DUF295 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania braziliensis

UniProt:

A4H6B5_LEIBR

TriTrypDb:

LbrM.10.1380 , LBRM2903_100023400

Length:

328

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6B5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6B5

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.329
CLV_C14_Caspase3-7	183	187	PF00656	0.327
CLV_C14_Caspase3-7	321	325	PF00656	0.455
CLV_NRD_NRD_1	21	23	PF00675	0.384
CLV_NRD_NRD_1	68	70	PF00675	0.345
CLV_PCSK_KEX2_1	21	23	PF00082	0.480
CLV_PCSK_KEX2_1	68	70	PF00082	0.369
CLV_PCSK_PC1ET2_1	21	23	PF00082	0.509
DEG_MDM2_SWIB_1	204	211	PF02201	0.345
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.356
DOC_MAPK_gen_1	11	19	PF00069	0.517
DOC_USP7_MATH_1	283	287	PF00917	0.341
DOC_USP7_UBL2_3	120	124	PF12436	0.314
LIG_AP2alpha_2	101	103	PF02296	0.365
LIG_BIR_III_4	206	210	PF00653	0.337
LIG_deltaCOP1_diTrp_1	71	76	PF00928	0.234
LIG_FHA_1	175	181	PF00498	0.346
LIG_FHA_1	217	223	PF00498	0.226
LIG_FHA_1	244	250	PF00498	0.349
LIG_FHA_1	26	32	PF00498	0.317
LIG_FHA_1	42	48	PF00498	0.345
LIG_FHA_2	134	140	PF00498	0.362
LIG_FHA_2	81	87	PF00498	0.349
LIG_LIR_Gen_1	176	185	PF02991	0.325
LIG_LIR_Gen_1	33	42	PF02991	0.314
LIG_LIR_Gen_1	75	80	PF02991	0.333
LIG_LIR_Gen_1	86	95	PF02991	0.362
LIG_LIR_Nem_3	110	116	PF02991	0.373
LIG_LIR_Nem_3	176	182	PF02991	0.328
LIG_LIR_Nem_3	206	211	PF02991	0.341
LIG_LIR_Nem_3	247	253	PF02991	0.353
LIG_LIR_Nem_3	259	263	PF02991	0.327
LIG_LIR_Nem_3	297	302	PF02991	0.337
LIG_LIR_Nem_3	313	319	PF02991	0.379
LIG_LIR_Nem_3	33	39	PF02991	0.363
LIG_LIR_Nem_3	75	79	PF02991	0.315
LIG_LIR_Nem_3	86	91	PF02991	0.362
LIG_PCNA_yPIPBox_3	233	243	PF02747	0.191
LIG_PDZ_Class_2	323	328	PF00595	0.412
LIG_Pex14_1	72	76	PF04695	0.273
LIG_Pex14_2	204	208	PF04695	0.345
LIG_Pex14_2	76	80	PF04695	0.234
LIG_PTB_Apo_2	252	259	PF02174	0.354
LIG_SH2_CRK	250	254	PF00017	0.365
LIG_SH2_CRK	260	264	PF00017	0.405
LIG_SH2_CRK	299	303	PF00017	0.345
LIG_SH2_CRK	319	323	PF00017	0.235
LIG_SH2_CRK	7	11	PF00017	0.507
LIG_SH2_NCK_1	88	92	PF00017	0.396
LIG_SH2_STAT5	142	145	PF00017	0.344
LIG_SH2_STAT5	215	218	PF00017	0.355
LIG_SH2_STAT5	230	233	PF00017	0.315
LIG_SH2_STAT5	243	246	PF00017	0.345
LIG_SH2_STAT5	260	263	PF00017	0.349
LIG_SH2_STAT5	88	91	PF00017	0.360
LIG_SH3_1	7	13	PF00018	0.431
LIG_SH3_2	270	275	PF14604	0.307
LIG_SH3_3	208	214	PF00018	0.275
LIG_SH3_3	246	252	PF00018	0.345
LIG_SH3_3	267	273	PF00018	0.329
LIG_SH3_3	7	13	PF00018	0.460
LIG_SUMO_SIM_par_1	154	160	PF11976	0.294
LIG_WRC_WIRS_1	245	250	PF05994	0.345
LIG_WRC_WIRS_1	36	41	PF05994	0.359
LIG_WRC_WIRS_1	73	78	PF05994	0.234
MOD_CK2_1	86	92	PF00069	0.355
