Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 20

Species:

Leishmania braziliensis

UniProt:

A4H6B3_LEIBR

TriTrypDb:

LbrM.10.1360 , LBRM2903_100023000

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6B3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6B3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.416
CLV_C14_Caspase3-7	16	20	PF00656	0.538
CLV_C14_Caspase3-7	178	182	PF00656	0.305
CLV_C14_Caspase3-7	68	72	PF00656	0.557
CLV_NRD_NRD_1	140	142	PF00675	0.413
CLV_PCSK_KEX2_1	140	142	PF00082	0.400
CLV_PCSK_SKI1_1	140	144	PF00082	0.269
DEG_APCC_DBOX_1	131	139	PF00400	0.291
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.487
DOC_MAPK_MEF2A_6	4	13	PF00069	0.402
DOC_MIT_MIM_1	137	146	PF04212	0.524
DOC_PP2B_LxvP_1	31	34	PF13499	0.558
DOC_WW_Pin1_4	53	58	PF00397	0.468
LIG_14-3-3_CanoR_1	132	142	PF00244	0.465
LIG_14-3-3_CanoR_1	4	9	PF00244	0.267
LIG_Actin_WH2_2	131	148	PF00022	0.492
LIG_Actin_WH2_2	227	245	PF00022	0.635
LIG_Actin_WH2_2	59	77	PF00022	0.502
LIG_BIR_III_4	51	55	PF00653	0.300
LIG_BRCT_BRCA1_1	138	142	PF00533	0.510
LIG_BRCT_BRCA1_1	63	67	PF00533	0.508
LIG_FHA_1	159	165	PF00498	0.533
LIG_FHA_2	111	117	PF00498	0.482
LIG_FHA_2	119	125	PF00498	0.465
LIG_FHA_2	149	155	PF00498	0.362
LIG_FHA_2	39	45	PF00498	0.463
LIG_LIR_Gen_1	170	179	PF02991	0.443
LIG_LIR_Gen_1	180	188	PF02991	0.338
LIG_LIR_Gen_1	190	198	PF02991	0.483
LIG_LIR_Nem_3	116	122	PF02991	0.455
LIG_LIR_Nem_3	139	145	PF02991	0.521
LIG_LIR_Nem_3	170	175	PF02991	0.411
LIG_LIR_Nem_3	180	186	PF02991	0.335
LIG_LIR_Nem_3	190	195	PF02991	0.475
LIG_LIR_Nem_3	56	61	PF02991	0.420
LIG_LIR_Nem_3	7	11	PF02991	0.390
LIG_REV1ctd_RIR_1	140	150	PF16727	0.276
LIG_SH2_PTP2	192	195	PF00017	0.464
LIG_SH2_STAT5	120	123	PF00017	0.381
LIG_SH2_STAT5	192	195	PF00017	0.464
LIG_SH2_STAT5	21	24	PF00017	0.415
LIG_SH2_STAT5	233	236	PF00017	0.484
LIG_SH2_STAT5	45	48	PF00017	0.518
LIG_SH2_STAT5	55	58	PF00017	0.495
LIG_SH3_3	160	166	PF00018	0.461
LIG_SUMO_SIM_par_1	147	154	PF11976	0.396
LIG_SUMO_SIM_par_1	194	200	PF11976	0.548
LIG_SUMO_SIM_par_1	9	14	PF11976	0.465
LIG_UBA3_1	118	123	PF00899	0.267
MOD_CK1_1	126	132	PF00069	0.565
MOD_CK1_1	226	232	PF00069	0.451
MOD_CK2_1	118	124	PF00069	0.501
MOD_CK2_1	131	137	PF00069	0.387
MOD_CK2_1	197	203	PF00069	0.550
MOD_CK2_1	221	227	PF00069	0.467
MOD_GlcNHglycan	146	149	PF01048	0.501
MOD_GlcNHglycan	199	202	PF01048	0.365
MOD_GlcNHglycan	58	61	PF01048	0.422
MOD_GlcNHglycan	92	95	PF01048	0.360
MOD_GSK3_1	144	151	PF00069	0.421
MOD_GSK3_1	234	241	PF00069	0.367
MOD_GSK3_1	61	68	PF00069	0.396
MOD_N-GLC_1	110	115	PF02516	0.547
MOD_N-GLC_1	188	193	PF02516	0.480
MOD_NEK2_1	110	115	PF00069	0.349
MOD_NEK2_1	131	136	PF00069	0.525
MOD_NEK2_1	188	193	PF00069	0.272
MOD_NEK2_1	61	66	PF00069	0.447
MOD_NEK2_2	148	153	PF00069	0.266
MOD_PIKK_1	66	72	PF00454	0.552
MOD_PK_1	123	129	PF00069	0.567
MOD_PKA_2	131	137	PF00069	0.513
MOD_PKA_2	74	80	PF00069	0.469
MOD_Plk_1	188	194	PF00069	0.426
MOD_Plk_4	148	154	PF00069	0.410
MOD_Plk_4	188	194	PF00069	0.267
MOD_Plk_4	4	10	PF00069	0.268
MOD_Plk_4	61	67	PF00069	0.403
MOD_ProDKin_1	53	59	PF00069	0.465
MOD_SUMO_for_1	206	209	PF00179	0.285
MOD_SUMO_rev_2	124	131	PF00179	0.566
TRG_DiLeu_BaEn_1	227	232	PF01217	0.522
TRG_ENDOCYTIC_2	192	195	PF00928	0.465
TRG_ENDOCYTIC_2	55	58	PF00928	0.501
TRG_ER_diArg_1	140	142	PF00400	0.424

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W4	Leptomonas seymouri	58%	100%
A0A0S4JKW0	Bodo saltans	27%	70%
A0A1X0NQF7	Trypanosomatidae	26%	100%
A0A3S7WRE7	Leishmania donovani	79%	100%
A0A422NBU0	Trypanosoma rangeli	30%	100%
A4HUN6	Leishmania infantum	79%	100%
C9ZVS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	93%
E9ACR0	Leishmania major	79%	100%
E9AND5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5BPA9	Trypanosoma cruzi	27%	100%