SpoU_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6A9_LEIBR

TriTrypDb:

LbrM.10.1320 , LBRM2903_100022500

Length:

1062

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005643	nuclear pore	3	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H6A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6A9

Function

Biological processes
Term	Name	Level	Count
GO:0006611	protein export from nucleus	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005049	nuclear export signal receptor activity	3	11
GO:0140104	molecular carrier activity	1	11
GO:0140142	nucleocytoplasmic carrier activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	661	665	PF00656	0.429
CLV_MEL_PAP_1	497	503	PF00089	0.440
CLV_NRD_NRD_1	119	121	PF00675	0.531
CLV_NRD_NRD_1	238	240	PF00675	0.494
CLV_NRD_NRD_1	542	544	PF00675	0.633
CLV_NRD_NRD_1	61	63	PF00675	0.251
CLV_NRD_NRD_1	714	716	PF00675	0.467
CLV_NRD_NRD_1	987	989	PF00675	0.400
CLV_PCSK_KEX2_1	119	121	PF00082	0.543
CLV_PCSK_KEX2_1	61	63	PF00082	0.390
CLV_PCSK_KEX2_1	714	716	PF00082	0.440
CLV_PCSK_SKI1_1	1031	1035	PF00082	0.478
CLV_PCSK_SKI1_1	119	123	PF00082	0.630
CLV_PCSK_SKI1_1	148	152	PF00082	0.465
CLV_PCSK_SKI1_1	240	244	PF00082	0.497
CLV_PCSK_SKI1_1	57	61	PF00082	0.404
CLV_PCSK_SKI1_1	612	616	PF00082	0.466
CLV_PCSK_SKI1_1	644	648	PF00082	0.385
CLV_PCSK_SKI1_1	706	710	PF00082	0.314
CLV_PCSK_SKI1_1	763	767	PF00082	0.477
CLV_PCSK_SKI1_1	970	974	PF00082	0.463
CLV_PCSK_SKI1_1	988	992	PF00082	0.223
DEG_APCC_DBOX_1	987	995	PF00400	0.447
DOC_CDC14_PxL_1	214	222	PF14671	0.369
DOC_CYCLIN_yCln2_LP_2	635	641	PF00134	0.435
DOC_CYCLIN_yCln2_LP_2	670	676	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	911	917	PF00134	0.502
DOC_CYCLIN_yCln2_LP_2	990	996	PF00134	0.406
DOC_MAPK_FxFP_2	727	730	PF00069	0.418
DOC_MAPK_gen_1	132	142	PF00069	0.374
DOC_MAPK_gen_1	61	68	PF00069	0.238
DOC_MAPK_gen_1	786	795	PF00069	0.474
DOC_MAPK_gen_1	986	994	PF00069	0.525
DOC_MAPK_MEF2A_6	436	445	PF00069	0.283
DOC_MAPK_MEF2A_6	61	68	PF00069	0.451
DOC_MAPK_MEF2A_6	986	994	PF00069	0.464
DOC_MIT_MIM_1	204	214	PF04212	0.430
DOC_PP1_RVXF_1	761	767	PF00149	0.434
DOC_PP2B_LxvP_1	990	993	PF13499	0.407
DOC_PP4_FxxP_1	727	730	PF00568	0.418
DOC_USP7_MATH_1	322	326	PF00917	0.373
DOC_USP7_MATH_1	473	477	PF00917	0.509
DOC_USP7_MATH_1	800	804	PF00917	0.473
DOC_USP7_MATH_1	87	91	PF00917	0.444
DOC_USP7_UBL2_3	340	344	PF12436	0.314
DOC_WW_Pin1_4	1012	1017	PF00397	0.491
DOC_WW_Pin1_4	510	515	PF00397	0.291
DOC_WW_Pin1_4	804	809	PF00397	0.571
LIG_14-3-3_CanoR_1	1012	1016	PF00244	0.545