MOD_GlcNHglycan	125	128	PF01048	0.418
MOD_GlcNHglycan	144	147	PF01048	0.276
MOD_GlcNHglycan	285	288	PF01048	0.345
MOD_GlcNHglycan	299	302	PF01048	0.345
MOD_GlcNHglycan	7	10	PF01048	0.487
MOD_GSK3_1	164	171	PF00069	0.359
MOD_GSK3_1	174	181	PF00069	0.344
MOD_GSK3_1	258	265	PF00069	0.366
MOD_LATS_1	168	174	PF00433	0.212
MOD_N-GLC_2	187	189	PF02516	0.198
MOD_N-GLC_2	255	257	PF02516	0.341
MOD_N-GLC_2	49	51	PF02516	0.345
MOD_NEK2_1	216	221	PF00069	0.379
MOD_NEK2_1	25	30	PF00069	0.412
MOD_NEK2_1	258	263	PF00069	0.445
MOD_NEK2_1	80	85	PF00069	0.350
MOD_PIKK_1	187	193	PF00454	0.407
MOD_PKA_2	116	122	PF00069	0.304
MOD_PKA_2	133	139	PF00069	0.289
MOD_PKA_2	80	86	PF00069	0.295
MOD_Plk_1	199	205	PF00069	0.352
MOD_Plk_1	258	264	PF00069	0.360
MOD_Plk_1	32	38	PF00069	0.370
MOD_Plk_1	86	92	PF00069	0.362
MOD_Plk_2-3	86	92	PF00069	0.345
MOD_Plk_4	199	205	PF00069	0.398
MOD_Plk_4	244	250	PF00069	0.340
MOD_Plk_4	258	264	PF00069	0.330
MOD_Plk_4	318	324	PF00069	0.410
MOD_Plk_4	32	38	PF00069	0.392
MOD_Plk_4	86	92	PF00069	0.362
TRG_ENDOCYTIC_2	250	253	PF00928	0.382
TRG_ENDOCYTIC_2	260	263	PF00928	0.411
TRG_ENDOCYTIC_2	299	302	PF00928	0.345
TRG_ENDOCYTIC_2	319	322	PF00928	0.229
TRG_ENDOCYTIC_2	60	63	PF00928	0.385
TRG_ENDOCYTIC_2	88	91	PF00928	0.393
TRG_NES_CRM1_1	148	160	PF08389	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	56%	100%
A0A0N1HYU8	Leptomonas seymouri	51%	100%
A0A0N1I429	Leptomonas seymouri	77%	100%
A0A0N1I5D6	Leptomonas seymouri	51%	100%
A0A0N1I720	Leptomonas seymouri	59%	100%
A0A0N1IL04	Leptomonas seymouri	53%	100%
A0A0N1PCE9	Leptomonas seymouri	54%	100%
A0A0R6XPC0	Leishmania donovani	51%	100%
A0A3Q8IHB3	Leishmania donovani	53%	100%
A0A3S5H6H4	Leishmania donovani	83%	100%
A0A3S5H6H5	Leishmania donovani	57%	100%
A0A3S7WRC9	Leishmania donovani	52%	100%
A0A3S7WRD5	Leishmania donovani	50%	100%
A0A3S7WRE8	Leishmania donovani	52%	100%
A4H6B6	Leishmania braziliensis	52%	100%
A4H6B7	Leishmania braziliensis	51%	100%
A4H6B8	Leishmania braziliensis	50%	100%
A4H6B9	Leishmania braziliensis	59%	100%
A4H6C0	Leishmania braziliensis	54%	100%
A4H6C1	Leishmania braziliensis	52%	100%
A4HUN8	Leishmania infantum	82%	100%
A4HUN9	Leishmania infantum	53%	100%
A4HUP0	Leishmania infantum	51%	100%
A4HUP1	Leishmania infantum	50%	100%
A4HUP2	Leishmania infantum	57%	100%
A4HUP3	Leishmania infantum	52%	100%
A4HUP4	Leishmania infantum	52%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
Q4QH83	Leishmania major	52%	100%
Q4QH84	Leishmania major	53%	100%
Q4QH85	Leishmania major	57%	100%
Q4QH86	Leishmania major	49%	100%
Q4QH87	Leishmania major	50%	100%
Q4QH88	Leishmania major	52%	100%
Q4QH89	Leishmania major	81%	100%