LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H6A6_LEIBR
TriTrypDb:
LbrM.10.1290 , LBRM2903_100022200 *
Length:
140

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4H6A6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H6A6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 65 69 PF00656 0.391
DEG_SCF_FBW7_2 67 74 PF00400 0.393
DEG_SPOP_SBC_1 61 65 PF00917 0.526
DOC_MAPK_HePTP_8 88 100 PF00069 0.205
DOC_MAPK_MEF2A_6 86 94 PF00069 0.428
DOC_PP2B_LxvP_1 53 56 PF13499 0.442
DOC_USP7_MATH_1 134 138 PF00917 0.510
DOC_USP7_MATH_1 56 60 PF00917 0.451
DOC_USP7_MATH_1 66 70 PF00917 0.438
DOC_WW_Pin1_4 113 118 PF00397 0.608
DOC_WW_Pin1_4 67 72 PF00397 0.509
LIG_Clathr_ClatBox_1 95 99 PF01394 0.208
LIG_EH1_1 81 89 PF00400 0.445
LIG_eIF4E_1 82 88 PF01652 0.336
LIG_FHA_1 62 68 PF00498 0.580
LIG_FHA_1 7 13 PF00498 0.321
LIG_FHA_1 79 85 PF00498 0.392
LIG_FHA_2 63 69 PF00498 0.540
LIG_LIR_Apic_2 116 122 PF02991 0.637
LIG_LIR_Gen_1 9 18 PF02991 0.361
LIG_LIR_Nem_3 9 13 PF02991 0.358
LIG_SH2_CRK 49 53 PF00017 0.355
LIG_SH2_STAT5 28 31 PF00017 0.591
LIG_SH3_3 39 45 PF00018 0.390
LIG_SUMO_SIM_anti_2 17 22 PF11976 0.227
LIG_SUMO_SIM_anti_2 32 39 PF11976 0.363
LIG_SUMO_SIM_anti_2 99 104 PF11976 0.208
LIG_SUMO_SIM_par_1 9 15 PF11976 0.330
LIG_SUMO_SIM_par_1 93 99 PF11976 0.291
LIG_TRFH_1 27 31 PF08558 0.500
LIG_TYR_ITIM 47 52 PF00017 0.324
LIG_UBA3_1 110 115 PF00899 0.349
MOD_CDK_SPxK_1 67 73 PF00069 0.393
MOD_GlcNHglycan 32 35 PF01048 0.316
MOD_GlcNHglycan 49 52 PF01048 0.219
MOD_GlcNHglycan 58 61 PF01048 0.566
MOD_GSK3_1 109 116 PF00069 0.468
MOD_GSK3_1 47 54 PF00069 0.427
MOD_GSK3_1 56 63 PF00069 0.427
MOD_GSK3_1 8 15 PF00069 0.281
MOD_N-GLC_1 61 66 PF02516 0.767
MOD_NEK2_1 98 103 PF00069 0.271
MOD_NEK2_2 104 109 PF00069 0.227
MOD_PK_1 86 92 PF00069 0.407
MOD_Plk_1 98 104 PF00069 0.209
MOD_Plk_4 134 140 PF00069 0.612
MOD_Plk_4 98 104 PF00069 0.370
MOD_ProDKin_1 113 119 PF00069 0.615
MOD_ProDKin_1 67 73 PF00069 0.509
TRG_ENDOCYTIC_2 49 52 PF00928 0.369
TRG_ER_diArg_1 122 125 PF00400 0.602
TRG_NES_CRM1_1 85 99 PF08389 0.191
TRG_Pf-PMV_PEXEL_1 125 129 PF00026 0.376

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I727 Leptomonas seymouri 59% 99%
A0A0S4IN42 Bodo saltans 36% 100%
A0A1X0NQE7 Trypanosomatidae 41% 100%
A0A3S7WRD7 Leishmania donovani 68% 100%
A0A422NBW5 Trypanosoma rangeli 45% 100%
A4HUN0 Leishmania infantum 68% 100%
C9ZVR4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 99%
E9ANC8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%
Q4QH96 Leishmania major 68% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS