Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6B0_LEIBR

TriTrypDb:

LbrM.10.1330 , LBRM2903_100022600

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H6B0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6B0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.344
CLV_C14_Caspase3-7	87	91	PF00656	0.507
CLV_MEL_PAP_1	259	265	PF00089	0.443
CLV_NRD_NRD_1	23	25	PF00675	0.452
CLV_NRD_NRD_1	285	287	PF00675	0.486
CLV_NRD_NRD_1	435	437	PF00675	0.451
CLV_NRD_NRD_1	482	484	PF00675	0.448
CLV_NRD_NRD_1	52	54	PF00675	0.534
CLV_PCSK_FUR_1	457	461	PF00082	0.512
CLV_PCSK_KEX2_1	380	382	PF00082	0.482
CLV_PCSK_KEX2_1	435	437	PF00082	0.526
CLV_PCSK_KEX2_1	459	461	PF00082	0.526
CLV_PCSK_KEX2_1	482	484	PF00082	0.448
CLV_PCSK_KEX2_1	52	54	PF00082	0.469
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.477
CLV_PCSK_PC1ET2_1	459	461	PF00082	0.543
CLV_PCSK_PC7_1	431	437	PF00082	0.526
CLV_PCSK_SKI1_1	102	106	PF00082	0.495
CLV_PCSK_SKI1_1	42	46	PF00082	0.410
CLV_PCSK_SKI1_1	482	486	PF00082	0.701
CLV_PCSK_SKI1_1	61	65	PF00082	0.485
DEG_SPOP_SBC_1	487	491	PF00917	0.570
DOC_CKS1_1	226	231	PF01111	0.364
DOC_MAPK_gen_1	357	364	PF00069	0.516
DOC_MAPK_MEF2A_6	357	366	PF00069	0.314
DOC_MAPK_MEF2A_6	96	105	PF00069	0.474
DOC_MAPK_RevD_3	273	287	PF00069	0.433
DOC_PP1_RVXF_1	379	386	PF00149	0.513
DOC_PP1_RVXF_1	51	58	PF00149	0.348
DOC_USP7_MATH_1	121	125	PF00917	0.511
DOC_USP7_MATH_1	158	162	PF00917	0.706
DOC_USP7_MATH_1	220	224	PF00917	0.574
DOC_USP7_MATH_1	294	298	PF00917	0.428
DOC_USP7_MATH_1	317	321	PF00917	0.452
DOC_USP7_MATH_1	33	37	PF00917	0.431
DOC_USP7_MATH_1	487	491	PF00917	0.556
DOC_USP7_MATH_1	552	556	PF00917	0.612
DOC_USP7_MATH_1	560	564	PF00917	0.581
DOC_USP7_MATH_1	9	13	PF00917	0.508
DOC_USP7_UBL2_3	21	25	PF12436	0.603
DOC_WW_Pin1_4	1	6	PF00397	0.577
DOC_WW_Pin1_4	225	230	PF00397	0.494
DOC_WW_Pin1_4	533	538	PF00397	0.483
DOC_WW_Pin1_4	547	552	PF00397	0.431
LIG_14-3-3_CanoR_1	262	270	PF00244	0.500
LIG_14-3-3_CanoR_1	289	296	PF00244	0.472
LIG_14-3-3_CanoR_1	301	307	PF00244	0.329
LIG_14-3-3_CanoR_1	466	472	PF00244	0.473
LIG_Clathr_ClatBox_1	75	79	PF01394	0.366
LIG_FHA_1	233	239	PF00498	0.425
LIG_FHA_1	258	264	PF00498	0.406
LIG_FHA_2	108	114	PF00498	0.510
LIG_FHA_2	118	124	PF00498	0.453
LIG_FHA_2	129	135	PF00498	0.405
LIG_FHA_2	146	152	PF00498	0.503
LIG_FHA_2	226	232	PF00498	0.547
LIG_LIR_Gen_1	184	192	PF02991	0.433
LIG_LIR_Gen_1	297	307	PF02991	0.281
LIG_LIR_Nem_3	184	188	PF02991	0.364
LIG_LIR_Nem_3	297	302	PF02991	0.296
LIG_LYPXL_S_1	266	270	PF13949	0.540
LIG_LYPXL_yS_3	267	270	PF13949	0.540
LIG_PCNA_PIPBox_1	461	470	PF02747	0.472
LIG_PCNA_yPIPBox_3	457	468	PF02747	0.476
LIG_SH2_CRK	497	501	PF00017	0.575
LIG_SH2_CRK	525	529	PF00017	0.534
LIG_SH2_STAP1	352	356	PF00017	0.580
LIG_SH2_STAP1	497	501	PF00017	0.643
LIG_SH2_STAT3	395	398	PF00017	0.406
LIG_SH2_STAT3	434	437	PF00017	0.523
LIG_SH2_STAT5	497	500	PF00017	0.614
LIG_SH3_3	265	271	PF00018	0.528
LIG_SUMO_SIM_anti_2	235	240	PF11976	0.388
LIG_TRAF2_1	120	123	PF00917	0.504
LIG_TRAF2_1	278	281	PF00917	0.401
LIG_TRAF2_1	416	419	PF00917	0.466
LIG_TRAF2_1	512	515	PF00917	0.379
LIG_TRAF2_1	66	69	PF00917	0.356