LIG_14-3-3_CanoR_1	1031	1039	PF00244	0.553
LIG_14-3-3_CanoR_1	119	125	PF00244	0.532
LIG_14-3-3_CanoR_1	18	27	PF00244	0.527
LIG_14-3-3_CanoR_1	239	243	PF00244	0.491
LIG_14-3-3_CanoR_1	436	442	PF00244	0.431
LIG_14-3-3_CanoR_1	500	508	PF00244	0.490
LIG_14-3-3_CanoR_1	543	552	PF00244	0.524
LIG_14-3-3_CanoR_1	618	623	PF00244	0.543
LIG_14-3-3_CanoR_1	677	683	PF00244	0.491
LIG_14-3-3_CanoR_1	697	701	PF00244	0.212
LIG_14-3-3_CanoR_1	706	716	PF00244	0.393
LIG_14-3-3_CanoR_1	801	810	PF00244	0.666
LIG_14-3-3_CanoR_1	820	830	PF00244	0.181
LIG_Actin_WH2_2	1044	1061	PF00022	0.531
LIG_Actin_WH2_2	224	241	PF00022	0.402
LIG_APCC_ABBA_1	624	629	PF00400	0.498
LIG_APCC_ABBA_1	840	845	PF00400	0.386
LIG_BIR_II_1	1	5	PF00653	0.400
LIG_BRCT_BRCA1_1	11	15	PF00533	0.409
LIG_BRCT_BRCA1_1	564	568	PF00533	0.311
LIG_BRCT_BRCA1_1	909	913	PF00533	0.400
LIG_CaM_NSCaTE_8	465	472	PF13499	0.454
LIG_Clathr_ClatBox_1	994	998	PF01394	0.355
LIG_deltaCOP1_diTrp_1	813	816	PF00928	0.469
LIG_EH1_1	901	909	PF00400	0.244
LIG_EH1_1	984	992	PF00400	0.496
LIG_EVH1_2	898	902	PF00568	0.359
LIG_FHA_1	1041	1047	PF00498	0.401
LIG_FHA_1	231	237	PF00498	0.347
LIG_FHA_1	258	264	PF00498	0.310
LIG_FHA_1	36	42	PF00498	0.349
LIG_FHA_1	371	377	PF00498	0.493
LIG_FHA_1	521	527	PF00498	0.432
LIG_FHA_1	532	538	PF00498	0.467
LIG_FHA_1	605	611	PF00498	0.392
LIG_FHA_1	661	667	PF00498	0.537
LIG_FHA_1	693	699	PF00498	0.427
LIG_FHA_1	847	853	PF00498	0.411
LIG_FHA_1	873	879	PF00498	0.434
LIG_FHA_1	971	977	PF00498	0.362
LIG_FHA_2	1055	1061	PF00498	0.484
LIG_FHA_2	113	119	PF00498	0.510
LIG_FHA_2	181	187	PF00498	0.624
LIG_FHA_2	191	197	PF00498	0.486
LIG_FHA_2	225	231	PF00498	0.483
LIG_FHA_2	242	248	PF00498	0.413
LIG_FHA_2	659	665	PF00498	0.521
LIG_FHA_2	667	673	PF00498	0.519
LIG_GBD_Chelix_1	1047	1055	PF00786	0.463
LIG_GBD_Chelix_1	224	232	PF00786	0.385
LIG_LIR_Apic_2	725	730	PF02991	0.429
LIG_LIR_Gen_1	241	250	PF02991	0.582
LIG_LIR_Gen_1	265	274	PF02991	0.462
LIG_LIR_Gen_1	277	286	PF02991	0.269
LIG_LIR_Gen_1	617	626	PF02991	0.450
LIG_LIR_Gen_1	8	19	PF02991	0.385
LIG_LIR_Gen_1	900	908	PF02991	0.482
LIG_LIR_Nem_3	241	246	PF02991	0.590
LIG_LIR_Nem_3	265	270	PF02991	0.456
LIG_LIR_Nem_3	277	282	PF02991	0.266
LIG_LIR_Nem_3	331	336	PF02991	0.321
LIG_LIR_Nem_3	424	430	PF02991	0.449
LIG_LIR_Nem_3	565	571	PF02991	0.424
LIG_LIR_Nem_3	617	623	PF02991	0.496
LIG_LIR_Nem_3	853	859	PF02991	0.446
LIG_LIR_Nem_3	900	905	PF02991	0.476
LIG_MAD2	718	726	PF02301	0.393
LIG_MYND_1	218	222	PF01753	0.450
LIG_MYND_1	726	730	PF01753	0.482
LIG_NRBOX	325	331	PF00104	0.436
LIG_NRBOX	487	493	PF00104	0.462
