RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H6A8_LEIBR

TriTrypDb:

LbrM.10.1310 , LBRM2903_100022400

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H6A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6A8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.527
CLV_NRD_NRD_1	14	16	PF00675	0.600
CLV_NRD_NRD_1	170	172	PF00675	0.414
CLV_NRD_NRD_1	61	63	PF00675	0.501
CLV_NRD_NRD_1	68	70	PF00675	0.535
CLV_NRD_NRD_1	7	9	PF00675	0.539
CLV_PCSK_KEX2_1	110	112	PF00082	0.641
CLV_PCSK_KEX2_1	14	16	PF00082	0.600
CLV_PCSK_KEX2_1	61	63	PF00082	0.501
CLV_PCSK_KEX2_1	68	70	PF00082	0.535
CLV_PCSK_KEX2_1	7	9	PF00082	0.539
CLV_PCSK_KEX2_1	92	94	PF00082	0.282
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.276
CLV_PCSK_SKI1_1	36	40	PF00082	0.472
CLV_PCSK_SKI1_1	49	53	PF00082	0.563
DEG_Nend_Nbox_1	1	3	PF02207	0.596
DOC_USP7_MATH_1	38	42	PF00917	0.588
DOC_USP7_UBL2_3	172	176	PF12436	0.340
DOC_WW_Pin1_4	178	183	PF00397	0.377
DOC_WW_Pin1_4	52	57	PF00397	0.476
LIG_14-3-3_CanoR_1	49	59	PF00244	0.520
LIG_FHA_2	28	34	PF00498	0.494
LIG_FHA_2	74	80	PF00498	0.341
LIG_Integrin_RGDW_4	77	80	PF00362	0.341
LIG_LIR_Apic_2	121	125	PF02991	0.397
LIG_LIR_Apic_2	155	161	PF02991	0.405
LIG_MYND_1	103	107	PF01753	0.448
LIG_SH3_2	148	153	PF14604	0.520
LIG_SH3_3	106	112	PF00018	0.489
LIG_SH3_3	142	148	PF00018	0.455
LIG_SH3_3	176	182	PF00018	0.289
LIG_SH3_3	98	104	PF00018	0.276
LIG_WW_2	103	106	PF00397	0.431
LIG_WW_2	148	151	PF00397	0.549
MOD_CK1_1	178	184	PF00069	0.376
MOD_CK2_1	27	33	PF00069	0.494
MOD_CK2_1	88	94	PF00069	0.300
MOD_GSK3_1	152	159	PF00069	0.511
MOD_GSK3_1	23	30	PF00069	0.545
MOD_NEK2_1	131	136	PF00069	0.321
MOD_NEK2_1	175	180	PF00069	0.370
MOD_NEK2_1	39	44	PF00069	0.635
MOD_PIKK_1	23	29	PF00454	0.456
MOD_PKA_2	131	137	PF00069	0.314
MOD_PKA_2	167	173	PF00069	0.367
MOD_PKB_1	71	79	PF00069	0.522
MOD_Plk_1	153	159	PF00069	0.437
MOD_Plk_4	131	137	PF00069	0.314
MOD_Plk_4	153	159	PF00069	0.437
MOD_Plk_4	39	45	PF00069	0.615
MOD_ProDKin_1	178	184	PF00069	0.380
MOD_ProDKin_1	52	58	PF00069	0.473
MOD_SUMO_rev_2	181	188	PF00179	0.578
TRG_ER_diArg_1	109	111	PF00400	0.481
TRG_ER_diArg_1	13	15	PF00400	0.577
TRG_ER_diArg_1	61	63	PF00400	0.488
TRG_ER_diArg_1	68	71	PF00400	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC91	Leptomonas seymouri	78%	100%
A0A1X0NQG6	Trypanosomatidae	85%	93%
A0A3R7KWS8	Trypanosoma rangeli	80%	73%
A0A3S7WRC4	Leishmania donovani	79%	100%
A4HUN2	Leishmania infantum	79%	100%
C9ZVR6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AND0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QH94	Leishmania major	81%	99%