	PF00498	0.247
LIG_LIR_Apic_2	199	204	PF02991	0.440
LIG_LIR_Gen_1	170	178	PF02991	0.382
LIG_LIR_Gen_1	70	81	PF02991	0.384
LIG_LIR_Nem_3	170	175	PF02991	0.385
LIG_LIR_Nem_3	305	311	PF02991	0.435
LIG_LIR_Nem_3	31	35	PF02991	0.428
LIG_LIR_Nem_3	53	59	PF02991	0.417
LIG_LIR_Nem_3	70	76	PF02991	0.345
LIG_PDZ_Class_2	315	320	PF00595	0.462
LIG_Pex14_2	197	201	PF04695	0.402
LIG_SH2_CRK	291	295	PF00017	0.402
LIG_SH2_CRK	311	315	PF00017	0.288
LIG_SH2_STAP1	25	29	PF00017	0.411
LIG_SH2_STAT5	135	138	PF00017	0.392
LIG_SH2_STAT5	208	211	PF00017	0.412
LIG_SH2_STAT5	223	226	PF00017	0.371
LIG_SH2_STAT5	54	57	PF00017	0.398
LIG_SH3_3	238	244	PF00018	0.402
LIG_SH3_3	260	266	PF00018	0.386
LIG_WRC_WIRS_1	29	34	PF05994	0.416
MOD_CK1_1	138	144	PF00069	0.384
MOD_CK1_1	167	173	PF00069	0.369
MOD_CK2_1	275	281	PF00069	0.279
MOD_GlcNHglycan	137	140	PF01048	0.331
MOD_GlcNHglycan	187	190	PF01048	0.383
MOD_GlcNHglycan	211	214	PF01048	0.394
MOD_GlcNHglycan	277	280	PF01048	0.402
MOD_GlcNHglycan	291	294	PF01048	0.402
MOD_GSK3_1	134	141	PF00069	0.364
MOD_GSK3_1	157	164	PF00069	0.409
MOD_GSK3_1	167	174	PF00069	0.390
MOD_GSK3_1	3	10	PF00069	0.533
MOD_GSK3_1	41	48	PF00069	0.411
MOD_LATS_1	132	138	PF00433	0.242
MOD_N-GLC_1	41	46	PF02516	0.406
MOD_NEK2_1	106	111	PF00069	0.399
MOD_NEK2_1	209	214	PF00069	0.435
MOD_NEK2_1	3	8	PF00069	0.698
MOD_NMyristoyl	1	7	PF02799	0.630
MOD_PIKK_1	202	208	PF00454	0.279
MOD_Plk_1	179	185	PF00069	0.411
MOD_Plk_1	41	47	PF00069	0.376
MOD_Plk_2-3	179	185	PF00069	0.402
MOD_Plk_2-3	243	249	PF00069	0.402
MOD_Plk_4	236	242	PF00069	0.397
MOD_Plk_4	50	56	PF00069	0.404
MOD_Plk_4	67	73	PF00069	0.358
MOD_Plk_4	7	13	PF00069	0.508
MOD_ProDKin_1	126	132	PF00069	0.377
MOD_SUMO_rev_2	16	24	PF00179	0.389
TRG_ENDOCYTIC_2	291	294	PF00928	0.402
TRG_ENDOCYTIC_2	311	314	PF00928	0.285
TRG_ER_diArg_1	81	83	PF00400	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	49%	100%
A0A0N1HYU8	Leptomonas seymouri	50%	100%
A0A0N1I429	Leptomonas seymouri	54%	98%
A0A0N1I5D6	Leptomonas seymouri	48%	100%
A0A0N1I720	Leptomonas seymouri	51%	100%
A0A0N1IL04	Leptomonas seymouri	50%	100%
A0A0N1PCE9	Leptomonas seymouri	83%	100%
A0A0R6XPC0	Leishmania donovani	48%	100%
A0A3Q8IHB3	Leishmania donovani	90%	100%
A0A3S5H6H4	Leishmania donovani	53%	98%
A0A3S5H6H5	Leishmania donovani	53%	100%
A0A3S7WRC9	Leishmania donovani	48%	100%
A0A3S7WRD5	Leishmania donovani	48%	100%
A0A3S7WRE8	Leishmania donovani	50%	100%
A4H6B5	Leishmania braziliensis	52%	100%
A4H6B7	Leishmania braziliensis	49%	100%
A4H6B8	Leishmania braziliensis	49%	100%
A4H6B9	Leishmania braziliensis	54%	100%
A4H6C0	Leishmania braziliensis	47%	100%
A4H6C1	Leishmania braziliensis	51%	100%
A4HUN8	Leishmania infantum	53%	98%
A4HUN9	Leishmania infantum	90%	100%
A4HUP0	Leishmania infantum	48%	100%
A4HUP1	Leishmania infantum	48%	100%
A4HUP2	Leishmania infantum	53%	100%
A4HUP3	Leishmania infantum	48%	100%
A4HUP4	Leishmania infantum	50%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	98%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
Q4QH83	Leishmania major	50%	100%
Q4QH84	Leishmania major	48%	100%
Q4QH85	Leishmania major	52%	100%
Q4QH86	Leishmania major	48%	100%
Q4QH87	Leishmania major	49%	100%
Q4QH88	Leishmania major	91%	100%
Q4QH89	Leishmania major	51%	100%