LIG_NRBOX	847	853	PF00104	0.404
LIG_PCNA_PIPBox_1	208	217	PF02747	0.268
LIG_PCNA_yPIPBox_3	285	296	PF02747	0.477
LIG_PCNA_yPIPBox_3	978	991	PF02747	0.515
LIG_PDZ_Class_3	1057	1062	PF00595	0.482
LIG_Pex14_2	568	572	PF04695	0.464
LIG_Pex14_2	888	892	PF04695	0.484
LIG_Rb_LxCxE_1	704	725	PF01857	0.472
LIG_SH2_CRK	253	257	PF00017	0.381
LIG_SH2_CRK	620	624	PF00017	0.501
LIG_SH2_CRK	717	721	PF00017	0.357
LIG_SH2_NCK_1	683	687	PF00017	0.328
LIG_SH2_SRC	253	256	PF00017	0.312
LIG_SH2_SRC	72	75	PF00017	0.322
LIG_SH2_SRC	996	999	PF00017	0.485
LIG_SH2_STAP1	11	15	PF00017	0.384
LIG_SH2_STAP1	253	257	PF00017	0.381
LIG_SH2_STAP1	620	624	PF00017	0.446
LIG_SH2_STAP1	74	78	PF00017	0.459
LIG_SH2_STAP1	843	847	PF00017	0.439
LIG_SH2_STAT3	342	345	PF00017	0.529
LIG_SH2_STAT5	1008	1011	PF00017	0.507
LIG_SH2_STAT5	361	364	PF00017	0.438
LIG_SH2_STAT5	399	402	PF00017	0.392
LIG_SH2_STAT5	538	541	PF00017	0.578
LIG_SH2_STAT5	571	574	PF00017	0.435
LIG_SH2_STAT5	620	623	PF00017	0.444
LIG_SH2_STAT5	645	648	PF00017	0.434
LIG_SH2_STAT5	779	782	PF00017	0.368
LIG_SH2_STAT5	996	999	PF00017	0.485
LIG_SUMO_SIM_anti_2	227	234	PF11976	0.436
LIG_SUMO_SIM_anti_2	325	331	PF11976	0.438
LIG_SUMO_SIM_anti_2	494	499	PF11976	0.404
LIG_SUMO_SIM_anti_2	903	910	PF11976	0.244
LIG_SUMO_SIM_par_1	111	118	PF11976	0.414
LIG_SUMO_SIM_par_1	227	234	PF11976	0.397
LIG_SUMO_SIM_par_1	254	260	PF11976	0.372
LIG_SUMO_SIM_par_1	325	331	PF11976	0.431
LIG_SUMO_SIM_par_1	698	704	PF11976	0.395
LIG_SUMO_SIM_par_1	903	910	PF11976	0.353
LIG_TRAF2_1	863	866	PF00917	0.313
LIG_TRAF2_1	946	949	PF00917	0.419
LIG_UBA3_1	1054	1059	PF00899	0.506
LIG_WRC_WIRS_1	121	126	PF05994	0.584
MOD_CDC14_SPxK_1	513	516	PF00782	0.280
MOD_CDK_SPxK_1	510	516	PF00069	0.287
MOD_CK1_1	1011	1017	PF00069	0.493
MOD_CK1_1	126	132	PF00069	0.484
MOD_CK1_1	156	162	PF00069	0.519
MOD_CK1_1	234	240	PF00069	0.449
MOD_CK1_1	241	247	PF00069	0.485
MOD_CK1_1	325	331	PF00069	0.231
MOD_CK1_1	381	387	PF00069	0.589
MOD_CK1_1	450	456	PF00069	0.529
MOD_CK1_1	510	516	PF00069	0.342
MOD_CK1_1	606	612	PF00069	0.414
MOD_CK1_1	665	671	PF00069	0.495
MOD_CK1_1	691	697	PF00069	0.560
MOD_CK1_1	770	776	PF00069	0.458
MOD_CK1_1	803	809	PF00069	0.611
MOD_CK1_1	88	94	PF00069	0.496
MOD_CK1_1	9	15	PF00069	0.439
MOD_CK2_1	1054	1060	PF00069	0.545
MOD_CK2_1	112	118	PF00069	0.486
MOD_CK2_1	180	186	PF00069	0.540
MOD_CK2_1	224	230	PF00069	0.486
MOD_CK2_1	241	247	PF00069	0.422
MOD_CK2_1	666	672	PF00069	0.487
MOD_CK2_1	707	713	PF00069	0.349
MOD_CK2_1	737	743	PF00069	0.497
MOD_CK2_1	88	94	PF00069	0.310
MOD_DYRK1A_RPxSP_1	1012	1016	PF00069	0.489
