Flagellar protofilament ribbon protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar protofilament ribbon protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4H6A7_LEIBR

TriTrypDb:

LbrM.10.1300 , LBRM2903_100022300

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4H6A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6A7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.421
CLV_MEL_PAP_1	111	117	PF00089	0.201
CLV_NRD_NRD_1	107	109	PF00675	0.370
CLV_NRD_NRD_1	140	142	PF00675	0.303
CLV_NRD_NRD_1	195	197	PF00675	0.349
CLV_NRD_NRD_1	214	216	PF00675	0.301
CLV_NRD_NRD_1	23	25	PF00675	0.421
CLV_NRD_NRD_1	285	287	PF00675	0.330
CLV_NRD_NRD_1	318	320	PF00675	0.317
CLV_NRD_NRD_1	338	340	PF00675	0.118
CLV_PCSK_FUR_1	283	287	PF00082	0.336
CLV_PCSK_FUR_1	316	320	PF00082	0.317
CLV_PCSK_KEX2_1	107	109	PF00082	0.370
CLV_PCSK_KEX2_1	140	142	PF00082	0.301
CLV_PCSK_KEX2_1	195	197	PF00082	0.349
CLV_PCSK_KEX2_1	214	216	PF00082	0.301
CLV_PCSK_KEX2_1	283	285	PF00082	0.328
CLV_PCSK_KEX2_1	318	320	PF00082	0.317
CLV_PCSK_PC7_1	280	286	PF00082	0.362
CLV_PCSK_PC7_1	314	320	PF00082	0.317
CLV_PCSK_SKI1_1	159	163	PF00082	0.301
CLV_PCSK_SKI1_1	215	219	PF00082	0.275
CLV_PCSK_SKI1_1	251	255	PF00082	0.252
CLV_PCSK_SKI1_1	261	265	PF00082	0.298
CLV_PCSK_SKI1_1	268	272	PF00082	0.365
CLV_PCSK_SKI1_1	285	289	PF00082	0.182
CLV_PCSK_SKI1_1	30	34	PF00082	0.317
CLV_PCSK_SKI1_1	40	44	PF00082	0.317
CLV_PCSK_SKI1_1	56	60	PF00082	0.317
CLV_PCSK_SKI1_1	7	11	PF00082	0.317
DEG_APCC_DBOX_1	225	233	PF00400	0.317
DEG_APCC_DBOX_1	283	291	PF00400	0.336
DEG_Nend_UBRbox_3	1	3	PF02207	0.405
DOC_CYCLIN_RxL_1	265	273	PF00134	0.372
DOC_CYCLIN_RxL_1	280	292	PF00134	0.325
DOC_MAPK_gen_1	19	28	PF00069	0.317
DOC_MAPK_gen_1	280	290	PF00069	0.331
DOC_USP7_UBL2_3	159	163	PF12436	0.301
LIG_14-3-3_CanoR_1	251	256	PF00244	0.195
LIG_14-3-3_CanoR_1	87	91	PF00244	0.386
LIG_Clathr_ClatBox_1	287	291	PF01394	0.336
LIG_eIF4E_1	54	60	PF01652	0.386
LIG_LIR_Nem_3	179	185	PF02991	0.401
LIG_LIR_Nem_3	352	358	PF02991	0.336
LIG_RPA_C_Fungi	209	221	PF08784	0.195
LIG_SH2_STAP1	54	58	PF00017	0.386
LIG_SH2_STAT3	54	57	PF00017	0.386
LIG_SH2_STAT5	355	358	PF00017	0.336
LIG_SUMO_SIM_par_1	286	292	PF11976	0.336
LIG_TRAF2_1	220	223	PF00917	0.380
LIG_TRAF2_1	297	300	PF00917	0.386
MOD_CK2_1	294	300	PF00069	0.448
MOD_GlcNHglycan	272	275	PF01048	0.195
MOD_NEK2_1	270	275	PF00069	0.458
MOD_NEK2_1	325	330	PF00069	0.421
MOD_PIKK_1	294	300	PF00454	0.195
MOD_PIKK_1	330	336	PF00454	0.317
MOD_PKA_2	243	249	PF00069	0.421
MOD_PKA_2	86	92	PF00069	0.309
MOD_Plk_1	222	228	PF00069	0.448
MOD_Plk_4	243	249	PF00069	0.317
MOD_SUMO_for_1	255	258	PF00179	0.201
MOD_SUMO_rev_2	16	23	PF00179	0.336
MOD_SUMO_rev_2	186	192	PF00179	0.448
TRG_DiLeu_BaEn_1	193	198	PF01217	0.421
TRG_DiLeu_BaEn_4	222	228	PF01217	0.421
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.336
TRG_ENDOCYTIC_2	260	263	PF00928	0.317
TRG_ER_diArg_1	195	197	PF00400	0.349
TRG_ER_diArg_1	218	221	PF00400	0.195
TRG_ER_diArg_1	282	285	PF00400	0.302
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.259
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL07	Leptomonas seymouri	85%	93%
A0A0S4INL6	Bodo saltans	53%	100%
A0A1X0NQD2	Trypanosomatidae	72%	95%
A0A3Q8IC89	Leishmania donovani	91%	91%
A0A3R7KAZ0	Trypanosoma rangeli	68%	95%
A4HUN1	Leishmania infantum	91%	91%
C9ZVR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	94%
E9ANC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	91%
Q0VC09	Bos taurus	30%	96%
Q32LJ7	Bos taurus	27%	96%
Q4QH95	Leishmania major	91%	100%
Q4R698	Macaca fascicularis	30%	96%
Q6AXN9	Rattus norvegicus	29%	96%
Q6AYL4	Rattus norvegicus	31%	96%
Q8N443	Homo sapiens	28%	96%
Q9D0B8	Mus musculus	30%	96%
Q9D4Q1	Mus musculus	30%	96%
Q9H4K1	Homo sapiens	28%	95%
V5BPA3	Trypanosoma cruzi	72%	95%