Class I SAM-dependent methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H6B4_LEIBR

TriTrypDb:

LbrM.10.1370 , LBRM2903_100023300

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H6B4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6B4

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1
GO:0032259	methylation	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	91	93	PF00675	0.345
CLV_PCSK_KEX2_1	175	177	PF00082	0.411
CLV_PCSK_KEX2_1	91	93	PF00082	0.380
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.411
CLV_PCSK_SKI1_1	129	133	PF00082	0.248
CLV_PCSK_SKI1_1	39	43	PF00082	0.576
CLV_PCSK_SKI1_1	69	73	PF00082	0.278
DOC_CYCLIN_yCln2_LP_2	150	156	PF00134	0.411
DOC_MAPK_gen_1	162	172	PF00069	0.360
DOC_MAPK_MEF2A_6	165	173	PF00069	0.399
DOC_PP1_RVXF_1	90	97	PF00149	0.278
DOC_PP4_FxxP_1	77	80	PF00568	0.248
DOC_USP7_MATH_1	10	14	PF00917	0.519
DOC_USP7_UBL2_3	232	236	PF12436	0.332
DOC_WW_Pin1_4	8	13	PF00397	0.529
LIG_14-3-3_CanoR_1	221	230	PF00244	0.536
LIG_AP2alpha_2	152	154	PF02296	0.248
LIG_FHA_1	142	148	PF00498	0.411
LIG_FHA_1	172	178	PF00498	0.411
LIG_FHA_2	140	146	PF00498	0.411
LIG_LIR_Apic_2	121	126	PF02991	0.405
LIG_LIR_Apic_2	76	80	PF02991	0.248
LIG_LIR_Gen_1	135	146	PF02991	0.506
LIG_LIR_Gen_1	152	160	PF02991	0.382
LIG_LIR_Gen_1	202	212	PF02991	0.412
LIG_LIR_Gen_1	60	71	PF02991	0.432
LIG_LIR_Nem_3	118	123	PF02991	0.411
LIG_LIR_Nem_3	135	141	PF02991	0.411
LIG_LIR_Nem_3	152	157	PF02991	0.434
LIG_LIR_Nem_3	159	164	PF02991	0.389
LIG_LIR_Nem_3	202	207	PF02991	0.412
LIG_LIR_Nem_3	60	66	PF02991	0.461
LIG_Pex14_1	206	210	PF04695	0.248
LIG_PTB_Apo_2	183	190	PF02174	0.411
LIG_PTB_Phospho_1	183	189	PF10480	0.411
LIG_SH2_CRK	138	142	PF00017	0.411
LIG_SH2_STAP1	120	124	PF00017	0.327
LIG_SH2_STAP1	4	8	PF00017	0.296
LIG_SH2_STAP1	63	67	PF00017	0.494
LIG_SH2_STAT5	124	127	PF00017	0.352
LIG_SH2_STAT5	189	192	PF00017	0.411
LIG_SH3_3	31	37	PF00018	0.431
LIG_SUMO_SIM_anti_2	226	232	PF11976	0.423
LIG_SUMO_SIM_par_1	168	174	PF11976	0.399
LIG_WRC_WIRS_1	181	186	PF05994	0.325
MOD_CK2_1	139	145	PF00069	0.371
MOD_CK2_1	210	216	PF00069	0.420
MOD_GlcNHglycan	223	226	PF01048	0.535
MOD_GSK3_1	152	159	PF00069	0.415
MOD_N-GLC_1	113	118	PF02516	0.423
MOD_NEK2_1	107	112	PF00069	0.282
MOD_NEK2_1	40	45	PF00069	0.487
MOD_PIKK_1	26	32	PF00454	0.297
MOD_Plk_1	113	119	PF00069	0.522
MOD_Plk_4	10	16	PF00069	0.560
MOD_ProDKin_1	8	14	PF00069	0.524
MOD_SUMO_rev_2	43	50	PF00179	0.502
TRG_DiLeu_BaEn_2	126	132	PF01217	0.337
TRG_ENDOCYTIC_2	138	141	PF00928	0.515
TRG_ENDOCYTIC_2	63	66	PF00928	0.507
TRG_ER_FFAT_2	135	145	PF00635	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF1	Leptomonas seymouri	60%	96%
A0A3S7WRE9	Leishmania donovani	72%	77%
A4HUN7	Leishmania infantum	72%	97%
E9ACR1	Leishmania major	72%	100%
E9AND6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	96%