MOD_GlcNHglycan	322	325	PF01048	0.256
MOD_GlcNHglycan	358	361	PF01048	0.396
MOD_GlcNHglycan	383	386	PF01048	0.511
MOD_GlcNHglycan	449	452	PF01048	0.580
MOD_GlcNHglycan	470	473	PF01048	0.494
MOD_GlcNHglycan	509	512	PF01048	0.382
MOD_GlcNHglycan	545	548	PF01048	0.548
MOD_GlcNHglycan	584	587	PF01048	0.494
MOD_GlcNHglycan	690	693	PF01048	0.513
MOD_GlcNHglycan	769	772	PF01048	0.462
MOD_GlcNHglycan	786	789	PF01048	0.267
MOD_GlcNHglycan	796	800	PF01048	0.466
MOD_GlcNHglycan	8	11	PF01048	0.415
MOD_GlcNHglycan	823	826	PF01048	0.352
MOD_GlcNHglycan	998	1002	PF01048	0.519
MOD_GSK3_1	1008	1015	PF00069	0.523
MOD_GSK3_1	1050	1057	PF00069	0.385
MOD_GSK3_1	119	126	PF00069	0.577
MOD_GSK3_1	14	21	PF00069	0.389
MOD_GSK3_1	230	237	PF00069	0.309
MOD_GSK3_1	300	307	PF00069	0.360
MOD_GSK3_1	389	396	PF00069	0.401
MOD_GSK3_1	431	438	PF00069	0.442
MOD_GSK3_1	446	453	PF00069	0.377
MOD_GSK3_1	5	12	PF00069	0.487
MOD_GSK3_1	529	536	PF00069	0.531
MOD_GSK3_1	538	545	PF00069	0.513
MOD_GSK3_1	602	609	PF00069	0.493
MOD_GSK3_1	614	621	PF00069	0.454
MOD_GSK3_1	658	665	PF00069	0.453
MOD_GSK3_1	684	691	PF00069	0.583
MOD_GSK3_1	692	699	PF00069	0.564
MOD_GSK3_1	72	79	PF00069	0.512
MOD_GSK3_1	800	807	PF00069	0.569
MOD_GSK3_1	81	88	PF00069	0.482
MOD_GSK3_1	846	853	PF00069	0.399
MOD_GSK3_1	868	875	PF00069	0.427
MOD_GSK3_1	972	979	PF00069	0.299
MOD_LATS_1	444	450	PF00433	0.343
MOD_N-GLC_1	309	314	PF02516	0.239
MOD_N-GLC_1	381	386	PF02516	0.368
MOD_N-GLC_1	447	452	PF02516	0.647
MOD_N-GLC_1	587	592	PF02516	0.294
MOD_N-GLC_1	627	632	PF02516	0.475
MOD_N-GLC_2	739	741	PF02516	0.345
MOD_N-GLC_2	937	939	PF02516	0.464
MOD_NEK2_1	1054	1059	PF00069	0.477
MOD_NEK2_1	112	117	PF00069	0.404
MOD_NEK2_1	14	19	PF00069	0.373
MOD_NEK2_1	190	195	PF00069	0.468
MOD_NEK2_1	238	243	PF00069	0.438
MOD_NEK2_1	257	262	PF00069	0.203
MOD_NEK2_1	389	394	PF00069	0.374
MOD_NEK2_1	4	9	PF00069	0.396
MOD_NEK2_1	447	452	PF00069	0.432
MOD_NEK2_1	491	496	PF00069	0.364
MOD_NEK2_1	507	512	PF00069	0.319
MOD_NEK2_1	531	536	PF00069	0.451
MOD_NEK2_1	562	567	PF00069	0.348
MOD_NEK2_1	584	589	PF00069	0.549
MOD_NEK2_1	614	619	PF00069	0.460
MOD_NEK2_1	657	662	PF00069	0.481
MOD_NEK2_1	795	800	PF00069	0.624
MOD_NEK2_1	821	826	PF00069	0.225
MOD_NEK2_1	851	856	PF00069	0.409
MOD_NEK2_1	956	961	PF00069	0.423
MOD_NEK2_1	976	981	PF00069	0.251
MOD_NEK2_2	23	28	PF00069	0.524
MOD_NEK2_2	463	468	PF00069	0.412
MOD_PIKK_1	32	38	PF00454	0.468
MOD_PIKK_1	435	441	PF00454	0.499
MOD_PIKK_1	551	557	PF00454	0.460
MOD_PIKK_1	676	682	PF00454	0.504
MOD_PIKK_1	76	82	PF00454	0.531
MOD_PIKK_1	801	807	PF00454	0.558