LIG_UBA3_1	453	459	PF00899	0.447
MOD_CDK_SPK_2	1	6	PF00069	0.456
MOD_CDK_SPxxK_3	533	540	PF00069	0.434
MOD_CK1_1	11	17	PF00069	0.552
MOD_CK1_1	124	130	PF00069	0.521
MOD_CK1_1	221	227	PF00069	0.400
MOD_CK1_1	252	258	PF00069	0.427
MOD_CK1_1	305	311	PF00069	0.485
MOD_CK1_1	509	515	PF00069	0.592
MOD_CK2_1	117	123	PF00069	0.551
MOD_CK2_1	127	133	PF00069	0.444
MOD_CK2_1	145	151	PF00069	0.531
MOD_CK2_1	305	311	PF00069	0.475
MOD_CK2_1	43	49	PF00069	0.450
MOD_CK2_1	509	515	PF00069	0.441
MOD_GlcNHglycan	11	14	PF01048	0.616
MOD_GlcNHglycan	160	163	PF01048	0.613
MOD_GlcNHglycan	250	254	PF01048	0.478
MOD_GlcNHglycan	263	266	PF01048	0.393
MOD_GlcNHglycan	271	274	PF01048	0.515
MOD_GlcNHglycan	311	314	PF01048	0.477
MOD_GlcNHglycan	319	322	PF01048	0.589
MOD_GlcNHglycan	490	493	PF01048	0.688
MOD_GlcNHglycan	508	511	PF01048	0.645
MOD_GlcNHglycan	97	101	PF01048	0.621
MOD_GSK3_1	103	110	PF00069	0.499
MOD_GSK3_1	117	124	PF00069	0.556
MOD_GSK3_1	145	152	PF00069	0.544
MOD_GSK3_1	221	228	PF00069	0.480
MOD_GSK3_1	257	264	PF00069	0.512
MOD_GSK3_1	302	309	PF00069	0.480
MOD_LATS_1	94	100	PF00433	0.395
MOD_N-GLC_1	125	130	PF02516	0.451
MOD_N-GLC_1	302	307	PF02516	0.389
MOD_N-GLC_2	91	93	PF02516	0.404
MOD_NEK2_1	115	120	PF00069	0.588
MOD_NEK2_1	188	193	PF00069	0.432
MOD_NEK2_1	249	254	PF00069	0.554
MOD_NEK2_1	485	490	PF00069	0.575
MOD_NEK2_2	33	38	PF00069	0.499
MOD_PIKK_1	103	109	PF00454	0.607
MOD_PIKK_1	121	127	PF00454	0.442
MOD_PIKK_1	289	295	PF00454	0.600
MOD_PK_1	218	224	PF00069	0.356
MOD_PKA_1	24	30	PF00069	0.576
MOD_PKA_2	198	204	PF00069	0.444
MOD_PKA_2	23	29	PF00069	0.466
MOD_PKA_2	261	267	PF00069	0.566
MOD_PKA_2	358	364	PF00069	0.573
MOD_PKA_2	504	510	PF00069	0.592
MOD_Plk_1	218	224	PF00069	0.441
MOD_Plk_1	279	285	PF00069	0.402
MOD_Plk_1	302	308	PF00069	0.392
MOD_Plk_1	96	102	PF00069	0.379
MOD_Plk_4	302	308	PF00069	0.449
MOD_ProDKin_1	1	7	PF00069	0.566
MOD_ProDKin_1	225	231	PF00069	0.494
MOD_ProDKin_1	533	539	PF00069	0.476
MOD_ProDKin_1	547	553	PF00069	0.432
MOD_SUMO_for_1	66	69	PF00179	0.562
MOD_SUMO_rev_2	418	423	PF00179	0.549
TRG_DiLeu_BaEn_1	111	116	PF01217	0.448
TRG_DiLeu_BaEn_1	311	316	PF01217	0.561
TRG_DiLeu_BaEn_4	280	286	PF01217	0.405
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.440
TRG_ENDOCYTIC_2	267	270	PF00928	0.434
TRG_ENDOCYTIC_2	352	355	PF00928	0.585
TRG_ENDOCYTIC_2	497	500	PF00928	0.592
TRG_ENDOCYTIC_2	525	528	PF00928	0.533
TRG_ER_diArg_1	332	335	PF00400	0.601
TRG_ER_diArg_1	356	359	PF00400	0.397
TRG_ER_diArg_1	388	391	PF00400	0.398
TRG_ER_diArg_1	434	436	PF00400	0.513
TRG_ER_diArg_1	481	483	PF00400	0.437
TRG_ER_diArg_1	520	523	PF00400	0.547
TRG_NES_CRM1_1	231	244	PF08389	0.454
TRG_Pf-PMV_PEXEL_1	289	293	PF00026	0.565
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W6	Leptomonas seymouri	52%	100%
A0A1X0NRY0	Trypanosomatidae	30%	97%
A0A3Q8I7T8	Leishmania donovani	78%	100%
A0A3R7MBP9	Trypanosoma rangeli	28%	97%
A4HUN4	Leishmania infantum	78%	100%
C9ZVR8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
E9AND2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QH92	Leishmania major	78%	100%
V5BJP6	Trypanosoma cruzi	29%	92%