MOD_PK_1	533	539	PF00069	0.534
MOD_PKA_1	119	125	PF00069	0.611
MOD_PKA_1	543	549	PF00069	0.564
MOD_PKA_2	1011	1017	PF00069	0.493
MOD_PKA_2	119	125	PF00069	0.535
MOD_PKA_2	238	244	PF00069	0.491
MOD_PKA_2	435	441	PF00069	0.535
MOD_PKA_2	499	505	PF00069	0.475
MOD_PKA_2	542	548	PF00069	0.532
MOD_PKA_2	676	682	PF00069	0.482
MOD_PKA_2	696	702	PF00069	0.216
MOD_PKA_2	800	806	PF00069	0.547
MOD_Plk_1	126	132	PF00069	0.483
MOD_Plk_1	272	278	PF00069	0.384
MOD_Plk_1	299	305	PF00069	0.297
MOD_Plk_1	32	38	PF00069	0.504
MOD_Plk_1	447	453	PF00069	0.592
MOD_Plk_1	627	633	PF00069	0.535
MOD_Plk_1	657	663	PF00069	0.487
MOD_Plk_1	742	748	PF00069	0.425
MOD_Plk_1	843	849	PF00069	0.425
MOD_Plk_1	976	982	PF00069	0.519
MOD_Plk_2-3	658	664	PF00069	0.426
MOD_Plk_4	1050	1056	PF00069	0.429
MOD_Plk_4	138	144	PF00069	0.470
MOD_Plk_4	224	230	PF00069	0.357
MOD_Plk_4	23	29	PF00069	0.420
MOD_Plk_4	231	237	PF00069	0.300
MOD_Plk_4	238	244	PF00069	0.309
MOD_Plk_4	300	306	PF00069	0.243
MOD_Plk_4	322	328	PF00069	0.357
MOD_Plk_4	437	443	PF00069	0.393
MOD_Plk_4	491	497	PF00069	0.354
MOD_Plk_4	533	539	PF00069	0.519
MOD_Plk_4	606	612	PF00069	0.483
MOD_Plk_4	618	624	PF00069	0.502
MOD_Plk_4	662	668	PF00069	0.554
MOD_Plk_4	678	684	PF00069	0.408
MOD_Plk_4	851	857	PF00069	0.344
MOD_Plk_4	9	15	PF00069	0.401
MOD_Plk_4	956	962	PF00069	0.400
MOD_ProDKin_1	1012	1018	PF00069	0.484
MOD_ProDKin_1	510	516	PF00069	0.287
MOD_ProDKin_1	804	810	PF00069	0.566
TRG_DiLeu_BaEn_1	294	299	PF01217	0.383
TRG_DiLeu_BaEn_1	411	416	PF01217	0.397
TRG_DiLeu_BaEn_4	405	411	PF01217	0.436
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.441
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.435
TRG_DiLeu_BaLyEn_6	609	614	PF01217	0.461
TRG_ENDOCYTIC_2	11	14	PF00928	0.378
TRG_ENDOCYTIC_2	253	256	PF00928	0.496
TRG_ENDOCYTIC_2	42	45	PF00928	0.466
TRG_ENDOCYTIC_2	620	623	PF00928	0.500
TRG_ENDOCYTIC_2	645	648	PF00928	0.392
TRG_ENDOCYTIC_2	717	720	PF00928	0.343
TRG_ER_diArg_1	101	104	PF00400	0.511
TRG_ER_diArg_1	119	121	PF00400	0.320
TRG_ER_diArg_1	60	62	PF00400	0.250
TRG_ER_diArg_1	714	716	PF00400	0.464
TRG_NES_CRM1_1	137	152	PF08389	0.399
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKL7	Leptomonas seymouri	63%	96%
A0A1X0NQX8	Trypanosomatidae	28%	100%
A0A3R7NI03	Trypanosoma rangeli	28%	100%
A0A3S7WRC3	Leishmania donovani	89%	100%
A4HUN3	Leishmania infantum	89%	100%
C9ZVR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AND1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QH93	Leishmania major	89%	100%
V5BTW0	Trypanosoma cruzi	28%	100%